Pairwise Alignments

Query, 876 a.a., DNA topoisomerase 1 from Vibrio cholerae E7946 ATCC 55056

Subject, 758 a.a., DNA topoisomerase I (RefSeq) from Desulfovibrio vulgaris Miyazaki F

 Score =  511 bits (1315), Expect = e-149
 Identities = 316/807 (39%), Positives = 447/807 (55%), Gaps = 108/807 (13%)

Query: 1   MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTAGQTATPTGKAAAASTKKAST 60
           MGK L+IVESPAK KTI K+LG ++ V +SVGHVRDLPT+                    
Sbjct: 1   MGKDLIIVESPAKVKTIKKFLGGNYAVHASVGHVRDLPTS-------------------- 40

Query: 61  TDKEQQKREKERAALIKKMGVDPYHGWQANYQILPGKEKVVAELQKLAKDADSVYLATDL 120
                            ++GVD  +G+   YQ++ GK+KVV+ L++ A  AD+VYLA D 
Sbjct: 41  -----------------ELGVDEANGFAPRYQVIDGKQKVVSALKEAAAKADNVYLAPDP 83

Query: 121 DREGEAIAWHLREIIGGDEKRYKRVVFNEITKNAIQQAFKQPGELNMDGVNAQQARRFMD 180
           DREGEAIAWH+ E+I       +R+ FNEIT  A+++A + P ELN +  +AQQARR +D
Sbjct: 84  DREGEAIAWHVAELIRDKNTNIQRIQFNEITARAVKEALENPRELNRNLFDAQQARRVLD 143

Query: 181 RVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFVPEEFWDINADTLTADKQ 240
           R+VG+ +SPLLWKKV RG+SAGRVQSVA++L+V+RE E +AF PEE+W   A    A   
Sbjct: 144 RLVGYKLSPLLWKKVKRGISAGRVQSVALRLIVDRENERRAFNPEEYWLFRARLAGATPP 203

Query: 241 DFRLLVAQKDGLAFKPVNETEALAAVAALNKAQYEVCKREDKPTTSKPSAPFITSTLQQA 300
            FR  + +  G      +  +A A  A++    + +   ++K    +P  PFITSTLQQ+
Sbjct: 204 PFRADLHKLHGKKPAIGSAADAAAVEASMQGQPFVITGIDEKERQRQPQPPFITSTLQQS 263

Query: 301 ASTRLGYGVKKTMMLAQRLYE---------AGYITYMRTDSTNLSAEAVENLRGYITKHY 351
           AS RLGY  K+TM +AQRLYE            ITYMRTDS  ++ EA +  R +I   +
Sbjct: 264 ASQRLGYSAKRTMNIAQRLYEGVELGEAGTVALITYMRTDSVRIADEARDAAREFIAATW 323

Query: 352 GEAYLPSQPNVYGSKQNAQEAHEAIRPSDVTVTADDLEG-MEADAHKLYALIWNQFVACQ 410
           G  +LP++   + +K  AQ+AHEAIRP DV+VT D +   +  D  +LY L+W +FVA Q
Sbjct: 324 GGDHLPAKARQFKTKGGAQDAHEAIRPVDVSVTPDSVRHLLPPDQFQLYRLVWQRFVASQ 383

Query: 411 MTPAQYDSTTVSVKAAEYTLKAKGRILKFDGWTRV--QRPLGKNEDQI---LPPVKVGDS 465
           M  A++  TTV++       +AKG  L F G+     Q+     E+     LP + VG+ 
Sbjct: 384 MAAARFHDTTVTIACGPVEWRAKGERLLFPGFLAASPQKEAQDGEEVAEGDLPKLSVGEE 443

Query: 466 LKLVSLDPKQHFTKPPARYTEAALVKELEKRGIGRPSTYASIISTIQDRGYVKVDQRRFF 525
           L  +S++ +Q FT+PPARYTEA+LV+ELE+RGIGRPSTYA+IIST+ DR Y +++++ F 
Sbjct: 444 LTALSVEKEQKFTQPPARYTEASLVRELEERGIGRPSTYAAIISTLLDRDYARLEEKHFA 503

Query: 526 AEKMGEIVTDRLDENFDDLMNYDFTARMEEKLDQIAEGEVNWTAVLDEFFADFSRDLETA 585
              +G +V D L  +F  LM+ DFTA+ME  LD++AEGE++W  +L++F   F+  LE A
Sbjct: 504 PTDLGAVVCDLLAGHFTTLMDVDFTAQMEGSLDKVAEGELDWVKLLEDFTGGFNPVLERA 563

Query: 586 EQ--DESLGGMKPNHIVMTNILCPTCSRPMGIRTASTGVFLGCSGYGLPPKERCKTTINL 643
            Q  D   GG+       + I C  C +PM I+    G FL CSGY       C+ T N 
Sbjct: 564 AQAMDTVKGGLP------SGIDCELCGKPMVIKFGKAGTFLACSGY-----PACRNTKNF 612

Query: 644 -GDEEGVINV---LEEDVETAALRAKKRCPICETAMDAYLIDDKRKLHVCGNNPN----- 694
             DE+G I V   L E+ E         CP C   +         +   C   P+     
Sbjct: 613 TRDEKGNIQVEQKLREEPEKVG-----TCPQCGGDLVLKKARTGSRFIACTKYPDCTYTA 667

Query: 695 ------------CEGFIVEEGEFKVKGYEGPTV---------------ECDKCGSD-MVL 726
                       CEG +VE+   + K +   +                 C  C S  +V+
Sbjct: 668 PFSTGVPCPREGCEGVLVEKSSKRGKIFYSCSAYPKCDYALWDWPVPGPCPDCNSPLLVI 727

Query: 727 KNGRF-GKYMGCTNDACKNTRKILKNG 752
           KN R  G+++ C    CK +R + ++G
Sbjct: 728 KNTRARGRHIACPEKTCKYSRDLDEDG 754



 Score = 26.2 bits (56), Expect = 0.008
 Identities = 11/33 (33%), Positives = 17/33 (51%)

Query: 767 LPCENSDAYFVLRDGASGLFFAASNFPKSRETR 799
           + CE      V++ G +G F A S +P  R T+
Sbjct: 578 IDCELCGKPMVIKFGKAGTFLACSGYPACRNTK 610