Pairwise Alignments

Query, 876 a.a., DNA topoisomerase 1 from Vibrio cholerae E7946 ATCC 55056

Subject, 823 a.a., DNA topoisomerase I from Methanococcus maripaludis JJ

 Score =  242 bits (617), Expect = 8e-68
 Identities = 238/842 (28%), Positives = 368/842 (43%), Gaps = 135/842 (16%)

Query: 5   LVIVESPAKAKTINKYLGK-------------------DFIVKSSVGHVRDLPTAGQTAT 45
           L+I E P  AK I + LGK                     +V S+VGH+  L    +T  
Sbjct: 4   LIICEKPNVAKKIAEALGKPKKKSHNSVPYYELERNGESIVVASAVGHLYTLQEKTKTKF 63

Query: 46  PTGKAAAASTKKASTTDKEQQKREKERAALIKKMGVDPYHGWQANYQILPGKEKVVAELQ 105
                   +   AST D+++                                +K +  L+
Sbjct: 64  GDYPVYDINWVPASTLDEKKYI------------------------------QKYIDALK 93

Query: 106 KLAKDADSVYLATDLDREGEAIAWHLREIIGGDEKRYKRVVFNEITKNAIQQAFKQPGEL 165
           K++KDA+  Y+ATD D EGE I +H      G +K   R+ F+ +TK  I +A++ P E+
Sbjct: 94  KVSKDANKFYVATDWDIEGELIGYHALNFSCG-QKNAHRLRFSSLTKKEILKAYENPNEI 152

Query: 166 NMDGVNAQQARRFMDRVVGFMVSPLLWKKVA-----RGLSAGRVQSVAVKLLVEREREIK 220
           +   V+A  +R  +D   G  VS  L + V+     + LS GRVQ  A+  LV++E EI+
Sbjct: 153 DFGLVDAGDSRHKIDWYFGINVSRALMQAVSSVKRWKTLSTGRVQGPALAFLVDKELEIR 212

Query: 221 AFVPEEFWDINADTLTADKQDFRLLVAQKDGLAFKPVNETEALAAVAALNKAQYEVCKRE 280
            FVP  +W + A             +   D +A   V+E E        NKA YE  K +
Sbjct: 213 NFVPTPYWVLEA-------------LLDNDLIA---VHELEKFWDEEQANKA-YEKVKGQ 255

Query: 281 DKPTTSK---------PSAPFITSTLQQAASTRLGYGVKKTMMLAQRLYEAGYITYMRTD 331
            + T S          P+ PF    LQ+ A     +  KKT  +AQ+LYE GY +Y RT 
Sbjct: 256 KQATVSDVKKSMKTIPPNPPFDLGALQREAHNMFRFSPKKTQEVAQKLYEKGYCSYPRTS 315

Query: 332 STNLSA------EAVENL-RGYITKHYGEAYLPSQPNVYGSKQNAQEAHEAIRPSDVTVT 384
           S  L        E ++NL +    K Y E  L         K++   AH A+   DV   
Sbjct: 316 SQKLPDDKAYMDEVLKNLSKNKNYKPYIETILNENRKPISGKKD-DPAHPAVHAVDVPK- 373

Query: 385 ADDLEGMEADAHKLYALIWNQFVACQMTPAQYDSTTVSVKAAEYTLKAKGRILKFDGWTR 444
               E +  D  KLY LI  + +A     A+ + + +++     T K  G     +GW  
Sbjct: 374 ----EKLPDDELKLYELIARRTIALYWDNAKREYSKINLDINGETFKLSGSRTVEEGWHE 429

Query: 445 VQRPLGKNEDQILPPVKVGDSLKLVSLDPKQHFTKPPARYTEAALVKELEKRGIGRPSTY 504
           +     K ++  LP +K  D + + +++ +   TKPP RYT A+++KELEKR +G  +T 
Sbjct: 430 IYY-YTKFDEIELPELKKNDVINVNNINFEAKETKPPKRYTMASIIKELEKRKLGTKATR 488

Query: 505 ASIISTIQDRGYVKVDQRRFFAEKMGEIVTDRLDENFDDLMNYDFTARMEEKLDQIAEGE 564
           A I+  +  RGYV ++        +G  VT+ L +   +++    T  +E+KL+ I + +
Sbjct: 489 ADILEKLTKRGYV-IEDGSLTVTDLGIGVTETLRKYCPEIVEETLTRDLEDKLELIQDKK 547

Query: 565 VNWTAVLDEFFADFSRDL-ETAEQDESLGGMKPNHIVMTNI------LCPTCSRPMGIRT 617
           +    V+ E     ++ L E   +++ +G    + +  TN        C      + IRT
Sbjct: 548 IKKEEVIQETKDKLTKILGEFRLKEKEIGTELVDKLDSTNRSLQIIGKCKCGGDMIIIRT 607

Query: 618 ASTGVFLGCSGYGLPPKERCKTTINLGDEEGVINVLEEDVETAALRAKKRCPICETAMDA 677
                F+GCS Y       C+ T  L  ++G I VL E              +CE   + 
Sbjct: 608 KGKKRFVGCSNY-----PDCEVTFPL-PQKGRIKVLNE--------------VCEKCQNP 647

Query: 678 YLIDDKRKLHVCGNNPNCEGFIVEEGEFKVKGYEGPTVECDKCGSDMVLKNGRFGKYMGC 737
            +  D+ K+ V   NP+C   I EE + +++  E     C KCG+ +++K G +G + GC
Sbjct: 648 VIGLDRIKICV---NPDCSTRISEEDKKEIEKAEKEEKICPKCGNKLLIKKGPYGVFRGC 704

Query: 738 TN-DACKNTRKILKNGEVAPPKEEPVHFPELPCENSDAYFVLRDGASGLFFAASNFPKSR 796
            N   CK T K+  NGE      E     + P   SD Y   R G  G F   SN+PK R
Sbjct: 705 ENYPKCKYTEKL--NGE----SNEKEIVGKCPKCGSDLY--KRKGRFGEFIGCSNYPKCR 756

Query: 797 ET 798
            T
Sbjct: 757 HT 758