Pairwise Alignments

Query, 876 a.a., DNA topoisomerase 1 from Vibrio cholerae E7946 ATCC 55056

Subject, 865 a.a., DNA topoisomerase I from Klebsiella michiganensis M5al

 Score = 1243 bits (3217), Expect = 0.0
 Identities = 614/875 (70%), Positives = 718/875 (82%), Gaps = 14/875 (1%)

Query: 1   MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTAGQTATPTGKAAAASTKKAST 60
           MGK+LVIVESPAKAKTINKYLG D++VKSSVGH+RDLPT+G          +AS K A +
Sbjct: 1   MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSG----------SASKKSADS 50

Query: 61  TDKEQQKREK--ERAALIKKMGVDPYHGWQANYQILPGKEKVVAELQKLAKDADSVYLAT 118
           T  +  K+ K  ER AL+ +MGVDP+H W A+Y+ILPGKEKVV+EL++LA+ AD +YLAT
Sbjct: 51  TSTKGAKKPKKDERGALVNRMGVDPWHDWDAHYEILPGKEKVVSELKQLAEKADHIYLAT 110

Query: 119 DLDREGEAIAWHLREIIGGDEKRYKRVVFNEITKNAIQQAFKQPGELNMDGVNAQQARRF 178
           DLDREGEAIAWHLRE+IGGDE+RY RVVFNEITKNAI+QAF++PGELN+D VNAQQARRF
Sbjct: 111 DLDREGEAIAWHLREVIGGDEQRYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRF 170

Query: 179 MDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFVPEEFWDINADTLTAD 238
           MDRVVG+MVSPLLWKK+ARGLSAGRVQSVAV+L+VEREREIKAFVPEE+W+++A T T  
Sbjct: 171 MDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWEVDASTTTPG 230

Query: 239 KQDFRLLVAQKDGLAFKPVNETEALAAVAALNKAQYEVCKREDKPTTSKPSAPFITSTLQ 298
                L V       F+PV+  E +AAVA L KA Y V +REDKPT+SKP APFITSTLQ
Sbjct: 231 GDALPLQVTHSGDKPFRPVSRDETMAAVALLEKASYSVLEREDKPTSSKPGAPFITSTLQ 290

Query: 299 QAASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSAEAVENLRGYITKHYGEAYLPS 358
           QAASTRLG+GVKKTMM+AQRLYEAG+ITYMRTDSTNLS +A+  +RGYI  ++G+ YLP 
Sbjct: 291 QAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALNMVRGYIGDNFGKKYLPE 350

Query: 359 QPNVYGSKQNAQEAHEAIRPSDVTVTADDLEGMEADAHKLYALIWNQFVACQMTPAQYDS 418
             N Y SK+N+QEAHEAIRPSDV V A+ L+ ME+DA KLY LIW QFVACQMTPAQYDS
Sbjct: 351 SANQYASKENSQEAHEAIRPSDVNVLAETLKDMESDAQKLYQLIWRQFVACQMTPAQYDS 410

Query: 419 TTVSVKAAEYTLKAKGRILKFDGWTRVQRPLGK-NEDQILPPVKVGDSLKLVSLDPKQHF 477
           TT++VKA ++ LKA+GR L+FDGWT+V   L K +ED+ LP V  G+SL LV L P QHF
Sbjct: 411 TTLTVKAGDFKLKARGRTLRFDGWTKVMPALRKGDEDRTLPLVNKGESLSLVELTPAQHF 470

Query: 478 TKPPARYTEAALVKELEKRGIGRPSTYASIISTIQDRGYVKVDQRRFFAEKMGEIVTDRL 537
           TKPPAR++EA+LVKELEKRGIGRPSTYASIISTIQDRGYV+V+ RRF+AEKMGEIVTDRL
Sbjct: 471 TKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRL 530

Query: 538 DENFDDLMNYDFTARMEEKLDQIAEGEVNWTAVLDEFFADFSRDLETAEQDESLGGMKPN 597
           +ENF DLMNYDFTA+ME++LDQ+A  +  W  VLD FF DF+  L+TAE+D   GGM+PN
Sbjct: 531 EENFRDLMNYDFTAQMEDRLDQVANHQAEWKQVLDNFFGDFTSQLQTAEKDPEEGGMQPN 590

Query: 598 HIVMTNILCPTCSRPMGIRTASTGVFLGCSGYGLPPKERCKTTINLGDEEGVINVLE-ED 656
            +V+T I CPTC R MGIRTASTGVFLGCSGY L PKERCKTTINL  E  V+NVLE ED
Sbjct: 591 PMVLTTIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGED 650

Query: 657 VETAALRAKKRCPICETAMDAYLIDDKRKLHVCGNNPNCEGFIVEEGEFKVKGYEGPTVE 716
            ET ALRAK+RC  C TAMD+YLID KRKLHVCGNNP C+G+ +EEGEF++KGY+GP VE
Sbjct: 651 AETNALRAKRRCKKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVE 710

Query: 717 CDKCGSDMVLKNGRFGKYMGCTNDACKNTRKILKNGEVAPPKEEPVHFPELPCENSDAYF 776
           C+KCGS+M LK GRFGKYM CTND CKNTRKIL+NGEVAPPKE+PV  PELPCE SDAYF
Sbjct: 711 CEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYF 770

Query: 777 VLRDGASGLFFAASNFPKSRETRAPLVEELKRFAERLPEKYQYLTSAPAHDPDGLPAVVR 836
           VLRDGA+G+F AA+ FPKSRETRAPLVEEL RF +RL EK +YL  AP  DP+G   +VR
Sbjct: 771 VLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLAEKLRYLADAPQQDPEGNKTMVR 830

Query: 837 FSRKEKEHYVRTETEGKPSGWMAVYQEGKWLVTDK 871
           FSRK K+ YV +E EGK +GW A Y +GKW    K
Sbjct: 831 FSRKTKQQYVASEKEGKATGWSAFYIDGKWTEAKK 865