Pairwise Alignments
Query, 2413 a.a., non-ribosomal peptide synthetase from Vibrio cholerae E7946 ATCC 55056
Subject, 3165 a.a., Amino acid adenylation from Pseudomonas syringae pv. syringae B728a
Score = 223 bits (568), Expect = 4e-61
Identities = 155/497 (31%), Positives = 249/497 (50%), Gaps = 24/497 (4%)
Query: 906 VRTEDKTAVICGEQTLSYAQLGEQVQRVMWQLKARGLTTGNVLAICLPRSVEHIVISLAS 965
VRT A+ G LSY QL EQ + L G+ +AIC+ R + ++ LA
Sbjct: 2593 VRTPQAIALRAGRAQLSYRQLNEQANCLAHHLIDLGVRPDQRVAICVERGLSMVIGLLAI 2652
Query: 966 ALSGIIWVPIDAASPKERLNYLLENCHADLVVMDKPCEFGNVIAFDALIEPVLFADGVPD 1025
+G +VP+D P+ERL Y++++ +++ D L + +
Sbjct: 2653 LKAGGAYVPLDPGYPRERLQYMVKDSTPVALLVQGSTR-------DLLDDEHALRIDLDS 2705
Query: 1026 VT---PLDQLSRLS--QSQQTAYYLYTSGTTGKPKCVVVNNQATSNVIGQTGQAWHLTSE 1080
VT DQ R+ ++ AY +YTSG+TG PK V+V ++ SN++ + S
Sbjct: 2706 VTWDAQRDQNPRVPGLTAEHLAYVIYTSGSTGTPKGVMVEHRNVSNLVQWSSVLCPPASG 2765
Query: 1081 DVVMSVTPLHHDMSVFDLFATLSFGATLVLPAGHEEKDALQWNRLIERHQVTIWVSVPAI 1140
V++ TP+ D SV+++F LS G LVL ++D ++I+ QV++ VPA+
Sbjct: 2766 TVLLQKTPISFDASVWEIFWPLSSGIPLVLARPDGQRDPAYLAQVIQERQVSVVQFVPAL 2825
Query: 1141 LEMLLSCTQAGQLHSLRLIAQGGDYIKPATIAQLRAGSNPPRLISLGGPTETT----IWS 1196
L+ L Q+ SL + GG + AQLR RL ++ GPTETT +W+
Sbjct: 2826 LQQFLDLPQSSACSSLTDVVCGGGELTVEMAAQLRKRLPEVRLHNVYGPTETTVDCSVWT 2885
Query: 1197 IWHELTADDVSVIPYGRPLAGNRYFIMDEIQRHVPQGVVGRIFTSGVNLAQGYLEDGELK 1256
+ + D + +P GRP++ R +++D + VPQGV+G++ G + +GYL L
Sbjct: 2886 LQPDQAVPD-TALPIGRPISNTRLYVLDAYDQPVPQGVIGQLHIGGAGVTRGYL---NLP 2941
Query: 1257 QTDFVTVLDE-HGHPVRAFRTGDQGYYRADGNIIFASRINGYVKVRGVRVSLPDIEKQLQ 1315
+TD +D R +R+GD RADGN+ F R + VK+ G+R+ DI+ L
Sbjct: 2942 KTDAERFIDSPFVAGDRLYRSGDLVRQRADGNLKFLGRNDDQVKIHGLRIEPGDIQACLI 3001
Query: 1316 THPALASVVVVDYADTNGDTALAALFSVKPQQSASSQALREFAKQSLPSSHIPSRFIALE 1375
+HP + +V+ + G L A ++ + LRE + LP +P+ F+ L+
Sbjct: 3002 SHPGIEQAIVLVRDEQPGGQRLVAYYT---GTQLPVETLREVLRAQLPDYMVPALFVHLD 3058
Query: 1376 ALPLSANGKVDRKQCQA 1392
A+PLS NGK+DRK A
Sbjct: 3059 AMPLSPNGKLDRKALPA 3075
Score = 182 bits (461), Expect = 1e-48
Identities = 150/496 (30%), Positives = 235/496 (47%), Gaps = 60/496 (12%)
Query: 913 AVICGEQTLSYAQLGEQVQRVMWQLKARGLTTGNVLAICLPRSVEHIVISLASALSGIIW 972
AVI G L+YAQL E+ R+ L G+ T +A+CL R +V LA +G +
Sbjct: 1547 AVIQGGHVLTYAQLNERANRLAHHLIGLGVKTDERIALCLHRGPARLVAMLAVLKAGAAY 1606
Query: 973 VPIDAASPKERLNYLLENCHADLVVMDKPCE--FGNVIAFDALIEPVLFADGV-PDVTPL 1029
VP+D P ER+ YLL++ +V+ + G+ + L + G P V L
Sbjct: 1607 VPVDPVYPAERIAYLLQDSTPRVVLTENSTHDLAGDTERVNIEQAEWLGSSGNNPSVADL 1666
Query: 1030 DQLSRLSQSQQTAYYLYTSGTTGKPKCVVVNNQATSNVIGQTGQAWHLTSEDVVMSVTPL 1089
D +Q+ AY +YTSG+TG+PK V+V + N++ QA+ L + SV
Sbjct: 1667 D-------AQKLAYVIYTSGSTGQPKGVMVEHCTLVNLVHWHCQAFALQAGSHTASVAGF 1719
Query: 1090 HHDMSVFDLFATLSFGATLVLP---AGHEEKDAL-QWNRLIERHQVTIWVSVPAILEML- 1144
D ++++ L GA L LP G+E D L W W+ P + L
Sbjct: 1720 GFDAMAWEVWPALCAGAVLHLPPAEVGNEHVDELLDW-----------WLEQPLQVGFLP 1768
Query: 1145 -----LSCTQAGQLHSLRLIAQGGDYIKPATIAQLRAGSNPP--RLISLGGPTETTIWSI 1197
+ + Q +LR + GGD +LR + P +I+ GPTETT+
Sbjct: 1769 TPVAEQAFRRPRQHPTLRTLLIGGD--------RLRQFDSDPGFAVINNYGPTETTV--- 1817
Query: 1198 WHELTADDVSVIP-----YGRPLAGNRYFIMDEIQRHVPQGVVGRIFTSGVNLAQGYLED 1252
A +V P G P+A R +++DE + VP GVVG ++ G +A+GYL
Sbjct: 1818 ----VATSGAVQPGGPLHIGGPIANTRVYVLDEQLQPVPVGVVGELYIGGAGVARGYLNR 1873
Query: 1253 GELKQTDFVTVLDEHGHPVRAFRTGDQGYYRADGNIIFASRINGYVKVRGVRVSLPDIEK 1312
++ + F+ R +R+GD + ADG++ + R + VK+RG+R+ L +IE
Sbjct: 1874 PQMTEERFIADPFSAATQARLYRSGDLVRWNADGSLDYLGRNDDQVKIRGMRIELGEIET 1933
Query: 1313 QLQTHPALASVVVVDYADTNGDTALAALFSVKPQQSASSQALREFAKQSLPSSHIPSRFI 1372
L + + VV+ G+ LA P +ALRE + LP+ +P F
Sbjct: 1934 ALASQAEVQDAVVL----VRGERLLAWFTESAP---VEPEALREALRARLPAHMVPLAFT 1986
Query: 1373 ALEALPLSANGKVDRK 1388
L+ALPL+++GK+DR+
Sbjct: 1987 RLDALPLTSHGKLDRR 2002
Score = 163 bits (412), Expect = 5e-43
Identities = 233/980 (23%), Positives = 407/980 (41%), Gaps = 97/980 (9%)
Query: 457 PLTPLQQAYLLGRSTQIALGGVAMHEFREY---RGHIDTQSLHSRLLYLVEHIPALRTRI 513
PLT Q+ L QI+ G ++ Y G +D +LH L LV LRT +
Sbjct: 10 PLTAAQRDVWLD---QISRGDSPLYNIGGYLQLSGAVDPVTLHKALEQLVCAHEVLRTVL 66
Query: 514 DQEKW-----IQWVSPCIALNWQAIDLQHLSREQALLAVEPVRQQYQQRMHDLTRSPW-Q 567
+Q + C+ ++ D+ + A + +R + L SP
Sbjct: 67 MPGAGADGMPLQSYAACLPVSLPLHDVSGYPEPEQ--AARALINDNMRRPYVLDGSPLLD 124
Query: 568 ICVVQLPIEEQEEFSSIVLTSFDALIVDG-------RTHALILAALLGSEEPDITQVVQN 620
C+++L + + LI+DG ++ + +AL+ ++ ++ +
Sbjct: 125 FCLIRLADDRHW-----LAGQAHHLILDGWGFGQLFKSLGELYSALMAGKDLELVAPGYS 179
Query: 621 ARDTQSISPQFASKKAQDEAYWKSKLHPDCPPPALPWKQALETITTSRYARESLQ-IPKE 679
A Q + + + D AYW K + D P P L + T + +Q +P
Sbjct: 180 AFIADDARYQASQRYSLDRAYWLEK-YRDLPEPLLVSRYHNRRATDPAPSHAWVQPLPGT 238
Query: 680 SVGKLNRCGIENGLFLNSLLTATILDVLSYWTTEIGMR----VGFPVLIPSSNAIDGNES 735
++ + + ++ +L VL + T R VG P+L S
Sbjct: 239 LHARMKQFAERH----HASAFHVLLAVLHVYFTRTAQRDEWIVGLPLLNRSGARFKATLG 294
Query: 736 SFVILEHEKSTLSLLSQASKLQREMLEALE----HLAFSGVDLNRLL-MNQAPQALVLPV 790
F + + + L E+ +AL+ H F +LNR L +++ +A + V
Sbjct: 295 HFAQVSAVRMAFDDGLDFAALVVEVRDALKRDFRHQRFPLSELNRSLELSREGRAQLFEV 354
Query: 791 VLTNGLSWKTLNPEDA----VTLFDGVTQTP-QVALDIRLTYDEQKNLIISFDYALAVLE 845
++ L DA V + +G TP V L DE ++ + A +E
Sbjct: 355 SVSYELEDHGYCYTDAQAQTVKVSNGYEATPLAVHLRSNSCNDEASLHLV---HHRAWIE 411
Query: 846 TELIREMLSALHHRLSQITSSASLAAP----LEPCIDLSHYRFNSDESASHDCDFLAKLA 901
+ + + L H L Q + +L P L +N E + D + +
Sbjct: 412 DDEAQAIAGRLLHILEQGLENPALKIQDFHLSVPAEQLQLTAWNQTERVTDDEQLIHRRI 471
Query: 902 QQLFVRTEDKTAVICGEQTLSYAQLGEQVQRVMWQLKARGLTTGNVLAICLPRSVEHIVI 961
+Q A I Q L+YAQL Q + +L +G+ + +AI R +E +V
Sbjct: 472 EQQARTRPYAVAAIFQGQHLTYAQLNRQANALAQRLIYQGVRPDDRVAIVSRRGLETLVG 531
Query: 962 SLASALSGIIWVPIDAASPKERLNYLLENCHADLVVMDKPCEFGNVIAFDALIEPVLFAD 1021
LA +G +VPID + P+ERL+YLL + A +VV+ + L P++ D
Sbjct: 532 LLAILKAGAAYVPIDPSHPRERLHYLLSD-SAPVVVLTLS---SLIKRLPPLAVPLIELD 587
Query: 1022 GVPDVTPLD---QLSRLSQSQQTAYYLYTSGTTGKPKCVVVNNQATSNVIGQTGQAWHLT 1078
D + Q++ LS S Y +YTSG+TG+PK V+V ++ +N++ QA+ +
Sbjct: 588 HCIDGQGAENNPQVAGLS-SDNLVYVIYTSGSTGQPKGVMVEHRTLANLVDWHCQAFDVK 646
Query: 1079 SEDVVMSVTPLHHDMSVFDLFATLSFGATL----VLPAGHEEKDALQWNRLIERHQVTIW 1134
+ + D ++++ TL GATL V G + + L W W
Sbjct: 647 ASSHTSCLAGFGFDAMAWEVWPTLCAGATLHVAPVQDGGEDIEAMLDW-----------W 695
Query: 1135 VSVPAILEML------LSCTQAGQLHSLRLIAQGGDYIKPATIAQLRAGSNPPRLISLGG 1188
+ P + L + +Q+ +LR + GGD ++ T + +++ G
Sbjct: 696 RAQPLDVSFLPTPVAEYAFSQSQDHPTLRTLLIGGDRLRQFT------HNRRYTVVNNYG 749
Query: 1189 PTETTIWSIWHELTADDVSVIPYGRPLAGNRYFIMDEIQRHVPQGVVGRIFTSGVNLAQG 1248
PTETT+ + ++ A+ + G P+A R +++DE + +P GV G ++ G +A+G
Sbjct: 750 PTETTVVATSGQVLAN--GSLHIGGPIANTRVYVLDEHLQAMPVGVPGELYIGGEGVARG 807
Query: 1249 YLEDGELKQTDFVTVLDEHGHPVRAFRTGDQGYYRADGNIIFASRINGYVKVRGVRVSLP 1308
YL +L FV R +R+GD + DG++ + R + VK+RG+R+ L
Sbjct: 808 YLNQPQLTDERFVVDPFSDMPQARMYRSGDLVRWNRDGSLDYLGRNDDQVKIRGMRIELG 867
Query: 1309 DIEKQLQTHPALASVVVVDYADTNGDTALAALFSVKPQQSASSQALREFAKQSLPSSHIP 1368
+IE L + VV+ + L A F+ + L + LP +P
Sbjct: 868 EIEAVLAGLDGVKDAVVL-----VRELHLLAWFT--ETSTVDIDTLAPAMRARLPGYMVP 920
Query: 1369 SRFIALEALPLSANGKVDRK 1388
F L +LPL+ANGK+DR+
Sbjct: 921 RAFTRLASLPLTANGKLDRR 940
Score = 70.1 bits (170), Expect = 6e-15
Identities = 82/370 (22%), Positives = 154/370 (41%), Gaps = 23/370 (6%)
Query: 1950 PLSLAQASLWKAMSKYAKFGLTHIFNLPFALKFLDEVNEQAFGEAFHWLLLRHAGLRTHF 2009
PL+ AQ +W + + ++ G + ++N+ L+ V+ +A L+ H LRT
Sbjct: 10 PLTAAQRDVW--LDQISR-GDSPLYNIGGYLQLSGAVDPVTLHKALEQLVCAHEVLRTVL 66
Query: 2010 ---GLEDGQPYQHVIAASNIE---HYQWFWTSKDNAAQSVARLLAQEAEHTFDLSQELPL 2063
DG P Q A + H + + AA+++ + + D S L
Sbjct: 67 MPGAGADGMPLQSYAACLPVSLPLHDVSGYPEPEQAARALINDNMRRP-YVLDGSPLLDF 125
Query: 2064 RLNFVRDEQTGTQYLSLLFHHIVLDEWSINILMDELAQVYQHSVQGTRPQWQTEPLP--F 2121
L + D++ +L+ HH++LD W L L ++Y + G +
Sbjct: 126 CLIRLADDR---HWLAGQAHHLILDGWGFGQLFKSLGELYSALMAGKDLELVAPGYSAFI 182
Query: 2122 HEFARKQRSSAFNQTHLNYWLTKFAGVPWAQPLFAADHPLSNSTGVDLGEGGWVEIKLPK 2181
+ AR Q S ++ YWL K+ +P +PL + + +T WV+ LP
Sbjct: 183 ADDARYQASQRYSLDRA-YWLEKYRDLP--EPLLVSRYHNRRATD-PAPSHAWVQ-PLPG 237
Query: 2182 STMVSLYQLAKARHASLFNVMYAAISASVHCLGAPEKLLVGTPASGRLDAEFFDTVGYFT 2241
+ + Q A+ HAS F+V+ A + ++ +VG P R A F T+G+F
Sbjct: 238 TLHARMKQFAERHHASAFHVLLAVLHVYFTRTAQRDEWIVGLPLLNRSGARFKATLGHFA 297
Query: 2242 TMGVQLVDFTKVQTVWQLIEQVKNSINQSMPYTDIPIDLIEEGLKGVEHETEGHMFEVFI 2301
+ + F L+ +V++++ + + P+ + L+ + E +FEV +
Sbjct: 298 QVSAVRMAFDDGLDFAALVVEVRDALKRDFRHQRFPLSELNRSLE-LSREGRAQLFEVSV 356
Query: 2302 QLHAKNKLHG 2311
++ HG
Sbjct: 357 SYELED--HG 364
Score = 61.2 bits (147), Expect = 3e-12
Identities = 115/541 (21%), Positives = 204/541 (37%), Gaps = 92/541 (17%)
Query: 1741 LVTWLVDPSV--------HLQLEGLRCEKLLFAAMHPKFEVALGVGLNCQGALVLE---- 1788
LV W D S+ +++ G+R E + E AL Q A+VL
Sbjct: 1900 LVRWNADGSLDYLGRNDDQVKIRGMRIEL-------GEIETALASQAEVQDAVVLVRGER 1952
Query: 1789 -LALDATVSPHVGAYLLEQFVAAIGGRTMPSSTTSSSHVSAIELTSNNPPTSNNAHAALA 1847
LA +P L E A + +P + T + A+ LTS+ AL
Sbjct: 1953 LLAWFTESAPVEPEALREALRARLPAHMVPLAFT---RLDALPLTSHGKLDRR----ALP 2005
Query: 1848 ESELELSAVNSSAVE----ECILAE-FRSALGVAEMTAEDDFFDFGGHSLIATRVIGRLL 1902
+ ELE + A E ++A+ + LG+ ++ D+FF+ GGHSL+A ++ R L
Sbjct: 2006 DPELEALTSQAYAAPVGETEILMADLWAHVLGLEKVGRHDNFFELGGHSLLAVSLVER-L 2064
Query: 1903 SEQGIELHINDMFSFPNAKQLAQQ--------AVLHRKPTSTSFAVSEVVESSK------ 1948
G+ + + + P LA L+R P ++ +++ S+
Sbjct: 2065 RNAGLSVDVRVLLGQPTVAALAASVGKGREIPTPLNRVPAGCTYITPDLLSLSQLDQTTI 2124
Query: 1949 ------APLSLAQASLWKAMSKYAKFGLTHIFNL----PFALKFLDEVNEQ----AFGEA 1994
P A ++ + L H P+ L+ V+ Q A A
Sbjct: 2125 ERIVATVPGGAANVQEIYPLAPLQEGILYHHLTAEQGDPYLLQLRMNVDSQERLEAVAAA 2184
Query: 1995 FHWLLLRHAGLRTHFGLEDGQPYQHVIAASNIEHYQWFWTSKDNAAQSV--ARLLAQEAE 2052
++ RH LRT + + Q V+ W D + V A++
Sbjct: 2185 LREVIARHDSLRTAIVWDGLETPQQVV-----------WRQADLLVERVPMAQIDTPAGS 2233
Query: 2053 HTFDLSQELPLRLNFVRDEQTGTQYLSLLFHHIVLDEWSINILMDELAQVYQHSVQGTRP 2112
DLS +RL + D +LLFHHIV+D ++ ++ +E+ + T+P
Sbjct: 2234 ARMDLSCAPLIRLAYCPDATGPGLSATLLFHHIVVDATALEVMREEMLAHLRGEPGPTQP 2293
Query: 2113 QWQTEPLPFHEFARKQRSSAFNQTHLNYWLTKFAGVPWAQPLFAADHPLSNSTGVDL-GE 2171
+P+ + + R H Y+ + + D P D+ G+
Sbjct: 2294 -----AVPYRNYVAQARLGVSEAEHEAYFREQLGDI---------DEPTLPFDLRDVQGD 2339
Query: 2172 GGWVE---IKLPKSTMVSLYQLAKARHASLFNVMYAAISASVHCLGAPEKLLVGTPASGR 2228
G +E LP + + L A+ S+ ++++ A + + ++++ GT GR
Sbjct: 2340 GHCIEEAPQMLPDALLQRLRTQARQLGVSVASLLHLAWARVLGAATGNDRVVFGTVLLGR 2399
Query: 2229 L 2229
L
Sbjct: 2400 L 2400
Score = 57.4 bits (137), Expect = 4e-11
Identities = 88/409 (21%), Positives = 165/409 (40%), Gaps = 48/409 (11%)
Query: 1861 VEECILAEFRSALGVAEMTAEDDFFDFGGHSLIATRVIGRLLSEQGIELHINDMFSFPNA 1920
VE + A + LG+ + D+FF+ GGHSL+A ++ +L + G++ ++ + S P
Sbjct: 962 VEIAMAAIWAQVLGIQRVGRHDNFFELGGHSLLAVSLVEQL-RKAGLKADVHVLLSQPTL 1020
Query: 1921 KQLAQ---QAVLHRKPTSTSFA-VSEVVESSKAPLSLAQASLWKAMSKYAKFGLTHI--- 1973
LA + PT+ A ++ + +SL Q+++ + ++ G ++
Sbjct: 1021 AALAACQADVSTFKVPTNLIPAGCKQITPGMLSLVSLEQSAIDRIVASVPG-GAANVQEI 1079
Query: 1974 ----------------------FNLPFALKFLDEVNEQAFGEAFHWLLLRHAGLRTHF-- 2009
+ L + L F ++ A ++ RH LRT
Sbjct: 1080 YPLAPLQEGILYHHLTAEQGDPYLLQWRLAFDTPERLYSWAAALQEVIDRHDILRTSVVW 1139
Query: 2010 -GLEDGQPYQHVIAASNIEHYQWFWTSKDNAAQSVARLLAQ--EAEHTFDLSQELPLRLN 2066
GLE P Q V + + + ++D + + RL Q H DL+Q +RL
Sbjct: 1140 QGLES--PQQVVWRNAELTVQAIEFEAEDPESTVIDRLQRQFDARHHRLDLTQAPLMRLV 1197
Query: 2067 FVRDEQTGTQYLSLLFHHIVLDEWSINILMDELAQVYQHSVQGTRPQWQTEPLPFHEFAR 2126
+ +G LLFHH+VLD ++ I+ E+ Q + G R +T P+P+ +
Sbjct: 1198 HAQQSSSGETVAILLFHHLVLDNTAMEIVSREM----QALLFGHRYDLKT-PVPYRNYVA 1252
Query: 2127 KQRSSAFNQTHLNYWLTKFAGVPWAQPLFAADHPLSNSTGVDLGEGGWVEIKLPKSTMVS 2186
+ R + +H ++ V +P ++ G D+ E L +
Sbjct: 1253 QVRLANDEASHTAFFTEMLGDVD--EPTLPFGIQDVHAGGSDIEE---ERRALDPELALR 1307
Query: 2187 LYQLAKARHASLFNVMYAAISASVHCLGAPEKLLVGTPASGRLDAEFFD 2235
L + A+ S ++M+ + + L ++ GT GR+ E D
Sbjct: 1308 LREQARLLGVSAASLMHVVWARVLGVLANRRDVVFGTVLLGRMGGEGAD 1356
Score = 41.6 bits (96), Expect = 2e-06
Identities = 23/57 (40%), Positives = 34/57 (59%), Gaps = 2/57 (3%)
Query: 1863 ECILAEFRSAL-GVAEMTAEDDFFDFGGHSLIATRVIGRLLSEQGIELHINDMFSFP 1918
E +LA S L GV ++ D+FF+ GGHSL+A + R L ++GIE + +F P
Sbjct: 3094 EVLLARLWSELLGVGQVGRHDNFFELGGHSLLAVSLTAR-LRQEGIEADVRALFEQP 3149
Score = 37.7 bits (86), Expect = 3e-05
Identities = 47/172 (27%), Positives = 72/172 (41%), Gaps = 18/172 (10%)
Query: 1423 LSEFEQRVWRQHQRHGDGRNQYATAY-RLSGKVNIARLITALSQLPNHFPVLNRRYVLDE 1481
L+ ++ VW GD Y +LSG V+ L AL QL VL R VL
Sbjct: 11 LTAAQRDVWLDQISRGDSPLYNIGGYLQLSGAVDPVTLHKALEQLVCAHEVL--RTVLMP 68
Query: 1482 ASG-----LTLYSA-KPTPLEIH-FEHVESMDEAFEHLVRWQ-NQPMDLAKQATLSFCLL 1533
+G L Y+A P L +H ++A L+ +P L L FCL+
Sbjct: 69 GAGADGMPLQSYAACLPVSLPLHDVSGYPEPEQAARALINDNMRRPYVLDGSPLLDFCLI 128
Query: 1534 SLGSEERVLGVISHQIISEQWDWRRVFECVTNGYNQIACDIDPVMEGEDLSL 1585
L + L +H +I + W + ++F+ + Y+ + M G+DL L
Sbjct: 129 RLADDRHWLAGQAHHLILDGWGFGQLFKSLGELYSAL-------MAGKDLEL 173