Pairwise Alignments

Query, 2413 a.a., non-ribosomal peptide synthetase from Vibrio cholerae E7946 ATCC 55056

Subject, 5372 a.a., Amino acid adenylation from Pseudomonas syringae pv. syringae B728a

 Score =  224 bits (570), Expect = 4e-61
 Identities = 153/503 (30%), Positives = 249/503 (49%), Gaps = 44/503 (8%)

Query: 907  RTEDKTAVICGEQTLSYAQLGEQVQRVMWQLKARGLTTGNVLAICLPRSVEHIVISLASA 966
            RT +  AV+ GEQ LSY QL E+  R+   L+ +G+   + + IC+ R  E +V  LA  
Sbjct: 4807 RTPEALAVVHGEQRLSYRQLNERANRLAHALRKQGVQPDSRVGICVERGPEMVVGLLAIL 4866

Query: 967  LSGIIWVPIDAASPKERLNYLLENCHADLVVMDKPCEFGNVIAFDALIEPVLFADGVPDV 1026
             +G  +VP+D A P +R+ Y+L++     V+     +              L AD    V
Sbjct: 4867 KAGGGYVPLDPAYPVDRIAYMLQDSAPAAVLAQTATQS-------------LLADVSVPV 4913

Query: 1027 TPLDQLSRLSQSQQT-----------AYYLYTSGTTGKPKCVVVNNQATSNVIGQTGQAW 1075
              LDQ S   +S Q            AY +YTSG+TG PK V++ ++ T N +     A+
Sbjct: 4914 INLDQDSWQDESVQNPEVPGLTSVHLAYLIYTSGSTGLPKGVMIEHRNTVNFLTWAHSAF 4973

Query: 1076 HLTSEDVVMSVTPLHHDMSVFDLFATLSFGATL-----VLPAGHEEKDALQWNRLIERHQ 1130
              ++ +  +  T L+ D++V++ F  L+ G ++     VL   H +            H 
Sbjct: 4974 AGSALEKTLFSTSLNFDLAVYECFGPLTSGGSIKVVQNVLELQHGD------------HD 5021

Query: 1131 VTIWVSVPAILEMLLSCTQAGQLHSLRLIAQGGDYIKPATIAQLRAGSNPPRLISLGGPT 1190
            + +  +VP+ L+ LL      +  S+  +   G+ +K + +  L   +   RL +L GP+
Sbjct: 5022 IGLINTVPSALKALLEINSLPK--SVHTVNVAGEALKRSLVENLFEKTGVQRLCNLYGPS 5079

Query: 1191 ETTIWSIWHELTADDVSVIPYGRPLAGNRYFIMDEIQRHVPQGVVGRIFTSGVNLAQGYL 1250
            ETT +S W  +  +       G+P+   +++++DE Q+ VP GV G I+  G  +A+GYL
Sbjct: 5080 ETTTYSSWVAMDREQGFAPHIGKPVGNTQFYLLDEQQQLVPLGVAGEIYIGGAGVARGYL 5139

Query: 1251 EDGELKQTDFVTVLDEHGHPVRAFRTGDQGYYRADGNIIFASRINGYVKVRGVRVSLPDI 1310
               +L    F+          R +RTGD G Y  DGNI +  R +  VK+RG R+ L +I
Sbjct: 5140 NRDDLTAERFLADTFSRHPQARMYRTGDLGRYLPDGNIEYLGRNDDQVKIRGFRIELGEI 5199

Query: 1311 EKQLQTHPALASVVVVDYADTNGDTALAALFSV-KPQQSASSQALREFAKQSLPSSHIPS 1369
            + +L  HPA+   VV    D  GD  L A ++V   Q   +  +LR +    LP+  +P 
Sbjct: 5200 DARLAKHPAVHEAVVTAREDVPGDKRLVAYYTVLSAQTEPAIDSLRGWLLGQLPAYMVPV 5259

Query: 1370 RFIALEALPLSANGKVDRKQCQA 1392
             ++ L+A+PL+ NGK+DRK   A
Sbjct: 5260 AYVRLDAMPLTPNGKLDRKALPA 5282



 Score =  214 bits (545), Expect = 3e-58
 Identities = 146/494 (29%), Positives = 243/494 (49%), Gaps = 19/494 (3%)

Query: 921  LSYAQLGEQVQRVMWQLKARGLTTGNVLAICLPRSVEHIVISLASALSGIIWVPIDAASP 980
            +SYA+L  +  R+   L   G+  G+ +AI L RS + +   LA      ++VP+D  +P
Sbjct: 2700 VSYAELNNRANRLARHLLGLGVQPGDSVAILLERSHDLLASQLAVLKCAAVYVPLDVNAP 2759

Query: 981  KERLNYLLENCHADLVVMDKPCEF---GNVIAFDALIEPVLFADGVPDVTPLDQLSRLSQ 1037
             ER ++++E+  A +++             +  D L         +  +   D       
Sbjct: 2760 VERQSFMIEDSRARVLLTHSQVSLTTGAQRVDLDGLT--------LERLKGTDLALPPQS 2811

Query: 1038 SQQTAYYLYTSGTTGKPKCVVVNNQATSNVIGQTGQAWHLTSEDVVMSVTPLHHDMSVFD 1097
            S+  AY +YTSG+TG PK V+V ++A S +    G A     + V  +  P   D S  D
Sbjct: 2812 SESVAYIMYTSGSTGTPKGVLVPHRAISRLAINNGYADFNAQDRVAFASNPAF-DASTLD 2870

Query: 1098 LFATLSFGATLVLPAGHEEKDALQWNRLIERHQVTI-WVSVPAILEMLLSCTQAGQLHSL 1156
            ++A L  G  +V+   H+    L + RL+    V++ W++     +      +A     L
Sbjct: 2871 VWAPLLNGGCVVVIGQHDLLSPLNFQRLLLEQSVSVLWMTAGLFHQYASGLGEA--FSRL 2928

Query: 1157 RLIAQGGDYIKPATIAQLRAGSNPPRLISLGGPTETTIWSIWHELTADDVSVIPYGRPLA 1216
            R +  GGD + PA I ++ A + P  L++  GPTE T +S  +E+ +     IP G+P+ 
Sbjct: 2929 RYLIVGGDVLDPAVIGRVLANNPPQHLLNGYGPTEATTFSATYEIVSVGNGSIPIGKPVG 2988

Query: 1217 GNRYFIMDEIQRHVPQGVVGRIFTSGVNLAQGYLEDGELKQTDFVTVLDEHGHPVRAFRT 1276
             +R +++D   +  P GV G ++  G  +A+GYL   EL    FV    +     R +RT
Sbjct: 2989 NSRLYVLDNQGQPAPLGVGGELYIGGQGVARGYLHRDELTLEKFVADPFDSDPQARLYRT 3048

Query: 1277 GDQGYYRADGNIIFASRINGYVKVRGVRVSLPDIEKQLQTHPALASVVVVDYADTNGDTA 1336
            GD   +RADGN+ +  R +  VK+RG RV L +IE +L  H  +   VV+   D  GD  
Sbjct: 3049 GDLVRWRADGNLEYLGRNDEQVKIRGFRVELGEIEARLAEHAEVREAVVLCRQDAPGDKR 3108

Query: 1337 LAALFSV-KPQQSASSQALREFAKQSLPSSHIPSRFIALEALPLSANGKVDRKQCQAHVQ 1395
            L A  +  +P+ +   + LR   +  LP   +P+ ++ L++LPL+ANGK+DRK       
Sbjct: 3109 LVAYVTAQQPETALDIEHLRSHLQGLLPDYMVPAAYVQLDSLPLTANGKLDRKALPVPDA 3168

Query: 1396 RQSIS---VEPVGQ 1406
            +  +S    EP+G+
Sbjct: 3169 QSLVSRGYEEPLGE 3182



 Score =  206 bits (525), Expect = 7e-56
 Identities = 238/905 (26%), Positives = 392/905 (43%), Gaps = 81/905 (8%)

Query: 533  IDLQHLSREQALLAVEPVRQQYQQRMHDLTRSP-WQICVVQLPIEEQEEFSSIVLT---S 588
            IDLQ   ++    A E   Q+  +R   L   P ++I +++L   E + F  ++     +
Sbjct: 112  IDLQR--QDDPFQAAEHWMQRQLERAFRLDGEPLFRIHLLKL---EAQRFYCMIYAHHIA 166

Query: 589  FDALIVDGRTHAL--ILAALLGSEEPDIT--QVVQNARDTQSISPQFASKKAQDEAYWKS 644
             D   +DG   +L  +  AL     PD+T    V   +D      + + + A D+ YW  
Sbjct: 167  LDGWGIDGLCASLSELYNALHDQHTPDLTAPSYVDFIKDDSQY--RGSRRFALDQTYWLD 224

Query: 645  KLHPDCPPPAL---PWKQALETITTSRYARESLQIPKESVGKLNRCGIENGLFLNSLLTA 701
            K + D P P L   P    ++    SR    S  + ++   +++    +  L LN+    
Sbjct: 225  K-YRDIPEPLLVPRPRPAQIQNEAPSRSGHLSYGLARDLEQQID----DLALSLNASSFH 279

Query: 702  TILDVLSYWTTEIGMR----VGFPVLIPSSNAIDGNESSFVILEHEKSTLSL-LSQASKL 756
             +L VL  + T    R    +G P+L   + +       F  L   +   S+ LS A  +
Sbjct: 280  VLLAVLYVYFTRAYQRDELVIGLPILNRPNASYKKTLGLFTQLSSVRLKFSVDLSFAELV 339

Query: 757  Q---REMLEALEHLAFSGVDLNRLL-MNQAPQALVLPVVLT----NGLSWKTLNPEDAVT 808
            Q   R + +      F   DLNRLL + +A +  +  +  +    N L         AV 
Sbjct: 340  QGICRAVKQDYRSQRFPVSDLNRLLELRRAERTQLFDLTFSYERNNHLLRFGQATAHAVK 399

Query: 809  LFDGVTQTPQVALDIRLTYDEQKNLIISFDYALAVLETELIREMLSALHHRLSQITSSAS 868
              +   QTP +A+ +R    E ++ +  + Y  A  + + I  +   L H L Q      
Sbjct: 400  SSNNHEQTP-LAIHLRTNAYEAESRL-HYIYNEAYFQHDEIAPLAERLRHVLEQ-----G 452

Query: 869  LAAPLEPCIDLSHYRFNS-------DESASHDCDFLAKLAQQLFVRTE---DKTAVICGE 918
            LA P  P    S             +    H  + L  + QQ   R     D  A++  E
Sbjct: 453  LANPHLPVHGFSLTGMTDTFKMQTWNAGQPHFANDLT-IHQQFEARAAERPDAAALVFEE 511

Query: 919  QTLSYAQLGEQVQRVMWQLKARGLTTGNVLAICLPRSVEHIVISLASALSGIIWVPIDAA 978
            QTLSY +L  +  +V  +L A G+   + +AIC+ R    I+  L    SG  +VP+D A
Sbjct: 512  QTLSYGELNARANQVAHRLLALGVRPDDRVAICVERGPAMIIGLLGILKSGAGYVPLDPA 571

Query: 979  SPKERLNYLLENCHADLVVMDKPCEFGNVIAFDALIEPVLFADGVP-----DVTPLDQLS 1033
             P ERL Y L +  A + ++ +             ++P L    VP     DV   D+ +
Sbjct: 572  YPLERLAYTLGDS-APVALLSQQS-----------VQPALPVSDVPLIYLDDVDLQDERA 619

Query: 1034 RLSQ----SQQTAYYLYTSGTTGKPKCVVVNNQATSNVIGQTGQAWHLTSEDVVMSVTPL 1089
               Q        AY +YTSG+TG PK V+V ++  + +   T   +    +DV       
Sbjct: 620  CNPQVSVRPSDLAYVIYTSGSTGLPKGVMVEHRNVARLFSATQDWFGFNEQDVWALFHSF 679

Query: 1090 HHDMSVFDLFATLSFGATLVLPAGHEEKDALQWNRLIERHQVTIWVSVPAILEMLLSCTQ 1149
              D SV++++  L  G  L++      +    +  L+    VT+    P+    L++   
Sbjct: 680  AFDFSVWEIWGALLHGGRLLIVPQLVSRSPEDFYNLLCSAGVTVLNQTPSAFRQLIAAQD 739

Query: 1150 -AGQLHSLRLIAQGGDYIKPATIAQ--LRAGSNPPRLISLGGPTETTIWSIWHELTADD- 1205
               Q+HSLR +  GG+ ++ A +     R  +   +L+++ G TETT+   ++ L  +D 
Sbjct: 740  DKEQVHSLRQVIFGGEALETAMLKPWYARKVNASTQLVNMYGITETTVHVTYYPLQPEDA 799

Query: 1206 --VSVIPYGRPLAGNRYFIMDEIQRHVPQGVVGRIFTSGVNLAQGYLEDGELKQTDFVTV 1263
              V   P G+ +   + +++D     +P G VG ++  G  +A+GYL   EL  T F+  
Sbjct: 800  RRVGASPIGKRIPDLQLYLLDAYGHPLPPGAVGELYVGGAGVARGYLNRDELNTTRFLDD 859

Query: 1264 LDEHGHPVRAFRTGDQGYYRADGNIIFASRINGYVKVRGVRVSLPDIEKQLQTHPALASV 1323
                    R +R+GD G +  DG++ +  R +  VK+RG R+ L +IE +L     +   
Sbjct: 860  PFASAPGARMYRSGDLGRWLPDGSLEYLGRNDEQVKIRGFRIELGEIEARLSACEGVRDA 919

Query: 1324 VVVDYADTNGDTALAALFSVKPQQSASSQALREFAKQSLPSSHIPSRFIALEALPLSANG 1383
            VVV   D  GD  L A       Q   +  LRE  + SL    +PS F++LEA PL+ANG
Sbjct: 920  VVVVREDEPGDQRLVAYVIGTAGQEPDATWLREQLRLSLAEHMLPSAFVSLEAFPLTANG 979

Query: 1384 KVDRK 1388
            K+DRK
Sbjct: 980  KLDRK 984



 Score =  199 bits (505), Expect = 1e-53
 Identities = 228/950 (24%), Positives = 391/950 (41%), Gaps = 94/950 (9%)

Query: 488  GHIDTQSLHSRLLYLVEHIPALRTRI---DQEKWIQWVSPCIALNWQAIDLQHLS-REQA 543
            G +D  +L   L  +VE    LR+R    +    + +   C        D++H   R + 
Sbjct: 3301 GMLDVTALTRALARIVERHETLRSRFVSREGSAQVLFAPTCADARLSVEDIRHAPHRLEG 3360

Query: 544  LLAVEPVRQQYQQRMHDLTRSPWQICVVQLPIEEQEEFSSIVLTSFDALIVDGRTHALIL 603
             + VE V         DL   P    +++  +    +   ++L +   ++ DG +  ++ 
Sbjct: 3361 CIRVEAVAP------FDLALGP----LIRAHLLRVTDERHVLLLTVHHIVADGWSMGVLS 3410

Query: 604  AALL--------GSEEPDITQVVQNARDTQSISPQFASKKAQDEA-YWKSKLHPDCPPPA 654
              LL        G  +P     +Q            + ++ Q +A YW+  L        
Sbjct: 3411 QELLALYPAFCQGQPDPLPPLAIQYTDYAVWQRRWLSGERLQHQAAYWRQALEGAPTLLT 3470

Query: 655  LPWKQALETITTSRYARESLQIPKESVGKLNRCGIENGLFLNSLLTATILDVLSYWTTEI 714
            LP  +          A  ++Q+       L +     G+ L   L A     L+  + + 
Sbjct: 3471 LPTDRPRPAQQDFAGASLAVQLNASLTADLRKLAQRQGVTLYMALMAAWATTLARLSGQA 3530

Query: 715  GMRVGFPVLIPSSNAIDGNESSFV----ILEHEKSTLSLLSQASKLQREMLEALEH--LA 768
             + +G PV       ++     FV    +      + S  +  ++++  +LEA EH  L 
Sbjct: 3531 DVVIGSPVAGRGRTELEDLVGLFVNTLAVRIDTSGSPSGEALLTQVKARVLEAQEHQDLP 3590

Query: 769  FSGVDLNRLLMNQAPQALVLPVVLTNGLSWKTLNPEDA------VTLFDGVTQTPQVALD 822
            F  V    + + +  ++L  P +  N L+W       A      V L   ++Q  +  L 
Sbjct: 3591 FEQV----VEVVRPTRSLAHPPLFQNTLNWMPGKHAAASLGDLRVELVGQISQVSKFDLS 3646

Query: 823  IRLTYDEQKNLIISFDYALAVLETELIREMLSALHHRLSQITSSASLAAPLEPCIDLSHY 882
            + L+ +  + L+ + DYA A+ +   ++  L      L  + +           +     
Sbjct: 3647 LNLS-EHGETLVGTLDYATALFDEVTVQRYLGYFVQVLETLAADEQAHLDRITLVGEEER 3705

Query: 883  RF-----NSDESASHDCDFLAKLAQQLFVRTEDKTAVICGEQTLSYAQLGEQVQRVMWQL 937
            R+     N+     HD   +  + +       +  A   GE  L Y ++  +   +   L
Sbjct: 3706 RYLLETLNTAALQVHDEQTVHAMIEARAASAPEGVAAQVGEHCLHYGEMNHRANALAHHL 3765

Query: 938  KARGLTTGNVLAICLPRSVEHIVISLASALSGIIWVPIDAASPKERLNYLLENCHADLVV 997
             + G+   + +A+   R ++ +V  LA   +G  +VP+D + P ER+ YLL +    +V+
Sbjct: 3766 ISLGVGVDDRVAVMARRGLDTLVAMLAVLKAGAGYVPVDPSHPDERIAYLLADSAPKVVL 3825

Query: 998  MDK------PCEFGNVIAFDALIEPVLFADGVPDVTPLDQLSRLSQSQQTAYYLYTSGTT 1051
              +      P     VIAFD    P    +  P V  L+       +   AY +YTSG+T
Sbjct: 3826 TQQALTSRVPETAAPVIAFDRPEWPQRLEN--PQVAGLN-------AAHLAYVIYTSGST 3876

Query: 1052 GKPKCVVVNNQATSNVIGQTGQAWHLTSEDVVMSVTPLHHDMSVFDLFATLSFGATLVLP 1111
            G+PK V+V ++   N+I    QA+ L +     SV     D   ++++  L  GATL LP
Sbjct: 3877 GQPKGVMVEHRTVGNLIDWHCQAFGLQAGSHTASVAGFGFDAMAWEVWPALCAGATLHLP 3936

Query: 1112 ---AGHEEKDAL-QWNRLIERHQVTIWVSVPAILEML------LSCTQAGQLHSLRLIAQ 1161
                G+E+ DAL  W           W++ P  +  L       + ++     +LR +  
Sbjct: 3937 PADVGNEQIDALLDW-----------WIAQPLQVAFLPTPVAEYAFSRNLSHPTLRTLLI 3985

Query: 1162 GGDYIKPATIAQLRAGSNPP--RLISLGGPTETTIWSIWHELTADDVSVIPYGRPLAGNR 1219
            GGD        +LR     P   +I+  GPTE T+ +    L  D    +  G+P+   R
Sbjct: 3986 GGD--------RLRQFQRDPGFTVINNYGPTEATVVATSGRLLPD--GSLDIGKPITNTR 4035

Query: 1220 YFIMDEIQRHVPQGVVGRIFTSGVNLAQGYLEDGELKQTDFVTVLDEHGHPVRAFRTGDQ 1279
             +++DE Q+ VP GV G ++ +G  +A+GYL   E+    F+          R +RTGD 
Sbjct: 4036 VYLLDEHQQLVPLGVAGELYVAGEGVARGYLNRPEMTAERFLRDPFHCDADARMYRTGDL 4095

Query: 1280 GYYRADGNIIFASRINGYVKVRGVRVSLPDIEKQLQTHPALASVVVVDYADTNGDTALAA 1339
              + ADG + +  R +  VK+RG+RV L +IE QL   P +   +V+   D  G   LAA
Sbjct: 4096 ARWNADGTLDYLGRNDDQVKIRGLRVELGEIEAQLSQLPGIEEALVLAREDEPGQPRLAA 4155

Query: 1340 LFSVKP-QQSASSQALREFAKQSLPSSHIPSRFIALEALPLSANGKVDRK 1388
             F  +    S     LR      LP   +PS F+ L A PL+ANGKVDR+
Sbjct: 4156 YFIERDGSLSMPVSELRAALLAVLPGYMVPSAFVRLAAWPLTANGKVDRR 4205



 Score =  189 bits (479), Expect = 1e-50
 Identities = 154/530 (29%), Positives = 256/530 (48%), Gaps = 34/530 (6%)

Query: 884  FNSDESASHDCDFLAKLAQQLFVRTEDKTAVICGEQTLSYAQLGEQVQRVMWQLKARGLT 943
            FN+ + A      L +L +       D  AV    Q LSYA+L +   ++  +L A G+ 
Sbjct: 1566 FNALDGAYPKDLLLHQLFEAQAAAQPDSMAVTYEGQHLSYAELNQWANQIAHRLIAEGIG 1625

Query: 944  TGNVLAICLPRSVEHIVISLASALSGIIWVPIDAASPKERLNYLLENCHADLVVMDKPCE 1003
              + +AIC+ R +E I   +    +G  +VP+D + P+ERL Y+LE+    +++  +   
Sbjct: 1626 ADDRVAICVERGLEMIAGLVGILKAGAGYVPLDPSYPEERLAYMLEDSAPKMLLTQRDLR 1685

Query: 1004 --FGNVIAFDALIEPVLFADGVPDVTPLD--QLSRLSQSQQTAYYLYTSGTTGKPKCVVV 1059
              F        L+E    A+   D  P    QL+ L+ +Q  AY +YTSG+TG+PK V +
Sbjct: 1686 ERFAQAAMPVLLLEADARAENAIDSAPTTNPQLAGLN-AQHLAYLIYTSGSTGQPKGVAM 1744

Query: 1060 NNQATSNV----IGQTGQAWHLTSEDVVMSVTPLHHDMSVFDLFATLSFGATLVLPAGHE 1115
             +    N+    I QT +  H       +    L  D++  ++F+TL  G  L L     
Sbjct: 1745 PHAPLVNLMHWQIAQTVE--HRRPRQRTLQFAALGFDVAFQEIFSTLCAGGELSLIHSDM 1802

Query: 1116 EKDALQ-WNRLIERHQVTIW---VSVPAILEMLLSCTQAGQLHSLRLIAQGGDYIKPATI 1171
              D  + +  + E+    ++   +++ A+ E +++  +  +     +I  G        +
Sbjct: 1803 RLDFRRLFQHICEQRIERLYMPCIALQALAEAVVAEPEQPECLLQDVITAGEQLRITEPM 1862

Query: 1172 AQLRAGSNPPRLISLGGPTETTIWSIWHELTADDVSVIPY--------GRPLAGNRYFIM 1223
                A  N  RL +  GPTE+      H +TA  +   P         G+P+A  R +++
Sbjct: 1863 RHFFARLNDARLHNHYGPTES------HVVTAMTLEGNPQAWPTLPSIGQPVANTRIYLL 1916

Query: 1224 DEIQRHVPQGVVGRIFTSGVNLAQGYLEDGELKQTDFVT---VLDEHGHP-VRAFRTGDQ 1279
            DE  R VP GV G ++  GV +A+GYL   +L    F+       E G+P  R ++TGD 
Sbjct: 1917 DEHMRPVPVGVAGELYIGGVCVARGYLNRDDLTADRFIADPFATREDGNPCARLYKTGDL 1976

Query: 1280 GYYRADGNIIFASRINGYVKVRGVRVSLPDIEKQLQTHPALASVVVVDYADTNGDTALAA 1339
            G ++ DGNII+  R +  +K+RG R+ L +IE +L  +P L    V+   D  G+  L A
Sbjct: 1977 GCWQDDGNIIYMGRNDDQIKIRGFRIELGEIEARLGQYPGLRDAAVLAREDVPGEKRLVA 2036

Query: 1340 LFSVKPQQS-ASSQALREFAKQSLPSSHIPSRFIALEALPLSANGKVDRK 1388
             FSV+  Q+   +  +R   +  LP   IP+ ++ LE LP+S NGK+DR+
Sbjct: 2037 YFSVQAGQALPEADHMRLHLQAVLPDYMIPAAYVHLEKLPVSPNGKLDRR 2086



 Score =  123 bits (309), Expect = 8e-31
 Identities = 117/432 (27%), Positives = 185/432 (42%), Gaps = 30/432 (6%)

Query: 1863 ECILAE-FRSALGVAEMTAEDDFFDFGGHSLIATRVIGRLLSEQGIELHINDMFSFPNAK 1921
            E  LAE +   L V  +   D FFD GGHSL+A R++ ++  + G+EL + ++F+     
Sbjct: 3184 EVALAEIWAEVLQVERVGRNDHFFDLGGHSLLAMRMVSQVRQQLGVELPLGELFALGELA 3243

Query: 1922 QLAQQAVLHRKPTSTSFAVSEVVESSKAPLSLAQASLWKAMSKYAKFGLTHIFNLPFALK 1981
             +A  A L     S   A+  V      PLS AQ  LW         G    +N+P AL 
Sbjct: 3244 AVA--AALSSVARSELTAILPVKRDQPMPLSFAQQRLWFLAQMD---GGNEAYNIPMALS 3298

Query: 1982 FLDEVNEQAFGEAFHWLLLRHAGLRTHFGLEDGQPYQHVIAASNIEHYQWFWTSKDNAAQ 2041
                ++  A   A   ++ RH  LR+ F   +G     V+ A      +       +A  
Sbjct: 3299 LEGMLDVTALTRALARIVERHETLRSRFVSREGSA--QVLFAPTCADARLSVEDIRHAPH 3356

Query: 2042 SVARLLAQEAEHTFDLSQELPLRLNFVR--DEQTGTQYLSLLFHHIVLDEWSINILMDEL 2099
             +   +  EA   FDL+    +R + +R  DE+     L L  HHIV D WS+ +L  EL
Sbjct: 3357 RLEGCIRVEAVAPFDLALGPLIRAHLLRVTDER---HVLLLTVHHIVADGWSMGVLSQEL 3413

Query: 2100 AQVYQHSVQGTRPQWQTEPLP-----FHEFARKQR---SSAFNQTHLNYWLTKFAGVPWA 2151
              +Y    QG     Q +PLP     + ++A  QR   S    Q    YW     G P  
Sbjct: 3414 LALYPAFCQG-----QPDPLPPLAIQYTDYAVWQRRWLSGERLQHQAAYWRQALEGAPTL 3468

Query: 2152 QPLFAADHPLSNSTGVDLGEGGWVEIKLPKSTMVSLYQLAKARHASLFNVMYAAISASVH 2211
              L   D P           G  + ++L  S    L +LA+ +  +L+  + AA + ++ 
Sbjct: 3469 LTL-PTDRPRPAQQDF---AGASLAVQLNASLTADLRKLAQRQGVTLYMALMAAWATTLA 3524

Query: 2212 CLGAPEKLLVGTPASGRLDAEFFDTVGYFTTMGVQLVDFTKVQTVWQLIEQVKNSINQSM 2271
             L     +++G+P +GR   E  D VG F       +D +   +   L+ QVK  + ++ 
Sbjct: 3525 RLSGQADVVIGSPVAGRGRTELEDLVGLFVNTLAVRIDTSGSPSGEALLTQVKARVLEAQ 3584

Query: 2272 PYTDIPIDLIEE 2283
             + D+P + + E
Sbjct: 3585 EHQDLPFEQVVE 3596



 Score = 70.1 bits (170), Expect = 1e-14
 Identities = 74/336 (22%), Positives = 140/336 (41%), Gaps = 18/336 (5%)

Query: 1951 LSLAQASLWKAMSKYAKFGLTHIFNLPFALKFLDEVNEQAFGEAFHWLLLRHAGLRTHF- 2009
            L+ AQ ++W         G + ++N+   L+    ++ + F  A   L+ +H  LR    
Sbjct: 32   LTAAQRNIWLDQMTQ---GDSPLYNIGGHLEIDGALDYELFQRAVDLLIAKHDALRMVLL 88

Query: 2010 --GLEDGQPYQHVIAASNIEHYQWFWTSKDNAAQSVARLLAQEAEHTFDLSQELPLRLNF 2067
                E+G P Q    +  +         +D+  Q+    + ++ E  F L  E   R++ 
Sbjct: 89   DQRDEEGVPLQTFATSMPMPVTPIDLQRQDDPFQAAEHWMQRQLERAFRLDGEPLFRIHL 148

Query: 2068 VRDEQTGTQYLSLLFHHIVLDEWSINILMDELAQVY-----QHSVQGTRPQWQTEPLPFH 2122
            ++ E     Y  +  HHI LD W I+ L   L+++Y     QH+   T P +  + +   
Sbjct: 149  LKLEAQRF-YCMIYAHHIALDGWGIDGLCASLSELYNALHDQHTPDLTAPSY-VDFIKDD 206

Query: 2123 EFARKQRSSAFNQTHLNYWLTKFAGVPWAQPLFAADHPLSNSTGVDLGEGGWVEIKLPKS 2182
               R  R  A +QT   YWL K+  +P  +PL       +          G +   L + 
Sbjct: 207  SQYRGSRRFALDQT---YWLDKYRDIP--EPLLVPRPRPAQIQNEAPSRSGHLSYGLARD 261

Query: 2183 TMVSLYQLAKARHASLFNVMYAAISASVHCLGAPEKLLVGTPASGRLDAEFFDTVGYFTT 2242
                +  LA + +AS F+V+ A +          ++L++G P   R +A +  T+G FT 
Sbjct: 262  LEQQIDDLALSLNASSFHVLLAVLYVYFTRAYQRDELVIGLPILNRPNASYKKTLGLFTQ 321

Query: 2243 MGVQLVDFTKVQTVWQLIEQVKNSINQSMPYTDIPI 2278
            +    + F+   +  +L++ +  ++ Q       P+
Sbjct: 322  LSSVRLKFSVDLSFAELVQGICRAVKQDYRSQRFPV 357



 Score = 68.2 bits (165), Expect = 4e-14
 Identities = 115/476 (24%), Positives = 193/476 (40%), Gaps = 80/476 (16%)

Query: 1802 YLLEQFVAAIGGRTMPSSTTSSSHVSAIELTSNNP--------PTSNNAHAALAESELEL 1853
            +L EQ   ++    +PS+  S   + A  LT+N          PT++    A A S+ E 
Sbjct: 949  WLREQLRLSLAEHMLPSAFVS---LEAFPLTANGKLDRKALPVPTAD----AFARSQYEA 1001

Query: 1854 SAVNSSAVEECILAEFRSALGVAEMTAEDDFFDFGGHSLIATRVIGRLLSEQGIELHIND 1913
                   VE  +   +   LGV ++   D FF+ GGHS++A ++I R + + G+   +  
Sbjct: 1002 P---EGLVETRLATLWVELLGVEQVGRHDQFFELGGHSMLAVKLIER-MRDIGLNADVRV 1057

Query: 1914 MFSFPNAKQLAQQAVLHRKPTSTSFAVSEV------VESSKAPLS-LAQASLWKAMSKYA 1966
            +F  P    LA  A    K T      S +      +  +  PL+ L+QA + + ++   
Sbjct: 1058 LFGQPT---LASLAAASGKTTDVQVPASRIPADCQRITPNMLPLARLSQAQIDRVVAA-V 1113

Query: 1967 KFGLTHIFNL---------------------PFALKFLDEVN--EQA--FGEAFHWLLLR 2001
              G++++ ++                     P+ L+ L   N  EQ   F EA   ++ R
Sbjct: 1114 PGGVSNVQDIYGLVPLQEGILYHHLSSGEGDPYLLQALLRFNSFEQLLDFTEALQQVIDR 1173

Query: 2002 HAGLRTHFGLED-GQPYQHV--IAASNIEHYQWFWTSKDNAAQSVARLLAQEAEHTFDLS 2058
            H  LRT    E+  +P Q V   A   +E +       D AAQ  A+   +      DL 
Sbjct: 1174 HDILRTAVAWEELDEPVQVVWRQARLRVEAFLPHPDQGDVAAQLQAQFDPRRIR--MDLH 1231

Query: 2059 QELPLRLNFVRDEQTGTQYLSLLFHHIVLDEWSINILMDELAQVYQHSVQGTRPQWQTEP 2118
            Q   +RL++  D    +    LLFHH++ D  S+ +L  E+    Q   +G         
Sbjct: 1232 QAPMMRLHYAEDPADHSWVAVLLFHHLIDDATSLALLGAEIEAFRQGRGEGL-----PAS 1286

Query: 2119 LPFHEFARKQRSSAFNQTHLNYWLTKFAGVPWAQPLFAADHPLSNSTGVDLGEGGWVEIK 2178
            +P+     + R S   + H  ++    A V      F       + +GVD       E  
Sbjct: 1287 VPYRNHVAQARLSVSREDHEAFFREMLADVDEPTLPFGLQDVQGDGSGVD-------EAL 1339

Query: 2179 LPKSTMVSLYQLAKAR-----HASLFNVMYAAISASVHCLGAPEKLLVGTPASGRL 2229
            LP +  ++    A AR     +ASL ++ +A +   V  L   + ++ GT   GRL
Sbjct: 1340 LPVALELAQRLRAHARRLGVSNASLHHLAWAQV---VGRLSGRQDVVFGTVLMGRL 1392



 Score = 62.0 bits (149), Expect = 3e-12
 Identities = 82/325 (25%), Positives = 134/325 (41%), Gaps = 27/325 (8%)

Query: 4   MTAMQAAYWLGR--QHDCLLDGVAAHLYAEFDGQALNRQALTEAVRALYAKHPMLRLAIT 61
           +TA Q   WL +  Q D  L  +  HL  E DG AL+ +    AV  L AKH  LR+ + 
Sbjct: 32  LTAAQRNIWLDQMTQGDSPLYNIGGHL--EIDG-ALDYELFQRAVDLLIAKHDALRMVLL 88

Query: 62  KDGQQKILPLSTF---HQLKVDDLSQWKPDEVESFVHTKRQRMTHQMLDLTQGNPI-EIS 117
               ++ +PL TF     + V  +   + D+         QR   +   L  G P+  I 
Sbjct: 89  DQRDEEGVPLQTFATSMPMPVTPIDLQRQDDPFQAAEHWMQRQLERAFRL-DGEPLFRIH 147

Query: 118 LTLLPEGKHRLHIDADMIACDAQSFRLLVDDLTSLYLEAI--EHRLEIIESDVVTFFQYL 175
           L  L   +    I A  IA D      L   L+ LY  A+  +H  ++     V F +  
Sbjct: 148 LLKLEAQRFYCMIYAHHIALDGWGIDGLCASLSELY-NALHDQHTPDLTAPSYVDFIKDD 206

Query: 176 DAQQADRALAKRKEVDKKWWQERLATIPAEPSLPYQPVPTDAVSANSQRFAHWFTPVER- 234
              +  R  A    +D+ +W ++   IP EP L  +P P    +    R  H    + R 
Sbjct: 207 SQYRGSRRFA----LDQTYWLDKYRDIP-EPLLVPRPRPAQIQNEAPSRSGHLSYGLARD 261

Query: 235 --KGLAEVARQHHLTLTQLTLALFSQVIANACQERQFRLNVPTFHRGNRSLDIEHTIGDF 292
             + + ++A   + +   + LA+       A Q  +  + +P  +R N S   + T+G F
Sbjct: 262 LEQQIDDLALSLNASSFHVLLAVLYVYFTRAYQRDELVIGLPILNRPNAS--YKKTLGLF 319

Query: 293 SNL----LIFSADVGTTQTLLSLCQ 313
           + L    L FS D+   + +  +C+
Sbjct: 320 TQLSSVRLKFSVDLSFAELVQGICR 344



 Score = 57.8 bits (138), Expect = 5e-11
 Identities = 75/311 (24%), Positives = 123/311 (39%), Gaps = 47/311 (15%)

Query: 1862 EECILAEFRSALGVAEMTAEDDFFDFGGHSLIATRVIGRLLSEQGIELHINDMFSFPNAK 1921
            E  + A +   L V  +  +D FF+ GGHSL+A ++I R+  + G+   +  +F  P   
Sbjct: 2109 ETMLAALWCEVLSVERVGRQDHFFELGGHSLLAVKLIERM-RQVGLSADVRVLFGQPTLA 2167

Query: 1922 QLAQ----------------QAVLHRKP------TSTSFAVSEVVESSKAPLSLAQ---- 1955
             LA                     H  P      T    ++  +V       +  Q    
Sbjct: 2168 ALAAAVGGGIEIDVPANGIPDGCTHIIPDMLTLTTLDPASIERIVAGVSGGAANVQDIYP 2227

Query: 1956 -ASLWKAMSKY---AKFGLTHIFNLPFALKFLDEVNEQAFGEAFHWLLLRHAGLRTHF-- 2009
             A L + +  +   A+ G  ++    FAL   D  + + F E    ++ RH  LRT    
Sbjct: 2228 LAPLQEGILYHHIAAEQGDPYLLQATFALH--DPTHVRRFAEGLQAMIDRHDILRTALVW 2285

Query: 2010 -GLEDGQPYQHVIAASNIEHYQWFWTSKDNAAQSVARLLAQ--EAEHTFDLSQELPLRLN 2066
             GLE  QP Q  +A   +E      T   +    VA+L  +    E+  DL+Q   + L 
Sbjct: 2286 EGLE--QPLQ--VALRRVELSMEQITLAQDGGDIVAQLQRRFDPREYRLDLNQAPLIHLA 2341

Query: 2067 FVRDEQTGTQYLSLLFHHIVLDEWSINILMDELAQVYQHSVQGTRPQWQTEPLPFHEFAR 2126
            F  D +       LLFHHI LD  +++++  E+       +QGT  Q     +P+  +  
Sbjct: 2342 FAEDSENQRWVAILLFHHIALDHTALDVMSVEMLA----HLQGTAAQLPA-AMPYRNYVG 2396

Query: 2127 KQRSSAFNQTH 2137
            + R     + H
Sbjct: 2397 QARLGVSRKQH 2407



 Score = 57.4 bits (137), Expect = 7e-11
 Identities = 90/412 (21%), Positives = 160/412 (38%), Gaps = 64/412 (15%)

Query: 1861 VEECILAEFRSALGVAEMTAEDDFFDFGGHSLIATRVIGRLLSEQGIELHINDMFSFPNA 1920
            VE  +   + S L V  +   D FF+ GGHSL+A  +I ++   QG+   I  +F+ P  
Sbjct: 4227 VETAVAEIWSSLLQVERVGRHDHFFELGGHSLLAVNLIAQM-RHQGLNADIRTLFTQPTL 4285

Query: 1921 KQLAQQAVLHRKPTSTSFAVSE-----------VVESSKAPLSLAQASLWKAMSKYAKFG 1969
              LA       + T    A+ +           + +  +A + L  AS+   ++      
Sbjct: 4286 AALAAAVGGASEITVPENAIPDDCTRITPEMLPLADLDQAAIDLIVASVPGGVAN----- 4340

Query: 1970 LTHIFNL------------------PFALKFLDEVNEQA----FGEAFHWLLLRHAGLRT 2007
            +  I++L                  P+ L+ + E+ ++A    F  A   ++ RH  LRT
Sbjct: 4341 VQDIYSLAPLQEGILYHHLAAEAGDPYVLQSVFEIADRARLNAFVGALQSVIDRHDILRT 4400

Query: 2008 HF---GLEDGQPYQHVIAASNIEHYQWFWTSKDNAAQSVARLLAQEAEHTFDLSQELPLR 2064
                 GLE   P Q V   + +   Q      +       +          D+SQ   LR
Sbjct: 4401 AVQWQGLET--PVQVVCRQAQLPMEQVELDPLEGPIMEQLQQRFDPRHSRLDMSQAPLLR 4458

Query: 2065 LNFVRDEQTGTQYLSLLFHHIVLDEWSINILMDELAQVYQHSVQGTRPQWQTEPLPFHEF 2124
            L F  D+        LLFHH+VLD  ++ +++ ++    Q  + G   Q     +P+  +
Sbjct: 4459 LVFAEDQPNQRWAAILLFHHMVLDHTALEVVLHDM----QAHLLGQAGQLDV-AIPYRNY 4513

Query: 2125 ARKQRSSAFNQTHLNYWLTKFAGVPWAQPLFAADHPLSNSTGVDLGEGGWVEIKLPKSTM 2184
              + R     + H  ++      +   +P            G D+GE       L     
Sbjct: 4514 VAQARLGVSREDHEAFFRELLGDID--EPTLPFGLLDVQGDGRDMGES-----SLTLDRQ 4566

Query: 2185 VSLYQLAKARH-----ASLFNVMYAAISASVHCLGAPEKLLVGTPASGRLDA 2231
            ++L   A+AR      ASLF++ +A + + V    +   ++ GT   GR+ +
Sbjct: 4567 LNLRLRAQARKLGVSAASLFHLAWAQVLSKV---SSKRTVVFGTVLIGRMQS 4615



 Score = 46.6 bits (109), Expect = 1e-07
 Identities = 90/414 (21%), Positives = 157/414 (37%), Gaps = 37/414 (8%)

Query: 1423 LSEFEQRVWRQHQRHGDGRNQY--ATAYRLSGKVNIARLITALSQLPNHFPVLNRRYVLD 1480
            LS  +QR+W   Q  G G   Y    A  L G +++  L  AL+++      L  R+V  
Sbjct: 3271 LSFAQQRLWFLAQMDG-GNEAYNIPMALSLEGMLDVTALTRALARIVERHETLRSRFVSR 3329

Query: 1481 EASGLTLYSAKPTPLEIHFEHVESMDEAFEHLVRWQN-QPMDLAKQATLSFCLLSLGSEE 1539
            E S   L++       +  E +       E  +R +   P DLA    +   LL +  E 
Sbjct: 3330 EGSAQVLFAPTCADARLSVEDIRHAPHRLEGCIRVEAVAPFDLALGPLIRAHLLRVTDER 3389

Query: 1540 RVLGVISHQIISEQWDWRRVFECVTNGYNQIACDIDP------VMEGEDLSLGFTPVMPQ 1593
             VL +  H I+++ W    + + +   Y    C   P       ++  D ++     +  
Sbjct: 3390 HVLLLTVHHIVADGWSMGVLSQELLALYPAF-CQGQPDPLPPLAIQYTDYAVWQRRWLSG 3448

Query: 1594 TPLSQALLPWLQPASHA-TWIEQSLPSANSAINTLCSRKYRIALHSSVLAEHGLAQPDKQ 1652
              L      W Q    A T +         A          + L++S+ A+  L +  ++
Sbjct: 3449 ERLQHQAAYWRQALEGAPTLLTLPTDRPRPAQQDFAGASLAVQLNASLTAD--LRKLAQR 3506

Query: 1653 EVLALIAALFARYLAASAKL-GQFELYVPHDVERKTR----ELNGSMIESQLVHIALKGF 1707
            + + L  AL A +    A+L GQ ++ +   V  + R    +L G  + +  V I   G 
Sbjct: 3507 QGVTLYMALMAAWATTLARLSGQADVVIGSPVAGRGRTELEDLVGLFVNTLAVRIDTSGS 3566

Query: 1708 ---ERPLSQLSQEILDAM-RQPLTGGVASETHASAAAL---------VTWLVDPSVHLQL 1754
               E  L+Q+   +L+A   Q L      E      +L         + W+        L
Sbjct: 3567 PSGEALLTQVKARVLEAQEHQDLPFEQVVEVVRPTRSLAHPPLFQNTLNWMPGKHAAASL 3626

Query: 1755 EGLRCEKLLFAAMHPKFEVALGV---GLNCQGALVLELAL--DATVSPHVGAYL 1803
              LR E +   +   KF+++L +   G    G L    AL  + TV  ++G ++
Sbjct: 3627 GDLRVELVGQISQVSKFDLSLNLSEHGETLVGTLDYATALFDEVTVQRYLGYFV 3680



 Score = 43.9 bits (102), Expect = 8e-07
 Identities = 21/63 (33%), Positives = 36/63 (57%), Gaps = 1/63 (1%)

Query: 1862 EECILAEFRSALGVAEMTAEDDFFDFGGHSLIATRVIGRLLSEQGIELHINDMFSFPNAK 1921
            E  I A ++  LGV ++   D FF+ GGHSL+A  ++ R + ++G+E  +  +F  P   
Sbjct: 5301 EILIAAIWQDLLGVTQVGRHDHFFEMGGHSLLAVSLMER-MRQEGLEAEVKSLFKHPTLM 5359

Query: 1922 QLA 1924
            + A
Sbjct: 5360 EYA 5362