Pairwise Alignments

Query, 876 a.a., DNA topoisomerase 1 from Vibrio cholerae E7946 ATCC 55056

Subject, 878 a.a., DNA topoisomerase I (NCBI ptt file) from Shewanella oneidensis MR-1

 Score = 1201 bits (3107), Expect = 0.0
 Identities = 601/878 (68%), Positives = 702/878 (79%), Gaps = 3/878 (0%)

Query: 1   MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTAGQTATPTGKAAAASTKKAST 60
           MGKSLVIVESPAKAKTINKYLGK+FIVKSSVGH+RDLPT+  +       +AA  KK S 
Sbjct: 1   MGKSLVIVESPAKAKTINKYLGKEFIVKSSVGHIRDLPTSSISDGTEKVKSAAEVKKMSP 60

Query: 61  TDKEQQKREKERAALIKKMGVDPYHGWQANYQILPGKEKVVAELQKLAKDADSVYLATDL 120
            +K + K+ K+  AL+ +MGV+P  GW A YQILPGKEKVV ELQ LA  AD +YLATDL
Sbjct: 61  EEKARYKKVKDHQALVSRMGVNPEKGWAAKYQILPGKEKVVKELQALADSADQIYLATDL 120

Query: 121 DREGEAIAWHLREIIGGDEKRYKRVVFNEITKNAIQQAFKQPGELNMDGVNAQQARRFMD 180
           DREGEAIAWHL+E+IGGD  RY+RVVFNEITK+AIQ+AF +P  L+ + VNAQQARRF+D
Sbjct: 121 DREGEAIAWHLQEVIGGDPSRYQRVVFNEITKSAIQEAFSKPASLDTNMVNAQQARRFLD 180

Query: 181 RVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFVPEEFWDINADTLTADKQ 240
           RVVGFMVSPLLWKKVARGLSAGRVQSVAV+L+VERE EIKAFVPEEFWD++A   T   +
Sbjct: 181 RVVGFMVSPLLWKKVARGLSAGRVQSVAVRLVVERESEIKAFVPEEFWDVHAQLNTPSSE 240

Query: 241 DFRLLVAQKDGLAFKPVNETEALAAVAALNKAQYEVCKREDKPTTSKPSAPFITSTLQQA 300
             R+ V +    AF+P NE +ALAAV AL+ A ++V  REDK T SKPSAPFITSTLQQA
Sbjct: 241 ALRMEVVKYLDSAFEPTNEQQALAAVQALSSASFKVIAREDKATQSKPSAPFITSTLQQA 300

Query: 301 ASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSAEAVENLRGYITKHYGEAYLPSQP 360
           ASTRLG+GVKKTMM+AQRLYEAG+ITYMRTDSTNLS EA++++R  I K YG  YLP++P
Sbjct: 301 ASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEALDSVREMIGKEYGAKYLPAEP 360

Query: 361 NVYGSKQNAQEAHEAIRPSDVTVTADDLEGMEADAHKLYALIWNQFVACQMTPAQYDSTT 420
             YGSK+ AQEAHEAIRPS+V V A  L  ME DA +LY LIW QFV+CQMTPA YD+T 
Sbjct: 361 IRYGSKEGAQEAHEAIRPSNVKVEAAALTDMERDAQRLYELIWRQFVSCQMTPALYDATK 420

Query: 421 VSVKAAEYTLKAKGRILKFDGWTRVQRPLGK--NEDQILPPVKVGDSLKLVSLDPKQHFT 478
           ++VKAA+Y LKA GRIL+FDGWTRVQ  + K   ED  LP V  GD L LV L+PKQHFT
Sbjct: 421 LTVKAADYELKATGRILRFDGWTRVQTAIKKKNEEDNTLPAVNEGDVLSLVELEPKQHFT 480

Query: 479 KPPARYTEAALVKELEKRGIGRPSTYASIISTIQDRGYVKVDQRRFFAEKMGEIVTDRLD 538
           KPPARY+EA+LVKELEKRGIGRPSTYA+IISTIQ+RGYVKV+ RRF+AEKMGEIV++RL 
Sbjct: 481 KPPARYSEASLVKELEKRGIGRPSTYATIISTIQERGYVKVENRRFYAEKMGEIVSERLV 540

Query: 539 ENFDDLMNYDFTARMEEKLDQIAEGEVNWTAVLDEFFADFSRDLETAEQDESLGGMKPNH 598
            +F +LM+YDFTA ME+ LD +A+GE++W  VLD F+ADF++ LE AE     GGM+ N 
Sbjct: 541 NSFAELMSYDFTASMEQTLDDVAKGELDWKKVLDGFYADFTKQLEKAELAPEEGGMRLNQ 600

Query: 599 IVMTNILCPTCSRPMGIRTASTGVFLGCSGYGLPPKERCKTTINLGDEEGVINVLEEDVE 658
           +VMTNI CPTC RPMGIRT +TGVFLGCSGY LPPKERCKTT+NL      I+   ED E
Sbjct: 601 MVMTNIKCPTCGRPMGIRTGTTGVFLGCSGYELPPKERCKTTMNLTPGIEAISD-SEDAE 659

Query: 659 TAALRAKKRCPICETAMDAYLIDDKRKLHVCGNNPNCEGFIVEEGEFKVKGYEGPTVECD 718
           T ALRAK RC IC TAMD+YL+D+KRKLHVCGNNP CEG+ VEEG+FK+KGYEGP +ECD
Sbjct: 660 TDALRAKHRCGICGTAMDSYLLDEKRKLHVCGNNPVCEGYEVEEGQFKIKGYEGPLIECD 719

Query: 719 KCGSDMVLKNGRFGKYMGCTNDACKNTRKILKNGEVAPPKEEPVHFPELPCENSDAYFVL 778
           +CG DM LKNGRFGKY GCTN+ CKNTRK+LKNGE APPKE+P++ PEL C  SDA+FVL
Sbjct: 720 RCGHDMELKNGRFGKYFGCTNEECKNTRKLLKNGEAAPPKEDPIYLPELKCSKSDAHFVL 779

Query: 779 RDGASGLFFAASNFPKSRETRAPLVEELKRFAERLPEKYQYLTSAPAHDPDGLPAVVRFS 838
           RDGA+G+F AAS FPKSRETRAPLVEEL ++ E L  KYQYL  AP  D DG  AVV+FS
Sbjct: 780 RDGAAGIFLAASTFPKSRETRAPLVEELVKYREFLWPKYQYLADAPIADDDGNKAVVKFS 839

Query: 839 RKEKEHYVRTETEGKPSGWMAVYQEGKWLVTDKRKNAK 876
           RK K+ YV TE +GK +GW A Y  GKW+     K AK
Sbjct: 840 RKTKDQYVATEVDGKATGWSAHYVNGKWVSESSAKKAK 877