Pairwise Alignments

Query, 876 a.a., DNA topoisomerase 1 from Vibrio cholerae E7946 ATCC 55056

Subject, 900 a.a., DNA topoisomerase I from Sinorhizobium meliloti 1021

 Score =  426 bits (1094), Expect = e-123
 Identities = 253/673 (37%), Positives = 374/673 (55%), Gaps = 83/673 (12%)

Query: 1   MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTAGQTATPTGKAAAASTKKAST 60
           M  ++V+VESP+KAKTINKYLG  + V +S GHVRDLP                      
Sbjct: 5   MSMNVVVVESPSKAKTINKYLGPGYKVLASFGHVRDLPA--------------------- 43

Query: 61  TDKEQQKREKERAALIKKMGVDPYHGWQANYQILPGKEKVVAELQKLAKDADSVYLATDL 120
                           K   V P   ++ ++++     K + ++    K +D + LATD 
Sbjct: 44  ----------------KDGSVRPDEDFEMSWEVDGASAKRMKDIADAVKSSDGLILATDP 87

Query: 121 DREGEAIAWHL------REIIGGDEKRYKRVVFNEITKNAIQQAFKQPGELNMDGVNAQQ 174
           DREGEAI+WH+      +++IG  +K  KRVVFN ITK A+  A  +P +++   V+A  
Sbjct: 88  DREGEAISWHVLDLLRKKKVIG--DKPVKRVVFNAITKKAVLDAMAEPRDIDASLVDAYL 145

Query: 175 ARRFMDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFVPEEFWDINADT 234
           ARR +D +VGF +SP+LW+K+    SAGRVQSVA++L+ +RE EI+ FV EE+W+I+A  
Sbjct: 146 ARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCDREAEIERFVTEEYWNISALL 205

Query: 235 LTADKQDFRLLVAQKDGLAFKPV---NETEALAAVAALNKAQYEVCKREDKPTTSKPSAP 291
            T    +F   +   DG    P    N  EA    + L+ A Y V   E KP    PS P
Sbjct: 206 KTPRGDEFEARLVSADGKRLPPKAIGNGEEANRLKSLLDGASYVVESVEAKPVKRNPSPP 265

Query: 292 FITSTLQQAASTRLGYGVKKTMMLAQRLYEA--------GYITYMRTDSTNLSAEAVENL 343
           F TSTLQQAAS++LG+   +TM +AQ+LYE         G ITYMRTD   ++ EA+E  
Sbjct: 266 FTTSTLQQAASSKLGFSASRTMQVAQKLYEGVDIGGETVGLITYMRTDGVQMAPEAIEAA 325

Query: 344 RGYITKHYGEAYLPSQPNVYGSK-QNAQEAHEAIRPSDVTVTADDLEG-MEADAHKLYAL 401
           R  I   +GE YLP +P  Y +K +NAQEAHEAIRP+D   T D +   ++ D  +LY L
Sbjct: 326 RQAIGSQFGERYLPEKPRFYSTKAKNAQEAHEAIRPTDFDRTPDQVRRFLDGDMLRLYDL 385

Query: 402 IWNQFVACQMTPAQYDSTTVSVKA----AEYTLKAKGRILKFDGWTRVQRPLGKN----- 452
           +W + +A QM  A+ + TT  + A     +  L+A G +++FDG+      + ++     
Sbjct: 386 VWKRGIASQMASAEIERTTAEIVADNAGKKAGLRATGSVIRFDGFIAAYTDMKEDGEQAD 445

Query: 453 ---EDQILPPVKVGDSLKLVSLDPKQHFTKPPARYTEAALVKELEKRGIGRPSTYASIIS 509
              ED  LP +   ++L    ++  QHFT+PP RY+EA L+K++E+ GIGRPSTYA+ ++
Sbjct: 446 DGDEDGRLPEINARENLAKQKINASQHFTEPPPRYSEATLIKKMEELGIGRPSTYAATVT 505

Query: 510 TIQDRGYVKVDQRRFFAEKMGEIVTDRLDENFDDLMNYDFTARMEEKLDQIAEGEVNWTA 569
           T+ DR YV++D+R+   +  G +VT  L+  F   + YDFTA +EEKLDQI+ GE+NW  
Sbjct: 506 TLIDRDYVEIDKRKLVPQAKGRLVTAFLESFFTRYVEYDFTASLEEKLDQISAGELNWKD 565

Query: 570 VLDEFFADFSRDLETAEQDESLGGMKPNHIVMTNI------------LCPTC-SRPMGIR 616
           VL +F+ DF   +E  ++      +   +  +  +            +C  C +  + ++
Sbjct: 566 VLRDFWKDFFSQIEDTKELRVTNVLDALNEELAPLVFPKREDGGDPRICQVCGTGKLSLK 625

Query: 617 TASTGVFLGCSGY 629
               G F+GCS Y
Sbjct: 626 LGKYGAFVGCSNY 638



 Score = 31.6 bits (70), Expect = 2e-04
 Identities = 24/90 (26%), Positives = 43/90 (47%), Gaps = 7/90 (7%)

Query: 717 CDKCGSDMV-LKNGRFGKYMGCTN-DACKNTRKIL--KNGEV-APPKEEPVHFPELPCEN 771
           C  CG+  + LK G++G ++GC+N   C  TR++    NG+  A    EP    + P  +
Sbjct: 614 CQVCGTGKLSLKLGKYGAFVGCSNYPECNYTRQLSSDSNGDAEAAAANEPQSLGKDP--H 671

Query: 772 SDAYFVLRDGASGLFFAASNFPKSRETRAP 801
           +     LR+G  G +    +  +++    P
Sbjct: 672 TGEEITLRNGRFGPYVQRGDGKEAKRASLP 701