Pairwise Alignments
Query, 2413 a.a., non-ribosomal peptide synthetase from Vibrio cholerae E7946 ATCC 55056
Subject, 1414 a.a., Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) from Mycobacterium tuberculosis H37Rv
Score = 261 bits (667), Expect = 6e-73
Identities = 264/999 (26%), Positives = 428/999 (42%), Gaps = 83/999 (8%)
Query: 454 QEMPLTPLQQAYLLGRSTQIALGGVAMHEFREYRG-HIDTQSLHSRLLYLVEHIPALRTR 512
+ PL P+Q A +GR LGGVA H + E+ G +D L + L P LR +
Sbjct: 98 EPFPLAPMQHAMWVGRHDHQQLGGVAGHLYVEFDGARVDPDRLRAAATRLALRHPMLRVQ 157
Query: 513 I--DQEKWIQWVSPCIALNWQAIDLQHLSRE---QALLAVEPVRQQYQQRMHDLTRSPWQ 567
D + I + DL+H++ + Q L + + Q L + ++
Sbjct: 158 FLPDGTQRIPPAAGSRDFPISVADLRHVAPDVVDQRLAGIRDAKSHQQ-----LDGAVFE 212
Query: 568 ICVVQLPIEEQEEFSSIVLTSFDALIVDGRTHALILAALLGSEEPDIT----QVVQNARD 623
+ + LP E + + + DA+ R LAAL EP + + A +
Sbjct: 213 LALTLLPGERTRLHVDLDMQAADAMSY--RILLADLAALYDGREPPALGYTYREYRQAIE 270
Query: 624 TQSISPQFASKKAQDEAYWKSKLHPDCPPPALPWKQALETITTSRYARESLQIPKESVGK 683
+ PQ + D +W ++ PPALP + E R R + ++
Sbjct: 271 AEETLPQ--PVRDADRDWWAQRIPQLPDPPALPTRAGGER-DRRRSTRRWHWLDPQTRDA 327
Query: 684 LNRCGIENGLFLNSLLTATILDVLSYWTTEIGMRVGFPV-----LIPSSNAIDGNESSFV 738
L G+ L A +VL+ W+ + P+ L P + + G+ +S +
Sbjct: 328 LFARARARGITPAMTLAAAFANVLARWSASSRFLLNLPLFSRQALHPDVDLLVGDFTSSL 387
Query: 739 ILEHEKS-TLSLLSQASKLQREMLEALEHLAFSGVDLNRLLMNQAPQALVLPVVLTNGLS 797
+L+ + + + ++A +Q + A H A+ G+ + R L ++ PVV T+ L
Sbjct: 388 LLDVDLTGARTAAARAQAVQEALRSAAGHSAYPGLSVLRDLSRHRGTQVLAPVVFTSALG 447
Query: 798 WKTLNPEDAVTLFDG----VTQTPQVALDIRLTYDEQKNLIISFDYALAVLETELIREML 853
L D F ++Q PQV LD ++T + +++++D V +I M
Sbjct: 448 LGDLFCPDVTEQFGTPGWIISQGPQVLLDAQVT-EFDGGVLVNWDVREGVFAPGVIDAMF 506
Query: 854 SALHHRLSQITS----------SASLAAPLEPCIDLSHYRFNSDESASHDCDFLAKLAQQ 903
+ L ++ + SA AA L+ A HD F + AQQ
Sbjct: 507 THQVDELLRLAAGDDAWDAPSPSALPAAQRAVRAALNGRTAAPSTEALHDGFF--RQAQQ 564
Query: 904 LFVRTEDKTAVICGEQTLSYAQLGEQVQRVMWQLKARGLTTGNVLAICLPRSVEHIVISL 963
D AV LSYAQL +Q V L+A GL G+ +A+ P++ E + L
Sbjct: 565 ----QPDAPAVFASSGDLSYAQLRDQASAVAAALRAAGLRVGDTVAVLGPKTGEQVAAVL 620
Query: 964 ASALSGIIWVPIDAASPKERLNYLLENCHADL-VVMDKPCEFGNVIAFDALIEPVLFADG 1022
+G +++PI P++R +L +L +V PC+ + P L
Sbjct: 621 GILAAGGVYLPIGVDQPRDRAERILATGSVNLALVCGPPCQVRVPV-------PTLLLAD 673
Query: 1023 VPDVTPLDQLSRLSQSQQTAYYLYTSGTTGKPKCVVVNNQATSNVIGQTGQAWHLTSEDV 1082
V P + + S AY L+TSG+TG+PK V V + A N + + + L + D
Sbjct: 674 VLAAAPAEFVPGPSDPTALAYVLFTSGSTGEPKGVEVAHDAAMNTVETFIRHFELGAADR 733
Query: 1083 VMSVTPLHHDMSVFDLFATLSFGATLVLPAGHEEKDALQWNRLIERHQVTIWVSVPAILE 1142
+++ L DMSV D+FA L G +V+ + +D W RLI+ ++VT +P L+
Sbjct: 734 WLALATLECDMSVLDIFAALRSGGAIVVVDEAQRRDPDAWARLIDTYEVTALNFMPGWLD 793
Query: 1143 MLLSCTQAGQLHSLRLIAQGGDYIKPATIAQLRAGSNPPRLISLGGPTETTIWSIWHEL- 1201
MLL G+L SLR +A GGD+++P +L+ + R LGG TET + + E+
Sbjct: 794 MLLE-VGGGRLSSLRAVAVGGDWVRPDLARRLQVQAPSARFAGLGGATETAVHATIFEVQ 852
Query: 1202 ----TADDVSVIPYGRPLAGNRYFIMDEIQRHVPQGVVGRIFTSGVNLAQGYLEDGELKQ 1257
D + +PYG P N ++ + P V G ++ SG +A+GY EL
Sbjct: 853 DAANLPPDWASVPYGVPFPNNACRVVADSGDDCPDWVAGELWVSGRGIARGYRGRPELTA 912
Query: 1258 TDFVTVLDEHGHPVRA-FRTGDQGYYRADGNIIFASRINGYVKVRGVRVSLPDIEKQLQ- 1315
FV H R +RTGD Y DG + F R + VK+ G RV L +IE LQ
Sbjct: 913 ERFVE------HDGRTWYRTGDLARYWHDGTLEFVGRADHRVKISGYRVELGEIEAALQR 966
Query: 1316 ---THPALASVVVVDYADTNGDTALAALFSVKPQQSASSQALREFAKQSLPSSHIPSRFI 1372
H A A+V+ G LAA V +++++R+ +P+ IP
Sbjct: 967 LPGVHAAAATVL------PGGSDVLAAAVCV-DDAGVTAESIRQQLADLVPAHMIPRHVT 1019
Query: 1373 ALEALPLSANGKVDRKQ----CQAHVQRQSISVEPVGQP 1407
L+ +P + +GK+DR + A V+R P P
Sbjct: 1020 LLDRIPFTDSGKIDRAEVGALLAAEVERSGDRSAPYAAP 1058
Score = 249 bits (636), Expect = 2e-69
Identities = 158/429 (36%), Positives = 221/429 (51%), Gaps = 16/429 (3%)
Query: 4 MTAMQAAYWLGRQHDCLLDGVAAHLYAEFDGQALNRQALTEAVRALYAKHPMLRLAITKD 63
+ MQ A W+GR L GVA HLY EFDG ++ L A L +HPMLR+ D
Sbjct: 102 LAPMQHAMWVGRHDHQQLGGVAGHLYVEFDGARVDPDRLRAAATRLALRHPMLRVQFLPD 161
Query: 64 GQQKILPL--STFHQLKVDDLSQWKPDEVESFVHTKRQRMTHQMLDLTQGNPIEISLTLL 121
G Q+I P S + V DL PD V+ + R +HQ LD G E++LTLL
Sbjct: 162 GTQRIPPAAGSRDFPISVADLRHVAPDVVDQRLAGIRDAKSHQQLD---GAVFELALTLL 218
Query: 122 PEGKHRLHIDADMIACDAQSFRLLVDDLTSLYLEAIEHRLEIIESDVVTFFQYLDAQQAD 181
P + RLH+D DM A DA S+R+L+ DL +LY L T+ +Y A +A+
Sbjct: 219 PGERTRLHVDLDMQAADAMSYRILLADLAALYDGREPPALGY------TYREYRQAIEAE 272
Query: 182 RALAKR-KEVDKKWWQERLATIPAEPSLPYQPVPTDAVSANSQRFAHWFTPVERKGLAEV 240
L + ++ D+ WW +R+ +P P+LP + + S R HW P R L
Sbjct: 273 ETLPQPVRDADRDWWAQRIPQLPDPPALPTR-AGGERDRRRSTRRWHWLDPQTRDALFAR 331
Query: 241 ARQHHLTLTQLTLALFSQVIANACQERQFRLNVPTFHRGNRSLDIEHTIGDFSNLLIFSA 300
AR +T A F+ V+A +F LN+P F R D++ +GDF++ L+
Sbjct: 332 ARARGITPAMTLAAAFANVLARWSASSRFLLNLPLFSRQALHPDVDLLVGDFTSSLLLDV 391
Query: 301 DVGTTQTLLSLCQQTANQLHQLLRHESYSGVSVMRDLSRKQGGVQRSPIVFTSGMEMRDE 360
D+ +T + Q L H +Y G+SV+RDLSR +G +P+VFTS + + D
Sbjct: 392 DLTGARTAAARAQAVQEALRSAAGHSAYPGLSVLRDLSRHRGTQVLAPVVFTSALGLGD- 450
Query: 361 EIFSDHVTQHLGRMNWVISQGAQVTLDAQIAPAYEGILLNWDVRMENFADKDITALFAHY 420
+F VT+ G W+ISQG QV LDAQ+ G+L+NWDVR FA I A+F H
Sbjct: 451 -LFCPDVTEQFGTPGWIISQGPQVLLDAQVTEFDGGVLVNWDVREGVFAPGVIDAMFTHQ 509
Query: 421 VD-LIRCVA 428
VD L+R A
Sbjct: 510 VDELLRLAA 518
Score = 30.8 bits (68), Expect = 0.002
Identities = 22/62 (35%), Positives = 30/62 (48%), Gaps = 6/62 (9%)
Query: 1865 ILAEFRSALGVAEMTAEDDFFDFGGHSLIATRVIGRLLS-EQGIELHINDMFSFPNAKQL 1923
IL A+GV DDFF GG S++AT+V+ + L + DMF+ L
Sbjct: 1073 ILGRANDAVGV-----HDDFFALGGDSVLATQVVAGIRRWLDSPSLMVADMFAARTIAAL 1127
Query: 1924 AQ 1925
AQ
Sbjct: 1128 AQ 1129