Pairwise Alignments

Query, 1226 a.a., methionine synthase from Vibrio cholerae E7946 ATCC 55056

Subject, 1192 a.a., 5-methyltetrahydrofolate--homocystein methyltransferase MetH (methionine synthase, vitamin-B12 dependent isozyme) (ms) from Mycobacterium tuberculosis H37Rv

 Score =  568 bits (1464), Expect = e-165
 Identities = 380/1217 (31%), Positives = 628/1217 (51%), Gaps = 76/1217 (6%)

Query: 13   LKQRILLIDGGMGTMIQSYKLQEEDYRGARFVDWHCDLKGNNDLLVLTQPQIIKEIHSAY 72
            L QR+++ DG MGT +Q+  L  +D+RG         L+G N++L  T+P +++ IH  Y
Sbjct: 17   LSQRVMVGDGAMGTQLQAADLTLDDFRG---------LEGCNEILNETRPDVLETIHRNY 67

Query: 73   LEAGADILETNTFNSTTIAMADYDMQSLSAEINFAAAKLAREVADEWTAKDPSRPRYVAG 132
             EAGAD +ETNTF      + DYD+     +++     +AR VADE  +  P R RYV G
Sbjct: 68   FEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGS--PDRKRYVLG 125

Query: 133  VLGPTNRTCSISPDVNDPGFRNVTFDGLVEAYSESTRALIKGGSDLILIETIFDTLNAKA 192
             +GP  +          P   +  +  + +AY+E+   ++ GG+D IL+ET  D L  KA
Sbjct: 126  SMGPGTKL---------PTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKA 176

Query: 193  CAFAVDSVFEELGISLPVMISGTITDASGRTLSGQTTEAFYNALRHVRPISFGLNCALGP 252
                        G  +PV    T+ + +G  L G    A   A+  +     GLNCA GP
Sbjct: 177  AVLGSRRAMTRAGRHIPVFAHVTV-ETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGP 235

Query: 253  DELRQYVEELSRISECYVSAHPNAGLP--NAFG-EYDLSAEEMAEHIAEWAQAGFLNLVG 309
             E+ +++  LSR +   VS  PNAGLP   A G EY L  +E+AE +A +     L+LVG
Sbjct: 236  AEMSEHLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVG 295

Query: 310  GCCGTTPEHIAAIAKAVEGVKPRALPDLKVECRLSGL-EPLNIGPETLFVNVGERTNVTG 368
            GCCGTTP HI  +A AV  +K R    +  E  +S L   +    +   + +GERTN  G
Sbjct: 296  GCCGTTPAHIREVAAAVANIK-RPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANG 354

Query: 369  SARFKRLIKEEQYDEALDVAREQVENGAQIIDINMDEGMLDAEACMVRFLNLCASEPEIS 428
            S  F+  +  E Y + LD+A++Q  +GA ++D+ +D    D  A M    +  A+    S
Sbjct: 355  SKGFREAMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATS---S 411

Query: 429  KVPVMVDSSKWEVIEAGLKCIQGKGIVNSISLKEG---KEKFIAQAKLVRRYGAAVIVMA 485
             +P+M+DS++  V++AGL+ + G+  +NS++ ++G   + +F     LV  +GAAV+ + 
Sbjct: 412  TLPIMLDSTETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALT 471

Query: 486  FDEVGQADTRERKLEICRRAYHILVDEVGFPPEDIIFDPNIFAVATGIDEHNNYALDFIN 545
             DE GQA T ++K+EI  R  + +    G     I+ D   F +ATG +E     ++ I 
Sbjct: 472  IDEEGQARTAQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIE 531

Query: 546  AVADIKRELPHAMISGGVSNVSFSFRGNNYVREAIHAVFLYHCFKHGMDMGIVNAGQLEI 605
            A+ ++K+  P    + G+SN+SF    N   R+ +++VFL+ C + G+D  IV+A ++  
Sbjct: 532  AIRELKKRHPDVQTTLGLSNISFGL--NPAARQVLNSVFLHECQEAGLDSAIVHASKILP 589

Query: 606  YDNVPLKLREAVEDVILNRRSDGTERLLEIAEAYRENSVGKEEDASALEWRAWPVAKRLE 665
             + +P + R    D++ +RR +  + L E+   +   S    ++    E    P+ +RL 
Sbjct: 590  MNRIPEEQRNVALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLA 649

Query: 666  HALVKGITEFIVQDTEEARQQASKPLEVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSARV 725
              +V G    +  D +EA  Q   PL++I   L+ GM  VG+LFG G+M LP V++SA V
Sbjct: 650  QRIVDGERNGLDADLDEAMTQ-KPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEV 708

Query: 726  MKQAVAYLEPFINAQKSGSTSNGKILLATVKGDVHDIGKNIVGVVLQCNNFEIIDLGVMV 785
            MK AVAYLEP +      S   G+I+LATVKGDVHDIGKN+V ++L  N +E++++G+  
Sbjct: 709  MKAAVAYLEPHMERSDDDS-GKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQ 767

Query: 786  PCEQILKVAREQNVDIIGLSGLITPSLDEMVHVAKEMERQGF--ELPLLIGGATTSKAHT 843
            P   IL+VA +++ D++G+SGL+  S   M    +EM  +G   + P+L+GGA  ++++ 
Sbjct: 768  PIATILEVAEDKSADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYV 827

Query: 844  AVKIEQNYHAPVVYVNNASRAVGVCTSLLS-------DEQRPGFIERLDLDYER-TRDQH 895
               + + Y   V Y  +A   + +  +++S       DE  P  I+  + + ER  R Q 
Sbjct: 828  ENDLAEIYQGEVHYARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQR 887

Query: 896  ARKTPKSRPVTLEQARANKAALDWANYTPPAPAKPGVHVFENIALATLRPYIDWTPFFM- 954
            +++    R    E     + +   A+   PAP   G  + + +A+A     +D    F+ 
Sbjct: 888  SKRIAAQRKAAEEPVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLG 947

Query: 955  TWSLMGK-------YPAILEHEEVGEEAKRLFHDANALLDKVEREGLL-KASGMCALFPA 1006
             W L G+       Y  ++E E  G    R +      LD++  +G+L  A+ +   FPA
Sbjct: 948  QWGLRGQRGGEGPSYEDLVETE--GRPRLRYW------LDRLSTDGILAHAAVVYGYFPA 999

Query: 1007 ASVGDDIEVYSDESRTQVAHVLYNLRQQTEKPKGANYCLSDYVAPK----ESGKRDWIGA 1062
             S G+DI V ++          ++  +Q    +G   C++D++  +    E G+ D +  
Sbjct: 1000 VSEGNDIVVLTEPKPDAPVRYRFHFPRQ---QRGRFLCIADFIRSRELAAERGEVDVLPF 1056

Query: 1063 FAVTGGIGERALADAYKAQGDDYNAIMIQAVADRLAEAFAEYLHEKVRKEI-----WGYA 1117
              VT G      A+   A     + + +  +  +L EA AEY H ++R+E+        A
Sbjct: 1057 QLVTMGQPIADFANELFASNAYRDYLEVHGIGVQLTEALAEYWHRRIREELKFSGDRAMA 1116

Query: 1118 SDENLSNDDLIRERYQGIRPAPGYPACPEHTEKATLWQMLNVEETIGMSLTTSYAMWPGA 1177
            +++  + +D  +  Y+G R A GY ACP+  ++A +  +L   E IG++L+    + P  
Sbjct: 1117 AEDPEAKEDYFKLGYRGARFAFGYGACPDLEDRAKMMALLE-PERIGVTLSEELQLHPEQ 1175

Query: 1178 SVSGWYFSHPDSRYFAV 1194
            S   +   HP+++YF V
Sbjct: 1176 STDAFVLHHPEAKYFNV 1192