Pairwise Alignments

Query, 949 a.a., isoleucine--tRNA ligase from Vibrio cholerae E7946 ATCC 55056

Subject, 1034 a.a., isoleucine--tRNA ligase from Methanococcus maripaludis JJ

 Score =  391 bits (1004), Expect = e-112
 Identities = 257/859 (29%), Positives = 421/859 (49%), Gaps = 91/859 (10%)

Query: 25  EPEMLQRWYQEDLYGAIRQAKKGKKSFVLHDGPPYANGDIHIGHALNKILKDVIIKSKTL 84
           + ++ + W +E+ Y  ++   +    +   DGPPY +G IH+G A NKI+KD +++ K +
Sbjct: 13  DKKVKEYWKKENTYKKVKALNEHGPEYYFVDGPPYCSGAIHLGTAWNKIIKDTVLRFKRI 72

Query: 85  SGFDAPYIPGWDCHGLPIELMVEKKVGKPGQ-----KVTAAEFREKCREYAAGQVEGQKE 139
            G++     GWD HGLPIE+ VE +     +     K+   EF  KC+E+A   +   + 
Sbjct: 73  QGYNVLDKAGWDMHGLPIEVKVENEFNIGSKKDIETKIGTQEFINKCKEFALNHLGHMQG 132

Query: 140 SFKRLGILGEWDKPYRTMDFVTEANIIRALGKIADNGHLLKGFKPVHWCTDCGSALAEAE 199
            F+ LG+  +++  Y  +           L K  +   L K  +  +WC  C ++LAE E
Sbjct: 133 QFENLGVWLDFENAYMPIKRDYMEMGWWTLKKAHEKELLTKDLRSGYWCPRCETSLAEHE 192

Query: 200 V--EYKNKVSPSIDVRFKAADEAAVLAKFGLAAGHEGKGDVSIVIWTTTPWTLPANRAVC 257
           V  EYK  + PS+ V+FK                   K D  I IWTTTPWTLP+N  VC
Sbjct: 193 VRGEYKEVLDPSVYVKFKLE-----------------KSDEYITIWTTTPWTLPSNMLVC 235

Query: 258 LRADLEYVLIQVEGEQ--PERIIVASELAKSVMDRA----GIEHFHNLGFATGADLELVQ 311
           +  + +Y  + VE E    E  I+A +L   VM +A     I  F       G  L  ++
Sbjct: 236 VNPEFDYAYVSVEFENGTVETWIIAEKLVNDVMKKAEKNNEISKFSISKVVKGDSLIGLK 295

Query: 312 FQHPFYSFTV------------PAILGDHVTTDSGTGVVHTAPGHGQEDFAVGQQYGLEV 359
           + HP                    + GDHVT + GTG+VHTAPG G++DF +G+++ + V
Sbjct: 296 YIHPLLEENEKQQEFAKIENVHTIVPGDHVTLEGGTGLVHTAPGFGEDDFNIGKEHNIPV 355

Query: 360 ANPVGSNGVYLPDTELFAGQHVFKANDSVLEVLKEKGALLHHHAYEHSYPHCWRHKTPII 419
             P+  NG Y     ++ G  V   ++SV+E L  K  L++    +H+YPHCWR KTP++
Sbjct: 356 YAPIDDNGKY--TDSIWKGTFVKDMDESVIETLLSKNLLVNSGKVKHTYPHCWRCKTPLL 413

Query: 420 FRATPQWFVSMEQAGLREQALTAIKGVHWMPDWGQSRIEGMVAGRPEWCISRQRTWGVPI 479
           FRAT QWF+S+ +  +++  +   K V W+PDW ++R    V+   +W ISRQR WG+P+
Sbjct: 414 FRATEQWFLSISK--IKDSIIEQGKTVDWVPDWVKTRYVNGVSFVGDWNISRQRYWGIPL 471

Query: 480 ALFVHKETAELHPNSADLIEKVAQLVEQKGIQAWWDLDTAEL---------LGAEDAANY 530
            +++ +E  +      ++I  V +L E+   +   D+D +++         L        
Sbjct: 472 PIWICEECGKY-----EVIGSVGELKERANEK---DVDLSDIHKPAVDKITLTCSCGGKM 523

Query: 531 EKVLDTLDVWFDSGVTHSAVVDARQEFNGAEADMYLEGSDQHRGWFQSSLISSVAMKGKA 590
           ++  D LDVW+DSG+   A + +++     +A    EG+DQ   WF S    S  +    
Sbjct: 524 KRTPDVLDVWYDSGLAPYASIGSKKL---KKAQFITEGNDQVTKWFYSQHALSAVVFDDT 580

Query: 591 PYKEVLTHGFVVDGQGRKMSKSIGNVVAPQDVTNKLGADILRLWVASTDYTGEVAVSDEI 650
            Y++ + HGF +D  G KMSKS+GN+V+P DVT++ GAD+LR ++ S +   E       
Sbjct: 581 SYEKCMMHGFTLDETGEKMSKSLGNIVSPDDVTDQYGADVLRFYLLSANKAWE---DLRF 637

Query: 651 LKRSADAYRRIRNT---ARFFLAN---LNGFNPTTDIIP-VEDMVALDRWAVGRALAAQQ 703
                D  R + NT   +  F AN   L+ F P  +    V+D    D W + R     +
Sbjct: 638 SYSEMDETRSMLNTLWNSYAFSANYMVLDDFVPNNEYFKHVKDE---DAWILSRINTVAK 694

Query: 704 EIIQAYQDYNLHAVVQRLMNFCSIEMGSFYLDVIKDRQYTAKRGGHAQRSCQTALFFIVE 763
           E ++A +  +LH     L +F   +   +Y+ +I+DR +  K       + QT L++++ 
Sbjct: 695 EAVEALEKPHLHVYTWALRDFILNDFSRWYIKLIRDRTWMEKNDVQKLSAYQT-LYYVIM 753

Query: 764 ALVRWMAPIMSFTADEIWNAMPAQQADGSARDKFVFTTEWFDGLFGLAEGEELNNAFWND 823
            L+  MAP+    ++EI+  +  +    S     +F  +         E E +N     D
Sbjct: 754 KLISIMAPVTPHLSEEIYQNLKTEDMPES-----IFMNKL------TIESEFINETLEKD 802

Query: 824 IQKVRGSVNKLLENARNEK 842
            + +R  V+ +L+     K
Sbjct: 803 TEIIREIVDSILKGRDKAK 821



 Score = 28.1 bits (61), Expect = 0.003
 Identities = 19/60 (31%), Positives = 30/60 (50%), Gaps = 3/60 (5%)

Query: 19  GDLAKREPEMLQRWYQEDL--YGAIRQAKKGKKSFVLHDGPPYANGDIHIGHALNKILKD 76
           G   KR P++L  WY   L  Y +I  +KK KK+  + +G        +  HAL+ ++ D
Sbjct: 520 GGKMKRTPDVLDVWYDSGLAPYASI-GSKKLKKAQFITEGNDQVTKWFYSQHALSAVVFD 578



 Score = 26.6 bits (57), Expect = 0.009
 Identities = 12/36 (33%), Positives = 21/36 (58%)

Query: 814 EELNNAFWNDIQKVRGSVNKLLENARNEKLIGGSLQ 849
           +EL   F +D+ KV  ++N +  +   EKL  G+L+
Sbjct: 873 KELGKIFRSDVPKVVAAINSVAPSELKEKLKSGNLK 908