Pairwise Alignments

Query, 876 a.a., DNA topoisomerase 1 from Vibrio cholerae E7946 ATCC 55056

Subject, 727 a.a., DNA topoisomerase III from Marinobacter adhaerens HP15

 Score =  108 bits (269), Expect = 2e-27
 Identities = 137/585 (23%), Positives = 232/585 (39%), Gaps = 77/585 (13%)

Query: 104 LQKLAKDADSVYLATDLDREGEAIAWHLREIIGGDEKRYKRVVFNEITKNAIQQAFKQPG 163
           L+ L + A ++  A D DREG+ +   +    G      +R++ N++T  A+ +A + P 
Sbjct: 91  LESLIRQAKTIIHAGDPDREGQLLVDEVIRYFGASAP-VQRILINDLTPAAVARAIQSPR 149

Query: 164 ELNMDG---VNAQQARRFMDRVVGFMVSPLLWKKVARG-----LSAGRVQSVAVKLLVER 215
           + N +     ++  AR+  D + G  ++        R       S GRVQ+  + L+VER
Sbjct: 150 D-NREFRRLSHSALARQRADWLYGINLTRFYTLSYQRQGEQGVYSVGRVQTPVLGLVVER 208

Query: 216 EREIKAFVPEEFWDINA-----------DTLTA---DKQDFRLLVAQKDGLAFKPVNETE 261
           +  I+ F P+ ++ I A            T TA     + F+  + +++ L  + V E  
Sbjct: 209 DTTIEHFQPKPYYRIEARFRAQEEEADQQTFTARWQPNEQFQDYLDEENRLLNREVAEQI 268

Query: 262 ALAAVAALNKAQYEVCKREDKPTTSKPSAPFITSTLQQAASTRLGYGVKKTMMLAQRLYE 321
           A     ++      + +   +  +  P  PF  S LQ  A      G K  +  AQ LYE
Sbjct: 269 A----DSVRNRPGTITESRFRDRSEAPPLPFSLSALQIEAGRLFRMGAKDVLDTAQNLYE 324

Query: 322 A-GYITYMRTDSTNLS----------AEAVENLRGYITKHYGEAYLPSQPNVYGSKQNAQ 370
               ITY R+D   L             A+  +   + +    A L  + + +  KQ   
Sbjct: 325 RHQLITYPRSDCRYLPEGHYSQREQVIRAIARVAPDLEEACNGADLGRRTSAWNDKQ--V 382

Query: 371 EAHEAIRPSDVTVTADDLEGMEADAHKLYALIWNQFVACQMTPAQYDSTTVSVKAAEYTL 430
           +AH AI P+        L   E    K+Y LI   ++      A +    ++V+ +E+  
Sbjct: 383 DAHHAIIPTSRPTPNGKLSDAE---EKIYGLISRYYLMQFAPDAVHREGKLTVRVSEHEF 439

Query: 431 KAKGRILKFDGWTRVQRPL----GKNEDQILPPVKVGDSLKLVSLDPKQHFTKPPARYTE 486
           +A    +   GW  ++  L     + E   LP ++ G+ +        +  T+PP  +T+
Sbjct: 440 RATETAILVPGWKTLELKLREARKEPEKAPLPRLEKGEPVFCDDSSLSERKTQPPQHFTD 499

Query: 487 AALVKEL-----------------EKRGIGRPSTYASIISTIQDRGYVKVDQRRFFAEKM 529
           A L+  +                 E  G+G  +T A+II T+  R Y+  D R   A   
Sbjct: 500 ATLLSAMTNIARFVTDTELRKTLRETDGLGTEATRAAIIDTLFKRDYLYRDSRHIRATDK 559

Query: 530 GEIVTDRLDENFDDLMNYDFTARMEEKLDQIAEGEVNWTAVLDEFFADFSRDLETAE--- 586
            + +   L E+   +   D TA  E  L+ I  GE +    LD    +    L+  +   
Sbjct: 560 AKALISALPES---VSKPDRTAVWEANLESIRRGEGDPRKFLDTLKEEIRGFLDRPQGRP 616

Query: 587 --QDESLGGMKPNHIVMTNILCPTCSRPMGIRTASTGVFLGCSGY 629
               ES+G   P         CP C  PM  R    G F  C+ Y
Sbjct: 617 TVDSESIGTTSPE----AQPHCPKCRAPMLEREGKFGRFFACTRY 657



 Score = 52.4 bits (124), Expect = 1e-10
 Identities = 29/83 (34%), Positives = 44/83 (53%), Gaps = 6/83 (7%)

Query: 717 CDKCGSDMVLKNGRFGKYMGCTN-DACKNTRKILKNGEVAPPKEEPVHFPELPCENSDAY 775
           C KC + M+ + G+FG++  CT    C+ TR +    E A P++     P +PC +  + 
Sbjct: 634 CPKCRAPMLEREGKFGRFFACTRYPDCRGTRPL----EEATPQDGTGQKP-IPCPHCFSP 688

Query: 776 FVLRDGASGLFFAASNFPKSRET 798
            V R G  G F+  SNFP  R+T
Sbjct: 689 LVRRKGKKGWFWGCSNFPGCRQT 711



 Score = 38.5 bits (88), Expect = 1e-06
 Identities = 27/103 (26%), Positives = 42/103 (40%), Gaps = 8/103 (7%)

Query: 647 EGVINVLEEDVETAALRAKKRCPICETAMDAYLIDDKRKL---HVCGNNPNCEGFIVEEG 703
           +G   V  E + T +  A+  CP C   M    ++ + K      C   P+C G    E 
Sbjct: 613 QGRPTVDSESIGTTSPEAQPHCPKCRAPM----LEREGKFGRFFACTRYPDCRGTRPLEE 668

Query: 704 EFKVKGYEGPTVECDKCGSDMVLKNGRFGKYMGCTN-DACKNT 745
                G     + C  C S +V + G+ G + GC+N   C+ T
Sbjct: 669 ATPQDGTGQKPIPCPHCFSPLVRRKGKKGWFWGCSNFPGCRQT 711



 Score = 27.7 bits (60), Expect = 0.003
 Identities = 18/51 (35%), Positives = 22/51 (43%), Gaps = 8/51 (15%)

Query: 579 SRDLETAEQDESLGGMKPNHIVMTNILCPTCSRPMGIRTASTGVFLGCSGY 629
           +R LE A   +  G  KP       I CP C  P+  R    G F GCS +
Sbjct: 663 TRPLEEATPQDGTG-QKP-------IPCPHCFSPLVRRKGKKGWFWGCSNF 705



 Score = 26.9 bits (58), Expect = 0.004
 Identities = 15/36 (41%), Positives = 19/36 (52%), Gaps = 1/36 (2%)

Query: 769 CENSDAYFVLRDGASGLFFAASNFPKSRETRAPLVE 804
           C    A  + R+G  G FFA + +P  R TR PL E
Sbjct: 634 CPKCRAPMLEREGKFGRFFACTRYPDCRGTR-PLEE 668