Pairwise Alignments

Query, 876 a.a., DNA topoisomerase 1 from Vibrio cholerae E7946 ATCC 55056

Subject, 760 a.a., DNA topoisomerase I (TIGR) from Desulfovibrio vulgaris Hildenborough JW710

 Score =  514 bits (1325), Expect = e-150
 Identities = 312/808 (38%), Positives = 449/808 (55%), Gaps = 113/808 (13%)

Query: 1   MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTAGQTATPTGKAAAASTKKAST 60
           MGK L+IVESPAK KTI K+LG  ++V++SVGHVRDLPT                     
Sbjct: 1   MGKDLIIVESPAKVKTIKKFLGGKYVVQASVGHVRDLPT--------------------- 39

Query: 61  TDKEQQKREKERAALIKKMGVDPYHGWQANYQILPGKEKVVAELQKLAKDADSVYLATDL 120
                            ++GVD  + +   Y+++ GK+KVV  L++ A  AD+VYLA D 
Sbjct: 40  ----------------NEIGVDEANNFAPQYRVIDGKQKVVDTLREAAAKADTVYLAPDP 83

Query: 121 DREGEAIAWHLREIIGGDEKRYKRVVFNEITKNAIQQAFKQPGELNMDGVNAQQARRFMD 180
           DREGEAIAWH+  +I G     KR+ FNEIT  A+++A + P +LN    +AQQARR +D
Sbjct: 84  DREGEAIAWHVAALIEGKADNIKRIQFNEITARAVREALENPRDLNRALFDAQQARRVLD 143

Query: 181 RVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFVPEEFWDI---------N 231
           R+VG+ +SPLLWKKV RG+SAGRVQSVA++L+V+RE E +AF PEE+W            
Sbjct: 144 RLVGYKLSPLLWKKVKRGISAGRVQSVALRLIVDRESERRAFTPEEYWLFRAMFAKNVPG 203

Query: 232 ADTLTADKQ--DFRLLVAQKDGLAFKPVNETEALAAVAALNKAQYEVCKREDKPTTSKPS 289
           A   + D Q   F+  +A+ DG      +   A A   A+    + +   E K    +P 
Sbjct: 204 ATPTSPDPQYAPFKAELAKIDGKKAHVADADAANALEDAMRGKPFVITAVERKKRERQPQ 263

Query: 290 APFITSTLQQAASTRLGYGVKKTMMLAQRLYE---------AGYITYMRTDSTNLSAEAV 340
            PFITSTLQQAA+ RLGY  K+TM +AQRLYE            ITYMRTDS  +S EA 
Sbjct: 264 PPFITSTLQQAANQRLGYSAKRTMNIAQRLYEGVELGEMGTVALITYMRTDSVRVSDEAR 323

Query: 341 ENLRGYITKHYGEAYLPSQPNVYGSKQNAQEAHEAIRPSDVTVTADDLEG-MEADAHKLY 399
           +  R ++T+ +G  + P++P  + +K +AQ+AHEA+RP DV VT D ++  +  D  +LY
Sbjct: 324 DAARAFVTETWGADFCPAKPRQFKTKGSAQDAHEAVRPVDVNVTPDSVKHLLPPDQFQLY 383

Query: 400 ALIWNQFVACQMTPAQYDSTTVSVKAAEYTLKAKGRILKFDGWTRVQRPLGKNEDQILPP 459
            L+W++FVA QM PA++D TTV++       +AKG  + F G+     P  +  D  LPP
Sbjct: 384 RLVWSRFVASQMAPARFDDTTVAIACGPAEWRAKGERMLFPGFLAAM-PQKEEGDAELPP 442

Query: 460 VKVGDSLKLVSLDPKQHFTKPPARYTEAALVKELEKRGIGRPSTYASIISTIQDRGYVKV 519
           ++ G++L  VS++ +Q FT+PPARYTEA+LV+ELE+RGIGRPSTYASIIST+ DR Y ++
Sbjct: 443 LQEGETLHPVSVEKEQKFTQPPARYTEASLVRELEERGIGRPSTYASIISTLIDRDYTRL 502

Query: 520 DQRRFFAEKMGEIVTDRLDENFDDLMNYDFTARMEEKLDQIAEGEVNWTAVLDEFFADFS 579
           + + F    +G  V D L  +F  LM+  FTA+ME+ LD++AEG ++W  +L  F ADF+
Sbjct: 503 EDKHFVPTDLGATVCDLLARHFTTLMDVGFTAQMEDSLDKVAEGGLDWVELLSRFSADFN 562

Query: 580 RDLETAEQD-ESLGGMKPNHIVMTNILCPTCSRPMGIRTASTGVFLGCSGYGLPPKERCK 638
             LE+A +  E++ G  P     T++ CP C +P+ ++    G FL C+ Y       CK
Sbjct: 563 PTLESAAKAMETVKGGLP-----TDVTCPECGKPVVVKFGKAGPFLACTAY-----PDCK 612

Query: 639 TTINLG-DEEGVINVLEEDVETAALRAKKRCPICETAMDAYLIDDKRKLHVCGNNPN--- 694
            T N   DE+G  +++ E      L A   CP C   +         +   C   P+   
Sbjct: 613 FTSNFSRDEKG--DIVIEQRAREELEAVGTCPECGKDLVVKKARTGSRFIACTGYPDCRH 670

Query: 695 --------------CEGFIVEEGEFKVKGY------------------EGPTVECDKCGS 722
                         C+G +VE+   + K +                   GP   C  CGS
Sbjct: 671 TEPFSTGIACPREGCDGQLVEKSSKRGKIFYSCNRFPKCDYALWDWPVPGP---CPVCGS 727

Query: 723 DMVLKNGRFGK--YMGCTNDACKNTRKI 748
            +++K     K  ++ C    C+ T+++
Sbjct: 728 PLLVKKSTRAKGLHIACPEKTCRYTQEL 755



 Score = 32.7 bits (73), Expect = 8e-05
 Identities = 25/97 (25%), Positives = 42/97 (43%), Gaps = 5/97 (5%)

Query: 707 VKGYEGPTVECDKCGSDMVLKNGRFGKYMGCT-NDACKNTRKILKN--GEVAPPKEEPVH 763
           VKG     V C +CG  +V+K G+ G ++ CT    CK T    ++  G++   +     
Sbjct: 575 VKGGLPTDVTCPECGKPVVVKFGKAGPFLACTAYPDCKFTSNFSRDEKGDIVIEQRAREE 634

Query: 764 FPEL-PCENSDAYFVLRDGASG-LFFAASNFPKSRET 798
              +  C       V++   +G  F A + +P  R T
Sbjct: 635 LEAVGTCPECGKDLVVKKARTGSRFIACTGYPDCRHT 671