Pairwise Alignments

Query, 894 a.a., DNA topoisomerase (ATP-hydrolyzing) subunit A from Vibrio cholerae E7946 ATCC 55056

Subject, 752 a.a., DNA topoisomerase IV subunit A from Klebsiella michiganensis M5al

 Score =  410 bits (1055), Expect = e-118
 Identities = 267/732 (36%), Positives = 415/732 (56%), Gaps = 68/732 (9%)

Query: 1   MSDLAKEITPVNIEDELRSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMNVLGNDWN 60
           MSD+A+ +    + +   ++YL+Y+M VI+ RALP + DGLKPV RR+++AM+ LG + +
Sbjct: 1   MSDMAERLA---LHEFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNAS 57

Query: 61  KAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGD-SAAA 119
             +KKSAR VGDV+GKYHPHGDSA Y+ +V MAQPFS RY LVDGQGN+G+ D   S AA
Sbjct: 58  AKFKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAA 117

Query: 120 MRYTEVRMSKIAHELLADLDKETVDYVPNYDGTEQIPAVLPTKIPNLLINGASGIAVGMA 179
           MRYTE R+SK A  LL++L + TVD+VPN+DGT Q P +LP ++PN+L+NG +GIAVGMA
Sbjct: 118 MRYTESRLSKYAELLLSELGQGTVDWVPNFDGTLQEPKMLPARLPNILLNGTTGIAVGMA 177

Query: 180 TNIPPHNLGEVIDGCLAYIDNEAITIDELMDYIPGPDFPT-AALISGRKGIIDAYKTGRG 238
           T+IPPHNL EV    +  I+    ++D+L+D + GPD+PT A +I+ R  I   Y+ GRG
Sbjct: 178 TDIPPHNLREVAQAAITLIEKPQTSLDDLLDIVQGPDYPTEAEIITPRAEIRKIYQNGRG 237

Query: 239 KVYMRSKAEIETDKNGKETIIVSEIPYQVNKARLIEKIAELVKEKKVEGISALRDESDKD 298
            V MR+   + T ++G   +++S +P+QV+ AR++E+IA  ++ KK+  +  LRDESD +
Sbjct: 238 SVRMRA---VWTKEDG--AVVISALPHQVSGARVLEQIAAQMRNKKLPMVDDLRDESDHE 292

Query: 299 G-MRIVIECKRDAVG-EVVLNNLYANTQLQTTF--GINMVALDNGQPKLFNLKEMLKCFV 354
              R+VI  + + V  E V+N+L+A T L+ ++   +NM+ LDN +P + NL E+L  ++
Sbjct: 293 NPTRLVIVPRSNRVDMEQVMNHLFATTDLEKSYRINLNMIGLDN-RPAVKNLLEILSEWL 351

Query: 355 DHRREVVTRRTIFELRKARERAHILEGLALALANIDEIIELIRRAATPAEAKEGLIARGW 414
             RR+ V RR  + L K  +R HILEGL +A  NIDE+IE+IR    P   K  L++R  
Sbjct: 352 TFRRDTVRRRLSYRLEKVLKRLHILEGLLVAFLNIDEVIEIIRHEDEP---KPALMSR-- 406

Query: 415 DLGNVAAMLERAGTDAARPEWLEPQYGIRDGKYFLTEQQAQAILDLRLHKLTGLEHEKIL 474
                                           + ++E QA+AIL+L+L  L  LE  KI 
Sbjct: 407 --------------------------------FGISETQAEAILELKLRHLARLEEMKIR 434

Query: 475 DEYKQLLEEIAALMHILASTERLMEVIREELEAIRAGFSDARRTEITAATHDIDMEE--L 532
            E  +L +E   L  ILAS  ++  ++++EL+A    + D RR+ +        M E  +
Sbjct: 435 GEQSELEKERDHLQAILASERKMNNLLKKELQADADAYGDDRRSPLREREEAKAMSEHDM 494

Query: 533 IAREDVVVTLSHEGYVKYQLLSDYEAQRRGGKGKSATKMKEEDYIERLLVANTHDNILLF 592
           +  E V + LS  G+V+     D +A             K  D  +  +   ++  ++  
Sbjct: 495 LPSEPVTIVLSQSGWVRSAKGHDIDA--------PGLNYKAGDSFKAAVKGKSNQPVVFI 546

Query: 593 STRGKTYRMKVYQLPLASRTARGKPIVNLLPLEENERITAILPVTEFSEDKFIFMATGDG 652
            T G++Y +    LP  S   +G+P+   L L     +  +L   E  + K +  +    
Sbjct: 547 DTTGRSYAIDPITLP--SARGQGEPLTGKLTLPPGATVEHML--MEADDQKLLLASDAGY 602

Query: 653 TVKKTSLDQFANVRANGLIALNLRDEDSLIGVDITDGESEIML-FSKFGKVVRFKESEET 711
               T  D  A  RA G   ++L D   ++   + + ES+++L  +  G+++ F  S+  
Sbjct: 603 GFICTFNDLVARNRA-GKTLISLPDNAHVMPPLVIEDESDMLLAITAAGRMLMFPVSDLP 661

Query: 712 AVVDENGQPVLD 723
            +    G  +++
Sbjct: 662 QLSKGKGNKIIN 673



 Score = 31.2 bits (69), Expect = 2e-04
 Identities = 32/133 (24%), Positives = 58/133 (43%), Gaps = 9/133 (6%)

Query: 738 MGRTAAGVRGMKLADGDQVVSLIVPKTEGDVL-TVTENGYGKRTSLSEYP--TKGRGTQG 794
           + R  AG   + L D   V+  +V + E D+L  +T  G      +S+ P  +KG+G + 
Sbjct: 612 VARNRAGKTLISLPDNAHVMPPLVIEDESDMLLAITAAGRMLMFPVSDLPQLSKGKGNK- 670

Query: 795 VVSIKVSERNGSVVGAVQVAEGDEFMMITNAGTLVRTRVAEVSQVGRNTQGVTLIRTSEG 854
           +++I  +E      G   +     F++   +   +     ++       Q VT  R   G
Sbjct: 671 IINIPSAEAAAGQDGLAHL-----FVLPPQSTLTIHVGKRKIKLRPEELQKVTGERGRRG 725

Query: 855 ESVVGLQRIDEIE 867
             + GLQ+ID +E
Sbjct: 726 SLMRGLQKIDRVE 738