Pairwise Alignments

Query, 2542 a.a., erythronolide synthase (RefSeq) from Shewanella amazonensis SB2B

Subject, 2126 a.a., Probable polyketide synthase Pks7 from Mycobacterium tuberculosis H37Rv

 Score =  300 bits (769), Expect = 1e-84
 Identities = 263/934 (28%), Positives = 403/934 (43%), Gaps = 120/934 (12%)

Query: 10  QDLRLNKRLK----------DTPIAIVGMASLFANSRYLND-FWDLICDKIDAITEVPAD 58
           + L+ N+RLK            P+A+VGM   +       +  W+L+    DA++E PAD
Sbjct: 14  RSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHGRDAVSEFPAD 73

Query: 59  R-WQIDDYFDADKRSPDKSYCKRGGFIPQV-DFNPMEFGLPPNILELTDSAQLLSLIVAK 116
           R W +   FD D  +  KSY + GGF+  V  F+   FG+ P+     D  Q L L V+ 
Sbjct: 74  RGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLLLEVSW 133

Query: 117 EVLEDAGVSENSAHDRDKIGITLGIGGGQKISQSLNARLQYPVLKKVFRESGISDADSEM 176
           E LE AG+   +     + G+  G+  G    Q               R  G        
Sbjct: 134 EALERAGIDPITLRG-SQTGVFAGVFHGSYGGQG--------------RVPG-------- 170

Query: 177 LIRKFQDQYIHWEENSFPGSLGNVIAGRIANRFDLGGMNCVVDAACAGSLAAIRMALTEL 236
                       E     GS  +V +GR+A    L G    VD AC+ SL A+ +A+  L
Sbjct: 171 ----------DLERYGLRGSTLSVASGRVAYVLGLQGPAVSVDTACSSSLVALHLAVQSL 220

Query: 237 TEGRADMMLTGGACTDNSAYMYMSFSKTPAFTVDEQIKPFDADSKGMMIGEGIGMVALKR 296
             G  D+ L GG     +  M++ FS+  A + D + K +   + G    EG G++ L R
Sbjct: 221 RLGECDLALVGGVTVMATPAMFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLAR 280

Query: 297 LEDAERDGDKIYAVIKGVGASSDGKFKSIYAPRPEGQAKALRRAYDDAGFPAHTLGLMEA 356
           L DA R G  + A+++G   + DG    +  P    Q + +  A   A      + ++E 
Sbjct: 281 LADARRLGHPVLALVRGSAVNQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEG 340

Query: 357 HGTGTAAGDVAEFSGLSLVMGESSDETQHIALGSIKSQVGHTKSTAGTAGLIKAALALHH 416
           HGTGT  GD  E   +    G+   + + + LGSIKS +GHT + AG AG+IK   A+ H
Sbjct: 341 HGTGTTLGDPIEAQAILATYGQRPAD-RPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRH 399

Query: 417 KVLPPTINVNKPNPKLNIEASPFYLSTETRPWLPRPDGTPRRAAVSSFGFGGTNFHLVME 476
            VLP T++V+ P P ++  A    L TE RPW     G PRRA VSSFG  GTN H+++E
Sbjct: 400 GVLPKTLHVDVPTPHVDWSAGAVSLLTEPRPW--HVPGRPRRAGVSSFGISGTNAHVILE 457

Query: 477 E------YQRDHGRTPYRLRSTQVPLLFAAPSREALSNDLKALCERLSNTEETFETLTAP 530
           E          HG  P       VP + +A S +AL+N  + L   +   +E    L   
Sbjct: 458 EAPAVEPVGAAHGNDP-----VAVPWVLSARSAQALTNQARRLLAWV-GADENVRPLDVG 511

Query: 531 FTLKGEPPKAEWPRLGIVAANAKALKACLEDAIEKLATSSDDWHTQDMSFRAQAMAKNTR 590
           ++L       +  R  +V A+    +  L + +  LA          ++ RAQ + K   
Sbjct: 512 WSLVNTRSLFD-HRAVVVGAD----RTQLMEGLTGLAAGVPG--ADVVAGRAQTVGK--- 561

Query: 591 VAALFAGQGSQYLGMGGELAMLYPEMRAEFIAADEVFHQ----------RGYPGRHGTGE 640
            A +F GQG+Q+LGMG +L    P         +    +          RG PG  G   
Sbjct: 562 TAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREHVEWSLLDVLRGAPGAPG--- 618

Query: 641 LSSHVFPIPKFDSDARKQDEEALTNTRIAQSAIGVVSMGQFEILKAAGLTPDAVAGHSFG 700
                                 L    + Q A+  V +   E+ ++ G+ PDAV GHS G
Sbjct: 619 ----------------------LDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQG 656

Query: 701 ELSALRAAGVIDQASYYRLAFARGDAMASVPKGKDAGTMAAVILPDASHRSTLDTLLTQ- 759
           E++A   AG +       +   R   +  +     AG M ++    A  +   + L +Q 
Sbjct: 657 EIAAAYVAGALSLRDAAAVVALRSRLLVRL---GGAGGMVSL----ACGQPQAEKLASQW 709

Query: 760 HESVVIANHNSPTQLVLAGPTDAVKQLVQALADKGIRAIALPVSGAFHTPLVGHAHAPFA 819
            + + IA  N  + +VLAG TDAV +L+Q    +GIRA  + V  A H+  V        
Sbjct: 710 GDRLNIAAVNGVSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELI 769

Query: 820 KAIDKESFSDAHAVLYANASGDKRPTDGKSLKQSLKAQMLEQVQFESQIESLYRDGVRVF 879
            A+       +    ++  +G+   T G + +   ++ + + VQFE  + + +  G RVF
Sbjct: 770 AALRGIEPRTSTVAFFSTVTGELMDTAGVNAEYWYRS-IRQPVQFERAVRNAFDGGYRVF 828

Query: 880 IEFGPKNTL-----SRLVDAILGERAKACLILSL 908
           +E  P   L       LVD   G   +  +I +L
Sbjct: 829 VESSPHPVLIAGIEETLVDCDRGATGEPIVIPTL 862



 Score = 65.1 bits (157), Expect = 1e-13
 Identities = 63/212 (29%), Positives = 92/212 (43%), Gaps = 18/212 (8%)

Query: 2085 GASAEYLSMDVSSAESIAKALGPIQAIAPVTGLIHGAGVLADKFIQDKTLDELKRVAGTK 2144
            GA    +S DV+  +++A  L  +    P+ G+ H AGVL D  I   T D +  V   K
Sbjct: 1746 GAQVAVVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDTVLRAK 1805

Query: 2145 VDG---LKGLLANLDGLKLVALFSSAAGFYGNKGQSDYAMANEILN-KAAHRLAHAKPDC 2200
            VDG   L  L  ++D L    +FSS AG  G   Q +YA AN  L+   A+R +      
Sbjct: 1806 VDGAWNLHELTEDMD-LSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRGLAGL 1864

Query: 2201 RVVAFDWGPWDGGMVTDSLKKMFQERGVYVIPRPLGAALFAEAVLG------RAESQILV 2254
             V    WG W+      ++ +   ER    + +   A L  E  LG      +A+  ++V
Sbjct: 1865 SVA---WGLWE---QASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTALQADRAVVV 1918

Query: 2255 GSSMQGNADQAGANLKKPEGHSGITLGRTLYR 2286
             + +   A  AGA    P   S +  G T  R
Sbjct: 1919 AARLD-RAALAGAGAALPALFSQLAAGPTRRR 1949