Pairwise Alignments

Query, 2542 a.a., erythronolide synthase (RefSeq) from Shewanella amazonensis SB2B

Subject, 1876 a.a., Phenolpthiocerol synthesis type-I polyketide synthase PpsA from Mycobacterium tuberculosis H37Rv

 Score =  289 bits (740), Expect = 3e-81
 Identities = 232/808 (28%), Positives = 349/808 (43%), Gaps = 70/808 (8%)

Query: 4   SKTQDAQDLRLNKRLKDTPIAIVGMASLFANSRYLND-FWDLICDKIDAITEVPADRWQI 62
           S   DA   R  +   D PIA+VGM   F       +  WD +C++  +I++VP  RWQ 
Sbjct: 85  SPDSDAAVKRGARNSLDEPIAVVGMGCRFPGGISCPEALWDFLCERRSSISQVPPQRWQP 144

Query: 63  DDYFDADKRSPDKSYCKRGGFIPQVD-FNPMEFGLPPNILELTDSAQLLSLIVAKEVLED 121
            +    +  +      + G F+P +D F+   F + P+  +  D  Q L L VA E LE 
Sbjct: 145 FEGGPPEVAAALARTTRWGSFLPDIDAFDAEFFEISPSEADKMDPQQRLLLEVAWEALEH 204

Query: 122 AGVSENSAHDRDKIGITLGIGGGQKISQSLNARLQYPVLKKVFRESGISDADSEMLIRKF 181
           AG+   +           G+  G  +S+                   ++ AD        
Sbjct: 205 AGIPPGTLRRS-----ATGVFAGACLSEY----------------GAMASADLS------ 237

Query: 182 QDQYIHWEENSFPGSLGNVIAGRIANRFDLGGMNCVVDAACAGSLAAIRMALTELTEGRA 241
             Q   W  +   G   ++IA R++   DL G +  VD AC+ SL AI +A   L     
Sbjct: 238 --QVDGWSNS---GGAMSIIANRLSYFLDLRGPSVAVDTACSSSLVAIHLACQSLRTQDC 292

Query: 242 DMMLTGGACTDNSAYMYMSFSKTPAFTVDEQIKPFDADSKGMMIGEGIGMVALKRLEDAE 301
            + +  G     S  ++  F +  A +   Q + FDA + G + GEG G+V LKRL DA+
Sbjct: 293 HLAIAAGVNLLLSPAVFRGFDQVGALSPTGQCRAFDATADGFVRGEGAGVVVLKRLTDAQ 352

Query: 302 RDGDKIYAVIKGVGASSDGKFKSIYAPRPEGQAKALRRAYDDAGFPAHTLGLMEAHGTGT 361
           RDGD++ AVI G   + DG+   + AP P  Q   LR AY +AG     +  +EAHGTGT
Sbjct: 353 RDGDRVLAVICGSAVNQDGRSNGLMAPNPAAQMAVLRAAYTNAGMQPSEVDYVEAHGTGT 412

Query: 362 AAGDVAEFSGLSLVMGESSDETQHIALGSIKSQVGHTKSTAGTAGLIKAALALHHKVLPP 421
             GD  E   L  V+G    E   + +GS+K+ +GHT++ AG AG IK  LA+ H  +PP
Sbjct: 413 LLGDPIEARALGTVLGRGRPEDSPLLIGSVKTNLGHTEAAAGIAGFIKTVLAVQHGQIPP 472

Query: 422 TINVNKPNPKLNIEASPFYLSTETRPWLPRPDGTPRRAAVSSFGFGGTNFHLVMEEYQRD 481
             +    NP +        +      W     G PRRA VSSFGFGGTN H+V+E+ Q  
Sbjct: 473 NQHFETANPHIPFTDLRMKVVDTQTEW--PATGHPRRAGVSSFGFGGTNAHVVIEQGQEV 530

Query: 482 HGRTPYRLRSTQVPLLFAAPSREALSNDLKALCERLSNTEETFETLTAPFTLKGEPPKAE 541
                  L      L+ A  + + +S     L + +              TL     ++ 
Sbjct: 531 RPAPGQGLSPAVSTLVVAGKTMQRVSATAGMLADWMEGPGADVALADVAHTLNHH--RSR 588

Query: 542 WPRLGIVAANAKALKACLEDAIEKLATSSDDWHTQDMSFRAQAMAKNTRVAALFAGQGSQ 601
            P+ G V A  +        AI  L   +   H   +   A   +       +++G+GSQ
Sbjct: 589 QPKFGTVVARDRT------QAIAGLRALAAGQHAPGVVNPADG-SPGPGTVFVYSGRGSQ 641

Query: 602 YLGMGGELAMLYPEMRAEFIAADEVFHQRGYPGRHGTGELSSHVFPIPKFDSDARKQDEE 661
           + GMG +L    P   A     + VF ++     H                 D     EE
Sbjct: 642 WAGMGRQLLADEPAFAAAVAELEPVFVEQAGFSLH-----------------DVLANGEE 684

Query: 662 ALTNTRIAQSAIGVVSMGQFEILKAAGLTPDAVAGHSFGELSALRAAGVIDQASYYRLAF 721
            +   +I    IG + +   E+  + G+ PD V GHS GE++A   AG +  A   R+  
Sbjct: 685 LVGIEQIQLGLIG-MQLALTELWCSYGVRPDLVIGHSMGEVAAAVVAGALTPAEGLRVTA 743

Query: 722 ARGDAMASVPKGKDAGTMAAVILPDASHRSTLDTLLTQHESVVIANHNSPTQLVLAGPTD 781
            R   MA +      G MA + L DA    T + L+     V +  +NSP Q V+AGPT+
Sbjct: 744 TRSRLMAPL---SGQGGMALLEL-DA---PTTEALIADFPQVTLGIYNSPRQTVIAGPTE 796

Query: 782 AVKQLVQALADKGIRAIALPVSGAFHTP 809
            + +L+  +  +   A  + +  A H P
Sbjct: 797 QIDELIARVRAQNRFASRVNIEVAPHNP 824



 Score = 76.6 bits (187), Expect = 4e-17
 Identities = 84/324 (25%), Positives = 131/324 (40%), Gaps = 43/324 (13%)

Query: 1902 SGADVELNQAALFGLTKTLAQEWPHTHCRALDVAAQLDATSLADAVIDALYGADDLLEWG 1961
            S A   L Q+ L+GL   +A E P      +D+A                   DDL E+G
Sbjct: 1404 SVAPSALRQSFLWGLAGVIAAEHPELWGGLVDLAIN-----------------DDLGEFG 1446

Query: 1962 IAADGRFAALATDAQQISAKTALNSTDKILVTGGAKGVTLDCAL-ALAARTHAHFILAGR 2020
             A     A          +K+ L   D +++      V  + A  +L  R  A +++ G 
Sbjct: 1447 PALAELLAK--------PSKSILVRRDGVVLAPALAPVRGEPARKSLQCRPDAAYLITGG 1498

Query: 2021 SKALSLNEFPVWAKGVAATELKQAAIQELLAGGKRPTPKEVDALIAPLASALEIQ-QALQ 2079
              AL L         + A  L       L+  G+ P P   D  +  L + L  +  A++
Sbjct: 1499 LGALGL---------LMADWLADRGAHRLVLTGRTPLPPRRDWQLDTLDTELRRRIDAIR 1549

Query: 2080 AFSDLGASAEYLSMDVSSAESIAKALGPIQ--AIAPVTGLIHGAGVLADKFIQDKTLDEL 2137
            A    G + E ++ DV   E +   L        AP+ G+IH AG+  D+ +   T D +
Sbjct: 1550 ALEMRGVTVEAVAADVGCREDVQALLAARDRDGAAPIRGIIHAAGITNDQLVTSMTGDAV 1609

Query: 2138 KRVAGTKVDGLKGLLANL--DGLKLVALFSSAAGFYGNKGQSDYAMANEILNKAAHRLAH 2195
            ++V   K+ G + L        +    L +SAAG +G  GQ  YA AN  L+  A   A 
Sbjct: 1610 RQVMWPKIGGSQVLHDAFPPGSVDFFYLTASAAGIFGIPGQGSYAAANSYLDALAR--AR 1667

Query: 2196 AKPDCRVVAFDWGPWDG-GMVTDS 2218
             +  C  ++ DW  W G G+  D+
Sbjct: 1668 RQQGCHTMSLDWVAWRGLGLAADA 1691