Pairwise Alignments

Query, 2413 a.a., non-ribosomal peptide synthetase from Vibrio cholerae E7946 ATCC 55056

Subject, 4328 a.a., Pyoverdine chromophore precursor synthetase PvdL from Pseudomonas fluorescens FW300-N2E2

 Score =  221 bits (562), Expect = 3e-60
 Identities = 241/970 (24%), Positives = 410/970 (42%), Gaps = 92/970 (9%)

Query: 487  RGHIDTQSLHSRLLYLVEHIPALRTRIDQEKWI--QWVSPCIALNWQAIDLQHLSREQAL 544
            RG +D  +L +    L+E   +LRTR  +   +  Q + P        IDL  L  +   
Sbjct: 701  RGELDEDALRTSFQQLIERHESLRTRFLERDGVALQQIDPAGEFKLHVIDLGDLPADSRE 760

Query: 545  LAVEPVRQQYQQRMHDLTRSPWQICVVQLPIEEQEEFSSIVLTSFDALIVDGRTHALIL- 603
                 VR+       DL + P    ++++ +   +E    +L +   +I DG + ++++ 
Sbjct: 761  ARARQVREDEAATPFDLEKGP----LLRVTLLRLDEDDHQLLVTLHHIIADGWSMSVLIE 816

Query: 604  ------AALLGSEEPDITQVVQNARDTQSISPQFASKKAQDE--AYWKSKLHPDCPPPAL 655
                  AA    +  ++  +     D  S   Q+ ++   +   +YWK +L  +     L
Sbjct: 817  EFSRLYAAASQGQVAELAPLPLQYADYGSWQRQWLAQGEAERQLSYWKQQLGAEQSALVL 876

Query: 656  PWKQALETITTSRYARESLQIPKESVGKLNRCGIENGLFLNSLLTATILDVLSYWTTEIG 715
                          AR SL++ K+    L      +      LL A    +L  +T +  
Sbjct: 877  GTDHPRSAQRQRSAARHSLRLDKDLGEALRHVAQAHDATPFMLLLAAFQALLQRYTGQSD 936

Query: 716  MRVGFPVLIPSSNAIDGNESSFVI-------LEHEKSTLSLLSQASKLQ----------- 757
            +R+G P          G    F+        ++  +   +LL+QA +             
Sbjct: 937  IRIGVPNANRPRLETQGLIGFFINTQVLRGQVDSRQPFAALLAQAREATLGAQAHQDLPF 996

Query: 758  REMLEALEHLAFSGVDLNRLLMNQAPQALV----LPVVLTNGLSWKTLNPEDAVTLFDGV 813
             ++LEA+      G  L +++ N   + L     LP +L   L W               
Sbjct: 997  EQLLEAIPEAREQG--LFQVMFNHQQRDLSALRRLPGLLAEELPW--------------- 1039

Query: 814  TQTPQVALDIRLTYDEQKN--LIISFDYALAVLETELIREMLSALHHRLSQITSSASLAA 871
              + +   D++L  +E +N  L +SFDYA  + E   I  + +   + L  + +    A 
Sbjct: 1040 -HSREAKFDLQLHSEEDRNGRLTLSFDYADELFEAATIERLATHYGNLLRAVCAGPQQAI 1098

Query: 872  PLEPCIDLSHYRFNSDESASHDC---DFLAKLAQQLFVRTEDKTAVICGEQTLSYAQLGE 928
               P +    +      SA+       +L +L  +    T  + A+      L YA+L  
Sbjct: 1099 GDVPLLTADEHSQQQQWSAAPCAPASQWLPELLNEQARNTPQRIALRWDGGQLDYAELHA 1158

Query: 929  QVQRVMWQLKARGLTTGNVLAICLPRSVEHIVISLASALSGIIWVPIDAASPKERLNYLL 988
            Q  R+   L+ +G+     +AI   RS + ++  LA   +G  +VP+DA  P ERL Y+L
Sbjct: 1159 QANRLAHYLRDKGVGPDVCVAIAAERSPQLLIGVLAIIKAGGAYVPLDADYPAERLAYML 1218

Query: 989  ENCHADLVVMDKP-------CEFGNVIAFDALIEPVLFADGVPDVTPLDQLSRLSQSQQT 1041
            ++   DL++           C+  +VIA DAL       +  P   P   L         
Sbjct: 1219 DDSGVDLLLTQTALLERLPACDGVSVIAMDAL-----HLEQWPSNPPGLHL----HGDHL 1269

Query: 1042 AYYLYTSGTTGKPKCVVVNNQATSNVIGQTGQAWHLTSEDVVMSVTPLHHDMSVFDLFAT 1101
            AY +YTSG+TG+PK V   + A +  +      + L + DV+M   P+  D+SV++ F  
Sbjct: 1270 AYVIYTSGSTGQPKGVGNTHAALAERLQWMQATYGLDAIDVLMQKAPISFDVSVWECFWP 1329

Query: 1102 LSFGATLVLPAGHEEKDALQWNRLIERHQVTIWVSVPAILEMLLSCTQAGQLHSLRLIAQ 1161
            L  G+ LVL    E +D  +  +L+++  VT    VP +L + +    + +  SLR +  
Sbjct: 1330 LITGSQLVLAGPGEHRDPHRIAQLVQQFGVTTLHFVPPLLSLFVDEPLSARCTSLRRLFS 1389

Query: 1162 GGDYIKPATIAQLRAGSNPPRLISLGGPTETTI-WSIWHELTADDVSVIPYGRPLAGNRY 1220
            GG+ +      ++ A     +L +  GPTET I  + WH  T  D    P GRPL     
Sbjct: 1390 GGEALPAELRNRVLAQLPSVQLHNRYGPTETAINVTHWH-CTEADGERSPIGRPLGNVLC 1448

Query: 1221 FIMDEIQRHVPQGVVGRIFTSGVNLAQGYLEDGELKQTDFVT-VLDEHGHPVRAFRTGDQ 1279
             ++D     VP GV G +   G+ LA+GYL    L    FV   L + G   R +RTGD+
Sbjct: 1449 RVLDSDLNPVPAGVPGELCIGGLGLARGYLGRPGLSAERFVADPLGQAG--ARLYRTGDR 1506

Query: 1280 GYYRADGNIIFASRINGYVKVRGVRVSLPDIEKQLQTHPALASVVVVDYADTNGDTALAA 1339
              + ADG I +  R++  VK+RG RV   +IE +L     +A V V+   +T+    L  
Sbjct: 1507 ARWNADGVIEYLGRLDQQVKLRGFRVEPQEIEARLLAQDGVAQVAVL-VRNTSAGPQLIG 1565

Query: 1340 LFS---VKPQQSASSQALREFAKQSLPSSHIPSRFIALEALPLSANGKVDRK-------Q 1389
             ++   V   Q   +  L+      LP   +P++ + L+ +PLS +GK+DR+       Q
Sbjct: 1566 YYTAPEVAQGQDELNTRLKAALAAELPDYMVPAQLLRLDVMPLSPSGKLDRRALPEPQWQ 1625

Query: 1390 CQAHVQRQSI 1399
             + HV+  S+
Sbjct: 1626 VREHVEPASV 1635



 Score =  210 bits (534), Expect = 5e-57
 Identities = 237/958 (24%), Positives = 396/958 (41%), Gaps = 65/958 (6%)

Query: 475  LGGVAMHEFREYRGHIDTQSLHSRLLYLVEHIPALRTRIDQEKWI--QWVSPCIALNWQA 532
            +GG+A       RG +D     + L  L+     LRT       +  Q V     L    
Sbjct: 1750 VGGMA-----RLRGVLDVGRFEAALQALILRHETLRTTFPSVDGVAHQQVHGETGLRMDW 1804

Query: 533  IDLQHLSREQALLAVEPVRQQYQQRMHDLTRSPW-QICVVQLPIEEQEEFSSI--VLTSF 589
             D   L+ +     V+ +      +  DL   P  + C+V+    E     ++  ++T  
Sbjct: 1805 KDFSMLAFDVREQRVQQLADSEAHKPFDLETGPLLRACLVKTAEHEHYFVLTLHHIVTEG 1864

Query: 590  DALIVDGRTHALILAALLGSEEPDITQVVQNARDTQSISPQF--ASKKAQDEAYWKSKLH 647
             A+ +  R  + +  A +   E  +  +     D      Q+  + ++ +   YW ++L 
Sbjct: 1865 WAMDIFARELSALYEAFIDDRESPLEPLPVQYLDYSVWQRQWLESGERQRQLDYWTTQLG 1924

Query: 648  PDCPPPALPWKQALETITTSRYARESLQIPKESVGKLNRCGIENGLFLNSLLTATILDVL 707
             + P   LP  +   ++ + R       +  +   ++     + GL L   +TA +  +L
Sbjct: 1925 REHPLLELPGDRPRPSVQSHRGELFRFDLSDDLAARVRAFNAQQGLTLFMTMTAALAVLL 1984

Query: 708  SYWTTEIGMRVGFPV---LIPSSNAIDGNESSFVILEHEKSTLSLLSQASKLQREMLEAL 764
              ++ +  +R+G PV   + P S  + G       L  +     L  Q S    E+ E +
Sbjct: 1985 YRYSGQTDLRIGAPVANRIRPESEGLIG-----AFLNTQVLRCQLDGQMSV--GELFEQV 2037

Query: 765  EHLAFSGVDLNRLLMNQAPQALVLP---------VVLTNGLSWKTLNPED--AVTLFDGV 813
             H    G     L  +   +AL  P          V+ N   W+         +T+   V
Sbjct: 2038 RHTVIEGQSHQDLPFDHLVEALQPPRSAAYNPLFQVMCNVQRWEFQQSRTLAGMTVEYLV 2097

Query: 814  TQTPQVALDIRLTY-DEQKNLIISFDYALAVLETELIREMLSALHHRLSQITSSASLAAP 872
                    D+ L   D  + L     Y+  + +   I  M     + L  +    +    
Sbjct: 2098 NDARATKFDLNLEVTDLDQRLGCCLTYSTDLFDEPRIARMAGHWRNLLEALLDDPARRLS 2157

Query: 873  LEPCIDLSHYRFNSD----ESASHDCD-FLAKLAQQLFVRTEDKTAVICGEQTLSYAQLG 927
              P +D    +   D    E   H  D  L +L  +      D  A+    QTL+YAQL 
Sbjct: 2158 ELPLLDTREQQQLLDSLGVEPGEHHLDRCLHELFDEQARMRPDAPALTFAGQTLTYAQLD 2217

Query: 928  EQVQRVMWQLKARGLTTGNVLAICLPRSVEHIVISLASALSGIIWVPIDAASPKERLNYL 987
                R+ W L+ RG+     + + L RS+E ++  LA   +G  +VP+D   P +RL+Y+
Sbjct: 2218 SSANRLAWMLRERGVGPQVRVGLALERSLEMVIGLLAILKAGGAYVPLDPEYPLDRLHYM 2277

Query: 988  LENCHADLVVMDKPCEFGNVIAFDALIEPV---LFADGVPDVT--PLDQLSRLSQSQQTA 1042
            +E+    L++ D+      + A  AL + V      D  P +   P   L  ++  Q  A
Sbjct: 2278 IEDSGISLLLSDR----AMLQALGALPDGVGCWCLEDDSPALAQYPDHALPLINLPQHQA 2333

Query: 1043 YYLYTSGTTGKPKCVVVNNQATSNVIGQTGQAWHLTSEDVVMSVTPLHHDMSVFDLFATL 1102
            Y +YTSG+TGKPK VVV++   +       Q + +  +D  +    ++ D +   L   L
Sbjct: 2334 YLIYTSGSTGKPKGVVVSHGEIAMHCQAVIQRFGMRPDDCELHFYSINFDAATERLLVPL 2393

Query: 1103 SFGATLVLPAGHEEKDALQWNRLIERHQVTIWVSVPAILEMLLS-CTQAGQLHSLRLIAQ 1161
              GA +VL A   + DA +   LI +H++ I    P+    L       GQ   +R+   
Sbjct: 2394 LSGAHVVLRA-QGQWDAEEICGLIRQHRINILGFTPSYGSQLAQWLATQGQTLPVRMCIT 2452

Query: 1162 GGDYIKPATIAQLRAGSNPPRLISLGGPTETTIW---SIWHELTADDVSVIPYGRPLAGN 1218
            GG+ +    + ++RA  NP    +  GPTET +    S+  E   +  + +P G  +   
Sbjct: 2453 GGEALTGEHLQRIRAAFNPSLFFNAYGPTETVVMPLASLAPEQLEEGAASVPIGSVIGAR 2512

Query: 1219 RYFIMDEIQRHVPQGVVGRIFTSGVNLAQGYLEDGELKQTDFVT--VLDEHGHPVRAFRT 1276
              +I+D     VP G  G ++  G  LAQGY +   +    FV      + G   R +RT
Sbjct: 2513 MAYILDADLALVPPGATGELYVGGAGLAQGYHQRPGMTAERFVADPFATDGG---RLYRT 2569

Query: 1277 GDQGYYRADGNIIFASRINGYVKVRGVRVSLPDIEKQLQTHPALASVVVVDYADTNGDTA 1336
            GD    RADG + +  RI+  VK+RG R+ L +IE +L  H A+   VV+   DT G   
Sbjct: 2570 GDLVRQRADGLVEYLGRIDHQVKIRGFRIELGEIETRLLEHDAVREAVVL-ALDTPGGKQ 2628

Query: 1337 LAA--LFSVKPQ----QSASSQALREFAKQSLPSSHIPSRFIALEALPLSANGKVDRK 1388
            LA   +  V  Q    Q+A   AL+   K  LP   +P+  I L ++PL+ANGK+DR+
Sbjct: 2629 LAGYLVSDVASQDDGRQAALRDALKNHLKAQLPDYMVPTHLILLASMPLTANGKLDRR 2686



 Score =  161 bits (408), Expect = 2e-42
 Identities = 135/497 (27%), Positives = 232/497 (46%), Gaps = 23/497 (4%)

Query: 911  KTAVICGEQTLSYAQLGEQVQRVMWQLKARGLTTGNVLAICLPRSVEHIVISLASALSGI 970
            + AV C + + SYA+L  +  R+   L A G+     +A+   R  E + + + S  +G 
Sbjct: 3730 RPAVSCLDTSYSYAELNARSNRLGHALIAAGVGLDQPVALLAERDAELLGMIVGSFKAGA 3789

Query: 971  IWVPIDAASPKERLNYLLENCHADLVVMDKPCEFGNVIAFDALI----EPVLFADGVP-D 1025
             ++P+D   P +RL  ++E     L+V  + C+       D         +L  + V   
Sbjct: 3790 GYLPLDPGLPSQRLGRIIELSRTPLLVCTQACQAQAQALLDEFACSGRPKLLVWEAVQAS 3849

Query: 1026 VTPLDQLSRLSQSQQTAYYLYTSGTTGKPKCVVVNNQATSNVIGQTGQAWHLTSEDVVMS 1085
               L+     S     AY +YTSG+TG PK V+V  +   N          L+  DV+  
Sbjct: 3850 ALSLENPGVYSGPDNLAYVIYTSGSTGLPKGVMVEQRGMLNNQLSKVPYLALSEVDVIAQ 3909

Query: 1086 VTPLHHDMSVFDLFATLSFGATL-VLP--AGHEEKDALQWNRLIERHQVTIWVSVPAILE 1142
                  D+SV+   A   FGA + ++P    H+ +  L+    +++  +T+  SVP++++
Sbjct: 3910 TASQSFDISVWQFLAAPLFGARVDIVPNAIAHDPQGLLEH---VQQQGITVLESVPSLIQ 3966

Query: 1143 MLLSCTQAGQLHSLRLIAQGGDYIKPATIAQLRAGSNPPRLISLGGPTETT--IWSIWHE 1200
             +L+  + G L  LR +   G+ + P    Q         L++  GP E +  +     +
Sbjct: 3967 GMLAQERIG-LDGLRWMLPTGEAMPPELAHQWLLRYPDIGLVNAYGPAECSDDVAFFRVD 4025

Query: 1201 LTADDVSVIPYGRPLAGNRYFIMDEIQRHVPQGVVGRIFTSGVNLAQGYLEDGELKQTDF 1260
            L +   + +P G P   NR +++D     VP G VG +  +G+ + +GY+ D    +T  
Sbjct: 4026 LASTRGTYLPIGTPTDNNRLYLLDGALDLVPLGAVGELCVAGIGVGRGYVSDP--LRTAP 4083

Query: 1261 VTVLDEHGHP-VRAFRTGDQGYYRADGNIIFASRINGYVKVRGVRVSLPDIEKQLQTHPA 1319
            V V +  G P  R +RTGD    R+DG + +  RI+  VK+RG R+ L +IE +L   P 
Sbjct: 4084 VFVPNPFGAPGERLYRTGDLARRRSDGVLEYVGRIDHQVKIRGYRIELGEIEARLHEQPE 4143

Query: 1320 LASVVVVDYADTNGDTALAALF----SVKPQQSASSQALREFAKQSLPSSHIPSRFIALE 1375
            +    V      NG   +  L     ++KP +    + +++  +  LP   +P  ++ LE
Sbjct: 4144 VRDGAVGVQEGVNGKHLVGYLVATDSALKPAERL--ERIKQRLRAELPEYMVPLHWLWLE 4201

Query: 1376 ALPLSANGKVDRKQCQA 1392
             LPL+ANGK+DRK   A
Sbjct: 4202 RLPLNANGKLDRKALPA 4218



 Score =  143 bits (361), Expect = 6e-37
 Identities = 142/567 (25%), Positives = 244/567 (43%), Gaps = 27/567 (4%)

Query: 1808 VAAIGGRTMPSSTTSSSHVSAIELTSNNPPTSNNAHAALAESELELSAVNSSAVEECILA 1867
            VA +    +P +++     SA      +    + A    AE E    +  SS ++  I  
Sbjct: 528  VALLNPGALPKTSSGKLQRSACRSRLADGSLDSYAQFPSAEVEDADESAPSSELQTLIGQ 587

Query: 1868 EFRSALGVAEMTAEDDFFDFGGHSLIATRVIGRLLSEQGIELHINDMFSFPNAKQLAQQA 1927
             +R  L V ++ A+D FF  GG+S+ AT++I RL    G+EL++  +F  P     A+  
Sbjct: 588  IWREQLQVEQVQADDHFFLLGGNSIAATQMIARLREILGLELNLRLLFEAPTLAAFAEAV 647

Query: 1928 VLHRKP-TSTSFAVSEVVESSKAPLSLAQASLWKAMSKYAKFGLTHIFNLPFALKFLDEV 1986
               ++       A+S +      P SLAQ  LW     +     +H +N+P AL    E+
Sbjct: 648  ANQQQDGGQPQGAISALSRDEALPQSLAQNRLW---ITWRLDPTSHAYNIPGALHLRGEL 704

Query: 1987 NEQAFGEAFHWLLLRHAGLRTHFGLEDGQPYQHVIAASNIE-HYQWFWTSKDNAAQSVAR 2045
            +E A   +F  L+ RH  LRT F   DG   Q +  A   + H         ++ ++ AR
Sbjct: 705  DEDALRTSFQQLIERHESLRTRFLERDGVALQQIDPAGEFKLHVIDLGDLPADSREARAR 764

Query: 2046 LLAQ-EAEHTFDLSQELPLRLNFVRDEQTGTQYLSLLFHHIVLDEWSINILMDELAQVYQ 2104
             + + EA   FDL +   LR+  +R ++   Q L  L HHI+ D WS+++L++E +++Y 
Sbjct: 765  QVREDEAATPFDLEKGPLLRVTLLRLDEDDHQLLVTL-HHIIADGWSMSVLIEEFSRLYA 823

Query: 2105 HSVQGTRPQWQTEPLPFHEFARKQR---SSAFNQTHLNYWLTKFAGVPWAQPLFAADHPL 2161
             + QG   +    PL + ++   QR   +    +  L+YW  +  G   +  +   DHP 
Sbjct: 824  AASQGQVAELAPLPLQYADYGSWQRQWLAQGEAERQLSYWKQQL-GAEQSALVLGTDHPR 882

Query: 2162 SNSTGVDLGEGGWVEIKLPKSTMVSLYQLAKARHASLFNVMYAAISASVHCLGAPEKLLV 2221
            S              ++L K    +L  +A+A  A+ F ++ AA  A +        + +
Sbjct: 883  SAQRQRSAARH---SLRLDKDLGEALRHVAQAHDATPFMLLLAAFQALLQRYTGQSDIRI 939

Query: 2222 GTPASGRLDAEFFDTVGYFTTMGVQLVDFTKVQTVWQLIEQVKNSINQSMPYTDIPIDLI 2281
            G P + R   E    +G+F    V        Q    L+ Q + +   +  + D+P    
Sbjct: 940  GVPNANRPRLETQGLIGFFINTQVLRGQVDSRQPFAALLAQAREATLGAQAHQDLP---F 996

Query: 2282 EEGLKGVEHETEGHMFEVFI-----QLHAKNKLHG---ELLLTEGHAIRFQ-QVDPDKSE 2332
            E+ L+ +    E  +F+V        L A  +L G   E L       +F  Q+  ++  
Sbjct: 997  EQLLEAIPEAREQGLFQVMFNHQQRDLSALRRLPGLLAEELPWHSREAKFDLQLHSEEDR 1056

Query: 2333 SG-LGLQFEILEERIEQKQTLRVMMSY 2358
            +G L L F+  +E  E     R+   Y
Sbjct: 1057 NGRLTLSFDYADELFEAATIERLATHY 1083



 Score =  134 bits (338), Expect = 3e-34
 Identities = 131/563 (23%), Positives = 228/563 (40%), Gaps = 46/563 (8%)

Query: 1858 SSAVEECILAEFRSALGVAEMTAEDDFFDFGGHSLIATRVIGRLLSEQGIELHINDMFSF 1917
            +S +E+ I   +R  LG+A +   DDFF  GGHSL+AT++I R      +EL +  +F  
Sbjct: 1633 ASVLEQQIAGIWRQVLGLARIGLRDDFFALGGHSLLATQIISRTRQTCDVELPLRTLFEA 1692

Query: 1918 PNAKQLAQQAVL-------HRKPTSTSFAVSEVVESSKAPLSLAQASLWKAMSKYAKFGL 1970
                  A+Q  L       +R+P      + +V  S   PLS +Q  +W           
Sbjct: 1693 SELGAFAEQVRLIQASGQANRQP-----PIEKVDRSQPVPLSYSQQRMWFLWQMEPD--- 1744

Query: 1971 THIFNLPFALKFLDEVNEQAFGEAFHWLLLRHAGLRTHFGLEDGQPYQHVIAASNI--EH 2028
            +  +N+    +    ++   F  A   L+LRH  LRT F   DG  +Q V   + +  + 
Sbjct: 1745 SPAYNVGGMARLRGVLDVGRFEAALQALILRHETLRTTFPSVDGVAHQQVHGETGLRMDW 1804

Query: 2029 YQWFWTSKDNAAQSVARLLAQEAEHTFDLSQELPLRLNFVRDEQTGTQYLSLLFHHIVLD 2088
              +   + D   Q V +L   EA   FDL     LR   V+  +    Y  L  HHIV +
Sbjct: 1805 KDFSMLAFDVREQRVQQLADSEAHKPFDLETGPLLRACLVKTAE-HEHYFVLTLHHIVTE 1863

Query: 2089 EWSINILMDELAQVYQHSVQGTRPQWQTEPLPFHEFARKQR---SSAFNQTHLNYWLTKF 2145
             W+++I   EL+ +Y+  +       +  P+ + +++  QR    S   Q  L+YW T+ 
Sbjct: 1864 GWAMDIFARELSALYEAFIDDRESPLEPLPVQYLDYSVWQRQWLESGERQRQLDYWTTQ- 1922

Query: 2146 AGVPWAQPLFAADHPLSNSTG------VDLGEGGWVEIKLPKSTMVSLYQLAKARHASLF 2199
                        +HPL    G      V    G      L       +      +  +LF
Sbjct: 1923 ---------LGREHPLLELPGDRPRPSVQSHRGELFRFDLSDDLAARVRAFNAQQGLTLF 1973

Query: 2200 NVMYAAISASVHCLGAPEKLLVGTPASGRLDAEFFDTVGYFTTMGVQLVDFTKVQTVWQL 2259
              M AA++  ++       L +G P + R+  E    +G F    V         +V +L
Sbjct: 1974 MTMTAALAVLLYRYSGQTDLRIGAPVANRIRPESEGLIGAFLNTQVLRCQLDGQMSVGEL 2033

Query: 2260 IEQVKNSINQSMPYTDIPIDLIEEGLKGVEHETEGHMFEVFIQLHAKNKLHGELLLTEGH 2319
             EQV++++ +   + D+P D + E L+         +F+V   +          L   G 
Sbjct: 2034 FEQVRHTVIEGQSHQDLPFDHLVEALQPPRSAAYNPLFQVMCNVQRWEFQQSRTL--AGM 2091

Query: 2320 AIRFQQVDPDKSESGLGLQFEILEERIEQKQTLRVMMSYMSKHYSPAQVALLTKVTSGMF 2379
             + +   D   ++  L L+   L++R      L   ++Y +  +   ++A +      + 
Sbjct: 2092 TVEYLVNDARATKFDLNLEVTDLDQR------LGCCLTYSTDLFDEPRIARMAGHWRNLL 2145

Query: 2380 ERFSDCIAQDIA-LPTLKKQVRQ 2401
            E   D  A+ ++ LP L  + +Q
Sbjct: 2146 EALLDDPARRLSELPLLDTREQQ 2168



 Score = 80.9 bits (198), Expect = 5e-18
 Identities = 136/576 (23%), Positives = 221/576 (38%), Gaps = 78/576 (13%)

Query: 1789 LALDATVSPHVGAYLLEQFVAAIGGRTMPSSTTSSSHVSA----------IELTSNNPPT 1838
            LALD      +  YL+    +   GR         +H+ A          + L ++ P T
Sbjct: 2619 LALDTPGGKQLAGYLVSDVASQDDGRQAALRDALKNHLKAQLPDYMVPTHLILLASMPLT 2678

Query: 1839 SNNA--HAALAESELELSAVN----SSAVEECILAEFRSALGVAEMTAEDDFFDFGGHSL 1892
            +N      AL   + EL+  +    S+A+E+ + A +   L V ++   D+FF+ GG S+
Sbjct: 2679 ANGKLDRRALPMPDPELNRQHYVAPSNALEQTLAAIWCDVLNVTQVGLNDNFFELGGDSI 2738

Query: 1893 IATRVIGRLLSEQGIELHINDMFSFPNAKQLAQQAVLHRKPTSTSFAVSEVVESSKAPLS 1952
            ++ +V+ R   +QGI     D+F     + LA  A   ++  +    +    ES   P+ 
Sbjct: 2739 LSIQVVSRA-RQQGIHFTPRDLFQHQTVQTLAAVATRSQQVLAEQGLLQG--ESGLTPIQ 2795

Query: 1953 LAQASLWKAMSKYAKFGLTHIFNLPFALKFLDEVNEQAFGEAFHWLLLRHAGLRTHFGLE 2012
                  W            H +N    L+    +  Q   +A   LL  H  LR  F   
Sbjct: 2796 H-----WFFERPIPN---RHHWNQALVLEPTTALAPQPLEQALRSLLQHHDALRLGFDES 2847

Query: 2013 DGQ---PYQHVIAASNIEHYQWFWTSKDNAAQSVARLLAQEAEHTFDLSQELPLRLNFVR 2069
             G     +Q +  A+ + H      S D A    A  L  E +  F+L+   PL    + 
Sbjct: 2848 TGHWQAEHQPLSDAALLRH-----VSVDTAQDCEA--LFAETQSRFNLATG-PLLRAVLA 2899

Query: 2070 DEQTGTQYLSLLFHHIVLDEWSINILMDELAQVYQHSVQGTRPQWQTEPLPFHEFARKQR 2129
                G Q L ++ HH+V+D  S  +LMD+L  VY+    G   Q   +  P  ++A + +
Sbjct: 2900 QFPDGQQRLLIVIHHLVVDGVSWRVLMDDLQTVYRPLAIGQAAQLSAKTSPMRDWAARLQ 2959

Query: 2130 SSAFNQT---HLNYWLTKFAGVPWAQPLFAADHPLSNSTGVDL-GEGGWVEIKLPKSTMV 2185
            + A +++    L +W  + +G     PL     P +N  G  L      V ++L      
Sbjct: 2960 AYAGSESLREELAWWQAQLSGA--QVPL-----PCANPEGGLLERHAETVSVRLDAERTR 3012

Query: 2186 SLYQLAKARHASLFNVMYAAISASVHC-LGAPEKLLVGTPASGRLDAEFFDTVGYFTTMG 2244
             L Q A + + +  N +     A V C        LV     GR     FD +    T+G
Sbjct: 3013 QLLQQAPSAYRTQVNDLLLTALARVLCRWSGHASTLVQLEGHGR--EALFDDIDLTRTVG 3070

Query: 2245 VQLVDFTKVQTVWQLIEQVKNSINQSMPYTDIPIDLIEEGLKGVEHETEGH-----MFEV 2299
                 FT V  V          ++ +       I  I+E L+ V H+  GH     + + 
Sbjct: 3071 W----FTSVYPV---------RLSPATEGFGASIKAIKEQLRAVPHKGLGHGVLRYLADA 3117

Query: 2300 FIQLHAKNKLH--------GELLLTEGHAIRFQQVD 2327
              +    N  H        G+L  T GH   FQ +D
Sbjct: 3118 ATRQTMANLPHAAITFNYLGQLDQTLGHDALFQPLD 3153



 Score = 74.7 bits (182), Expect = 3e-16
 Identities = 128/566 (22%), Positives = 222/566 (39%), Gaps = 68/566 (12%)

Query: 921  LSYAQLGEQVQRVMWQLKARGLTTGNVLAICLPRSVEHIVISLASALSGIIWVPIDAASP 980
            LSY  L  + + +   L+A     G+   +  P   +++        +G+I VP  A  P
Sbjct: 41   LSYRDLDLRARTIAAALQAEA-ALGDRAVLLFPSGPDYVAAFFGCLYAGVIAVP--AYPP 97

Query: 981  KERLNYLLENCHADLVVMDKPCEFGNVIAFDALIEPVLFADGVPDVTPLDQL--SRLSQ- 1037
            +    +  E     L+ +    E   ++    L EP+   +  P V  +D L  SR  Q 
Sbjct: 98   ESTRRHHQER----LLSIIADAEPRLLLTRSDLREPLQAIESAPPVLCVDTLDPSRAGQW 153

Query: 1038 ------SQQTAYYLYTSGTTGKPKCVVVN--NQATSNVIGQTGQAWHLTSEDVVMSVTPL 1089
                      A+  YTSG+T  PK V V+  N   + ++ + G    L  +DV++S  PL
Sbjct: 154  RMPTLQDDDIAFLQYTSGSTALPKGVQVSHGNLVANELLIRHGFGIDLNPDDVIVSWLPL 213

Query: 1090 HHDMSVFD-LFATLSFGATLVLPA-GHEEKDALQWNRLIERHQVTIWVSVPAILEMLL-- 1145
            +HDM +   L   +  G   VL +  +     L+W   I  +  TI         +    
Sbjct: 214  YHDMGLIGGLLQPVFSGVPCVLMSPAYFLARPLRWLEAISEYGGTISGGPDFAYRLCSER 273

Query: 1146 ---SCTQAGQLHSLRLIAQGGDYIKPATIAQLR-----AGSNPPRLISLGGPTETTIWSI 1197
               S  Q   L   R+   G + I+  T+ +        G  P   ++  G  E T++  
Sbjct: 274  VSDSALQRLDLSGWRVAYSGSEPIRLDTLERFAEKFAPCGFTPDNFMASYGLAEATLFVA 333

Query: 1198 WH-------ELTADDVS-------------VIPYGRPLAGNRYFIMDEIQRH-VPQGVVG 1236
                      L  DD +             V+  G    G+   I++      +    VG
Sbjct: 334  GTPRRHGIPSLRVDDAALAQNRAEPGQGSAVMSCGVSQPGHAVLIVEPATAQPLADNQVG 393

Query: 1237 RIFTSGVNLAQGYLEDGELKQTDFVTVLDEHGHPVRAF-RTGDQGYYRADGNIIFASRIN 1295
             ++ +G ++A GY  + E     FV       H  R + RTGD G+ R DG +    R+ 
Sbjct: 394  EVWAAGPSIALGYWRNPEASAKTFVQ------HDGRTWLRTGDLGFLR-DGELFITGRLK 446

Query: 1296 GYVKVRGVRVSLPDIEKQLQTH-PALASVVVVDYADTNGDT---ALAALFSVKPQQSASS 1351
              + VRG  +   DIE+ ++     +    V  +A  +G      +AA  S   Q+    
Sbjct: 447  DLLIVRGHNLYPQDIEQAIEREVEVVRKGRVAAFAVNDGGEEGIGIAAEISRSVQKILPP 506

Query: 1352 QALREFAKQSLPSS--HIPSRFIALE--ALPLSANGKVDRKQCQAHVQRQSISVEPVGQP 1407
            +AL +  +Q++  +    PS    L   ALP +++GK+ R  C++ +   S+       P
Sbjct: 507  EALIKAIRQAVAEACQQAPSVVALLNPGALPKTSSGKLQRSACRSRLADGSLD-SYAQFP 565

Query: 1408 NQSQPLSPPTLSSASLSEFEQRVWRQ 1433
            +     +  +  S+ L     ++WR+
Sbjct: 566  SAEVEDADESAPSSELQTLIGQIWRE 591



 Score = 69.7 bits (169), Expect = 1e-14
 Identities = 120/497 (24%), Positives = 197/497 (39%), Gaps = 41/497 (8%)

Query: 25   AAHLYAEFDGQALNRQALTEAVRALYAKHPMLRLA-ITKDGQ--QKILPLSTFHQLKVDD 81
            A HL  E D       AL  + + L  +H  LR   + +DG   Q+I P   F +L V D
Sbjct: 697  ALHLRGELD-----EDALRTSFQQLIERHESLRTRFLERDGVALQQIDPAGEF-KLHVID 750

Query: 82   LSQWKPDEVESFVHTKRQRMTHQMLDLTQGNPIEISLTLLPEGKHRLHIDADMIACDAQS 141
            L     D  E+     R+       DL +G  + ++L  L E  H+L +    I  D  S
Sbjct: 751  LGDLPADSREARARQVREDEAATPFDLEKGPLLRVTLLRLDEDDHQLLVTLHHIIADGWS 810

Query: 142  FRLLVDDLTSLYLEAIEHRLEIIESDVVTFFQYLDAQQADRALAKRKEVDKK--WWQERL 199
              +L+++ + LY  A + ++  +    +   QY D     R    + E +++  +W+++L
Sbjct: 811  MSVLIEEFSRLYAAASQGQVAELAPLPL---QYADYGSWQRQWLAQGEAERQLSYWKQQL 867

Query: 200  ATIPAEPSLPYQPVPTDAV-SANSQRFAHWFTPVERKGLAE----VARQHHLTLTQLTLA 254
                AE S     + TD   SA  QR A   +    K L E    VA+ H  T   L LA
Sbjct: 868  G---AEQSALV--LGTDHPRSAQRQRSAARHSLRLDKDLGEALRHVAQAHDATPFMLLLA 922

Query: 255  LFSQVIANACQERQFRLNVPTFHRGNRSLDIEHTIGDFSNLLIFSADVGTTQTLLSLCQQ 314
             F  ++     +   R+ VP  +R    L+ +  IG F N  +    V + Q   +L  Q
Sbjct: 923  AFQALLQRYTGQSDIRIGVPNANRPR--LETQGLIGFFINTQVLRGQVDSRQPFAALLAQ 980

Query: 315  TANQLHQLLRHESYSGVSVMRDL--SRKQGGVQRSPIVFTSGMEMRDEEIFSDHVTQHLG 372
                      H+      ++  +  +R+QG  Q   ++F    + RD             
Sbjct: 981  AREATLGAQAHQDLPFEQLLEAIPEAREQGLFQ---VMFNH--QQRDLSALRRLPGLLAE 1035

Query: 373  RMNWVISQGAQVTLDAQIAPAYEGIL-LNWDVRMENFADKDITALFAHYVDLIRCVALHP 431
             + W  S+ A+  L         G L L++D   E F    I  L  HY +L+R V   P
Sbjct: 1036 ELPWH-SREAKFDLQLHSEEDRNGRLTLSFDYADELFEAATIERLATHYGNLLRAVCAGP 1094

Query: 432  EMMQQSVQQIDAQLGYARRESIQEMPLTPLQQ--AYLLGRSTQIALGGVAMHEFREYRGH 489
            +     V  + A   +++++     P  P  Q    LL    +     +A+   R   G 
Sbjct: 1095 QQAIGDVPLLTAD-EHSQQQQWSAAPCAPASQWLPELLNEQARNTPQRIAL---RWDGGQ 1150

Query: 490  IDTQSLHSRLLYLVEHI 506
            +D   LH++   L  ++
Sbjct: 1151 LDYAELHAQANRLAHYL 1167



 Score = 67.4 bits (163), Expect = 5e-14
 Identities = 69/323 (21%), Positives = 130/323 (40%), Gaps = 14/323 (4%)

Query: 1971 THIFNLPFALKFLDEVNEQAFGEAFHWLLLRHAGLRTHFGLEDGQPYQHVI---AASNIE 2027
            T ++ +    +   E++ Q F +A+  ++ RH  LR  F    G+    +I    ++ ++
Sbjct: 3271 TGLYYMQDRYRINSELDPQRFAQAWQAVIARHEALRASFCWNVGEDMLQIIHRPGSTPVD 3330

Query: 2028 HYQWFWTSKDNAAQSVARLLAQEAEHTFDLSQELPLRLNFVRDEQTGTQYLSLLFHHIVL 2087
            +  W    +D     +  LL  E E  FDL  + P  L  +R       +  +  HHI++
Sbjct: 3331 YLDWSEVPEDAQEAKLQALLKNEREAGFDLLNQAPFHLRLIR-VGAARYWFMMSNHHILI 3389

Query: 2088 DEWSINILMDELAQVYQHSVQGTRPQWQTEPLPFHEFARKQRSSAFNQTHLNYWLTKFAG 2147
            D W  ++LMD+  ++Y    +   PQ  T P  + ++    +  +  +    +W     G
Sbjct: 3390 DAWCRSLLMDDFFEIYTALGENREPQ-LTVPPRYRDYIGWLQHQSLAEAR-QWWQRNLQG 3447

Query: 2148 VPWAQPLFAADHPLSNSTGVDLGE--GGWVEIKLPKSTMVSLYQLAKARHASLFNVMYAA 2205
                 P+   D P       D G    G    +L       L +LA+A   ++     AA
Sbjct: 3448 FERTTPI-PGDRPFLREHAGDSGGMIVGDCYTRLDARDGARLRELAQAHQLTVNTFAQAA 3506

Query: 2206 ISASVHCLGAPEKLLVGTPASGRLD--AEFFDTVGYF---TTMGVQLVDFTKVQTVWQLI 2260
             +  +  +     +L G   +GR     +   TVG F     + VQ+ +  +  +V Q +
Sbjct: 3507 WALVLRRVSGDRDVLFGVTVAGRPVELPQMQRTVGLFINSIALRVQMPEDHQRCSVRQWL 3566

Query: 2261 EQVKNSINQSMPYTDIPIDLIEE 2283
              + +   Q   Y  +P+  I+E
Sbjct: 3567 SDLLDHNMQLREYEYLPLVSIQE 3589



 Score = 43.5 bits (101), Expect = 8e-07
 Identities = 103/514 (20%), Positives = 195/514 (37%), Gaps = 66/514 (12%)

Query: 36   ALNRQALTEAVRALYAKHPMLRLAI---TKDGQQKILPLSTFHQLKVDDLSQWKPDEVES 92
            AL  Q L +A+R+L   H  LRL     T   Q +  PLS    L+   +S     + E+
Sbjct: 2820 ALAPQPLEQALRSLLQHHDALRLGFDESTGHWQAEHQPLSDAALLR--HVSVDTAQDCEA 2877

Query: 93   FVHTKRQRMTHQMLDLTQGNPIEISLTLLPEGKHRLHIDADMIACDAQSFRLLVDDLTSL 152
                 + R      +L  G  +   L   P+G+ RL I    +  D  S+R+L+DDL ++
Sbjct: 2878 LFAETQSRF-----NLATGPLLRAVLAQFPDGQQRLLIVIHHLVVDGVSWRVLMDDLQTV 2932

Query: 153  YLEAIEHRLEIIESDVVTFFQYLDAQQADRALAKRKEVDKKWWQERL--ATIP-----AE 205
            Y      +   + +       +    QA       +E +  WWQ +L  A +P      E
Sbjct: 2933 YRPLAIGQAAQLSAKTSPMRDWAARLQAYAGSESLRE-ELAWWQAQLSGAQVPLPCANPE 2991

Query: 206  PSLPYQPVPTDAVSANSQRFAHWFTPVERKGLAEVARQHHLTLTQLTLALFSQVIANACQ 265
              L  +   T +V  +++R         R+ L +    +   +  L L   ++V+     
Sbjct: 2992 GGLLERHAETVSVRLDAER--------TRQLLQQAPSAYRTQVNDLLLTALARVLCRWSG 3043

Query: 266  ERQFRLNVPTFHRGN--RSLDIEHTIGDFSNLL---IFSADVGTTQTLLSLCQQTANQLH 320
                 + +    R      +D+  T+G F+++    +  A  G   ++ ++ +Q     H
Sbjct: 3044 HASTLVQLEGHGREALFDDIDLTRTVGWFTSVYPVRLSPATEGFGASIKAIKEQLRAVPH 3103

Query: 321  QLLRHESYSGVSVMRDLSRKQ--GGVQRSPIVFTSGMEMRDEEIFSDHVTQHLGRMNWVI 378
            + L H     +  + D + +Q    +  + I F + +   D+ +  D + Q L      I
Sbjct: 3104 KGLGH---GVLRYLADAATRQTMANLPHAAITF-NYLGQLDQTLGHDALFQPLDAPLGAI 3159

Query: 379  SQ-----GAQVTLDAQIAPAYEGILLNWDVRMENFADKDITALFAHYVDLIRCVALH--- 430
                     ++++D+Q++     +LL W    E    + I  L   Y+D ++ +  H   
Sbjct: 3160 HDPDAPLPNELSVDSQVSGG--ELLLRWTFSRERHDRQAIATLAGAYLDELQRLIEHCLT 3217

Query: 431  -------------PEMMQQSVQQIDAQLGYARRESIQEM-PLTPLQQAYLLGRSTQIALG 476
                          ++ Q  +  +    G      I+++ PLTP+Q+  LL    +   G
Sbjct: 3218 DEAGGLTPSDFPLAKLTQGQLDSLPVPAG-----QIEDVYPLTPMQEGMLLHTLLEPGTG 3272

Query: 477  GVAMHEFREYRGHIDTQSLHSRLLYLVEHIPALR 510
               M +       +D Q        ++    ALR
Sbjct: 3273 LYYMQDRYRINSELDPQRFAQAWQAVIARHEALR 3306



 Score = 40.8 bits (94), Expect = 5e-06
 Identities = 60/307 (19%), Positives = 113/307 (36%), Gaps = 28/307 (9%)

Query: 37   LNRQALTEAVRALYAKHPMLRLAITKD-GQQKILPLSTFHQLKVD--DLSQWKPDEVESF 93
            L+ Q   +A +A+ A+H  LR +   + G+  +  +       VD  D S+   D  E+ 
Sbjct: 3286 LDPQRFAQAWQAVIARHEALRASFCWNVGEDMLQIIHRPGSTPVDYLDWSEVPEDAQEAK 3345

Query: 94   VHTKRQRMTHQMLDLTQGNPIEISLTLLPEGKHRLHIDADMIACDAQSFRLLVDDLTSLY 153
            +    +       DL    P  + L  +   ++   +    I  DA    LL+DD   +Y
Sbjct: 3346 LQALLKNEREAGFDLLNQAPFHLRLIRVGAARYWFMMSNHHILIDAWCRSLLMDDFFEIY 3405

Query: 154  LEAIEHRLEIIE-----SDVVTFFQYLDAQQADRALAKRKEVDKKWWQERL----ATIPA 204
                E+R   +       D + + Q+    +A           ++WWQ  L     T P 
Sbjct: 3406 TALGENREPQLTVPPRYRDYIGWLQHQSLAEA-----------RQWWQRNLQGFERTTPI 3454

Query: 205  EPSLPYQPVPTDAVSANSQRFAHWFTPVERKG---LAEVARQHHLTLTQLTLALFSQVIA 261
                P+  +   A  +        +T ++ +    L E+A+ H LT+     A ++ V+ 
Sbjct: 3455 PGDRPF--LREHAGDSGGMIVGDCYTRLDARDGARLRELAQAHQLTVNTFAQAAWALVLR 3512

Query: 262  NACQERQFRLNVPTFHRGNRSLDIEHTIGDFSNLLIFSADVGTTQTLLSLCQQTANQLHQ 321
                +R     V    R      ++ T+G F N +     +       S+ Q  ++ L  
Sbjct: 3513 RVSGDRDVLFGVTVAGRPVELPQMQRTVGLFINSIALRVQMPEDHQRCSVRQWLSDLLDH 3572

Query: 322  LLRHESY 328
             ++   Y
Sbjct: 3573 NMQLREY 3579



 Score = 37.4 bits (85), Expect = 6e-05
 Identities = 25/98 (25%), Positives = 42/98 (42%), Gaps = 8/98 (8%)

Query: 1861 VEECILAEFRSALGVAEMTAEDDFFDFGGHSLIATRVIGRLLSEQGIELHINDMFSFPNA 1920
            +E+ +   +   L V  +   D+FF+ GGHSL+AT++  R+       + +  MF     
Sbjct: 4236 LEQTLADIWAQVLKVERVGVRDNFFELGGHSLLATQIASRVQKALQRNVPLRAMFECSTV 4295

Query: 1921 KQLAQQAVLHRKPTSTSFAVSEVVESSKAPLSLAQASL 1958
            ++LA              A SE+ E     L+   A L
Sbjct: 4296 QELADYI--------DGLAASEITEEKVDRLNDLMAEL 4325



 Score = 31.2 bits (69), Expect = 0.004
 Identities = 33/122 (27%), Positives = 49/122 (40%), Gaps = 9/122 (7%)

Query: 1447 AYRLSGKVNIARLITALSQLPNHFPVLNRRYVLDEASGLTLYSAKPT-PLEIHFEHVESM 1505
            A  L G+++   L T+  QL      L  R++  E  G+ L    P    ++H   +  +
Sbjct: 697  ALHLRGELDEDALRTSFQQLIERHESLRTRFL--ERDGVALQQIDPAGEFKLHVIDLGDL 754

Query: 1506 D----EAFEHLVRWQNQ--PMDLAKQATLSFCLLSLGSEERVLGVISHQIISEQWDWRRV 1559
                 EA    VR      P DL K   L   LL L  ++  L V  H II++ W    +
Sbjct: 755  PADSREARARQVREDEAATPFDLEKGPLLRVTLLRLDEDDHQLLVTLHHIIADGWSMSVL 814

Query: 1560 FE 1561
             E
Sbjct: 815  IE 816



 Score = 31.2 bits (69), Expect = 0.004
 Identities = 34/167 (20%), Positives = 61/167 (36%), Gaps = 19/167 (11%)

Query: 1401 VEPVGQPNQSQPLSPPTLSS-ASLSEFEQRVWRQHQRHGDG-RNQYATAYRLSGKVNIAR 1458
            ++  GQ N+  P+     S    LS  +QR+W   Q   D          RL G +++ R
Sbjct: 1705 IQASGQANRQPPIEKVDRSQPVPLSYSQQRMWFLWQMEPDSPAYNVGGMARLRGVLDVGR 1764

Query: 1459 LITALSQL-----------PNHFPVLNRRYVLDEASGLTLYSAKPTPLEIHFEHVESMDE 1507
               AL  L           P+   V +++   +    +          ++  + V+ + +
Sbjct: 1765 FEAALQALILRHETLRTTFPSVDGVAHQQVHGETGLRMDWKDFSMLAFDVREQRVQQLAD 1824

Query: 1508 AFEHLVRWQNQPMDLAKQATLSFCLLSLGSEERVLGVISHQIISEQW 1554
            +  H      +P DL     L  CL+     E    +  H I++E W
Sbjct: 1825 SEAH------KPFDLETGPLLRACLVKTAEHEHYFVLTLHHIVTEGW 1865