Pairwise Alignments
Query, 2413 a.a., non-ribosomal peptide synthetase from Vibrio cholerae E7946 ATCC 55056
Subject, 4336 a.a., Non-ribosomal peptide synthase:Amino acid adenylation from Pseudomonas syringae pv. syringae B728a
Score = 215 bits (547), Expect = 2e-58
Identities = 209/795 (26%), Positives = 342/795 (43%), Gaps = 47/795 (5%)
Query: 632 ASKKAQDEAYWKSKLHPDCPPPALPWKQALETITTSRYARESLQIPKESVGKLNRCGIEN 691
A ++ + YW ++L + P LP + + + + + + K+ N
Sbjct: 1915 AGERQRQLDYWTAQLGNEHPLLELPADRPRPPVQSHQGELYRFDLNADLAAKVRAFNARN 1974
Query: 692 GLFLNSLLTATILDVLSYWTTEIGMRVGFPV---LIPSSNAIDGNESSFVILEHEKSTLS 748
GL L +TAT+ +L ++ + +R+G PV + P S + G L + +
Sbjct: 1975 GLTLFMTMTATLAVLLYRYSGQNDLRIGAPVANRIRPESEGLIG-----AFLNTQVLRVQ 2029
Query: 749 LLSQASKLQREMLEALEHLAFSGVDLNRLLMNQAPQALVLP---------VVLTNGLSWK 799
L Q S Q + E + H G L + +AL P V+ N W+
Sbjct: 2030 LDGQMSVAQ--LFEQVRHTVIEGQSHQDLPFDHLVEALQPPRSAAYNPLFQVMCNVQRWE 2087
Query: 800 TLNPED--AVTLFDGVTQTPQVALDIRLTYDE-QKNLIISFDYALAVLETELIREM---- 852
+ +T+ V D+ L E L Y+ + + I +M
Sbjct: 2088 FQQSRELAGMTVEYLVNDARATKFDLNLEVTELDHRLGCCLTYSTDLFDEPRIAQMAEHW 2147
Query: 853 ---LSALHHRLSQITSSASLAAPLEPCIDLSHYRFNSDESASHDCDFLAKLAQQLFVRTE 909
L AL Q S L E L + E C + L + R
Sbjct: 2148 LNLLQALLADPQQRLSELPLLQETERQHLLDSLGVEAGEQRLDQC--IHSLFAEQAHRRA 2205
Query: 910 DKTAVICGEQTLSYAQLGEQVQRVMWQLKARGLTTGNVLAICLPRSVEHIVISLASALSG 969
D A+ QTLSYA+L + ++ W L+ RG+ + + LPRS++ +V LA +G
Sbjct: 2206 DAPALTFAGQTLSYAELDAKANQLAWMLRERGVGPQIRVGLALPRSLDMVVGLLAILKAG 2265
Query: 970 IIWVPIDAASPKERLNYLLENCHADLVVMDKPCEFGNVIAFDALIEPVLFADGVPDVTPL 1029
+VP+D P ERL+Y++E+ L++ D+ F + A + D P +
Sbjct: 2266 GAYVPLDPEYPLERLHYMIEDSGVGLLLSDRAL-FAALGELPAGVARWCLEDDQPSLASF 2324
Query: 1030 --DQLSRLSQSQQTAYYLYTSGTTGKPKCVVVNNQATSNVIGQTGQAWHLTSEDVVMSVT 1087
D+L +S Q AY +YTSG+TGKPK VVV++ + + + + +D +
Sbjct: 2325 SSDELPFISLPQHQAYLIYTSGSTGKPKGVVVSHGEIAMHCQAVIRRFDMRPDDCELHFY 2384
Query: 1088 PLHHDMSVFDLFATLSFGATLVLPAGHEEKDALQWNRLIERHQVTIWVSVPAILEMLLS- 1146
++ D + L L GA +VL A + DA + LI + QV I P+ L
Sbjct: 2385 SINFDAATERLLVPLLSGARVVLRA-QGQWDAEEICTLIRQQQVNILGFTPSYGSQLAQW 2443
Query: 1147 CTQAGQLHSLRLIAQGGDYIKPATIAQLRAGSNPPRLISLGGPTETTIW---SIWHELTA 1203
GQ +R+ GG+ + + ++RA P L + GPTET + S+ +
Sbjct: 2444 LATQGQTLPVRMCITGGEALTGEHLQRIRAVFQPELLFNAYGPTETVVMPLASLAPQQLE 2503
Query: 1204 DDVSVIPYGRPLAGNRYFIMDEIQRHVPQGVVGRIFTSGVNLAQGYLEDGELKQTDFVT- 1262
+ + +P GR + +I+D VPQG G ++ G LAQGY + + FV
Sbjct: 2504 EGEASVPIGRVVGARVAYILDADLALVPQGASGELYIGGAGLAQGYHQRPGMTAERFVAD 2563
Query: 1263 VLDEHGHPVRAFRTGDQGYYRADGNIIFASRINGYVKVRGVRVSLPDIEKQLQTHPALAS 1322
+G R +RTGD RADG + + RI+ VK+RG R+ L +IE +L H A+
Sbjct: 2564 PFASNGG--RLYRTGDLVRQRADGLVEYLGRIDHQVKIRGFRIELGEIETRLLEHAAVRE 2621
Query: 1323 VVVVDYADTNGDTALAALFS-----VKPQQSASSQALREFAKQSLPSSHIPSRFIALEAL 1377
+V+ +G L S QQ+ ++L+ K LP +P+ I L+++
Sbjct: 2622 AIVLALDTPSGKQLAGYLVSDVAGQGDEQQAQWRESLKSHLKAQLPDYMVPTHLILLDSM 2681
Query: 1378 PLSANGKVDRKQCQA 1392
PL+ANGK+DR+ A
Sbjct: 2682 PLTANGKLDRRALPA 2696
Score = 201 bits (512), Expect = 2e-54
Identities = 231/960 (24%), Positives = 404/960 (42%), Gaps = 77/960 (8%)
Query: 487 RGHIDTQSLHSRLLYLVEHIPALRTRIDQEKWI--QWVSPCIALNWQAIDLQHLSREQAL 544
RG +D+ +L S L+E +LRTR ++ + Q + + +D+ L +
Sbjct: 710 RGELDSTALRSSFQRLIERHESLRTRFYEQDGVALQRIDAPSEFHLDTLDISDLPGAERQ 769
Query: 545 LAVEPVRQQYQQRMHDLTRSPWQICVVQLPIEEQEEFSSIVLTSFDALIVDGRTHALIL- 603
+R+Q + DL P + V L ++E+E +L + +I DG + +++
Sbjct: 770 ARAVAIREQQARLPFDLQHGPL-LRVTLLRLDEEEHQ---LLVTLHHIIADGWSLNVLID 825
Query: 604 -------AALLGSEEPDITQVVQNARDTQSISPQFASKKAQDE-AYWKSKLHPDCPPPAL 655
+A+ G ++ A Q A+ +A+ + YW+ +L + P L
Sbjct: 826 EFSRLYASAVQGQTLELAPLPLRYADYGQWQREWLANGEAERQLTYWQQQLGGEQPVLTL 885
Query: 656 PWKQALETITTSRYARESLQIPKESVGKLNRCGIENGLFLNSLLTATILDVLSYWTTEIG 715
+R SL++ E + L A +L ++ +
Sbjct: 886 NTDHPRSARQQHSASRYSLRLSAELSAAVRNTAQAWQSTSFMFLLAGFQTLLHRYSGQAD 945
Query: 716 MRVGFPVLIPSSNAIDGNESSFVILEHEKSTLSLLSQ-------ASKLQREMLEALEHLA 768
+RVG P + G F+ +TL L +Q ++ L + ALE A
Sbjct: 946 IRVGVPGANRPRHETQGLIGFFI------NTLVLRAQLDPRLPFSTLLAQTRQAALEAQA 999
Query: 769 FSGVDLNRLLMNQAPQALVLPVVLTNGLSWKTLNPED----AVTLFDGVT------QTPQ 818
V +L+ P +GL N + A+ G+ + +
Sbjct: 1000 HQDVPFEQLVE-------AFPRAREHGLFQVMFNHQQRDLGALRRLPGLLAEELPWHSRE 1052
Query: 819 VALDIRLTYDEQKN--LIISFDYALAVLETELIREMLSALHHRLSQITSSASLAAPLEPC 876
D++L +E +N L + FDYA + E I M L+Q++ A LA
Sbjct: 1053 AKFDLQLHSEEDRNGRLTLCFDYADELFEHHTIVAMAQHYVRLLTQVSQQAQLALGDVQL 1112
Query: 877 IDLSHYRFNSDESASHDCD---FLAKLAQQLFVRTEDKTAVICGEQTLSYAQLGEQVQRV 933
+ + SA+ +L +L +T ++ A++ +L +A L Q R+
Sbjct: 1113 LSAEEQEQQAQWSAAPCAPATLWLPELLNHQARQTPERIALVWEGGSLDFASLHTQANRL 1172
Query: 934 MWQLKARGLTTGNVLAICLPRSVEHIVISLASALSGIIWVPIDAASPKERLNYLLENCHA 993
L+ +G+ +AI RS + ++ LA +G +VP+D P +RL Y+L++
Sbjct: 1173 AHYLRDKGVGPDIKVAIAAERSPQLLIGLLAILKAGGAYVPLDPDYPMDRLAYMLQDSGV 1232
Query: 994 DLVVM------DKPCEFGN-VIAFDALIEPVLFADGVPDVTPLDQLSRLSQSQQTAYYLY 1046
+L++ D P G +A D L D P P L AY +Y
Sbjct: 1233 ELLLTQSHLLGDLPSAEGVCTVAMDTL-----HLDNWPVSAPRLNL----HGDNLAYVIY 1283
Query: 1047 TSGTTGKPKCVVVNNQATSNVIGQTGQAWHLTSEDVVMSVTPLHHDMSVFDLFATLSFGA 1106
TSG+TG+PK V + A + + + L DV+M P+ D+SV++ F L G
Sbjct: 1284 TSGSTGQPKGVGNTHAALAERLQWMQDTYALDESDVLMQKAPISFDVSVWECFWPLITGC 1343
Query: 1107 TLVLPAGHEEKDALQWNRLIERHQVTIWVSVPAILEMLLSCTQAGQLHSLRLIAQGGDYI 1166
L+L E +D + +LI + VT VP +L++ + A Q +SLR + GG+ +
Sbjct: 1344 RLLLAGPGEHRDPQRIAQLINAYSVTTLHFVPPLLQLFIDEPLAQQCNSLRRLFSGGEAL 1403
Query: 1167 KPATIAQLRAGSNPPRLISLGGPTETTIWSIWHELTADDVSVIPYGRPLAGNRYFIMDEI 1226
++ +L + GPTET I + D P GRPL ++D
Sbjct: 1404 PGELRNRVLEQLPGVQLHNRYGPTETAINVTHWQCRISDGLRSPIGRPLGNVLCRVLDSE 1463
Query: 1227 QRHVPQGVVGRIFTSGVNLAQGYLEDGELKQTDFVT-VLDEHGHPVRAFRTGDQGYYRAD 1285
+P+ V G + G+ LA+GYL L FV L + G R +RTGD + AD
Sbjct: 1464 LNPLPRVVAGELCIGGIGLARGYLRRPGLTAERFVADPLGQAGE--RLYRTGDLVRWAAD 1521
Query: 1286 GNIIFASRINGYVKVRGVRVSLPDIEKQLQTHPALASVVVVDYADTNGDTALAALFSVKP 1345
G + + R++ VK+RG RV +IE +L P + V+ +T L ++ +
Sbjct: 1522 GALEYLGRLDQQVKLRGFRVEPQEIEARLLAQPGVGQAAVL-LRETVAGPQLIGYYTAEA 1580
Query: 1346 QQSASSQALREFAKQSLPSSHIPSRFIALEALPLSANGKVDRK-------QCQAHVQRQS 1398
Q+ ++ ++ LP +P++ + L+++PLS +GK+DR+ Q + HV+ Q+
Sbjct: 1581 GQNVEAERIKSALALELPDYMVPAQLVRLDSMPLSPSGKLDRRALPEPQWQTREHVEPQT 1640
Score = 172 bits (436), Expect = 1e-45
Identities = 145/517 (28%), Positives = 230/517 (44%), Gaps = 14/517 (2%)
Query: 886 SDESASHDCDFLAKLAQQLFVRTEDKTAVICGEQTLSYAQLGEQVQRVMWQLKARGLTTG 945
SD + D ++ Q+ E + AV C ++ LSYA L R+ L G+
Sbjct: 3715 SDHAYPLDKSYVELFEAQVAAHPE-RIAVSCLDRQLSYAALNIASNRLGHALIEAGVGFD 3773
Query: 946 NVLAICLPRSVEHIVISLASALSGIIWVPIDAASPKERLNYLLENCHADLVVMDKPCEFG 1005
+A+ R VE + + S +G ++P+D A P RL+ ++ L+V C
Sbjct: 3774 QPVAVLAERGVELPGMIIGSFKAGAGYLPLDPALPNSRLSDIIGQSATPLLVCSAECLEQ 3833
Query: 1006 NVIAFDALIEPV-----LFADGVPDVTPLDQLSRLSQSQQTAYYLYTSGTTGKPKCVVVN 1060
DAL E ++ D + R S AY ++TSG+TG PK V+V
Sbjct: 3834 GRALLDALPEASRPQLRVWEDLQQSDSAQHNPGRYSAPDNLAYVIFTSGSTGLPKGVMVE 3893
Query: 1061 NQATSNVIGQTGQAWHLTSEDVVMSVTPLHHDMSVFDLFATLSFGATLVLPAGHEEKDAL 1120
N L+ DV+ D+SV+ A FGA + + +D
Sbjct: 3894 QHGMLNNQLSKLPYLSLSDRDVIAQTASQSFDISVWQFLAAPLFGARVDIVPNDIARDPQ 3953
Query: 1121 QWNRLIERHQVTIWVSVPAILEMLLSCTQAGQLHSLRLIAQGGDYIKPATIAQLRAGSNP 1180
++ ++++ SVP+++ LL+ A L SLR + G+ + P +Q
Sbjct: 3954 ALLAHVQAQRISVLESVPSLITRLLAEPHAA-LDSLRWMLPTGEAMPPELASQWLQRYPQ 4012
Query: 1181 PRLISLGGPTETTIWSIWHELTADDV--SVIPYGRPLAGNRYFIMDEIQRHVPQGVVGRI 1238
L++ GP E + + + A + +P G P NR +++D+ VP G VG +
Sbjct: 4013 IGLVNAYGPAECSDDVAFFRVDAQSTRSAYLPIGSPTDNNRLYLLDDALDLVPLGAVGEL 4072
Query: 1239 FTSGVNLAQGYLEDGELKQTDFVTVLDEHGHP-VRAFRTGDQGYYRADGNIIFASRINGY 1297
+G + +GY+ D + +T V V G P R +RTGD R DG + + R++
Sbjct: 4073 CVAGAGVGRGYVADPQ--RTVPVFVPHPFGAPGERLYRTGDLARRRKDGVLEYVGRVDHQ 4130
Query: 1298 VKVRGVRVSLPDIEKQLQTHPALASVVVVDYADTNGDTALAALF--SVKPQQSASSQALR 1355
VK+RG R+ L +IE +L PA+ VV+D A G A L S A +R
Sbjct: 4131 VKIRGYRIELGEIETRLLELPAIRESVVLDVAGPLGKVLAAYLVPRSTAQDHEALRDEVR 4190
Query: 1356 EFAKQSLPSSHIPSRFIALEALPLSANGKVDRKQCQA 1392
K SLP +P+ + LEA+PL+ NGK+ RK A
Sbjct: 4191 NHLKASLPDYMVPTHLVLLEAMPLTPNGKLHRKALPA 4227
Score = 141 bits (355), Expect = 3e-36
Identities = 147/563 (26%), Positives = 241/563 (42%), Gaps = 55/563 (9%)
Query: 1837 PTSNNAHAALAESELELSAVNSSAVEECILAEFRSALGVAEMTAEDDFFDFGGHSLIATR 1896
P S++ A A S + S ++ I + L +++A+D FF GG+S+IAT+
Sbjct: 569 PASDSTLAGCAPS-------SGSDLQAQIATVWCEQLQCEQVSADDHFFLLGGNSIIATQ 621
Query: 1897 VIGRLLSEQGIELHINDMFSFPNAKQLAQQAVLHRKPTS-----TSFAVSEVVESSKAPL 1951
V+ RL GI+L++ +F P A Q + S T A++ + + P
Sbjct: 622 VVARLRETLGIDLNLRLLFEAPTLAAFAAQVETLQTAASQGDSQTQSAIARLPGNEHLPQ 681
Query: 1952 SLAQASLWKAMSKYAKFGLTHIFNLPFALKFLDEVNEQAFGEAFHWLLLRHAGLRTHFGL 2011
S+AQ LW + +N+P L E++ A +F L+ RH LRT F
Sbjct: 682 SMAQNRLWFLWQLDPH---SSAYNVPGGLHLRGELDSTALRSSFQRLIERHESLRTRFYE 738
Query: 2012 EDGQPYQHVIAASNIEHYQWFWTSKDNAAQSVARLLA---QEAEHTFDLSQELPLRLNFV 2068
+DG Q + A S H S A+ AR +A Q+A FDL LR+ +
Sbjct: 739 QDGVALQRIDAPSEF-HLDTLDISDLPGAERQARAVAIREQQARLPFDLQHGPLLRVTLL 797
Query: 2069 RDEQTGTQYLSLLFHHIVLDEWSINILMDELAQVYQHSVQGTRPQWQTEPLPFHEFARKQ 2128
R ++ Q L L HHI+ D WS+N+L+DE +++Y +VQG + PL + ++ + Q
Sbjct: 798 RLDEEEHQLLVTL-HHIIADGWSLNVLIDEFSRLYASAVQGQTLELAPLPLRYADYGQWQ 856
Query: 2129 RSSAFN---QTHLNYWLTKFAGVPWAQPLFA--ADHPLSNSTGVDLGEGGWVEIKLPKST 2183
R N + L YW + G QP+ DHP S ++L
Sbjct: 857 REWLANGEAERQLTYWQQQLGG---EQPVLTLNTDHPRS---ARQQHSASRYSLRLSAEL 910
Query: 2184 MVSLYQLAKARHASLFNVMYAAISASVHCLGAPEKLLVGTPASGRLDAEFFDTVGYFTTM 2243
++ A+A ++ F + A +H + VG P + R E +G+F
Sbjct: 911 SAAVRNTAQAWQSTSFMFLLAGFQTLLHRYSGQADIRVGVPGANRPRHETQGLIGFFINT 970
Query: 2244 GVQLVDFTKVQTVWQLIEQVKNSINQSMPYTDIPID-LIEEGLKGVEHETEGHMFEVFI- 2301
V L+ Q + + ++ + D+P + L+E + EH +F+V
Sbjct: 971 LVLRAQLDPRLPFSTLLAQTRQAALEAQAHQDVPFEQLVEAFPRAREH----GLFQVMFN 1026
Query: 2302 ----QLHAKNKLHG---ELLLTEGHAIRFQ-QVDPDKSESG-LGLQFEILEERIEQKQTL 2352
L A +L G E L +F Q+ ++ +G L L F+ +E E +
Sbjct: 1027 HQQRDLGALRRLPGLLAEELPWHSREAKFDLQLHSEEDRNGRLTLCFDYADELFEHHTIV 1086
Query: 2353 RVMMSYMSKHYSPAQVALLTKVT 2375
M++HY V LLT+V+
Sbjct: 1087 A-----MAQHY----VRLLTQVS 1100
Score = 134 bits (337), Expect = 3e-34
Identities = 126/483 (26%), Positives = 200/483 (41%), Gaps = 33/483 (6%)
Query: 1861 VEECILAEFRSALGVAEMTAEDDFFDFGGHSLIATRVIGRLLSEQGIELHINDMFSFPNA 1920
+++ I A +R LGV + DDFF+ GGHSL+AT++I R+ I+L + +F
Sbjct: 1642 LQKQIAAVWRQVLGVPRVGLRDDFFELGGHSLLATQIISRVRQACDIDLPLRTLFEASEL 1701
Query: 1921 KQLAQQ--AVLHRKPTSTSFAVSEVVESSKAPLSLAQASLWKAMSKYAKFGLTHIFNLPF 1978
A Q A+ S+ ++ V S PLS +Q +W + +N+
Sbjct: 1702 GAFAAQVEAIQQSGARSSLQPIARVDRSQPVPLSYSQQRMWFLWQMEPD---SPAYNVGG 1758
Query: 1979 ALKFLDEVNEQAFGEAFHWLLLRHAGLRTHFGLEDGQPYQHVIAASNIEHYQWFWTSK-- 2036
+ +N + F A L+LRH LRT F +G Q V S++ QW S
Sbjct: 1759 MARLKGVLNIECFEAALQALILRHETLRTTFPSINGVACQRVSEQSDL-RVQWQDYSALP 1817
Query: 2037 -DNAAQSVARLLAQEAEHTFDLSQELPLRLNFVRDEQTGTQYLSLLFHHIVLDEWSINIL 2095
+ Q + L EA FDL + PL F+ Y L HHIV + W+++I
Sbjct: 1818 VEARQQRIQALADSEAHQPFDL-ETGPLLRAFLVKASDLEHYFVLTLHHIVTEGWAMDIF 1876
Query: 2096 MDELAQVYQHSVQGTRPQWQTEPLPFH-----EFARKQRSSAFNQTHLNYWLTKFAGVPW 2150
EL Q+Y+ ++G RP EPL H + R+ + Q L+YW +
Sbjct: 1877 ARELGQLYEAFLEG-RPS-PLEPLAVHYLDYSVWQRQWMEAGERQRQLDYWTAQLGN--- 1931
Query: 2151 AQPL--FAADHPLSNSTGVDLGEGGWVEIKLPKSTMVSLYQLAKARHASLFNVMYAAISA 2208
PL AD P V +G L + +LF M A ++
Sbjct: 1932 EHPLLELPADRP---RPPVQSHQGELYRFDLNADLAAKVRAFNARNGLTLFMTMTATLAV 1988
Query: 2209 SVHCLGAPEKLLVGTPASGRLDAEFFDTVGYFTTMGVQLVDFTKVQTVWQLIEQVKNSIN 2268
++ L +G P + R+ E +G F V V +V QL EQV++++
Sbjct: 1989 LLYRYSGQNDLRIGAPVANRIRPESEGLIGAFLNTQVLRVQLDGQMSVAQLFEQVRHTVI 2048
Query: 2269 QSMPYTDIPIDLIEEGLKGVEHETEGHMFEVFI-----QLHAKNKLHG---ELLLTEGHA 2320
+ + D+P D + E L+ +F+V + +L G E L+ + A
Sbjct: 2049 EGQSHQDLPFDHLVEALQPPRSAAYNPLFQVMCNVQRWEFQQSRELAGMTVEYLVNDARA 2108
Query: 2321 IRF 2323
+F
Sbjct: 2109 TKF 2111
Score = 72.8 bits (177), Expect = 1e-15
Identities = 133/600 (22%), Positives = 228/600 (38%), Gaps = 76/600 (12%)
Query: 895 DFLAKLAQQLFVRTEDKTAV--ICGEQ----TLSYAQLGEQVQRVMWQLKARGLTTGNVL 948
D LA+ Q+ + T D+ A+ + E L+Y L + + + L+ R G+
Sbjct: 8 DTLAQALQRRALHTPDRLALRFLTDENDQGLVLTYRDLDLRARTIAAALQ-RQAVPGDRA 66
Query: 949 AICLPRSVEHIVISLASALSGIIWVPI-----DAASPKERLNYLLENCHADLVVMDKPCE 1003
+ +++ +G+I VP + +ERL ++ + L++ +
Sbjct: 67 ILLFHSGPDYVAAFFGCLYAGVIAVPAYPPESNRRHHQERLLSIIADAEPRLLLTGADLQ 126
Query: 1004 -----FGNVIAFDALIEPVLFADGVPDVTPLDQLSRLSQSQQTAYYLYTSGTTGKPKCVV 1058
+ A DA P+L D +P + Q+ A+ YTSG+T PK V
Sbjct: 127 PALLQMDELAAADA--PPLLCVDTLPAAPAQEWQGPQLQADDIAFLQYTSGSTALPKGVQ 184
Query: 1059 VN--NQATSNVIGQTGQAWHLTSEDVVMSVTPLHHDMSVFD-LFATLSFGATLVLPA-GH 1114
V N + + + G +DV++S PL+HDM + L + G +L A +
Sbjct: 185 VTHGNLVANESLIRHGFGIDANPDDVIVSWLPLYHDMGLIGGLLQPIFSGVPCILMAPAY 244
Query: 1115 EEKDALQWNRLIERHQVTIWVSVPAILEMLLSCTQAGQLHSLRL----IAQGGDYIKPAT 1170
L+W I + TI ++ + L L L +A G +P
Sbjct: 245 FLARPLRWLEAISEYGGTISGGPDFAYQLCSARVSDSALERLDLSRWRVAYSGS--EPIR 302
Query: 1171 IAQLRA--------GSNPPRLISLGGPTETTIWSIWHEL--------------------T 1202
LRA G P ++ G E T++ +
Sbjct: 303 EDSLRAFADKFASCGFTPDSFMASYGLAEATLYVAGGKRGKGIPSLRLNAQALARNVVEP 362
Query: 1203 ADDVSVIPYGRPLAGNRYFIMDEIQRHV-PQGVVGRIFTSGVNLAQGYLEDGELKQTDFV 1261
D V+ G G+ I D + V + VG ++ SG ++A GY + E FV
Sbjct: 363 GDGQPVMSCGTGQPGHGVLIADPVSLQVLGENQVGEVWASGPSIAHGYWRNPEATARAFV 422
Query: 1262 TVLDEHGHPVRAFRTGDQGYYRADGNIIFASRINGYVKVRGVRVSLPDIEKQLQTHP--- 1318
+H RTGD G+ R G + R+ + VRG + DIEK +++
Sbjct: 423 ----QHAGQTW-LRTGDLGFQR-HGELYITGRLKDMLIVRGHNLYPQDIEKLIESEVDVV 476
Query: 1319 ---ALASVVVVDYADTNGDTALAALFSVKPQQSASSQALREFAKQSLPSS--HIPSRFIA 1373
+A+ V D + +AA S Q+ + AL + +Q++ + PS +
Sbjct: 477 RKGRVAAFAVTQ--DGSEGIGIAAEISRSVQKILTPDALIKIIRQTVAEAFQEAPSVVVL 534
Query: 1374 LE--ALPLSANGKVDRKQCQAHVQRQSISVEPVGQPNQSQPLSPPTLSSASLSEFEQRVW 1431
L ALP +++GK+ R C+ + S+ V + S S + L VW
Sbjct: 535 LNPGALPKTSSGKLQRSACRTRLADGSLDSYAVFPASDSTLAGCAPSSGSDLQAQIATVW 594
Score = 65.5 bits (158), Expect = 2e-13
Identities = 88/400 (22%), Positives = 158/400 (39%), Gaps = 44/400 (11%)
Query: 1858 SSAVEECILAEFRSALGVAEMTAEDDFFDFGGHSLIATRVIGRLLSEQGIELHINDMFSF 1917
+S +E+ + A + + L V ++ D+FF+ GG S+++ +V+ R + GI D+F
Sbjct: 2710 ASELEQQLAAIWCAVLNVEKVGLNDNFFELGGDSILSIQVVSRA-RQLGIHFSPRDLFQH 2768
Query: 1918 PNAKQLAQQAVLHRKPTSTSFAVSEVVESSKAPLS----LAQASLWKAMSKYAKFGLTHI 1973
+ LA A E++++ + L L W + +
Sbjct: 2769 QTVQTLAAVATTR-----------ELIQAEQGLLDGNSGLTPIQHWFFDTPIPE---RQH 2814
Query: 1974 FNLPFALKFLDEVNEQAFGEAFHWLLLRHAGLRTHFGLEDG--QPYQHVIAASNIEHYQW 2031
+N L+ L ++ +A LL +H LR F +G Q + A +
Sbjct: 2815 WNQSLLLEPLSALHPNLLAQALRALLEQHDALRLSFTEHEGTWQAEHRAVTADTL----L 2870
Query: 2032 FWTSKDNAAQSVARLLAQEAEHTFDLSQELPLRLNFVRDEQTGTQYLSLLFHHIVLDEWS 2091
+ A+ A L + + + DL LR V D G Q L ++ HH+V+D S
Sbjct: 2871 IQAQVSDMAECAA--LYADTQRSLDLHNGPLLRALLV-DGPQGQQRLLMVIHHLVVDGVS 2927
Query: 2092 INILMDELAQVYQHSVQGTRPQWQTEPLPFHEFARKQRSSAFNQT---HLNYWLTKFAGV 2148
+L+D+L Y+ T ++ + F ++A + ++ A N++ L+ W + G
Sbjct: 2928 WRVLLDDLQNAYRQLRDATPVRFAAKTSAFRDWAARLQAYAGNESLREELHVWQRQLGGS 2987
Query: 2149 PWAQPLFAADHPLSNSTGVDLGEGGWVEIKLPKSTMVSLYQLAKARHASLFNVMYAAISA 2208
+ P N V ++L L Q A + + + N + A
Sbjct: 2988 ATSLPCHNPQGGRQNR------HAQTVSVRLDAERTRQLLQQAPSAYRTQVNDLLLTALA 3041
Query: 2209 SVHC--LGAPEKLLVGTPASGRL----DAEFFDTVGYFTT 2242
V C G P L+ GR D + TVG+FT+
Sbjct: 3042 QVVCRWSGQP-STLIQLEGHGRENLFDDIDLTRTVGWFTS 3080
Score = 58.9 bits (141), Expect = 2e-11
Identities = 94/432 (21%), Positives = 167/432 (38%), Gaps = 37/432 (8%)
Query: 27 HLYAEFDGQALNRQALTEAVRALYAKHPMLRLAI-TKDGQ--QKILPLSTFHQLKVDDLS 83
HL E D AL + + L +H LR +DG Q+I S FH L D+S
Sbjct: 708 HLRGELDSTALR-----SSFQRLIERHESLRTRFYEQDGVALQRIDAPSEFH-LDTLDIS 761
Query: 84 QWKPDEVESFVHTKRQRMTHQMLDLTQGNPIEISLTLLPEGKHRLHIDADMIACDAQSFR 143
E ++ R++ DL G + ++L L E +H+L + I D S
Sbjct: 762 DLPGAERQARAVAIREQQARLPFDLQHGPLLRVTLLRLDEEEHQLLVTLHHIIADGWSLN 821
Query: 144 LLVDDLTSLYLEAIE-HRLEIIESDVVTFFQYLDAQQADRALAKRKEVDKK--WWQERLA 200
+L+D+ + LY A++ LE+ + +Y D Q R E +++ +WQ++L
Sbjct: 822 VLIDEFSRLYASAVQGQTLELAPLPL----RYADYGQWQREWLANGEAERQLTYWQQQLG 877
Query: 201 TIPAEPSLPYQPVPTDAVSANSQRFAHWFTPVERKGLAEVARQHHLTLTQLTLALFSQVI 260
+L + ++ R++ + + A+ T LA F ++
Sbjct: 878 GEQPVLTLNTDHPRSARQQHSASRYSLRLSAELSAAVRNTAQAWQSTSFMFLLAGFQTLL 937
Query: 261 ANACQERQFRLNVPTFHRGNRSLDIEHTIGDFSNLLIFSADVGTTQTLLSLCQQTANQLH 320
+ R+ VP +R + + IG F N L+ A + +L QT
Sbjct: 938 HRYSGQADIRVGVPGANRPRH--ETQGLIGFFINTLVLRAQLDPRLPFSTLLAQTRQAAL 995
Query: 321 QLLRHESYSGVSVMRDL--SRKQGGVQRSPIVFTS-----GMEMRDEEIFSDHVTQHLGR 373
+ H+ ++ +R+ G Q ++F G R + ++ + H
Sbjct: 996 EAQAHQDVPFEQLVEAFPRAREHGLFQ---VMFNHQQRDLGALRRLPGLLAEELPWH--- 1049
Query: 374 MNWVISQGAQVTLDAQIAPAYEG-ILLNWDVRMENFADKDITALFAHYVDLIRCVALHPE 432
S+ A+ L G + L +D E F I A+ HYV L+ V+ +
Sbjct: 1050 -----SREAKFDLQLHSEEDRNGRLTLCFDYADELFEHHTIVAMAQHYVRLLTQVSQQAQ 1104
Query: 433 MMQQSVQQIDAQ 444
+ VQ + A+
Sbjct: 1105 LALGDVQLLSAE 1116
Score = 56.6 bits (135), Expect = 9e-11
Identities = 65/308 (21%), Positives = 125/308 (40%), Gaps = 14/308 (4%)
Query: 1986 VNEQAFGEAFHWLLLRHAGLRTHFGLEDGQPYQHVI---AASNIEHYQWFWTSKDNAAQS 2042
++ Q F +A+ ++ RH LR F G+ VI ++ I++ W +
Sbjct: 3295 LDPQRFAQAWQAVIARHEALRASFCWNIGETMLQVIHKPGSTPIDYLDWRDVPAEKQEPH 3354
Query: 2043 VARLLAQEAEHTFDLSQELPLRLNFVRDEQTGTQYLSLLFHHIVLDEWSINILMDELAQV 2102
+ LL E E F L + P L +R ++ ++ + HHI++D W ++LM++ +
Sbjct: 3355 LQALLKSEREAGFALLDQPPFHLRLIRVDEARYWFM-MSNHHILIDAWCRSLLMNDFFDI 3413
Query: 2103 YQHSVQGTRPQWQTEPLPFHEFARKQRSSAFNQTHLNYWLTKFAGVPWAQPLFAADHPLS 2162
Y +G Q P + ++ + Q ++W G P+ +D P
Sbjct: 3414 YTALGEGRDAQLAPAP-RYRDYIGWLQRRGLTQAR-DWWRDNLRGFERPTPI-PSDRPFL 3470
Query: 2163 NSTGVDLG--EGGWVEIKLPKSTMVSLYQLAKARHASLFNVMYAAISASVHCLGAPEKLL 2220
D G G +L + L +LA+ ++ AA + ++ + ++
Sbjct: 3471 REHAGDSGGMVVGDCYTRLDERDGAQLRELAQQHQLTVNTFAQAAWALTLRRMSGDRDVV 3530
Query: 2221 VGTPASGRLD--AEFFDTVGYF---TTMGVQLVDFTKVQTVWQLIEQVKNSINQSMPYTD 2275
G +GR + TVG F + V + + +V Q + Q+ +S Q Y
Sbjct: 3531 FGVTVAGRPVELPQMQRTVGLFINTIALRVGMPADDQRCSVRQWLGQLLDSNMQLREYEY 3590
Query: 2276 IPIDLIEE 2283
+P+ I+E
Sbjct: 3591 LPLVTIQE 3598
Score = 50.1 bits (118), Expect = 9e-09
Identities = 109/520 (20%), Positives = 200/520 (38%), Gaps = 75/520 (14%)
Query: 36 ALNRQALTEAVRALYAKHPMLRLAITK-----DGQQKILPLSTFH-QLKVDDLSQWKPDE 89
AL+ L +A+RAL +H LRL+ T+ + + + T Q +V D+++
Sbjct: 2826 ALHPNLLAQALRALLEQHDALRLSFTEHEGTWQAEHRAVTADTLLIQAQVSDMAECAALY 2885
Query: 90 VESFVHTKRQRMTHQMLDLTQGNPIEISLTLLPEGKHRLHIDADMIACDAQSFRLLVDDL 149
+ T + LDL G + L P+G+ RL + + D S+R+L+DDL
Sbjct: 2886 AD----------TQRSLDLHNGPLLRALLVDGPQGQQRLLMVIHHLVVDGVSWRVLLDDL 2935
Query: 150 TSLY---LEAIEHRLEIIESDVVTFFQYLDAQQADRALAKRKEVDKKWWQERLATIPAEP 206
+ Y +A R S + L A + +L + V WQ +L +
Sbjct: 2936 QNAYRQLRDATPVRFAAKTSAFRDWAARLQAYAGNESLREELHV----WQRQLG--GSAT 2989
Query: 207 SLPYQPVPTDAVSANSQRFAHWFTPVERKGLAEVARQHHLT-LTQLTLALFSQVIANACQ 265
SLP + ++Q + + L + A + T + L L +QV+
Sbjct: 2990 SLPCHNPQGGRQNRHAQTVSVRLDAERTRQLLQQAPSAYRTQVNDLLLTALAQVVCRWSG 3049
Query: 266 ERQFRLNVPTFHRGN--RSLDIEHTIGDFSNLLIF------SADVGTTQTLLSLCQQTAN 317
+ + + R N +D+ T+G F++ +AD +++ ++ +Q
Sbjct: 3050 QPSTLIQLEGHGRENLFDDIDLTRTVGWFTSAYPLRLTPAPAADSAPGESIKAIKEQLRQ 3109
Query: 318 QLHQLLRHESYSGVSVMRDL--SRKQGGVQRSPI--VFTSGMEMRDEEIFSDHVTQHLGR 373
H+ L G V+R L S Q +Q P+ + + + D+ D + + L
Sbjct: 3110 VPHKGL------GYGVLRYLADSASQAAMQALPVAPITFNYLGQFDQSFADDALFRPLQE 3163
Query: 374 MNWVISQGA----------QVTLDAQIAPAYEG-ILLNWDVRMENFADKDITALFAHYVD 422
S GA ++++D+Q+ Y G +LL W E + I AL Y+
Sbjct: 3164 -----SPGAAHDPQAPLPNELSIDSQV---YGGELLLRWTFSAERYEPAAIEALAQDYLR 3215
Query: 423 LIRCVALH-----------PEMMQQSVQQIDAQLGYARRESIQEM-PLTPLQQAYLLGRS 470
++ + H + ++ Q I+++ PLTP+Q+ LL
Sbjct: 3216 QLQTLIAHCLADGSGGLTPSDFPLAALDQAQLDALPVPPSQIEDVYPLTPMQEGMLLHTL 3275
Query: 471 TQIALGGVAMHEFREYRGHIDTQSLHSRLLYLVEHIPALR 510
+ G M + +D Q ++ ALR
Sbjct: 3276 LEPGTGLYYMQDRYRIDSALDPQRFAQAWQAVIARHEALR 3315
Score = 40.4 bits (93), Expect = 7e-06
Identities = 21/65 (32%), Positives = 34/65 (52%)
Query: 1861 VEECILAEFRSALGVAEMTAEDDFFDFGGHSLIATRVIGRLLSEQGIELHINDMFSFPNA 1920
+E+ + + L V + D+FF+ GGHSL+AT+V+ R + + MF F
Sbjct: 4244 MEQQLATIWADVLKVERVGITDNFFELGGHSLLATQVVTRAQKRLQRNVPLRAMFEFNTV 4303
Query: 1921 KQLAQ 1925
+ LAQ
Sbjct: 4304 QALAQ 4308
Score = 34.3 bits (77), Expect = 5e-04
Identities = 43/169 (25%), Positives = 68/169 (40%), Gaps = 30/169 (17%)
Query: 1400 SVEPVGQPNQSQPLSPPTLSSASLSEFEQRVWRQHQRHGDG-RNQYATAYRLSGKVNIAR 1458
S++P+ + ++SQP+ LS +QR+W Q D RL G +NI
Sbjct: 1719 SLQPIARVDRSQPVP--------LSYSQQRMWFLWQMEPDSPAYNVGGMARLKGVLNIEC 1770
Query: 1459 LITALSQL-------PNHFPVLNRRYV--LDEASGLTL----YSAKPTPLEIHFEHVESM 1505
AL L FP +N + E S L + YSA P+E + ++++
Sbjct: 1771 FEAALQALILRHETLRTTFPSINGVACQRVSEQSDLRVQWQDYSA--LPVEARQQRIQAL 1828
Query: 1506 DEAFEHLVRWQNQPMDLAKQATLSFCLLSLGSEERVLGVISHQIISEQW 1554
++ H QP DL L L+ E + H I++E W
Sbjct: 1829 ADSEAH------QPFDLETGPLLRAFLVKASDLEHYFVLTLHHIVTEGW 1871
Score = 30.4 bits (67), Expect = 0.007
Identities = 30/113 (26%), Positives = 45/113 (39%), Gaps = 11/113 (9%)
Query: 1450 LSGKVNIARLITALSQLPNHFPVLNRRYVLDEASGLTLYSAKPTPLEIHFEHVESMD--- 1506
L G+++ L ++ +L L R+ + L A P E H + ++ D
Sbjct: 709 LRGELDSTALRSSFQRLIERHESLRTRFYEQDGVALQRIDA---PSEFHLDTLDISDLPG 765
Query: 1507 ---EAFEHLVRWQNQ--PMDLAKQATLSFCLLSLGSEERVLGVISHQIISEQW 1554
+A +R Q P DL L LL L EE L V H II++ W
Sbjct: 766 AERQARAVAIREQQARLPFDLQHGPLLRVTLLRLDEEEHQLLVTLHHIIADGW 818