Pairwise Alignments

Query, 936 a.a., 2-oxoglutarate dehydrogenase subunit E1 from Vibrio cholerae E7946 ATCC 55056

Subject, 1231 a.a., Multifunctional alpha-ketoglutarate metabolic enzyme from Mycobacterium tuberculosis H37Rv

 Score =  686 bits (1769), Expect = 0.0
 Identities = 373/873 (42%), Positives = 529/873 (60%), Gaps = 40/873 (4%)

Query: 89   KQVKVLQLINAYRFRGHEAAKLDPLGL-----WNRPEVAELNPSFHNLTQEDMEETFNVG 143
            K  +V+ LI AYR RGH  A  DPL L      + P++  L    H LT  D++  F V 
Sbjct: 368  KNARVMNLIAAYRNRGHLMADTDPLRLDKARFRSHPDLEVLT---HGLTLWDLDRVFKVD 424

Query: 144  SFAIGKDTMKLKDIYQSLQKIYCGSVGAEYMHITDTEQKRWIQQRLEPVVGTPVFSKEEK 203
             FA G    KL+D+   L+  YC  +G EY HI D EQK W++QR+E     P  +++  
Sbjct: 425  GFA-GAQYKKLRDVLGLLRDAYCRHIGVEYAHILDPEQKEWLEQRVETKHVKPTVAQQ-- 481

Query: 204  RTFLEELTAAEGLERYLGAKFPGAKRFSLEGGDALVPMTKEMIRHAGASGMREVVIGMAH 263
            +  L +L AAE  E +L  K+ G KRFSLEG ++++PM    I      G+ EVVIGM H
Sbjct: 482  KYILSKLNAAEAFETFLQTKYVGQKRFSLEGAESVIPMMDAAIDQCAEHGLDEVVIGMPH 541

Query: 264  RGRLNMLVNVLGKKPQDLFDEFAGK--HGEGWGTGDVKYHQGFSADFATPGGD--VHLAL 319
            RGRLN+L N++GK    +F EF G     +  G+GDVKYH G +  +    GD  + ++L
Sbjct: 542  RGRLNVLANIVGKPYSQIFTEFEGNLNPSQAHGSGDVKYHLGATGLYLQMFGDNDIQVSL 601

Query: 320  AFNPSHLEIVNPVVMGSVRARQDRLG----DEDGSK---VLPITIHGDSAIAGQGVVAET 372
              NPSHLE V+PV+ G VRA+QD L     D DG +   V+P+ +HGD+A AGQGVVAET
Sbjct: 602  TANPSHLEAVDPVLEGLVRAKQDLLDHGSIDSDGQRAFSVVPLMLHGDAAFAGQGVVAET 661

Query: 373  FNMSQARGFCVGGTVRIVVNNQVGFTTSNPRDTRSTMYCTDIAKMVQAPIFHVNSDDPEA 432
             N++   G+ VGGT+ I+VNNQ+GFTT+ P  +RS+ YCTD+AKM+ APIFHVN DDPEA
Sbjct: 662  LNLANLPGYRVGGTIHIIVNNQIGFTTA-PEYSRSSEYCTDVAKMIGAPIFHVNGDDPEA 720

Query: 433  VAFVTRLALDYRNEFKRDVVIDLVCYRRHGHNEADEPNATQPLMYQKIKKHPTPRKLYAD 492
              +V RLA+D+R  FK+DVVID++CYRR GHNE D+P+ T P +Y  +      RK Y +
Sbjct: 721  CVWVARLAVDFRQRFKKDVVIDMLCYRRRGHNEGDDPSMTNPYVYDVVDTKRGARKSYTE 780

Query: 493  VLTERGECDLETATQLVNEYRDALDHGEVVVKEWRPMAMHSVDWSPYLGHDWHIPWNSEY 552
             L  RG+  ++ A   + +Y+  L+    V  E R +  H V  S  +  D  IP     
Sbjct: 781  ALIGRGDISMKEAEDALRDYQGQLER---VFNEVRELEKHGVQPSESVESDQMIPAGLAT 837

Query: 553  AMER--LQDLGRRVCQYPESHVLHSRVEKIYQDRLSMISGEKMLDWGMAETLAYATLLDD 610
            A+++  L  +G      P     H RV+ + + R  M + E  +DW   E LA  +L+ +
Sbjct: 838  AVDKSLLARIGDAFLALPNGFTAHPRVQPVLEKRREM-AYEGKIDWAFGELLALGSLVAE 896

Query: 611  GKRIRISGQDSGRGTFFHRHAVLHNQNDASTYIPLSQIHAGQ------GPFEVFDSVLSE 664
            GK +R+SGQDS RGTF  RH+VL +++    + PL  +          G F V+DS LSE
Sbjct: 897  GKLVRLSGQDSRRGTFSQRHSVLIDRHTGEEFTPLQLLATNSDGSPTGGKFLVYDSPLSE 956

Query: 665  EAVLAFEYGYATAEPSGLTLWEAQFGDFANGAQVVIDQFISSGEQKWGRLCGLTMLLPHG 724
             A + FEYGY    P  + LWEAQFGDF NGAQ +ID+FISSGE KWG+L  + +LLPHG
Sbjct: 957  YAAVGFEYGYTVGNPDAVVLWEAQFGDFVNGAQSIIDEFISSGEAKWGQLSNVVLLLPHG 1016

Query: 725  YEGQGPEHSSARLERYLQLCAEQNMQVVVPSTPAQVYHMIRRQVVRPMRRPLVVMSPKSL 784
            +EGQGP+H+SAR+ER+LQL AE +M + +PSTP+  +H++RR  +  ++RPL+V +PKS+
Sbjct: 1017 HEGQGPDHTSARIERFLQLWAEGSMTIAMPSTPSNYFHLLRRHALDGIQRPLIVFTPKSM 1076

Query: 785  LRHPLCVSSMEDLAHGTFQPAIGE---IDAL-NPSQVKRVVFCSGKVYYDLLEQRRANEQ 840
            LRH   VS ++D     F+  + E    D + + ++V R++  SGK+YY+L  ++  + +
Sbjct: 1077 LRHKAAVSEIKDFTEIKFRSVLEEPTYEDGIGDRNKVSRILLTSGKLYYELAARKAKDNR 1136

Query: 841  QDVAIVRIEQLYPFPLEEVQAAIANYTNVVDYVWCQEEPQNQGAWYSSQHNFRAAIPAG- 899
             D+AIVR+EQL P P   ++  +  Y NV ++ W QEEP NQGAW          +P   
Sbjct: 1137 NDLAIVRLEQLAPLPRRRLRETLDRYENVKEFFWVQEEPANQGAWPRFGLELPELLPDKL 1196

Query: 900  ADLKYAGRPASASPAVGYMSVHMKQQKALIEDA 932
            A +K   R A ++P+ G   VH  +Q+ ++++A
Sbjct: 1197 AGIKRISRRAMSAPSSGSSKVHAVEQQEILDEA 1229