Pairwise Alignments

Query, 894 a.a., DNA topoisomerase (ATP-hydrolyzing) subunit A from Vibrio cholerae E7946 ATCC 55056

Subject, 838 a.a., DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) from Mycobacterium tuberculosis H37Rv

 Score =  741 bits (1914), Expect = 0.0
 Identities = 392/865 (45%), Positives = 554/865 (64%), Gaps = 62/865 (7%)

Query: 3   DLAKEITPVNIEDELRSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMNVLGNDWNKA 62
           D    I PV+IE E++ SY+DYAMSVIVGRALP+VRDGLKPVHRRVL+AM   G   +++
Sbjct: 10  DSLDRIEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRS 69

Query: 63  YKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRY 122
           + KSAR V + +G YHPHGD+++YD++VRMAQP+SLRY LVDGQGNFGS   D  AAMRY
Sbjct: 70  HAKSARSVAETMGNYHPHGDASIYDSLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRY 129

Query: 123 TEVRMSKIAHELLADLDKETVDYVPNYDGTEQIPAVLPTKIPNLLINGASGIAVGMATNI 182
           TE R++ +A E+L ++D+ETVD++PNYDG  Q P VLP++ PNLL NG+ GIAVGMATNI
Sbjct: 130 TEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNI 189

Query: 183 PPHNLGEVIDGCLAYIDN----EAITIDELMDYIPGPDFPTAALISGRKGIIDAYKTGRG 238
           PPHNL E+ D     ++N    E  T+  +M  + GPDFPTA LI G +G  DAYKTGRG
Sbjct: 190 PPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRG 249

Query: 239 KVYMRSKAEIETDKNGKETIIVSEIPYQVNKARLIEKIAELVKEKKVEGISALRDES-DK 297
            + MR   E+E D  G+ +++++E+PYQVN    I  IAE V++ K+ GIS + D+S D+
Sbjct: 250 SIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDR 309

Query: 298 DGMRIVIECKRDAVGEVVLNNLYANTQLQTTFGINMVALDNGQPKLFNLKEMLKCFVDHR 357
            G+RIVIE KRDAV +VV+NNLY +TQLQT+FG NM+A+ +G P+   L ++++ +VDH+
Sbjct: 310 VGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQ 369

Query: 358 REVVTRRTIFELRKARERAHILEGLALALANIDEIIELIRRAATPAEAKEGLIARGWDLG 417
            +V+ RRT + LRKA ERAHIL GL  AL  +DE+I LIR + T   A+ GLI       
Sbjct: 370 LDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLI------- 422

Query: 418 NVAAMLERAGTDAARPEWLEPQYGIRDGKYFLTEQQAQAILDLRLHKLTGLEHEKILDEY 477
                           E L+           + E QAQAILD++L +L  LE ++I+D+ 
Sbjct: 423 ----------------ELLD-----------IDEIQAQAILDMQLRRLAALERQRIIDDL 455

Query: 478 KQLLEEIAALMHILASTERLMEVIREELEAIRAGFSDARRTEITAATHDIDMEELIARED 537
            ++  EIA L  ILA  ER   ++R+EL  I     D RRT I AA  D+  E+LIARED
Sbjct: 456 AKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAADGDVSDEDLIARED 515

Query: 538 VVVTLSHEGYVKYQLLSDYEAQRRGGKGKSATKMKEEDYIERLLVANTHDNILLFSTRGK 597
           VVVT++  GY K      Y +Q+RGGKG     +K++D +    V +THD IL F+T+G+
Sbjct: 516 VVVTITETGYAKRTKTDLYRSQKRGGKGVQGAGLKQDDIVAHFFVCSTHDLILFFTTQGR 575

Query: 598 TYRMKVYQLPLASRTARGKPIVNLLPLEENERITAILPVTEFSEDKFIFMATGDGTVKKT 657
            YR K Y LP ASRTARG+ + NLL  +  ERI  ++ +  +++  ++ +AT +G VKK+
Sbjct: 576 VYRAKAYDLPEASRTARGQHVANLLAFQPEERIAQVIQIRGYTDAPYLVLATRNGLVKKS 635

Query: 658 SLDQFANVRANGLIALNLRDEDSLIGVDITDGESEIMLFSKFGKVVRFKESEETAVVDEN 717
            L  F + R+ G++A+NLRD D L+G  +     +++L S  G+ +RF  ++E       
Sbjct: 636 KLTDFDSNRSGGIVAVNLRDNDELVGAVLCSAGDDLLLVSANGQSIRFSATDE------- 688

Query: 718 GQPVLDENGQPEIKFKGVRPMGRTAAGVRGMKLADGDQVVSLIVPKTEGDVLTVTENGYG 777
                            +RPMGR  +GV+GM+    D+++SL V +    +L  T  GY 
Sbjct: 689 ----------------ALRPMGRATSGVQGMRFNIDDRLLSLNVVREGTYLLVATSGGYA 732

Query: 778 KRTSLSEYPTKGRGTQGVVSIKVSERNGSVVGAVQVAEGDEFMMITNAGTLVRTRVAEVS 837
           KRT++ EYP +GRG +GV+++    R G +VGA+ V +  E   +T+ G ++RT   +V 
Sbjct: 733 KRTAIEEYPVQGRGGKGVLTVMYDRRRGRLVGALIVDDDSELYAVTSGGGVIRTAARQVR 792

Query: 838 QVGRNTQGVTLIRTSEGESVVGLQR 862
           + GR T+GV L+   EG++++ + R
Sbjct: 793 KAGRQTKGVRLMNLGEGDTLLAIAR 817