Pairwise Alignments

Query, 876 a.a., DNA topoisomerase 1 from Vibrio cholerae E7946 ATCC 55056

Subject, 867 a.a., DNA topoisomerase I, bacterial from Pseudomonas stutzeri RCH2

 Score = 1167 bits (3020), Expect = 0.0
 Identities = 571/874 (65%), Positives = 696/874 (79%), Gaps = 9/874 (1%)

Query: 1   MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTAGQT-ATPTGKAAAASTKKAS 59
           MGKSLVIVESPAKAKTINKYLG  ++VKSS+GH+RDLPT+G     P  +  AA+ +   
Sbjct: 1   MGKSLVIVESPAKAKTINKYLGNQYVVKSSIGHIRDLPTSGSANKEPVKRGKAAAAEAPV 60

Query: 60  TTDKEQQKREKERAALIKKMGVDPYHGWQANYQILPGKEKVVAELQKLAKDADSVYLATD 119
            + KE+ KR+     LI +MGVDP HGW+A Y+ILPGKEKV+ EL++LAK+AD++YLATD
Sbjct: 61  LSPKEKAKRQ-----LITRMGVDPEHGWKAKYEILPGKEKVIEELRRLAKEADTIYLATD 115

Query: 120 LDREGEAIAWHLREIIGGDEKRYKRVVFNEITKNAIQQAFKQPGELNMDGVNAQQARRFM 179
           LDREGEAIAWHLRE IGGD+ RYKRVVFNEITK AIQ+AF +PG+L+++ VNAQQARRF+
Sbjct: 116 LDREGEAIAWHLRESIGGDDSRYKRVVFNEITKKAIQEAFSKPGDLDLNRVNAQQARRFL 175

Query: 180 DRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFVPEEFWDINADTLTADK 239
           DRVVG+MVSPLLW K+ARGLSAGRVQSVAVKL+VEREREI+AFVPEE+W+++AD  +A +
Sbjct: 176 DRVVGYMVSPLLWAKIARGLSAGRVQSVAVKLVVEREREIRAFVPEEYWEVHADLASAQQ 235

Query: 240 QDFRLLVAQKDGLAFKPVNETEALAAVAALNKAQYEVCKREDKPTTSKPSAPFITSTLQQ 299
              R  VA+++G AFKP+NE +A AA+  L  A+Y V KREDKPT+SKPSAPFITSTLQQ
Sbjct: 236 AKVRFEVARENGEAFKPLNEAQANAALEKLKGAKYSVSKREDKPTSSKPSAPFITSTLQQ 295

Query: 300 AASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSAEAVENLRGYITKHYGEAYLPSQ 359
           AAS RLG+GVKKTMM+AQRLYEAGYITYMRTDSTNLSA+A+  +RG+I   +G+ YLP +
Sbjct: 296 AASNRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSADAIGMVRGFIEGEFGDKYLPEK 355

Query: 360 PNVYGSKQNAQEAHEAIRPSDVTVTADDLEGMEADAHKLYALIWNQFVACQMTPAQYDST 419
           PNVY SK+ AQEAHEAIRPSDV +    L GME DA +LY LIW QFVACQM PAQY ST
Sbjct: 356 PNVYSSKEGAQEAHEAIRPSDVNLRPTQLSGMERDAERLYELIWRQFVACQMPPAQYLST 415

Query: 420 TVSVKAAEYTLKAKGRILKFDGWTRVQRPLGK-NEDQILPPVKVGDSLKLVSLDPKQHFT 478
           +V+V A ++ L+AKGRILKFDG+T+V     K  ED +LP +  GD +KL+ LDP QHFT
Sbjct: 416 SVTVAAGDFELRAKGRILKFDGYTKVMPQQSKAGEDDVLPEMNKGDDMKLLKLDPSQHFT 475

Query: 479 KPPARYTEAALVKELEKRGIGRPSTYASIISTIQDRGYVKVDQRRFFAEKMGEIVTDRLD 538
           KPPARY+EA+LVKE+EKRGIGRPSTYA+IISTIQDRGYV +  RRF++EKMG+IVT+RL 
Sbjct: 476 KPPARYSEASLVKEMEKRGIGRPSTYAAIISTIQDRGYVSLHNRRFYSEKMGDIVTERLS 535

Query: 539 ENFDDLMNYDFTARMEEKLDQIAEGEVNWTAVLDEFFADFSRDLETAEQDESLGGMKPNH 598
           E+F++LM+Y FTA MEE LD +A+GE +W  VLDEF+ DF + LE AE  E+  GM+ N 
Sbjct: 536 ESFNNLMDYGFTAGMEEHLDDVAQGERDWKHVLDEFYGDFRKKLEVAEASEN--GMRANQ 593

Query: 599 IVMTNILCPTCSRPMGIRTASTGVFLGCSGYGLPPKERCKTTINLGDEEGVINVLEEDVE 658
             +T+I C  C RPM IRTASTGVFLGCSGY LPPKERCK+T+NL   + +    E + E
Sbjct: 594 PTLTDIPCKVCGRPMMIRTASTGVFLGCSGYSLPPKERCKSTVNLVPGDEIAADDEGESE 653

Query: 659 TAALRAKKRCPICETAMDAYLIDDKRKLHVCGNNPNCEGFIVEEGEFKVKGYEGPTVECD 718
           +  L  K RCPIC TAMDAYL+D+ +KLH+CGNNP+C G+ +E+G++++KGYEGP++ECD
Sbjct: 654 SRVLLGKHRCPICSTAMDAYLLDETQKLHICGNNPDCSGYEIEKGQYRIKGYEGPSLECD 713

Query: 719 KCGSDMVLKNGRFGKYMGCTNDACKNTRKILKNGEVAPPKEEPVHFPELPCENSDAYFVL 778
           KCGS+M LK GRFGK+ GCTN  CKNTRK+LKNGE APPK + V  PEL CE  D  +VL
Sbjct: 714 KCGSEMQLKTGRFGKFFGCTNAECKNTRKLLKNGEAAPPKMDAVKMPELKCEKVDDTYVL 773

Query: 779 RDGASGLFFAASNFPKSRETRAPLVEELKRFAERLPEKYQYLTSAPAHDPDGLPAVVRFS 838
           RDGASGLF AAS FPK+RETRAPLV EL    + +  KY +L  AP  DP+G  AV+RFS
Sbjct: 774 RDGASGLFLAASQFPKNRETRAPLVRELIPHKDEIDPKYHFLLDAPQKDPEGRFAVIRFS 833

Query: 839 RKEKEHYVRTETEGKPSGWMAVYQEGKWLVTDKR 872
           RK KE YV+TE +GKP+GW A Y  GKW V DKR
Sbjct: 834 RKTKEQYVQTEVDGKPTGWKAFYDGGKWKVEDKR 867