Pairwise Alignments

Query, 894 a.a., DNA topoisomerase (ATP-hydrolyzing) subunit A from Vibrio cholerae E7946 ATCC 55056

Subject, 936 a.a., DNA gyrase, A subunit from Pseudomonas stutzeri RCH2

 Score = 1159 bits (2999), Expect = 0.0
 Identities = 591/942 (62%), Positives = 732/942 (77%), Gaps = 73/942 (7%)

Query: 1   MSDLAKEITPVNIEDELRSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMNVLGNDWN 60
           M +LAKEI PVNIEDEL+ SYLDYAMSVI+GRALPD RDGLKPVHRRVLFAM+ LGNDWN
Sbjct: 1   MGELAKEILPVNIEDELKQSYLDYAMSVIIGRALPDARDGLKPVHRRVLFAMSELGNDWN 60

Query: 61  KAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAM 120
           K YKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGS+DGDSAAAM
Sbjct: 61  KPYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSVDGDSAAAM 120

Query: 121 RYTEVRMSKIAHELLADLDKETVDYVPNYDGTEQIPAVLPTKIPNLLINGASGIAVGMAT 180
           RYTEVRM+K+AHELLADL+KETVD+VPNYDGTEQIPAV+PTK+PNLL+NG+SGIAVGMAT
Sbjct: 121 RYTEVRMAKLAHELLADLEKETVDWVPNYDGTEQIPAVMPTKVPNLLVNGSSGIAVGMAT 180

Query: 181 NIPPHNLGEVIDGCLAYIDNEAITIDELMDYIPGPDFPTAALISGRKGIIDAYKTGRGKV 240
           NIPPHNLGEVIDGCLA IDN  ITIDELM +IPGPDFPTA +I+GR GII+AY+TGRG++
Sbjct: 181 NIPPHNLGEVIDGCLALIDNADITIDELMQFIPGPDFPTAGIINGRAGIIEAYRTGRGRI 240

Query: 241 YMRSKAEIET-DK-NGKETIIVSEIPYQVNKARLIEKIAELVKEKKVEGISALRDESDKD 298
           Y+R++A+IE  DK  G++ I+++E+PYQ+NKARLIEKIAELVKEKK+EGI+ LRDESDKD
Sbjct: 241 YIRARADIEDIDKVGGRQQIVITELPYQLNKARLIEKIAELVKEKKIEGITELRDESDKD 300

Query: 299 GMRIVIECKRDAVGEVVLNNLYANTQLQTTFGINMVALDNGQPKLFNLKEMLKCFVDHRR 358
           GMR+VIE +R  V EV+LNNLYA TQLQ+ FGIN+VAL +GQP+  NLKE+L+ FV HRR
Sbjct: 301 GMRVVIELRRGEVPEVILNNLYAQTQLQSVFGINVVALIDGQPRTLNLKELLEAFVRHRR 360

Query: 359 EVVTRRTIFELRKARERAHILEGLALALANIDEIIELIRRAATPAEAKEGLIARGWDLGN 418
           EVVTRRT++ELRKARER HILEG A+AL+NID +I +I+ + TPAEAK+ LI+  W+   
Sbjct: 361 EVVTRRTVYELRKARERGHILEGQAVALSNIDPVIAVIKASPTPAEAKDALISTAWESSA 420

Query: 419 VAAMLERAGTDAARPEWLEPQYGIRDGKYFLTEQQAQAILDLRLHKLTGLEHEKILDEYK 478
           V AM+ERAG DA RPE L+PQ+G+RDGKYFL+ +QAQAILDLRLH+LTGLEHEK+L EY+
Sbjct: 421 VEAMVERAGADACRPEGLDPQFGLRDGKYFLSPEQAQAILDLRLHRLTGLEHEKLLSEYQ 480

Query: 479 QLLEEIAALMHILASTERLMEVIREELEAIRAGFSDARRTEITAATHDIDMEELIAREDV 538
           ++L +I  L+ IL +  RLMEVIREELE ++  F DARRTEI  +  D+ + +LI  E+ 
Sbjct: 481 EILTQIGELIRILTNPVRLMEVIREELEGVKRDFGDARRTEILESRLDLTLADLITEEER 540

Query: 539 VVTLSHEGYVKYQLLSDYEAQRRGGKGKSATKMKEEDYIERLLVANTHDNILLFSTRGKT 598
           VVT+SH GY K Q L+ Y+AQRRGG+GK+AT +KEEDY+E LLVAN+H  +LLFS++GK 
Sbjct: 541 VVTISHGGYAKSQPLAAYQAQRRGGRGKAATGVKEEDYVEHLLVANSHTTLLLFSSKGKV 600

Query: 599 YRMKVYQLPLASRTARGKPIVNLLPLEENERITAILPV---------TEFSED------- 642
           Y +K Y++P ASRT+RG+P+VNLLPL+E ERITA+L V          E  +D       
Sbjct: 601 YWLKTYEIPEASRTSRGRPLVNLLPLDEGERITAMLQVDLEALRKQAAEGEDDLDDAEGL 660

Query: 643 -------------------------KFIFMATGDGTVKKTSLDQFANVRANGLIALNLRD 677
                                     +IFMAT +GTVKKT L QF+  R +GLIAL L +
Sbjct: 661 VIEHDDADEVESDDADSDEKDEPTGSYIFMATANGTVKKTPLVQFSRPRTSGLIALKLEE 720

Query: 678 EDSLIGVDITDGESEIMLFSKFGKVVRFKESEETAVVDENGQPVLDENGQPEIKFKGVRP 737
            D+LI   +TDG  E+M+FS  GKV+RFKES+                         VR 
Sbjct: 721 GDTLIAAAVTDGAQEVMMFSDGGKVIRFKESK-------------------------VRI 755

Query: 738 MGRTAAGVRGMKLADGDQVVSLIVPKTEGDVLTVTENGYGKRTSLSEYPTKGRGTQGVVS 797
           MGR A GVRGM+L +G +++S+++P+T   +LT +  GYGKRT++ E+P +GRG QGV++
Sbjct: 756 MGRNARGVRGMRLPEGQRIISMLIPETGAQILTASVRGYGKRTAMEEFPRRGRGGQGVIA 815

Query: 798 IKVSERNGSVVGAVQVAEGDEFMMITNAGTLVRTRVAEVSQVGRNTQGVTLIRTSEGESV 857
           +  +ERNG +VGAVQV EG+E M+I++ GTLVRTRV EVS +GRNTQGVTLI+ S+GE +
Sbjct: 816 MVTNERNGPLVGAVQVLEGEEIMLISDQGTLVRTRVDEVSSLGRNTQGVTLIKLSKGEHL 875

Query: 858 VGLQRIDEIEESELPEGEEALVENDA-----PVAQDDDGEQE 894
           VGL+R+ E  E ++ E  EAL+++DA     PV   +  E E
Sbjct: 876 VGLERVQEPSEEDVLEDIEALLDDDALEKEMPVLSTEPSEDE 917