Pairwise Alignments

Query, 1297 a.a., phosphoribosylformylglycinamidine synthase from Vibrio cholerae E7946 ATCC 55056

Subject, 754 a.a., Phosphoribosylformylglycinamidine synthase II PurL (FGAM synthase II) from Mycobacterium tuberculosis H37Rv

 Score =  169 bits (429), Expect = 7e-46
 Identities = 210/775 (27%), Positives = 328/775 (42%), Gaps = 113/775 (14%)

Query: 197 LGRNPNDIELMMFAQANSEHCRHKIFNADWTIDGVKQDKSLFKMIKNTFEQTPDYVLSAY 256
           LGR P D EL M++   SEHC +K         G           + T ++    +L+  
Sbjct: 35  LGRRPTDTELAMYSVMWSEHCSYKSSKVHLRYFG-----------ETTSDEMRAAMLAGI 83

Query: 257 KDNAAVMTGSTVGRFFPDPESRQYTYHHEDAHILMKVETHNHPTAISPWPGASTGSGGEI 316
            +NA V+    +G               +   +  KVE+HNHP+ + P+ GA+TG GG +
Sbjct: 84  GENAGVVD---IG---------------DGWAVTFKVESHNHPSYVEPYQGAATGVGGIV 125

Query: 317 RDEGATGIGGKPKAGLVGFTTSNLRIPGFEQPWESDFGKPSRIVNALDIMLEGPLGGAAF 376
           RD  A  +G +P A +       LR    + P        +R V  LD ++ G +GG  +
Sbjct: 126 RDIMA--MGARPVAVM-----DQLRFGAADAP-------DTRRV--LDGVVRG-IGG--Y 166

Query: 377 NNEFGRPNLLGYFRTYEEKVTS--HAGEEVRGYHKPIMIAGGMGNIRAEHIQKKEIP-VG 433
            N  G PN+ G      E V    +AG        P++ A  +G +R E +        G
Sbjct: 167 GNSLGLPNIGG------ETVFDPCYAGN-------PLVNALCVGVLRQEDLHLAFASGAG 213

Query: 434 AKLIVLGGPAMNIGLGG-GAASSMASGQSAEDLDFASVQRENPEMERRCQEVIDRCWQLG 492
            K+I+ G      G+GG    +S             SVQ  +P ME+    +I+ C +L 
Sbjct: 214 NKIILFGARTGLDGIGGVSVLASDTFDAEGSRKKLPSVQVGDPFMEK---VLIECCLELY 270

Query: 493 DKNPIAFIHDVGAGGISNALPELVNDGDRGGKFQLRNVPNDEPGMSPLEIWCNESQERYV 552
               +  I D+G  G+S A  EL + GD G   QL +VP     M+P E+ C+ESQER  
Sbjct: 271 AGGLVIGIQDLGGAGLSCATSELASAGDGGMTIQLDSVPLRAKEMTPAEVLCSESQERMC 330

Query: 553 LAVAAEDMPLFDAICQRERAPYAVVGEATEERHLTLEDSHFANTPIDMPMDILLGKPPKM 612
             V+ +++  F A+C++      V+GE T+   L +  +    T +D+P   +  + P  
Sbjct: 331 AVVSPKNVDAFLAVCRKWEVLATVIGEVTDGDRLQI--TWHGETVVDVPPRTVAHEGPVY 388

Query: 613 HREAS------------TLKVSSPALERSGIELNEAVDRVLRLPAVAEKTFLITIGDRSV 660
            R  +            + K+S P    +G EL   +  +L  P +  + F+    DR V
Sbjct: 389 QRPVARPDTQDALNADRSAKLSRPV---TGDELRATLLALLGSPHLCSRAFITEQYDRYV 445

Query: 661 TGLVARDQMVGPWQVPVANCAVTAASFDSYHGEAMSMGERTPVALLDFGASARLAVGEAI 720
            G     +         A+  +      +  G A+S        LLD  A A+LA+ EA 
Sbjct: 446 RGNTVLAEH--------ADGGMLRIDESTGRGIAVSTDASGRYTLLDPYAGAQLALAEAY 497

Query: 721 TNIAATDIGELKRIKLSANWMSPAGHPGEDAGLYEAVKAVGEELCPALGITIPVGKDSMS 780
            N+A T    +  +    N+ SP   PG      +AV+ + +  C  LGI +  G  S  
Sbjct: 498 RNVAVTGATPV-AVTNCLNFGSPE-DPGVMWQFTQAVRGLADG-CADLGIPVTGGNVSF- 553

Query: 781 MKTKWQENGEQKEVTSPLSLIITAFARVEDIRKTVTPQLRTDLGETSLILIDLGNGQNRL 840
               + + G    + +P   ++     ++D+R+ +   L  + GET ++   LG+ ++  
Sbjct: 554 ----YNQTGSAAILPTP---VVGVLGVIDDVRRRIPTGLGAEPGETLML---LGDTRDEF 603

Query: 841 GATALAQV-YKQLGDKPADVDNAAQLKGFFDAVQTLVRNDKLV-AYHDKGDGGLLVTLAE 898
             +  AQV    LG  P  VD A +      AV +    D LV A HD  +GGL   + E
Sbjct: 604 DGSVWAQVTADHLGGLPPVVDLARE--KLLAAVLSSASRDGLVSAAHDLSEGGLAQAIVE 661

Query: 899 MAFAGHCGIKANIETLGDDALAALFNEELGAV-VQVKNDELNAVLATLAAHGLEA 952
            A AG  G +  +   G D    LF+E  G V V V   E +       A GL A
Sbjct: 662 SALAGETGCRIVLPE-GADPFVLLFSESAGRVLVAVPRTEESRFRGMCEARGLPA 715



 Score = 37.4 bits (85), Expect = 5e-06
 Identities = 32/105 (30%), Positives = 49/105 (46%), Gaps = 12/105 (11%)

Query: 881 LVAYHDKGDGGLLVTLAEMAFAGHCGIKANIETLG--------DDALAALFNEELGAVVQ 932
           ++   D G  GL    +E+A AG  G+   ++++          + L +   E + AVV 
Sbjct: 275 VIGIQDLGGAGLSCATSELASAGDGGMTIQLDSVPLRAKEMTPAEVLCSESQERMCAVVS 334

Query: 933 VKNDELNAVLATLAAHGLEACAHVIGEVEASDRLLITCGEEVLIE 977
            KN  ++A LA       E  A VIGEV   DRL IT   E +++
Sbjct: 335 PKN--VDAFLAV--CRKWEVLATVIGEVTDGDRLQITWHGETVVD 375