Pairwise Alignments

Query, 761 a.a., 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase from Vibrio cholerae E7946 ATCC 55056

Subject, 759 a.a., Probable 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase MetE (methionine synthase, vitamin-B12 independent isozyme) from Mycobacterium tuberculosis H37Rv

 Score =  642 bits (1657), Expect = 0.0
 Identities = 360/763 (47%), Positives = 462/763 (60%), Gaps = 23/763 (3%)

Query: 3   TTHILGYPRIGEKRELKFALEKYWRGEIDQAALKQVGSQIRQKNWALQKEAGLDFVTAGD 62
           T  I G PRIG +RELK A E YW G   ++ L+ V + +R+  W+    AGLD V    
Sbjct: 11  TATITGSPRIGPRRELKRATEGYWAGRTSRSELEAVAATLRRDTWSALAAAGLDSVPVNT 70

Query: 63  FAWYDHVLTTTLLLGHVPKRHSHGFPDLDTLFRVGRGQSQNACGCGTGSAASDMTKWFNT 122
           F++YD +L T +LLG +P R S     LD  F   RG  Q         A  +MTKWF+T
Sbjct: 71  FSYYDQMLDTAVLLGALPPRVSPVSDGLDRYFAAARGTDQ--------IAPLEMTKWFDT 122

Query: 123 NYHYIVPEFSSNDTFNVSWPQLFEEVNEALQAGHDVKPVLLGPISYLYLGKEVEEGFDRL 182
           NYHY+VPE   + TF +   ++  E+ EAL  G   +PV++GPI++L L K V+     +
Sbjct: 123 NYHYLVPEIGPSTTFTLHPGKVLAELKEALGQGIPARPVIIGPITFLLLSKAVDGAGAPI 182

Query: 183 TLLPRLLTAYQAILSKLAKQGVQWVQIDEPILALELEP---RWQEAFKLAYQVIRGDVKL 239
             L  L+  Y  +LS LA  G QWVQ DEP L  +L P      EA   A   +     +
Sbjct: 183 ERLEELVPVYSELLSLLADGGAQWVQFDEPALVTDLSPDAPALAEAVYTALCSVSNRPAI 242

Query: 240 LLTTYFDSVLDTLDKIVELPVDGLHVDISAAPAQLETIVNRLP--SDWVLSAGVINGRNV 297
            + TYF      L  +   PV+ + VD+ A     +T V  +P  +   L AGV++GRNV
Sbjct: 243 YVATYFGDPGAALPALARTPVEAIGVDLVAGA---DTSVAGVPELAGKTLVAGVVDGRNV 299

Query: 298 WRADLSAILARLQPVKTLLGERLWVA--SSCSLLHSPVDLDLEGDLSAETRSWFAFAKQK 355
           WR DL A L  L    TLLG    VA  +SCS LH P  L+ E DL    RSW AF  +K
Sbjct: 300 WRTDLEAALGTLA---TLLGSAATVAVSTSCSTLHVPYSLEPETDLDDALRSWLAFGAEK 356

Query: 356 VTEVALLGRAL-EGDAAAILACDTYSQPIVARKSSHIVNKASVQTRINNITAALAERSAP 414
           V EV +L RAL +G  A      +    I +RK    ++   ++ RI  I A+ A R   
Sbjct: 357 VREVVVLARALRDGHDAVADEIASSRAAIASRKRDPRLHNGQIRARIEAIVASGAHRGNA 416

Query: 415 YIERAHHQAEVLGLPFLPTTTIGSFPQTGEIRTERSAYRQGKLSEQEYVQALKGHIADAV 474
              RA   A  L LP LPTTTIGS+PQT  IR  R+A R G++ E EYV+ ++  I + +
Sbjct: 417 AQRRASQDAR-LHLPPLPTTTIGSYPQTSAIRVARAALRAGEIDEAEYVRRMRQEITEVI 475

Query: 475 KRQEALGLDVLVHGEAERNDMVEYFAENLAGFQTTQFGWVQSYGSRCVKPAIVVADIERE 534
             QE LGLDVLVHGE ERNDMV+YFAE LAGF  TQ GWVQSYGSRCV+P I+  D+ R 
Sbjct: 476 ALQERLGLDVLVHGEPERNDMVQYFAEQLAGFFATQNGWVQSYGSRCVRPPILYGDVSRP 535

Query: 535 KPITVEWSTYAQSLTSKQMKGMLTGPVTILCWTFPREDISRQEIAQQLALALRDEVADLQ 594
           + +TVEW TYAQSLT K +KGMLTGPVTIL W+F R+D    + A Q+ALA+RDE  DLQ
Sbjct: 536 RAMTVEWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQ 595

Query: 595 DAGINIIQIDEPAIREGLPLKKRDHQTYLDWAVQAFKISAGSARPETQIHTHMCYSEFNE 654
            AGI +IQ+DEPA+RE LPL++ D   YL WAV AF+++       TQIHTH+CYSEF E
Sbjct: 596 SAGIAVIQVDEPALRELLPLRRADQAEYLRWAVGAFRLATSGVSDATQIHTHLCYSEFGE 655

Query: 655 IIESVAALDADVITIETSRSNMELLKAFEEFNYPNEIGPGVYDIHSPNIPAQAWIEDLLR 714
           +I ++A LDADV +IE +RS+ME+L       + N +GPGVYDIHSP +P+   + D LR
Sbjct: 656 VIGAIADLDADVTSIEAARSHMEVLDDLNAIGFANGVGPGVYDIHSPRVPSAEEMADSLR 715

Query: 715 KAAEKIPAQRLWVNPDCGLKTRNWPEVEAALTNMVNAAKALRA 757
            A   +PA+RLWVNPDCGLKTRN  EV A+L NMV AA+ +RA
Sbjct: 716 AALRAVPAERLWVNPDCGLKTRNVDEVTASLHNMVAAAREVRA 758