Pairwise Alignments

Query, 876 a.a., DNA topoisomerase 1 from Vibrio cholerae E7946 ATCC 55056

Subject, 900 a.a., DNA topoisomerase TopA from Phaeobacter inhibens DSM 17395

 Score =  440 bits (1132), Expect = e-127
 Identities = 281/703 (39%), Positives = 385/703 (54%), Gaps = 93/703 (13%)

Query: 5   LVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTAGQTATPTGKAAAASTKKASTTDKE 64
           +V+VESPAKAKTINKYLG D+ V +S GHVRDLP                          
Sbjct: 3   VVVVESPAKAKTINKYLGSDYTVLASYGHVRDLPA------------------------- 37

Query: 65  QQKREKERAALIKKMGVDPYHGWQANYQILPGKEKVVAELQKLAKDADSVYLATDLDREG 124
                       K   V+P   +   +++     K V  +    KD +++ LATD DREG
Sbjct: 38  ------------KNGSVEPDDDFAMTWEVGADSRKHVKAIADALKDDNALILATDPDREG 85

Query: 125 EAIAWHLREIIGGDEKRYK-----RVVFNEITKNAIQQAFKQPGELNMDGVNAQQARRFM 179
           EAI+WHL+E +       K     RV FN ITK A+ +A K P ++++  V A  ARR +
Sbjct: 86  EAISWHLQEALTKRRSIKKDTAVSRVTFNAITKEAVTEAMKNPRQVDLPLVEAYLARRAL 145

Query: 180 DRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFVPEEFWDINADTLTADK 239
           D +VGF +SP+LW+K+    SAGRVQSV ++L+VERE EI+AF P+E+W + A   T   
Sbjct: 146 DYLVGFNLSPVLWRKLPGARSAGRVQSVCLRLIVEREMEIEAFKPQEYWSVKASLATPRG 205

Query: 240 QDF--RLLVAQKDGL-AFKPVNETEALAAVAALNKAQYEVCKREDKPTTSKPSAPFITST 296
           Q+F  RL V   D L  +   N T A  AV A+      V   E KP +  PSAPF+TST
Sbjct: 206 QEFEARLTVLGGDKLDKYALANSTAAELAVQAVASRALTVQSVEAKPASRNPSAPFMTST 265

Query: 297 LQQAASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSAEAVENLRGYITKHYGEAYL 356
           LQQ AS + G G K+ M  AQRLYEAGYITYMRTD  +++ EAV+  R  I   YG  Y+
Sbjct: 266 LQQEASRKFGMGAKQCMNAAQRLYEAGYITYMRTDGIDMAPEAVQEARAEIANRYGAEYV 325

Query: 357 PSQPNVYGSK-QNAQEAHEAIRPSDVTVTADDLEGMEADAHKLYALIWNQFVACQMTPAQ 415
           P  P +Y +K +NAQEAHE IRP+++   A  L+  E D  KLY LIW + +ACQM  A+
Sbjct: 326 PGSPRIYKNKAKNAQEAHECIRPTEMGRDAKSLKVSEDDQRKLYDLIWKRTLACQMEGAR 385

Query: 416 YDSTTVSVKA--AEYTLKAKGRILKFDGWTRVQRP----LGKNEDQILPPVKVGDSLKLV 469
            + TTV + +   +  L+A G+++ FDG+ RV       +  ++D+ LP +  G+SLK  
Sbjct: 386 LERTTVDIGSNDGQVVLRATGQVMLFDGFLRVYEEGRDDVVDDDDKRLPQIMQGESLKFA 445

Query: 470 SL----------------DPK-----QHFTKPPARYTEAALVKELEKRGIGRPSTYASII 508
           +                 D K     QH T+PP R+TEA LVK +E+ GIGRPSTYAS+I
Sbjct: 446 ASLAAQAEKADTGGAILSDDKAVLGLQHHTQPPPRFTEATLVKRMEELGIGRPSTYASVI 505

Query: 509 STIQDRGYVKVDQRRFFAEKMGEIVTDRLDENFDDLMNYDFTARMEEKLDQIAEGEVNWT 568
           +TIQDR YV+ D+ R F E  G IVT  L   F   + Y+FTA +E +LD ++ G+ ++ 
Sbjct: 506 TTIQDREYVRKDKNRLFPEDKGRIVTIFLLNFFRTYVGYEFTANLEGELDDVSAGDRDYK 565

Query: 569 AVLDEFFADFS------RDLETAE----QDESLGGM--KPNHIVMTNILCPTC-SRPMGI 615
            +L  F+ DFS       DL   E     D++L      P    +   +CP C +  + +
Sbjct: 566 DLLSRFWRDFSAAISETSDLRITEVLDVLDDALAPQLYPPREDGVDPRVCPKCGAGQLHL 625

Query: 616 RTASTGVFLGCSGYGLPPKERCKTTINLGDE--EGVINVLEED 656
           +T+ TG F+GC  Y       C  T  +  E  EG   +L ED
Sbjct: 626 KTSRTGGFVGCGNY-----PECNYTRPISGEGAEGYERILGED 663