Pairwise Alignments
Query, 2413 a.a., non-ribosomal peptide synthetase from Vibrio cholerae E7946 ATCC 55056
Subject, 2032 a.a., non-ribosomal peptide synthetase from Klebsiella michiganensis M5al
Score = 278 bits (710), Expect = 9e-78
Identities = 256/925 (27%), Positives = 402/925 (43%), Gaps = 62/925 (6%)
Query: 457 PLTPLQQAYLLGRSTQIALGGVAMHEFREYRGH-IDTQSLHSRLLYLVEHIPALRTRIDQ 515
PLTP+Q AYL GR LGGV H ++E+ GH + L + L++ P L
Sbjct: 116 PLTPVQHAYLTGRMPGQTLGGVGCHLYQEFAGHYLTAPQLEQAITILLQRHPMLHIAFRA 175
Query: 516 EKWIQWVSPCIALNWQAIDLQHLSREQALLAVEPVRQQYQQRMHDLTRSPWQICVVQLPI 575
+ W+ DL+ +E +RQ+ R+ +++ +
Sbjct: 176 DGQQVWLPQPYWNGVTVHDLRQTDEASRQAYLETLRQRLSHRL------------LRVEM 223
Query: 576 EEQEEFSSIVL--------TSFDALIVDGRTHALI---LAALLGSEEPDITQVVQNARDT 624
E +F +L + D LI+D + L L ALL E + R
Sbjct: 224 GETFDFQLTLLPDNRHRLHVNIDLLIMDASSFTLFFDELNALLAGESLPPGDPRYDFR-A 282
Query: 625 QSISPQFASKKAQDEA--YWKSKLHPDCPPPALPWKQALETITTSRYARESLQIPKESVG 682
+ Q ++ D+A YW +K P P LP T+ R R + +P
Sbjct: 283 YLLHQQKINQPLLDKARVYWLAKASMLPPAPVLPLACEPATLREVRNTRRRMIVPTTRWN 342
Query: 683 KLNRCGIENGLFLNSLLTATILDVLSYW--TTEIGMRVGFPVLIPSSNAIDGNESSF--- 737
++ ENG+ L VL W T + + + P A+D + F
Sbjct: 343 AFSQRAGENGVTPTMALATCFAAVLGRWGGLTRLLLNITLFDRQPLHPAVDEMLADFTNI 402
Query: 738 VILEHEKSTLSLLSQASKLQREMLEALEHLAFSGVDLNRLLMNQAPQALVLPVVLTNGLS 797
++L+ ++ + A K Q E EH +SGV+L R L Q PVV T+ L
Sbjct: 403 LLLDTACDGDTVSNLARKNQLTFTEDWEHRHWSGVELLRELKRQQSHPHGAPVVFTSNLG 462
Query: 798 WKTLNPEDAVTLFD---GVTQTPQVALDIRLTYDEQKNLIISFDYALAVLETELIREMLS 854
+ L + G++QTPQV +D L ++ + + + +D A+ L+ + +
Sbjct: 463 RSLYSSRAESPLGEPEWGISQTPQVWID-HLAFEHRGEIWLQWDSNDALFPPALVETLFN 521
Query: 855 ALHHRLSQITSSASL-AAPLEPCIDLSHYRFNSDESASHDCDFLAKLAQQLF---VRTED 910
A ++Q+ S P + S +A+ L + +F +R
Sbjct: 522 AYCQLINQLCDDESAWKKPFADRMPQSQREIRQRVNATDAPVPQGLLHEGIFRIALRQPQ 581
Query: 911 KTAVICGEQTLSYAQLGEQVQRVMWQLKARGLTTGNVLAICLPRSVEHIVISLASALSGI 970
AV +Y +L E +R +L A G+ G+ +AI + + +V LA LSG
Sbjct: 582 ALAVTDAHYQWNYRELTENARRCAGRLIACGVQPGDNVAITMSKGAGQLVAVLAVLLSGA 641
Query: 971 IWVPIDAASPKERLNYLLENCHADLVVMDKPCEFGNVIAFDALIEPVLFADGVPDVTPL- 1029
++VP+ P R + + + LV+ C+ D + P L + PL
Sbjct: 642 VYVPVSLDQPAARRRKIYADANVRLVLT---CQHDASAWSDDI--PQLTWQQAIEAEPLA 696
Query: 1030 DQLSRLSQSQQTAYYLYTSGTTGKPKCVVVNNQATSNVIGQTGQAWHLTSEDVVMSVTPL 1089
DQ +R Q AY +YTSG+TG PK VV++++A N + + D V++++ L
Sbjct: 697 DQAARAPT--QPAYIIYTSGSTGTPKGVVISHRAALNTCCDINTRYQVGPGDRVLALSAL 754
Query: 1090 HHDMSVFDLFATLSFGATLVLPAGHEEKDALQWNRLIERHQVTIWVSVPAILEMLLSCTQ 1149
H D+SV+D+F LS G LV+ ++ +D W LI+RHQVT+W SVPA+ +MLL+ +
Sbjct: 755 HFDLSVYDIFGVLSAGGALVIVMENQRRDPHAWCELIQRHQVTLWNSVPALFDMLLTWCE 814
Query: 1150 A---GQLHSLRLIAQGGDYIKPATIAQLRAGSNPPRLISLGGPTETTIWSIWHEL--TAD 1204
LR + GD+I A+ A + I++GG TE +IWS E+ D
Sbjct: 815 GFADAAPEKLRAVMLSGDWIGLDLPARYHAFRPQGQFIAMGGATEASIWSNACEINRVPD 874
Query: 1205 DVSVIPYGRPLAGNRYFIMDEIQRHVPQGVVGRIFTSGVNLAQGYLEDGELKQTDFVTVL 1264
IPYG PLA RY ++DE+ R P V G ++ G+ +A+GY D + FVT
Sbjct: 875 HWRAIPYGFPLANQRYRVVDELGRDCPDWVPGELWIGGIGVAEGYFNDPVRSEQQFVTQS 934
Query: 1265 DEHGHPVRAFRTGDQGYYRADGNIIFASRINGYVKVRGVRVSLPDIEKQLQTHPALASVV 1324
+ R +RTGD G Y DG + F R + VKV G R+ L +IE L +
Sbjct: 935 N-----ARWYRTGDLGCYWPDGTLEFLGRRDKQVKVGGYRIELGEIESALSQLAGVKQST 989
Query: 1325 VVDYADTNGDTALAALFSVKPQQSA 1349
VV + + A V PQ SA
Sbjct: 990 VVAIGEKEKNLAA----WVVPQGSA 1010
Score = 171 bits (433), Expect = 1e-45
Identities = 122/424 (28%), Positives = 194/424 (45%), Gaps = 16/424 (3%)
Query: 4 MTAMQAAYWLGRQHDCLLDGVAAHLYAEFDGQALNRQALTEAVRALYAKHPMLRLAITKD 63
+T +Q AY GR L GV HLY EF G L L +A+ L +HPML +A D
Sbjct: 117 LTPVQHAYLTGRMPGQTLGGVGCHLYQEFAGHYLTAPQLEQAITILLQRHPMLHIAFRAD 176
Query: 64 GQQKILPLSTFHQLKVDDLSQWKPDEVESFVHTKRQRMTHQMLDLTQGNPIEISLTLLPE 123
GQQ LP ++ + V DL Q ++++ T RQR++H++L + G + LTLLP+
Sbjct: 177 GQQVWLPQPYWNGVTVHDLRQTDEASRQAYLETLRQRLSHRLLRVEMGETFDFQLTLLPD 236
Query: 124 GKHRLHIDADMIACDAQSFRLLVDDLTSLYLEAIEHRLEIIESDVVTFFQ--YLDAQQAD 181
+HRLH++ D++ DA SF L D+L +L + D F+ L Q+ +
Sbjct: 237 NRHRLHVNIDLLIMDASSFTLFFDELNALLAGE-----SLPPGDPRYDFRAYLLHQQKIN 291
Query: 182 RALAKRKEVDKKWWQERLATIPAEPSLPYQPVPTDAVSANSQRFAHWFTPVERKGLAEVA 241
+ L + V +W + + +P P LP P + R ++ A
Sbjct: 292 QPLLDKARV---YWLAKASMLPPAPVLPLACEPATLREVRNTRRRMIVPTTRWNAFSQRA 348
Query: 242 RQHHLTLTQLTLALFSQVIANACQERQFRLNVPTFHRGNRSLDIEHTIGDFSNLLIFSAD 301
++ +T T F+ V+ + LN+ F R ++ + DF+N+L+
Sbjct: 349 GENGVTPTMALATCFAAVLGRWGGLTRLLLNITLFDRQPLHPAVDEMLADFTNILLLDT- 407
Query: 302 VGTTQTLLSLCQQTANQLHQLLRHESYSGVSVMRDLSRKQGGVQRSPIVFTSGMEMRDEE 361
T+ +L ++ + H +SGV ++R+L R+Q +P+VFTS +
Sbjct: 408 ACDGDTVSNLARKNQLTFTEDWEHRHWSGVELLRELKRQQSHPHGAPVVFTSNL---GRS 464
Query: 362 IFSDHVTQHLGRMNWVISQGAQVTLDAQIAPAYEG-ILLNWDVRMENFADKDITALFAHY 420
++S LG W ISQ QV +D +A + G I L WD F + LF Y
Sbjct: 465 LYSSRAESPLGEPEWGISQTPQVWID-HLAFEHRGEIWLQWDSNDALFPPALVETLFNAY 523
Query: 421 VDLI 424
LI
Sbjct: 524 CQLI 527
Score = 143 bits (361), Expect = 3e-37
Identities = 118/426 (27%), Positives = 192/426 (45%), Gaps = 21/426 (4%)
Query: 4 MTAMQAAYWLGRQHDCLLDGVAAHLYAEFDGQALNRQALTEAVRALYAKHPMLRLAITKD 63
+T +Q AY +GRQ L GV +H + EF+ L+ L + L A+H MLR A+ +D
Sbjct: 1498 LTDVQQAYLVGRQPGFALGGVGSHFFVEFEIADLDIHRLEKVWNRLIARHDMLR-AVVRD 1556
Query: 64 GQQKILPLSTFHQLKVDDLSQWKPDEVESFVHTKRQRMTHQMLDLTQGNPIEISLTLLPE 123
GQQ++L + + L P+E R R+ HQ+L+ ++ + +
Sbjct: 1557 GQQRVLEQTPPWVIPAHILHN--PEEALQV----RDRLAHQVLNPGVWPVFDLQVGFIDG 1610
Query: 124 GKHRLHIDADMIACDAQSFRLLVDDLTSLYLEAIEHRLEIIESDVVTFFQYLDAQQADRA 183
RL + D + D S ++L+ +L Y + ++ VTF YL A
Sbjct: 1611 MPARLWLCLDNLLLDGLSMQILLSELEHGY----RYPQQLPPPLPVTFRDYLQQP----A 1662
Query: 184 LAKRKEVDKKWWQERLATIPAEPSLPYQPVPTDAVSANSQRFAHWFTPVERKGLAEVARQ 243
L WWQ +L IP P+LP + +P D + R + + L + A
Sbjct: 1663 LRTPNPDSLTWWQTQLDDIPPAPALPLRCLPQDVETPRFARLSGAMDSARWRRLKQRAAD 1722
Query: 244 HHLTLTQLTLALFSQVIANACQERQFRLNVPTFHRGNRSLDIEHTIGDFSNLLIFSADVG 303
HLT + + L+++S V+A + F LN+ F R I +GDF++L++ S
Sbjct: 1723 AHLTPSAVLLSVWSTVLAAWSAQPDFTLNLTLFDRRPLHPQINQILGDFTSLMLLSWH-- 1780
Query: 304 TTQTLLSLCQQTANQLHQLLRHESYSGVSVMRDLSRKQG-GVQRSPIVFTSGMEMRDEEI 362
++ L + +L + L H S + VMR L+R+Q P+VFTS + +
Sbjct: 1781 PDESWLQSARLLQQRLSESLNHRDVSAIRVMRQLARRQNVPAVPMPVVFTSALGFEQDNF 1840
Query: 363 FSDHVTQHLGRMNWVISQGAQVTLDAQIAPAYEGILLNWDVRMENFADKDITALFAHYVD 422
+ ++L + W ISQ QV LD Q+ + + NWD F D + FA Y
Sbjct: 1841 LA---RRNLLKPVWGISQTPQVWLDHQVYESEGELRFNWDFVAALFPDGQVERQFAQYCA 1897
Query: 423 LIRCVA 428
L+ +A
Sbjct: 1898 LLNRMA 1903
Score = 91.7 bits (226), Expect = 1e-21
Identities = 129/522 (24%), Positives = 223/522 (42%), Gaps = 58/522 (11%)
Query: 447 YARRESIQEMPLTPLQQAYLLGRSTQIALGGVAMHEFREYR-GHIDTQSLHSRLLYLVEH 505
++ E + LT +QQAYL+GR ALGGV H F E+ +D L L+
Sbjct: 1487 HSPEERYRPFALTDVQQAYLVGRQPGFALGGVGSHFFVEFEIADLDIHRLEKVWNRLIAR 1546
Query: 506 IPALR--TRIDQEKWIQ----WVSPCIALNWQAIDLQHLSREQALLAVEPVRQQYQQRMH 559
LR R Q++ ++ WV P L+ + E+AL Q + R+
Sbjct: 1547 HDMLRAVVRDGQQRVLEQTPPWVIPAHILH---------NPEEAL--------QVRDRLA 1589
Query: 560 DLTRSPWQICVVQLPIEEQEEFSSIVLTSFDALIVDGRTHALILAAL-LGSEEPD--ITQ 616
+P V L + + + + D L++DG + ++L+ L G P
Sbjct: 1590 HQVLNPGVWPVFDLQVGFIDGMPARLWLCLDNLLLDGLSMQILLSELEHGYRYPQQLPPP 1649
Query: 617 VVQNARDTQSISPQFASKKAQDEAYWKSKLHPDCPPPALPWKQALETITTSRYARESLQI 676
+ RD P + +W+++L P PALP + + + T R+AR S +
Sbjct: 1650 LPVTFRDYLQ-QPALRTPNPDSLTWWQTQLDDIPPAPALPLRCLPQDVETPRFARLSGAM 1708
Query: 677 PKESVGKLNRCGIENGLFLNSLLTATILDVLSYWTTEIGMRVGFPV-----LIPSSNAID 731
+L + + L +++L + VL+ W+ + + + L P N I
Sbjct: 1709 DSARWRRLKQRAADAHLTPSAVLLSVWSTVLAAWSAQPDFTLNLTLFDRRPLHPQINQIL 1768
Query: 732 GNESSFVILEHEKSTLSLLSQASKLQREMLEALEHLAFSGVDLNR-LLMNQAPQALVLPV 790
G+ +S ++L S L A LQ+ + E+L H S + + R L Q A+ +PV
Sbjct: 1769 GDFTSLMLLSWHPDE-SWLQSARLLQQRLSESLNHRDVSAIRVMRQLARRQNVPAVPMPV 1827
Query: 791 VLTNGLSWKT---LNPEDAVTLFDGVTQTPQVALDIRLTYDEQKNLIISFDYALAVLETE 847
V T+ L ++ L + + G++QTPQV LD ++ Y+ + L ++D+ A+
Sbjct: 1828 VFTSALGFEQDNFLARRNLLKPVWGISQTPQVWLDHQV-YESEGELRFNWDFVAALFPDG 1886
Query: 848 LIREMLS---ALHHRLSQITSS-----ASLAAPLEPCIDLSHY--------RFNSDESA- 890
+ + AL +R+++ SS A L PL+ +H R +DES+
Sbjct: 1887 QVERQFAQYCALLNRMAEDDSSWQLPLAELVPPLKVTEQCAHRLRPERAQPRIAADESSV 1946
Query: 891 SHDCDFLAKLAQQLFVRTEDKTAVICGEQTLSYAQLGEQVQR 932
S CD ++ + TE+ G +L+ QL +QR
Sbjct: 1947 SLICDAFREVVGEPVAPTEN--FFEAGATSLNLVQLHVLLQR 1986
Score = 61.2 bits (147), Expect = 2e-12
Identities = 88/343 (25%), Positives = 140/343 (40%), Gaps = 41/343 (11%)
Query: 1826 VSAIELTSNNP---PTSNNAHAALAESELELSAVNSSAVEECILAEFRSALGVAEMTAED 1882
+ A+ LT+N T H AE+ E + +E + ++ L + ++ E
Sbjct: 1372 LDALPLTANGKIDYQTLKRCHTPEAENRTEAD-LPLGDIEMQVAVIWQPLLSMGAVSRET 1430
Query: 1883 DFFDFGGHSLIATRVIGRLLSEQGIELHINDMFSFPNAKQLAQQAVLHRKPTSTSFAVSE 1942
DFF GG SL+ATR+IG+ L + G ++D+F+ P A P F S
Sbjct: 1431 DFFQHGGDSLLATRLIGQ-LHQAGYAARLSDLFNHPRLADFAATLRKTDLPVEQPFVHSP 1489
Query: 1943 VVESSKAPLSLA---QASLWKAMSKYAKFGLTHIFNLPFALKFLDEVNEQAFGEAFHWLL 1999
E P +L QA L +A G+ F + F + LD + ++ L+
Sbjct: 1490 --EERYRPFALTDVQQAYLVGRQPGFALGGVGSHFFVEFEIADLD---IHRLEKVWNRLI 1544
Query: 2000 LRHAGLRTHFGLEDGQPY------QHVIAASNIEHYQWFWTSKDNAAQSVARLLAQEAEH 2053
RH LR + DGQ VI A + + + +D A V L
Sbjct: 1545 ARHDMLRA--VVRDGQQRVLEQTPPWVIPAHILHNPEEALQVRDRLAHQV---LNPGVWP 1599
Query: 2054 TFDLSQELPLRLNFVRDEQTGTQYLSLLFHHIVLDEWSINILMDELAQVYQHSVQGTRPQ 2113
FD L++ F+ D +L L +++LD S+ IL+ EL Y++ PQ
Sbjct: 1600 VFD------LQVGFI-DGMPARLWLCL--DNLLLDGLSMQILLSELEHGYRY------PQ 1644
Query: 2114 WQTEPLP--FHEFARKQRSSAFNQTHLNYWLTKFAGVPWAQPL 2154
PLP F ++ ++ N L +W T+ +P A L
Sbjct: 1645 QLPPPLPVTFRDYLQQPALRTPNPDSLTWWQTQLDDIPPAPAL 1687
Score = 40.8 bits (94), Expect = 2e-06
Identities = 38/121 (31%), Positives = 57/121 (47%), Gaps = 13/121 (10%)
Query: 1354 LREFAKQSLPSSHIPSRFIALEALPLSANGKVD---RKQCQA-HVQRQSISVEPVGQ-PN 1408
L+ + LP +P R + L+ALPL+ANGK+D K+C + ++ + P+G
Sbjct: 1352 LQSALAERLPGWMVPKRIVLLDALPLTANGKIDYQTLKRCHTPEAENRTEADLPLGDIEM 1411
Query: 1409 QSQPLSPPTLSSASLSEFEQRVWRQHQRHGDGRNQYATAYRLSGKVNIARLITALSQLPN 1468
Q + P LS ++S R Q GD A RL G+++ A LS L N
Sbjct: 1412 QVAVIWQPLLSMGAVS----RETDFFQHGGDS----LLATRLIGQLHQAGYAARLSDLFN 1463
Query: 1469 H 1469
H
Sbjct: 1464 H 1464