Pairwise Alignments

Query, 1226 a.a., methionine synthase from Vibrio cholerae E7946 ATCC 55056

Subject, 1244 a.a., 5-methyltetrahydrofolate--homocysteine methyltransferase (NCBI ptt file) from Shewanella oneidensis MR-1

 Score = 1610 bits (4169), Expect = 0.0
 Identities = 810/1230 (65%), Positives = 969/1230 (78%), Gaps = 17/1230 (1%)

Query: 9    LEQQLKQRILLIDGGMGTMIQSYKLQEEDYRGARFVDWHCDLKGNNDLLVLTQPQIIKEI 68
            +  QL  RIL++DG MGTMIQ YKL+E DYRG RF DWH D+KGNNDLLVLTQP IIK+I
Sbjct: 15   IRNQLSTRILILDGAMGTMIQGYKLEEADYRGERFKDWHTDVKGNNDLLVLTQPHIIKQI 74

Query: 69   HSAYLEAGADILETNTFNSTTIAMADYDMQSLSAEINFAAAKLAREVADEWTAKDPSRPR 128
            H+ YL AGADI+ETNTFN+TTIAMADYDMQSLSAEIN   A+LARE  D    +   +PR
Sbjct: 75   HTDYLLAGADIIETNTFNATTIAMADYDMQSLSAEINREGARLAREACDA-IEQATGKPR 133

Query: 129  YVAGVLGPTNRTCSISPDVNDPGFRNVTFDGLVEAYSESTRALIKGGSDLILIETIFDTL 188
            YVAGVLGPTNRTCSISPDVNDPGFRN+ FD LV AY ESTRALI+GG+D+I++ETIFDTL
Sbjct: 134  YVAGVLGPTNRTCSISPDVNDPGFRNIHFDELVTAYCESTRALIEGGADIIMVETIFDTL 193

Query: 189  NAKACAFAVDSVFEEL-----GISLPVMISGTITDASGRTLSGQTTEAFYNALRHVRPIS 243
            NAKA  FA+++VF+EL        LPVMISGTITDASGRTL+GQTTEAFYN+LRH++P+S
Sbjct: 194  NAKAALFAIETVFDELFGANSPARLPVMISGTITDASGRTLTGQTTEAFYNSLRHIKPLS 253

Query: 244  FGLNCALGPDELRQYVEELSRISECYVSAHPNAGLPNAFGEYDLSAEEMAEHIAEWAQAG 303
             GLNCALGP ELR YVEELSRI+ECYVSAHPNAGLPN FG YD + E+MA+ I EWA+ G
Sbjct: 254  IGLNCALGPKELRPYVEELSRIAECYVSAHPNAGLPNEFGGYDETPEDMAKVIQEWAREG 313

Query: 304  FLNLVGGCCGTTPEHIAAIAKAVEGVKPRALPDLKVECRLSGLEPLNIGPETLFVNVGER 363
             LN++GGCCG+TPEHI  I +AVE   PR LP++ V CRL+GLEPL I  +TLFVNVGER
Sbjct: 314  MLNIIGGCCGSTPEHIKVIREAVEQFAPRVLPEIPVACRLAGLEPLTIDAQTLFVNVGER 373

Query: 364  TNVTGSARFKRLIKEEQYDEALDVAREQVENGAQIIDINMDEGMLDAEACMVRFLNLCAS 423
            TNVTGSA+F +LIKE ++++ALDVAREQVE+GAQIIDINMDEGMLD    M +FLNL AS
Sbjct: 374  TNVTGSAKFLKLIKEGKFEQALDVAREQVESGAQIIDINMDEGMLDGVEIMHKFLNLIAS 433

Query: 424  EPEISKVPVMVDSSKWEVIEAGLKCIQGKGIVNSISLKEGKEKFIAQAKLVRRYGAAVIV 483
            EP+IS+VP+M+DSSKWEVIEAGLKCIQGKGIVNSISLKEG+EKFI QA LV+RYGAA I+
Sbjct: 434  EPDISRVPIMIDSSKWEVIEAGLKCIQGKGIVNSISLKEGEEKFIEQATLVKRYGAAAII 493

Query: 484  MAFDEVGQADTRERKLEICRRAYHILVDEVGFPPEDIIFDPNIFAVATGIDEHNNYALDF 543
            MAFDE GQADT+ RK+EIC RAY +LVD+VGFPPEDIIFDPNIFA+ATGIDEH+NYA+DF
Sbjct: 494  MAFDEQGQADTKARKVEICTRAYRVLVDKVGFPPEDIIFDPNIFAIATGIDEHDNYAVDF 553

Query: 544  INAVADIKRELPHAMISGGVSNVSFSFRGNNYVREAIHAVFLYHCFKHGMDMGIVNAGQL 603
            I+A+ +IK  LPHAMISGGVSNVSFSFRGNN VREAIHAVFLYH  K GMDMGIVNAGQL
Sbjct: 554  IDAIKEIKATLPHAMISGGVSNVSFSFRGNNPVREAIHAVFLYHAIKVGMDMGIVNAGQL 613

Query: 604  EIYDNVPLKLREAVEDVILN-----RRSDGTERLLEIAEAYR--ENSVGKEEDASALEWR 656
             I+D++  +L+  VE+V+LN       S+ TE+LLEIAE +R   +S  K+ED   LEWR
Sbjct: 614  AIFDDIDPELKVRVENVVLNLPCPVEGSNNTEQLLEIAEKFRGDGSSSAKKED---LEWR 670

Query: 657  AWPVAKRLEHALVKGITEFIVQDTEEARQQASKPLEVIEGPLMDGMNVVGDLFGEGKMFL 716
            +WPV +RL HALVKGITEFI +DTE ARQ AS+PL+VIEGPLMDGMN+VGDLFG GKMFL
Sbjct: 671  SWPVNQRLAHALVKGITEFIDEDTEAARQAASRPLDVIEGPLMDGMNIVGDLFGSGKMFL 730

Query: 717  PQVVKSARVMKQAVAYLEPFINAQKSGSTSNGKILLATVKGDVHDIGKNIVGVVLQCNNF 776
            PQVVKSARVMK+AVAYL PFI  +K    SNGKIL+ TVK DVHDIGKNIVGVVL CN F
Sbjct: 731  PQVVKSARVMKKAVAYLNPFIEKEKVAGQSNGKILMVTVKSDVHDIGKNIVGVVLACNGF 790

Query: 777  EIIDLGVMVPCEQILKVAREQNVDIIGLSGLITPSLDEMVHVAKEMERQGFELPLLIGGA 836
            E+ DLGVMV  E+IL+  +E N+DIIG+SGLITPSLDEMVH  K   R+G  +P +IGGA
Sbjct: 791  EVFDLGVMVSVERILEAVKEHNIDIIGMSGLITPSLDEMVHNVKTFHREGLTIPAIIGGA 850

Query: 837  TTSKAHTAVKIEQNYHAPVVYVNNASRAVGVCTSLLSDEQRPGFIERLDLDYERTRDQHA 896
            T SK HTAVKI  +Y    +Y+ +ASRAV + + L+++E R   I+    +Y+  R +  
Sbjct: 851  TCSKIHTAVKIAPHYPHGAIYIADASRAVPMVSKLVNNETRQATIDETYAEYDDMRTKRL 910

Query: 897  RKTPKSRPVTLEQARANKAALDWANYTPPAPAKPGVHVFENIALATLRPYIDWTPFFMTW 956
             +  +   V+LE AR N+   DWANY+P  P   G  VF++  L  L   IDWTPFF  W
Sbjct: 911  SQAKRKEIVSLEAARENRCQHDWANYSPFKPNVLGRQVFDDYPLTDLVDRIDWTPFFRAW 970

Query: 957  SLMGKYPAILEHEEVGEEAKRLFHDANALLDKVEREGLLKASGMCALFPAASVG-DDIEV 1015
             L G YP IL  + VG EA++LF D  A+L K+  E  L A G+  LFPA +VG DDIE+
Sbjct: 971  ELHGHYPEILSDKVVGVEAQKLFSDGKAMLKKIIEEKWLTAKGVIGLFPANTVGFDDIEL 1030

Query: 1016 YSDESRTQVAHVLYNLRQQTEKPKGANYCLSDYVAPKESGKRDWIGAFAVTGGIGERALA 1075
            Y+DE+RT+V    ++LR Q E+    N+CL+D+VAPK+SG  D++G FAVT G G     
Sbjct: 1031 YTDETRTEVELTTHHLRMQLERVGNDNFCLADFVAPKDSGVADYMGGFAVTAGHGIDEHV 1090

Query: 1076 DAYKAQGDDYNAIMIQAVADRLAEAFAEYLHEKVRKEIWGYASDENLSNDDLIRERYQGI 1135
              ++A  DDYNAIM++ +ADRLAEAFAE +HE+VRKE WGYA+DE L N+ LIRE+Y+GI
Sbjct: 1091 ARFEANHDDYNAIMLKCLADRLAEAFAERMHERVRKEFWGYAADEQLDNEALIREKYKGI 1150

Query: 1136 RPAPGYPACPEHTEKATLWQMLNVEETIGMSLTTSYAMWPGASVSGWYFSHPDSRYFAVA 1195
            RPAPGYPACP+HTEK  LW++L   ETI +++T SYAM+P A+VSGWYF+HP SRYF V+
Sbjct: 1151 RPAPGYPACPDHTEKGLLWELLKPNETIDLNITESYAMFPTAAVSGWYFAHPKSRYFGVS 1210

Query: 1196 QIQPDQLHSYAERKGWRLEEAEKWLAPNLD 1225
             I  DQ+  YA+RKG  + E EKWLAP LD
Sbjct: 1211 NIGRDQVEDYAKRKGMTVAETEKWLAPVLD 1240