Pairwise Alignments

Query, 1226 a.a., methionine synthase from Vibrio cholerae E7946 ATCC 55056

Subject, 1190 a.a., methionine synthase (B12-dependent) from Synechococcus elongatus PCC 7942

 Score =  576 bits (1485), Expect = e-168
 Identities = 384/1216 (31%), Positives = 636/1216 (52%), Gaps = 81/1216 (6%)

Query: 17   ILLIDGGMGTMIQSYKLQEEDYRGARFVDWHCDLKGNNDLLVLTQPQIIKEIHSAYLEAG 76
            +L+ DGGMGT +Q   L  ED+ G        + +G N+ L+ T+P+ I  +H  +LEAG
Sbjct: 16   VLVFDGGMGTTLQFQNLTAEDFGGP-------ETEGCNEWLIRTKPEAIATVHRQFLEAG 68

Query: 77   ADILETNTFNSTTIAMADYDMQSLSAEINFAAAKLAREVADEWTAKDPSRPRYVAGVLGP 136
            AD++ET+TF +T+I +A+Y ++  +  +N  AAKLA+ +A E++   P +PR+VAG +GP
Sbjct: 69   ADVIETDTFGATSIVLAEYGLEDHAYALNVEAAKLAKAIAAEFST--PEKPRFVAGSMGP 126

Query: 137  TNRTCSISPDVNDPGFRNVTFDGLVEAYSESTRALIKGGSDLILIETIFDTLNAKACAFA 196
            T +          P   ++ +D +  +++E  R L +GG DL ++ET  D L  KA    
Sbjct: 127  TTKL---------PTLGHIGYDEMKASFAEQARGLWEGGVDLFIVETCQDVLQIKAALNG 177

Query: 197  VDSVFEELGISLPVMISGTITDASGRTLSGQTTEAFYNALRHVRPISFGLNCALGPDELR 256
            +  +F E G   P+M+S T+ + +G  L G    A    L        GLNCA GPD + 
Sbjct: 178  IAEIFSEKGDRRPLMVSVTM-ETTGTMLVGSDVAAMLAILEPYPIDILGLNCATGPDRMV 236

Query: 257  QYVEELSRISECYVSAHPNAGLPNAFG---EYDLSAEEMAEHIAEWAQAGFLNLVGGCCG 313
            ++++ LS  S   +S  PNAG+P   G    Y L+  E+   +  + +   + ++GGCCG
Sbjct: 237  EHIKYLSEHSPFVISCIPNAGIPENVGGHAHYRLTPMELRMALHRFVEDLGVQVIGGCCG 296

Query: 314  TTPEHIAAIAKAVEGVKPRALPDLKVECRLSGLEPLNIGP-------------ETLFVNV 360
            T PEHIA +A+    ++ +  P ++ +      +P N  P             +  F+ +
Sbjct: 297  TKPEHIAQLAEVATQLQAKDRP-VRRDRDHQQRQPFNYVPSAASIYGTTPYIQDNSFLII 355

Query: 361  GERTNVTGSARFKRLIKEEQYDEALDVAREQVENGAQIIDINMDEGMLDAEACMVRFLNL 420
            GER N +GS + + L+ EE +D  + +AR QV+ GA ++D+N+D    D E  M   ++ 
Sbjct: 356  GERLNASGSKKVRELLNEEDWDGLVAIARSQVKEGAHVLDVNVDYVGRDGERDMGELVSR 415

Query: 421  CASEPEISKVPVMVDSSKWEVIEAGLKCIQGKGIVNSISLKEGKEKFIAQAKLVRRYGAA 480
              +   +   P+M+DS++W+ +EAGLK   GK I+NS + ++G E+F    +L ++YGA 
Sbjct: 416  LVTNVNL---PLMLDSTEWQKMEAGLKKAGGKCILNSTNYEDGDERFFKVLELAKQYGAG 472

Query: 481  VIVMAFDEVGQADTRERKLEICRRAYHILVDEVGFPPEDIIFDPNIFAVATGIDEHNNYA 540
            ++V   DE G A T E+K  I +RAY   + E G P  +I +DP    ++TGI+E     
Sbjct: 473  IVVGTIDEEGMARTAEKKFAIAQRAYRDAL-EFGIPAHEIFYDPLALPISTGIEEDRGNG 531

Query: 541  LDFINAVADIKRELPHAMISGGVSNVSFSFRGNNYVREAIHAVFLYHCFKHGMDMGIVNA 600
             + I ++  I+  LP   I  GVSN+SF    N   R  +++VFL+   + GMD  IV+A
Sbjct: 532  RETIESIRLIRENLPGVHILLGVSNISFGL--NPAARIVLNSVFLHDACEAGMDGAIVSA 589

Query: 601  GQLEIYDNVPLKLREAVEDVILNRR--SDGT---ERLLEIAEAYRENSVGKEEDASALEW 655
             ++     +  K  +   D+I +RR   +G    + L E+   + E    KE  AS    
Sbjct: 590  AKILPLSKIDEKPLQVCRDLIGDRRRFENGICVYDPLTELTTLF-EGVSAKEARASGPSL 648

Query: 656  RAWPVAKRLEHALVKGITEFIVQDTEEARQQASKPLEVIEGPLMDGMNVVGDLFGEGKMF 715
               P+ +RL+  ++ G    + Q    A +Q   PLE+I   L+DGM VVGDLFG G+M 
Sbjct: 649  ADLPLEERLKQHIIDGERIGLDQALATALEQYP-PLEIINTFLLDGMKVVGDLFGSGQMQ 707

Query: 716  LPQVVKSARVMKQAVAYLEPFINAQKSGSTSNGKILLATVKGDVHDIGKNIVGVVLQCNN 775
            LP V++SA  MK AVAYLEPF++ +++  +  G  L+ATVKGDVHDIGKN+V ++L  N 
Sbjct: 708  LPFVLQSAETMKSAVAYLEPFMDKEETNDSGKGTFLIATVKGDVHDIGKNLVDIILTNNG 767

Query: 776  FEIIDLGVMVPCEQILKVAREQNVDIIGLSGLITPSLDEMVHVAKEMERQGFELPLLIGG 835
            ++++++G+  P E I++  R+ N D I +SGL+  S   M         +G  +P+++GG
Sbjct: 768  YKVVNIGIKQPVENIIQAYRDCNADCIAMSGLLVKSTAFMKENLATFNEEGISVPVILGG 827

Query: 836  ATTSKAHTAVKIEQNYHAPVVYVNNASRAVGVCTSLLSDEQRPGFIERLDLDYERTRD-- 893
            A  +        +Q Y   V+Y  +A   +     L++ + +  + ++L    E+ +   
Sbjct: 828  AALTPKFVYEDCQQTYKGQVIYGKDAFADLHFMDQLMAAKSKDQWDDQLGFLDEQGQPLQ 887

Query: 894  -----QHARKTPKSR----PVTLEQARANKAALDWANYTPPAPAKPGVHVFENIALATLR 944
                   A +  +SR     V ++  R+   A+D    TPP      +   + I  A + 
Sbjct: 888  VAAIASEAAEPTESRESVAEVVIDLERSEAVAVDIDRPTPPFWGSK-ILGPDEIPFAEVF 946

Query: 945  PYIDWTPFFMTWSLMGKYPAILEHEEVGEE-----AKRLFHDANALLDKVEREGLLKASG 999
             Y+D    F     +G++      E+  EE     A+++         ++  E LL+   
Sbjct: 947  SYLDRQALF-----VGQWQFRKPKEQSREEYDAFIAEKVEPILQQWTTRILAEDLLEPQV 1001

Query: 1000 MCALFPAASVGDDIEVYSDESRTQVAHVLYNLRQQTEKPKGANYCLSDYVAPKESGKRDW 1059
            +   FP  +VG+ ++++    R +        RQ++ +      C++D+ AP+E G +D 
Sbjct: 1002 VYGYFPCVAVGNSLQLFDPNDRDRPTARFDFPRQRSLR----RLCIADFFAPEELGIQDV 1057

Query: 1060 IGAFAVTGGIGERALADAYKA-QGDDY-NAIMIQAVADRLAEAFAEYLHEKVRKEIWGYA 1117
                AVT  +G +A   A +   GD Y + +    +A +LAEA AE+ H ++R+E+ GY 
Sbjct: 1058 FPMQAVT--VGHKATEFAAQLFAGDQYSDYLYFHGLAVQLAEALAEWTHARIRREL-GYG 1114

Query: 1118 SDENLSNDDLIRERYQGIRPAPGYPACPEHTEKATLWQMLNVEETIGMSLTTSYAMWPGA 1177
            S E  S  D++ +RYQG R + GYPACP   +     ++L  +  IGMS+  S  ++P  
Sbjct: 1115 SLEPESLRDILAQRYQGSRYSFGYPACPNVADSRIQLELLEADR-IGMSMDESEQLYPEQ 1173

Query: 1178 SVSGWYFSHPDSRYFA 1193
            S +     HP ++YF+
Sbjct: 1174 STTAIVAYHPAAKYFS 1189