Pairwise Alignments

Query, 1226 a.a., methionine synthase from Vibrio cholerae E7946 ATCC 55056

Subject, 818 a.a., vitamin B12-dependent methionine synthase without a reactivation domain (EC 2.1.1.13) (from data) from Desulfovibrio vulgaris Miyazaki F

 Score =  306 bits (784), Expect = 5e-87
 Identities = 252/867 (29%), Positives = 401/867 (46%), Gaps = 71/867 (8%)

Query: 16  RILLIDGGMGTMIQSYKLQEEDYRGARFVDWHCDLKGNNDLLVLTQPQIIKEIHSAYLEA 75
           R L+ DGGMGTM+QS  L                   + +L  L +P ++  IH+ YL A
Sbjct: 12  RRLVFDGGMGTMLQSRGLPPGV---------------SPELFCLARPDVLVGIHADYLRA 56

Query: 76  GADILETNTFNSTTIAMADYDMQSLSAEINFAAAKLAREVADEWTAKDPSRPRYVAGVLG 135
           GAD+L TNTF      +          E N A A+ ARE           R  +VAG +G
Sbjct: 57  GADVLTTNTFGGCIHKLGTGPGAPDVVEFNRAMARAAREAV-----LASGREAFVAGSVG 111

Query: 136 PTNRTCSISPDVNDPGFRNVTFDGLVEAYSESTRALIKGGSDLILIETIFDTLNAKACAF 195
           P+        D+ DP         LV A+    R L++GG DLIL ET FD   A+A   
Sbjct: 112 PSGHFMRPLGDL-DPA-------ELVAAFRAQIRGLVQGGVDLILAETQFDLAEARAIVL 163

Query: 196 AVDSVFEELGISLPVMISGTITDASGRTLSGQTTEAFYNALRHVRPISFGLNCALGPDEL 255
           A  +  +     LPV +S  +T  +G +L+G   E F  ++ ++     G NC+ GP+++
Sbjct: 164 AARAECD-----LPVGVS--MTFENGVSLTGTRPEVFVQSMLNMGVDLVGTNCSAGPEQM 216

Query: 256 RQYVEELSRISECYVSAHPNAGLPNAFG---EYDLSAEEMAEHIAEWAQAGFLNLVGGCC 312
            +  +EL  ISE  V   PNAGLP        + L  ++ A H A +A +G + ++GGCC
Sbjct: 217 AEVADELLAISEVPVLVEPNAGLPELVDGKTVFRLGPDDFARHTARFAASG-VRMLGGCC 275

Query: 313 GTTPEHIAAIAKAVEGVKPRALPDLKVECRLSGL------EPLNIGPETLFVNVGERTNV 366
           GTTP+HIAA+  A++ +    +PD     R  G+      + ++IG  +    +GER N 
Sbjct: 276 GTTPDHIAALRGALDNLSGGLVPD---PARRDGIVLTTRAQAVHIGAGSPIRIIGERINP 332

Query: 367 TGSARFKRLIKEEQYDEALDVAREQVENGAQIIDINMDEGMLDAEACMVRFLNLCASEPE 426
           TG       ++  ++ +AL  A EQVE GA ++D+N+   M+D    +   +    +   
Sbjct: 333 TGKKLLTAELQAGEFAQALRFADEQVEAGAPLLDVNVGAPMVDEAVLLPALVERLVAR-- 390

Query: 427 ISKVPVMVDSSKWEVIEAGLKCIQGKGIVNSISLKEGKEKFIAQAKLVRRYGAAVIVMAF 486
              +P+ +DSS  + I A L    G  +VNSIS + G+ + +    L R +GA  I++  
Sbjct: 391 -HSLPLSLDSSNADAIAAALPFHPGSPLVNSISGEPGRMEHL--GPLCRDHGAPFILLPL 447

Query: 487 DEVGQADTRERKLEICRRAYHILVDEVGFPPEDIIFDPNIFAVATGIDEHNNYALDFINA 546
                  T   ++ I         D +  P   ++ D    AV++   E   + LD I  
Sbjct: 448 KGRKLPVTAAERIAIIEELLQ-QADSLRIPRRLVMVDVLALAVSSKA-EAARHCLDTIRW 505

Query: 547 VADIKRELPHAMISGGVSNVSFSFRGNNYVREAIHAVFLYHCFKHGMDMGIVNAGQLEIY 606
            A   + LP  +   G+SN+SF        RE +++ FL      G+   I + G   I 
Sbjct: 506 CA--AQGLPTTI---GLSNISFGLP----ARELLNSTFLAMAAGAGLSSCIAHPGNARIR 556

Query: 607 DNVPLKLREAVEDVILNRRSDGTERLLEIAEAYRENSVGKEEDASALEWRAWPVAKRLEH 666
           + V         D       +G        +A      G               A  LE 
Sbjct: 557 EAVAASSVLLGLDANAESFIEGYSGWTPGGDATGATPAGVAGGTGGGTGGVKAKAATLEE 616

Query: 667 ALVKGITEFIVQDTEEARQQASKPLEVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSARVM 726
           A+++G  E  +   E A  + + P  +++  L+ G+  VG  +   + FLPQ+++SA  M
Sbjct: 617 AVIRGDREGALALVERALSEGADPFSLVQEKLIPGITEVGRRYERREYFLPQLIRSAETM 676

Query: 727 KQAVAYLEPFINAQKSGSTSNGKILLATVKGDVHDIGKNIVGVVLQCNNFEIIDLGVMVP 786
           + A   L+P + AQ+ G  +   I++ATV+GD+HDIGKNIV ++L  + F+++DLG  V 
Sbjct: 677 QHAFRKLQPLLEAQR-GHEARPVIIMATVEGDIHDIGKNIVTLMLGNHGFDVVDLGKDVK 735

Query: 787 CEQILKVAREQNVDIIGLSGLITPSLDEMVHVAKEMERQGFELPLLIGGATTSKAHTAVK 846
              I++ A      +IGLS L+T ++  M    + +  +G  + +++GGA  + A+    
Sbjct: 736 AADIVEAAERHGARVIGLSALMTTTMVRMEDTVRLVRERGLPVKVMVGGAVVTPAYAEAI 795

Query: 847 IEQNYHAPVVYVNNASRAVGVCTSLLS 873
               Y A      +A  AV V   LL+
Sbjct: 796 GADGYSA------DAVEAVRVAKELLT 816