Pairwise Alignments

Query, 1039 a.a., AcrB/AcrD/AcrF family protein from Vibrio cholerae E7946 ATCC 55056

Subject, 1041 a.a., cation/multidrug efflux pump AcrB from Caulobacter crescentus NA1000

 Score =  307 bits (786), Expect = 3e-87
 Identities = 253/1014 (24%), Positives = 463/1014 (45%), Gaps = 51/1014 (5%)

Query: 18   LLVFILVAGVATYLTIPKESSPDVTIPIIYVSVSHQGISPSDAERLIVRPLEQEMRSIEG 77
            + + +++AGV  YL +P +  P+V  P + V+V+  G +P + E  + RP+E  + SI  
Sbjct: 31   VFIALMIAGVGAYLGLPIKQFPNVEFPAVTVTVTQSGAAPGEMETQVTRPIEDAVASISN 90

Query: 78   VKEMTATASEGHASVVLEFNVGVDLAKAMADVRDAVDLAKPKLPADSDEPTVNEVTLAAE 137
            VK + ++  +G ++  +EFN+G DL K   +VR  VD A+  LP + DEP V  + + + 
Sbjct: 91   VKTIRSSVVQGASTTTIEFNLGEDLQKVTDEVRSKVDQARAVLPREVDEPLVQRLEITSA 150

Query: 138  QPVLSVVLYGTVPERTTV--LIARQLRDKLESFRQILSVDIAGDREEIVEIIVDPLLMES 195
             P+++  +       T +   I   +   L+  + +  V   G  +  + +I+DP  M S
Sbjct: 151  -PIITYAVSAPGMSATDLSWFIDDTVTRALQGEKGVAQVARVGGVDREINVIIDPDRMAS 209

Query: 196  YGLDQSDIYNLIALNNRVVAAGFVDTGYGRFSVKVPSVFESLKDVLELPIKVEGKQVITF 255
            +G+    +   +A  +     G    G    +++V     +++ + ++ I V G + +  
Sbjct: 210  FGVTAPQLNQALASFSVDAPGGRASIGGREQTLRVLGAATTIEQLRQITIPVAGGRYVKL 269

Query: 256  GDVATVRKSFRDPESFARLDGKPAIVLDIKKRSGENIIETVELVKAVLGEAQARDDWPNN 315
             DVA V +   +   FARLDGKP +   + K    + +   + VKA + +   +   P  
Sbjct: 270  TDVAQVGQGSEEERGFARLDGKPVVAFQVMKTRDSSDVAVEDRVKAAVDKLAEKT--PGV 327

Query: 316  LLVKTIWDESEDVKLMLNDLQNNILSAIILVVVVIIAILGV-RTSLLVGVSIPGSFLTGL 374
              VK I+   ++ +      ++ +L  ++L  +V+   L   R +L+  +++P S +   
Sbjct: 328  TFVK-IFSTVDETRASFKATEHTLLEGMLLASLVVFLFLREWRATLITALAMPVSLVPTF 386

Query: 375  LVLAVFGLTVNIVVLFALIMAVGMLVDGAIVVTEFADRRMQEGMHRSEAYRDAAKRMAWP 434
              +A  G ++N+V L AL + +G+LVD A+V  E  ++R+  G    +A  + A  +   
Sbjct: 387  AFMAFMGFSLNVVTLLALTLVIGILVDDAVVEIENIEKRVARGQRPFQAAMEGADAIGLA 446

Query: 435  ITASTATTLAAFAPLLFWPDVTGEFMKYLPLTLMATLTASLVMALLFVPVLGSLFGRPQK 494
            + A+T T +A F P+ F P + G+F K   LT+   +  SLV+A L  P+L + F +P K
Sbjct: 447  VVATTFTIVAVFVPVSFMPGMPGQFFKEFGLTVAVAVLFSLVVARLLTPLLAAYFLKPAK 506

Query: 495  VTQANQARMVALHNGDFSQATGITKAYYSTLAIAIRHPI-KILCGALLMSAAIAFAYGKA 553
                 +                    Y + L  ++ H I   + G L+   +I  A    
Sbjct: 507  APHPRKP---------------FEGFYRNILDWSLDHRILACIIGGLIFVGSIMLA---G 548

Query: 554  GLGAEFFPEVDPPFFSVKVRSYGDLSLNEKDRIMSDIEQVMLGHDEFESVYTRTGGDDEI 613
             L   F P  +  ++ +KV+     ++ + DR +  +  +M    E  +V+ + G +   
Sbjct: 549  LLPTAFQPPANNNYYYLKVQGPPGATVADMDRTVQQVTTLMRKRPEVTNVFAQVGSNIGS 608

Query: 614  GVVQITPVDWQYRRSVKAIIEELE-QVTDTFPGVEIEYK-FPDAGPPVEHD---LEIEIS 668
            G    +  D +       +  + E  VT+    V    +  PDA   ++ D    E++ +
Sbjct: 609  GWGGQSSADIRDATITIVLRGDRELSVTEIKQEVRASLRDIPDARVNLQGDWGSSEVQ-T 667

Query: 669  ARVADD---LDKAAQQVRLWAEANPALTNLSDNGSKPGIDWKIDIRRDDASRFAADATLV 725
              V++D   L++ A ++    +    + +   +    G +  I  + D+A+R    +  +
Sbjct: 668  ILVSEDGPLLERTAAKIEREMQGLSTVADPRPSSPPSGPEILIRPKADEAARLGVSSADI 727

Query: 726  GNTVQFVTNG-LKIGDYLPDDSDEEVDILVRYPSEYR-DIGRFDQLRVKTAQ-GLVPLTN 782
                +  T G +          +  + I VR P+E R D+     LRV TA  G   L  
Sbjct: 728  AAIARVATVGDIDANVAKMTQGERRIPIRVRLPAESRQDLEALGALRVPTANGGSTRLDT 787

Query: 783  FAQIIPEQKQDTIHRVDGRRVISVMADLKEGYNLALELPAIEQALRELNLPSSVEFRIRG 842
             A++  +     I R   +R ++V ADL  G  L   +  ++      NLP+ V     G
Sbjct: 788  VAELSFQAGPAKIDRFGRKRQMTVEADLNNGAQLGEAMADVDNLPTMKNLPAGVAPASAG 847

Query: 843  QNEEQEHSAVFLEKAFMVALAAMAIILITQFNSFYQAFLILTAVIFSTVGVFAGLLIFQK 902
              E           A + A+  +  +L+  F SF++   IL+A+  +  G F GLL+  +
Sbjct: 848  DQEAFVELFTGFAVALLSAVGLVFGVLVLLFRSFFKPITILSALPLAIGGAFFGLLVMGQ 907

Query: 903  PFGIIMSGIGVIALAGIVVNNNIVLIDTYNQLLKRGLSREEAILRTGVQRLRPVLLTTVT 962
                + S IG + L G+   N+I+L++   +  + G+S+ EAIL    +R RP+++TT+ 
Sbjct: 908  SLS-MPSLIGFLMLMGLAAKNSILLVEYAIEQERAGMSQREAILDACHERARPIVMTTLA 966

Query: 963  TILGLLPMVLEMNIDIINQKIEFGAPSTQWWSQLATAVAGGLAFATVLTLVLTP 1016
             + G+LP  L      I    EF  P       +A AV GGL  +TVL+LVL P
Sbjct: 967  MMAGMLPTALG-----IGTGAEFRQP-------MAVAVIGGLITSTVLSLVLVP 1008



 Score = 58.9 bits (141), Expect = 2e-12
 Identities = 90/398 (22%), Positives = 161/398 (40%), Gaps = 50/398 (12%)

Query: 107  ADVRDAVDLAKPKLPADSDEPTVNEVTLAAEQPVLSVVLYGTVPERTTVLIARQLRDKLE 166
            A +RD  D A+  L  D     V  + ++ + P+L         ERT   I R+++    
Sbjct: 644  ASLRDIPD-ARVNLQGDWGSSEVQTILVSEDGPLL---------ERTAAKIEREMQGLST 693

Query: 167  SFRQILSVDIAGDREEIVEIIVDPLLMES--YGLDQSDIYNLIALNNRVVAAGFVDT--- 221
                  S   +G      EI++ P   E+   G+  +DI    A   RV   G +D    
Sbjct: 694  VADPRPSSPPSGP-----EILIRPKADEAARLGVSSADI----AAIARVATVGDIDANVA 744

Query: 222  ----GYGRFSVKVPSVFESLKDV-----LELPIKVEGKQVITFGDVATVRKSFRDPESFA 272
                G  R  ++V    ES +D+     L +P    G   +   D          P    
Sbjct: 745  KMTQGERRIPIRVRLPAESRQDLEALGALRVPTANGGSTRL---DTVAELSFQAGPAKID 801

Query: 273  RLDGKPAIVLDIKKRSGENIIETVELVKAVLGEAQARDDWPNNLLVKTIWDESEDVKLML 332
            R   K  + ++    +G  + E +    A +       + P  +   +  D+   V+L  
Sbjct: 802  RFGRKRQMTVEADLNNGAQLGEAM----ADVDNLPTMKNLPAGVAPASAGDQEAFVELFT 857

Query: 333  NDLQNNILSAIILVVVVIIAILG-----VRTSLLVGVSIPGSFLTGLLVLAVFGLTVNIV 387
                  +LSA+ LV  V++ +       +     + ++I G+F  GLLV+   G ++++ 
Sbjct: 858  G-FAVALLSAVGLVFGVLVLLFRSFFKPITILSALPLAIGGAFF-GLLVM---GQSLSMP 912

Query: 388  VLFALIMAVGMLVDGAIVVTEFADRRMQEGMHRSEAYRDAAKRMAWPITASTATTLAAFA 447
             L   +M +G+    +I++ E+A  + + GM + EA  DA    A PI  +T   +A   
Sbjct: 913  SLIGFLMLMGLAAKNSILLVEYAIEQERAGMSQREAILDACHERARPIVMTTLAMMAGML 972

Query: 448  PLLFWPDVTGEFMKYLPLTLMATLTASLVMALLFVPVL 485
            P         EF + + + ++  L  S V++L+ VPV+
Sbjct: 973  PTALGIGTGAEFRQPMAVAVIGGLITSTVLSLVLVPVV 1010