Pairwise Alignments

Query, 1401 a.a., DNA-directed RNA polymerase subunit beta' from Vibrio cholerae E7946 ATCC 55056

Subject, 1316 a.a., DNA-directed RNA polymerase (beta from Mycobacterium tuberculosis H37Rv

 Score =  771 bits (1990), Expect = 0.0
 Identities = 417/813 (51%), Positives = 544/813 (66%), Gaps = 45/813 (5%)

Query: 152  TDLERGQMLTEEE-YLDRLEEWGDEFTAKMGAEAIKDLLASMDLPAEAEQMREELDTTNS 210
            T L   Q++ +E  Y + ++ +G+ FT  MGAE+I+ L+ + D+ AEAE +R+ +     
Sbjct: 227  TKLAPKQLIVDENLYRELVDRYGEYFTGAMGAESIQKLIENFDIDAEAESLRDVIRNGKG 286

Query: 211  ETKRKKLTKRLKLVEAFVASGNKPEWMILTVLPVLPPDLRPLVPLDGGRFATSDLNDLYR 270
            + K + L KRLK+V AF  SGN P  M+L  +PV+PP+LRP+V LDGGRFATSDLNDLYR
Sbjct: 287  QKKLRAL-KRLKVVAAFQQSGNSPMGMVLDAVPVIPPELRPMVQLDGGRFATSDLNDLYR 345

Query: 271  RVINRNNRLKRLLELAAPDIIVRNEKRMLQESVDALLDNGRRGRAITGSNKRPLKSLADM 330
            RVINRNNRLKRL++L AP+IIV NEKRMLQESVDAL DNGRRGR +TG   RPLKSL+D+
Sbjct: 346  RVINRNNRLKRLIDLGAPEIIVNNEKRMLQESVDALFDNGRRGRPVTGPGNRPLKSLSDL 405

Query: 331  IKGKQGRFRQNLLGKRVDYSGRSVITVGPYLRLHQCGLPKKMALELFKPFIYSKLETRGL 390
            +KGKQGRFRQNLLGKRVDYSGRSVI VGP L+LHQCGLPK MALELFKPF+  +L     
Sbjct: 406  LKGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGLPKLMALELFKPFVMKRLVDLNH 465

Query: 391  ATTIKAAKKMVEREEAVVWDILDEVIREHPVLLNRAPTLHRLGIQAFEPVLIEGKAIQLH 450
            A  IK+AK+MVER+   VWD+L+EVI EHPVLLNRAPTLHRLGIQAFEP+L+EGKAIQLH
Sbjct: 466  AQNIKSAKRMVERQRPQVWDVLEEVIAEHPVLLNRAPTLHRLGIQAFEPMLVEGKAIQLH 525

Query: 451  PLVCAAYNADFDGDQMAVHVPLTLEAQLEARTLMMSTNNILSPASGDPIIVPSQDVVLGL 510
            PLVC A+NADFDGDQMAVH+PL+ EAQ EAR LM+S+NNILSPASG P+ +P  D+V GL
Sbjct: 526  PLVCEAFNADFDGDQMAVHLPLSAEAQAEARILMLSSNNILSPASGRPLAMPRLDMVTGL 585

Query: 511  YYMTREKINAKGE-----------GMYLTGPAEAEKAYRTKTAELHARVKVRITE----- 554
            YY+T E     GE           G+Y + PAEA  A       + A++KVR+T+     
Sbjct: 586  YYLTTEVPGDTGEYQPASGDHPETGVY-SSPAEAIMAADRGVLSVRAKIKVRLTQLRPPV 644

Query: 555  ----TIKHENGKLTTETKMIDTTVGRAMLWQIVPKGLPYSLVNQKLGKKQISNLLNEAYR 610
                 +   +G    +  M +TT+GR M  +++P G P+  VN+++ KK  + ++N+   
Sbjct: 645  EIEAELFGHSGWQPGDAWMAETTLGRVMFNELLPLGYPF--VNKQMHKKVQAAIINDLAE 702

Query: 611  KLGLKDTVIFADQIMYTGFAYAALSGVSVGIDDMVVPAAKYTEIAEAEEEVREIQEQFQS 670
            +  +       D++   GF +A  SGV+V + D++VP  K   +   EE   ++++QFQ 
Sbjct: 703  RYPMIVVAQTVDKLKDAGFYWATRSGVTVSMADVLVPPRKKEILDHYEERADKVEKQFQR 762

Query: 671  GLVTAGERYNKVIDIWASTNDRVAKAMMENLSSEQVINRQGEQEKQESFNSIYMMADSGA 730
            G +   ER   +++IW    D V +A+ E+   +               N I  + DSGA
Sbjct: 763  GALNHDERNEALVEIWKEATDEVGQALREHYPDD---------------NPIITIVDSGA 807

Query: 731  RGSAAQIRQLAGMRGLMARPDGSIIETPITANFKEGLNVLQYFISTHGARKGLADTALKT 790
             G+  Q R LAGM+GL+  P G  I  P+ ++F+EGL VL+YFI+THGARKGLADTAL+T
Sbjct: 808  TGNFTQTRTLAGMKGLVTNPKGEFIPRPVKSSFREGLTVLEYFINTHGARKGLADTALRT 867

Query: 791  ANSGYLTRRLVDVAQDVVVTEHDCGTLEGVVMTPHIEGGDVKVA----LTELALGRVVSE 846
            A+SGYLTRRLVDV+QDV+V EHDC T  G+V+       D  +     +   A  R +  
Sbjct: 868  ADSGYLTRRLVDVSQDVIVREHDCQTERGIVVELAERAPDGTLIRDPYIETSAYARTLGT 927

Query: 847  DILKPGTDEVLIPRNTLLDEKWCKVINDNSVDQIKVRSVVTCDSDFGCCAQCYGRDLARG 906
            D +      V++ R   L +     +    + Q+KVRSV+TC +  G CA CYGR +A G
Sbjct: 928  DAVDE-AGNVIVERGQDLGDPEIDALLAAGITQVKVRSVLTCATSTGVCATCYGRSMATG 986

Query: 907  HLVNQGEAVGVIAAQSIGEPGTQLTMRTFHIGG 939
             LV+ GEAVG++AAQSIGEPGTQLTMRTFH GG
Sbjct: 987  KLVDIGEAVGIVAAQSIGEPGTQLTMRTFHQGG 1019



 Score =  223 bits (569), Expect = 7e-62
 Identities = 121/261 (46%), Positives = 172/261 (65%), Gaps = 12/261 (4%)

Query: 1127 KSGGNKDITGGLPRVADLFEARKPKEPAILAEHSGTVSFGKETKGKRRLIITRDSGD-TY 1185
            + G  +DITGGLPRV +LFEAR P+  A +A+ +G V      +  +  I+  D G+   
Sbjct: 1017 QGGVGEDITGGLPRVQELFEARVPRGKAPIADVTGRVRLEDGERFYKITIVPDDGGEEVV 1076

Query: 1186 EEMIPKHRQLNVF-----------EGERIERGDVIADGPESPHDILRLRGIHAVTTYIAN 1234
             + I K ++L VF           +G+ +E G  + +G   PH++LR++G   V  ++  
Sbjct: 1077 YDKISKRQRLRVFKHEDGSERVLSDGDHVEVGQQLMEGSADPHEVLRVQGPREVQIHLVR 1136

Query: 1235 EVQEVYRLQGVKINDKHIETIVRQMLRKCTITFAGDSEFLPGETVEYSQVKIANRKLVEE 1294
            EVQEVYR QGV I+DKHIE IVRQMLR+ TI  +G +EFLPG  ++ ++ +  NR++V E
Sbjct: 1137 EVQEVYRAQGVSIHDKHIEVIVRQMLRRVTIIDSGSTEFLPGSLIDRAEFEAENRRVVAE 1196

Query: 1295 GKEPARFERELLGITKASLATESFISAASFQETTRVLTEAAVSGKRDDLRGLKENVIVGR 1354
            G EPA     L+GITKASLAT+S++SAASFQETTRVLT+AA++ + D L GLKENVI+G+
Sbjct: 1197 GGEPAAGRPVLMGITKASLATDSWLSAASFQETTRVLTDAAINCRSDKLNGLKENVIIGK 1256

Query: 1355 LIPAGTGFAYHQDRQAKRAQE 1375
            LIPAGTG   +++   +  +E
Sbjct: 1257 LIPAGTGINRYRNIAVQPTEE 1277



 Score =  205 bits (521), Expect = 3e-56
 Identities = 101/209 (48%), Positives = 139/209 (66%), Gaps = 20/209 (9%)

Query: 17  FDAIKIGLASPDMIRSWSFGEVKKPETINYRTFKPERDGLFCARIFGPVKDYECLCGKYK 76
           FD ++IGLA+ + IR WS+GEVKKPETINYRT KPE+DGLFC +IFGP +D+EC CGKYK
Sbjct: 7   FDELRIGLATAEDIRQWSYGEVKKPETINYRTLKPEKDGLFCEKIFGPTRDWECYCGKYK 66

Query: 77  RLKHRGVICEKCGVEVTQTKVRRDRMGHIELASPVAHIWFLKSLPSRIGLLMDMPLRDIE 136
           R++ +G+ICE+CGVEVT+ KVRR+RMGHIELA+PV HIW+ K +PSR+G L+D+  +D+E
Sbjct: 67  RVRFKGIICERCGVEVTRAKVRRERMGHIELAAPVTHIWYFKGVPSRLGYLLDLAPKDLE 126

Query: 137 RVLYFEMYVVTEPGMTDLERGQMLTEEEYLDRLEEWGDEFTAKMGAE--AIKDLLASMDL 194
           +++YF  YV+T     ++   ++ T E              A+M  E  A++D     D 
Sbjct: 127 KIIYFAAYVITSVD-EEMRHNELSTLE--------------AEMAVERKAVED---QRDG 168

Query: 195 PAEAEQMREELDTTNSETKRKKLTKRLKL 223
             EA   + E D    E +  K   R K+
Sbjct: 169 ELEARAQKLEADLAELEAEGAKADARRKV 197