Pairwise Alignments

Query, 548 a.a., acetolactate synthase 2 catalytic subunit from Vibrio cholerae E7946 ATCC 55056

Subject, 618 a.a., Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase) from Mycobacterium tuberculosis H37Rv

 Score =  466 bits (1199), Expect = e-135
 Identities = 257/565 (45%), Positives = 350/565 (61%), Gaps = 23/565 (4%)

Query: 1   MTGAQLVVAALKQQGIKTVFGYPGGAIMPIYDALYDGG-VEHILCRHEQGAAMAAIGMAR 59
           +TGAQ V+ +L++ G+  +FG PGGA++P+YD L+D   + H+L RHEQGA  AA G A 
Sbjct: 38  LTGAQAVIRSLEELGVDVIFGIPGGAVLPVYDPLFDSKKLRHVLVRHEQGAGHAASGYAH 97

Query: 60  STQKVAVCMATSGPGATNLVTGLADAFLDSVPLVAITGQVASSHIGTDAFQEMDVIGMSL 119
            T +V VCMATSGPGATNLVT LADA +DS+P+VAITGQV    IGTDAFQE D+ G+++
Sbjct: 98  VTGRVGVCMATSGPGATNLVTPLADAQMDSIPVVAITGQVGRGLIGTDAFQEADISGITM 157

Query: 120 SCTKHSYLVTDINELAPTLAEAFEVAQTGRPGPVLVDIAKDVQLGKA-----PVSALPSF 174
             TKH++LV   +++   LAEAF +A +GRPG VLVDI KDV  G+      P   LP +
Sbjct: 158 PITKHNFLVRSGDDIPRVLAEAFHIAASGRPGAVLVDIPKDVLQGQCTFSWPPRMELPGY 217

Query: 175 TPPAMPHVDATHLANAQALLAQSKRPVLYVGGGVQLANATDTVREFLRLNPMPSVSTLKG 234
            P   PH  +  +  A  L+A +++PVLYVGGGV    AT+ +RE   L  +P V+TL  
Sbjct: 218 KPNTKPH--SRQVREAAKLIAAARKPVLYVGGGVIRGEATEQLRELAELTGIPVVTTLMA 275

Query: 235 LGTIERHDPHYLGMLGMHGTKAANLIVQECDLLIAVGARFDDRVTGKLDTFAPHAKVIHV 294
            G         LGM GMHGT AA   +Q  DLLIA+G RFDDRVTGKLD+FAP AKVIH 
Sbjct: 276 RGAFPDSHRQNLGMPGMHGTVAAVAALQRSDLLIALGTRFDDRVTGKLDSFAPEAKVIHA 335

Query: 295 DIDAAEFNKLRHAHAALRGDINLILPQL--ELSH-------DISPWVHHSESLRSGFKWR 345
           DID AE  K RHA   + GD+  ++ +L   L H       +++ W  +   +R  +   
Sbjct: 336 DIDPAEIGKNRHADVPIVGDVKAVITELIAMLRHHHIPGTIEMADWWAYLNGVRKTYPLS 395

Query: 346 YDHPGDNIFAP-LLLKQLSDMMPDSSIVSTDVGQHQMWAAQHIQPRAPQNFISSAGLGTM 404
           Y    D   +P  ++++L ++    ++    VGQHQMWAAQ I+   P+++++S GLGTM
Sbjct: 396 YGPQSDGSLSPEYVIEKLGEIAGPDAVFVAGVGQHQMWAAQFIRYEKPRSWLNSGGLGTM 455

Query: 405 GFGLPAAMGAAVARPDDQSILISGDGSFMMNVQELGTLKRRQIPVKMVLLDNQRLGMVRQ 464
           GF +PAAMGA +A P  +   I GDG F M  QEL T     IPVK+ L++N  LGMVRQ
Sbjct: 456 GFAIPAAMGAKIALPGTEVWAIDGDGCFQMTNQELATCAVEGIPVKVALINNGNLGMVRQ 515

Query: 465 WQSLFFDGRHSETILDDN----PDFVMLAKAFNIPGKTISRKEEVEPALREMLA-SKTAY 519
           WQSLF+  R+S+T L  +    PDFV LA+A    G    R+E+V   + +  A +    
Sbjct: 516 WQSLFYAERYSQTDLATHSHRIPDFVKLAEALGCVGLRCEREEDVVDVINQARAINDCPV 575

Query: 520 LLHVLIDEEENVWPLVPPGASNTDM 544
           ++  ++  +  VWP+V  G SN ++
Sbjct: 576 VIDFIVGADAQVWPMVAAGTSNDEI 600