Pairwise Alignments

Query, 647 a.a., DNA topoisomerase III from Vibrio cholerae E7946 ATCC 55056

Subject, 823 a.a., DNA topoisomerase I from Methanococcus maripaludis S2

 Score =  167 bits (424), Expect = 1e-45
 Identities = 157/628 (25%), Positives = 276/628 (43%), Gaps = 73/628 (11%)

Query: 1   MTRLFIAEKPSLARAIADALPKPHKKEQGCI------RCANGDIVTWCIGHLLEQVEPDA 54
           MT L I EKP++A+ IA+AL KP KK    +      R     +V   +GHL    E   
Sbjct: 1   MTGLIICEKPNVAKKIAEALGKPKKKSHNSVPYYELERNGESIVVASAVGHLYTLQEKT- 59

Query: 55  YDERYKKWNMADLPIIPEQW----QLRPRKSSSQQLTVVRKLLKEATQIIHAGDPDREGQ 110
                 K    D P+    W     L  +K   + +  ++K+ K+A +   A D D EG+
Sbjct: 60  ------KTKFGDYPVYDINWVPASTLDEKKYIQKYIDALKKVSKDANKFYVATDWDIEGE 113

Query: 111 LLVDEVIDYCKVPKSKKETVQRLLISDLNLSAVKRALQGLRSNREFIPLSVSALARSRAD 170
           L+    +++       ++   RL  S L    + +A +    N     L  +  +R + D
Sbjct: 114 LIGYHALNF----SCGQKNAHRLRFSSLTKKEILKAYEN--PNEIDFGLVDAGDSRHKID 167

Query: 171 WLYGMNMSRAYTLLGKKAGYQGVLSVGRVQTPVLGLVVRRDEEIEHFIPHDYFTLDALIP 230
           W +G+N+SRA             LS GRVQ P L  +V ++ EI +F+P  Y+ L+AL+ 
Sbjct: 168 WYFGINVSRALMQAVSSVKRWKTLSTGRVQGPALAFLVDKELEIRNFVPTPYWVLEALLD 227

Query: 231 YQNGTEYFDIRARWKPSEACLPWQDEEGRVTNRKLVDNVASRIANQPATVTESEQDQTKQ 290
             +     ++   W   +A   ++  +G+                + ATV++ ++     
Sbjct: 228 -NDLIAVHELEKFWDEEQANKAYEKVKGQ----------------KQATVSDVKKSMKTI 270

Query: 291 AAPLPYSLSALQIDAAKRYNFSAQQVLDLCQSLYEKHKLITYPRSDCRYLP--KEHLAQA 348
               P+ L ALQ +A   + FS ++  ++ Q LYEK    +YPR+  + LP  K ++ + 
Sbjct: 271 PPNPPFDLGALQREAHNMFRFSPKKTQEVAQKLYEK-GYCSYPRTSSQKLPDDKAYMDEV 329

Query: 349 PDVVAAIANNAQEMVTAVNDADLSLRSKAWNDSKVDAHHAIIPTPKKASVNALSGHEMKV 408
              ++   N    + T +N+    +  K  + +    H   +P  K      L   E+K+
Sbjct: 330 LKNLSKNKNYKPYIETILNENRKPISGKNDDPAHPAVHAVDVPKEK------LPDDELKL 383

Query: 409 YQLIARQYLMQFYPAAIYAEAKLVFNIAGGIFIAKGRQLLSAGWKVLTGQQDEQEECVDK 468
           Y+LIAR+ +  ++  A    +K+  +I G  F   G + +  GW  +       E    +
Sbjct: 384 YELIARRTIALYWDNAKREYSKINLDINGETFKLSGSRTVEEGWHEIYYYTKFDEV---E 440

Query: 469 VPPLPVGIVLQCREGEIKQRQTEPPRHFTEATLLQAMTGIARFVADKELKKILRETDGLG 528
           +P L    V+       + ++T+PP+ +T A+++            KEL+K       LG
Sbjct: 441 LPELKKNDVINVNNINFEAKETKPPKRYTMASII------------KELEK-----RKLG 483

Query: 529 TEATRAGILDTLFKRGLLQRDNKLIKSTPAGRGLIHALPS---EATYPDMTAHWEHQLQA 585
           T+ATRA IL+ L KRG +  D  L   T  G G+   L     E     +T   E +L+ 
Sbjct: 484 TKATRADILEKLTKRGYVIEDGSL-TVTDLGIGVTETLRKYCPEIVEETLTRDLEDKLEL 542

Query: 586 IAEKGQAYQPFMQTLQGRLEQLIEQVQV 613
           I +K    +  +Q  + +L +++ + ++
Sbjct: 543 IQDKKIKKEEVIQETKDKLTKILGEFRL 570