Pairwise Alignments
Query, 2542 a.a., erythronolide synthase (RefSeq) from Shewanella amazonensis SB2B
Subject, 2553 a.a., Beta-ketoacyl synthase (RefSeq) from Dinoroseobacter shibae DFL-12
Score = 751 bits (1938), Expect = 0.0
Identities = 505/1424 (35%), Positives = 733/1424 (51%), Gaps = 152/1424 (10%)
Query: 23 IAIVGMASLFANSRYLNDFWDLICDKIDAITEVPADRWQIDDYFDADKRSPDKSYCKRGG 82
IAI G+ ++ +R +W+ I D +DAI EVP RW YFD ++ +PDK Y K GG
Sbjct: 695 IAITGVGTILPKARDFAAYWENILDAVDAIEEVPERRWDWRRYFDENRDAPDKIYSKWGG 754
Query: 83 FIPQVDFNPMEFGLPPNILELTDSAQLLSLIVAKEVLEDAGVSENSAHD---RDKIGITL 139
F+ ++DFNP+++G+PP + + QLL+L ++ LE+AG + D R K + +
Sbjct: 755 FLDEIDFNPVKYGIPPKTMPSIEPLQLLALETVRQALENAGFKDGVIEDAELRRKTSVII 814
Query: 140 GIGGGQ-KISQSLNARLQYPVLKKVFRESGISDADSEMLIRKFQDQYIHWEENSFPGSLG 198
G+GGG + Q R P + E ++DA + W E+SFPG L
Sbjct: 815 GVGGGAGPLGQRYAVRSSMPAINGAMTE--VADA-----------RLPTWTEDSFPGILL 861
Query: 199 NVIAGRIANRFDLGGMNCVVDAACAGSLAAIRMALTELTEGRADMMLTGGACTDNSAYMY 258
NVIAGR+ANRFDLGG+N VDAAC SLAA+ MA EL +DM++ GGA + + + +
Sbjct: 862 NVIAGRVANRFDLGGVNFTVDAACGSSLAAVMMASRELENHTSDMVIVGGADSFQNPFDF 921
Query: 259 MSFSKTPAFTVDEQIKPFDADSKGMMIGEGIGMVALKRLEDAERDGDKIYAVIKGVGASS 318
++FSKT A + + + FDA + G+ I EG+ M+ L+RL+ AE GD+IYAV++GV SS
Sbjct: 922 VAFSKTRALSPRGRCRTFDASADGIAISEGLAMMVLRRLDAAEAAGDRIYAVLRGVAGSS 981
Query: 319 DGKFKSIYAPRPEGQAKALRRAYDDAGFPAHTLGLMEAHGTGTAAGDVAEFSGLSLVMGE 378
DGK S+ APR EGQ +ALRRAY AG T+G +EAHGTGT GD E LS V E
Sbjct: 982 DGKDLSLTAPRAEGQQEALRRAYAHAGISPGTVGAVEAHGTGTVVGDRTEIQSLSKVFAE 1041
Query: 379 SSDETQHIALGSIKSQVGHTKSTAGTAGLIKAALALHHKVLPPTINVNKPNPKLNIEASP 438
+ D+ Q +GS+KS +GHTK+ AG AG+IK A+ALHH+VLP T+NV +PNP + SP
Sbjct: 1042 ARDDRQFCGVGSVKSMIGHTKAAAGCAGMIKMAMALHHRVLPATLNVTEPNPSADFPNSP 1101
Query: 439 FYLSTETRPWLPRPDGTPRRAAVSSFGFGGTNFHLVMEEYQRDH---GRTPYRLRSTQVP 495
FY+ TETRPWL P TPRRA VS+FGFGGTNFH+V+EEY + + P+R T
Sbjct: 1102 FYVLTETRPWL-NPTDTPRRAGVSAFGFGGTNFHVVLEEYTGGYLPRHQAPFRRDWTHEL 1160
Query: 496 LLFAAPSREALSNDLKALCERLSNTEETFETLTAPFTLKGEPPKAEWPRLGIVAANAKAL 555
+F+A S+ L++ LK ++ +L + R IVA + +
Sbjct: 1161 FVFSAASQTDLADALKRASAAMAQAPSGVRAADVAASLAKRFDPSAKARFAIVAGSLEDA 1220
Query: 556 KACLEDAIEKLATSSDDWHTQD---MSFRAQAMAKNTRVAALFAGQGSQYLGMGGELAML 612
A + A E L + + D + D F A+A +VA LF GQGSQY GM +L M
Sbjct: 1221 SARIARAAEGLRSDAGDLRSVDPMGAFFSAEAPVTPEQVAFLFPGQGSQYPGMAADLTMT 1280
Query: 613 YPEMRAEFIAADEVFHQRGYPGRHGTGELSSHVFPIPKFDSDARKQDEEALTNTRIAQSA 672
+P++R + AA R LS +FP P D + R EAL T +AQ A
Sbjct: 1281 FPQVREDLEAATRTLSAR------LDTPLSERIFPRPTLDPEERDAQIEALKRTDVAQPA 1334
Query: 673 IGVVSMGQFEILKAAGLTPDAVAGHSFGELSALRAAGVIDQASYYRLAFARGDAMASVPK 732
IG VS+ ++++ GL +AGHSFGE +AL AAG D A+ LA ARGDA+
Sbjct: 1335 IGAVSLALLNLVRSFGLEAHRMAGHSFGEYTALHAAGSFDAATLLGLAHARGDAIVQA-G 1393
Query: 733 GKDAGTMAAVILPDASHRSTLDTLLTQHESVVIANHNSPTQLVLAGPTDAVKQLVQALAD 792
G D GTMAAV + R+ L V +AN N+P Q V+AGPT AV Q L+
Sbjct: 1394 GDDLGTMAAVNAGPEAVRAALG----DAPEVTLANMNAPDQTVIAGPTQAVLAAEQRLSA 1449
Query: 793 KGIRAIALPVSGAFHTPLVGHAHAPFAKAIDKESFSDAHAVLYANASGDKRPTDGKSLKQ 852
G+ A LPV+ FH+ V A A A++ + V+YANA+ P + ++
Sbjct: 1450 AGLSARLLPVACGFHSDCVAPARDRLAAALETAEIAAPGRVVYANATAQVYPEVPEDVRA 1509
Query: 853 SLKAQMLEQVQFESQIESLYRDGVRVFIEFGPKNTLSRLVDAILGERAKACLILSLDAQA 912
L +++ V F + +++ G R+F+E GP LSRL + IL ++ L + ++
Sbjct: 1510 QLARHLVDPVDFLGSVRAMHDAGARLFLEIGPGAVLSRLTNRILEDKPHLALTADMKGRS 1569
Query: 913 --------VGSQGRADSKLKLAAV-------ELATAGFAITNPDPYREQLSHKAMPKSPL 957
+G A ++ LA + +L G+ ++ P+ P+ +
Sbjct: 1570 GIQQFLCLLGGSAAAGLEIDLARLWDGRETRDLDVTGWNLSLPED----------PQRAM 1619
Query: 958 TVKLSASNYLSPATAARMQASLKDGQISKQ---TQIVEKIVEKTQYVPKAAPAQPAPAVQ 1014
KL A+N A DG ++ ++ E + +T VP PA A
Sbjct: 1620 LWKLDAAN-----------ARPIDGVPPRKGFAARLEEDPMPQTAPVPTPPPAAAPAASA 1668
Query: 1015 TTAASEQTSPAPT---AGAGTNVGTGTLEALFAAQQQLAALHQQFLTIPAQYGEGVQALM 1071
A + PAP AG T +G + A + HQ+ + A++ + +A+M
Sbjct: 1669 DPAQLDAPRPAPVVAPAGPATALGAASQPVSAALADSVMKRHQELM---AKFLDNNRAVM 1725
Query: 1072 QKQLELASAGLPVPAATERALELFHQHQADTLKIHSDFMRAQVLGSEQMLSALSGQTLVS 1131
+ L +AG P + +
Sbjct: 1726 MQWL---AAGQAAPG------------------------------------------VAA 1740
Query: 1132 QAPQTAAAVVAAPVAAASQVMAAPVVKAPEAPVTAPVAAQ---VAAPMPAPAMVIPAAAS 1188
P AA APV V AP AP AP AAQ VA P P P +P A
Sbjct: 1741 PMPVPHAAAPVAPVPTPPAVAPAPAPSPAPAPQAAPAAAQPQPVATPAPVP---VPEPA- 1796
Query: 1189 VAALPIQDIMLQVVAAKTGYPTEMLDLSMDMEADLGIDSIKRVEILGTVQDELPTLPELD 1248
++ + D +L +++ +TGYPT+MLD +++EADLG+DSIKRVEILG ++ +L LP+
Sbjct: 1797 LSETAVTDALLALISDRTGYPTDMLDPDLNLEADLGVDSIKRVEILGALRGDL--LPDAG 1854
Query: 1249 AAT------LAECRTLEDIVAYMHKVAG--TSPVTAATSH--SQAVPTPVSASADITAVM 1298
A ++ RT+ IVA +V +P TA + A TP + +T +
Sbjct: 1855 EAAREKMGPVSRERTVRGIVAKFMEVVAEFATPATAPAPEVAASAPATPALSETAVTDAL 1914
Query: 1299 LKVVADKTGYPTEMLDLAMDMEADLGIDSIKRVEILGTVQDELPMLPELDAAT------L 1352
L +++D+TGYPT+MLD +++EADLG+DSIKRVEILG ++ +L LP+ A +
Sbjct: 1915 LALISDRTGYPTDMLDPDLNLEADLGVDSIKRVEILGALRGDL--LPDAGEAAREKMGPV 1972
Query: 1353 AECRTLEDIVAYMHSMTGAAVSQAPVSQTAAPASHQAAHSSSDI 1396
+ RT+ IVA + + A AA A+ AA + + +
Sbjct: 1973 SRERTVRGIVAKFMEVVAEFTAPATAPAPAAAATPVAAQAEAPL 2016
Score = 273 bits (698), Expect = 3e-76
Identities = 253/819 (30%), Positives = 369/819 (45%), Gaps = 106/819 (12%)
Query: 1473 AAVSQAAVSQVAAQGATQSTQNSSDITAVMLNVVADKTGYPAEMLELAMDMEADLGIDSI 1532
AA V+ A + + + +T +L +++D+TGYP +ML+ +++EADLG+DSI
Sbjct: 1777 AAAQPQPVATPAPVPVPEPALSETAVTDALLALISDRTGYPTDMLDPDLNLEADLGVDSI 1836
Query: 1533 KRVEILGTVQ-DALPGLPEIDPSTLAEC---RTLGDIIACYGTDGAQDATDNGKAEAQQT 1588
KRVEILG ++ D LP E + RT+ I+A +
Sbjct: 1837 KRVEILGALRGDLLPDAGEAAREKMGPVSRERTVRGIVAKF------------------- 1877
Query: 1589 EADADTGIEVEVDIAVSALAAAQDIVASESATASAFESDNATAAAAAATLPTPTPQQVLD 1648
+EV + A A A A ++ AS AT + E+ V D
Sbjct: 1878 -------MEVVAEFATPATAPAPEVAASAPATPALSET------------------AVTD 1912
Query: 1649 TMLTVVAEKTGYPVEMLDLAMDMEADLGIDSIKRVEILGTVQ-ERLPGLAEV---DAATL 1704
+L +++++TGYP +MLD +++EADLG+DSIKRVEILG ++ + LP E +
Sbjct: 1913 ALLALISDRTGYPTDMLDPDLNLEADLGVDSIKRVEILGALRGDLLPDAGEAAREKMGPV 1972
Query: 1705 AECRTLGQIVESFSLPNQYVGTDASTDTELAPHTGVALKK---------------LQAAD 1749
+ RT+ IV F A+ A T VA + + +A
Sbjct: 1973 SRERTVRGIVAKFMEVVAEFTAPATAPAPAAAATPVAAQAEAPLAVDPDSWRPRFIMSAR 2032
Query: 1750 RLEAPSATGLFAAKGRVIILDDGHNAGV---LAGRLDAKGHAVTVIRCDSLGHQSVLDAS 1806
+ AP+A I+ DD AGV +A L ++G V ++ + LD S
Sbjct: 2033 PVPAPAAENWIVPGATYILTDD--EAGVAEAVAAHLQSQGAGVRLL------SPATLDFS 2084
Query: 1807 IDARTLSQGGDMDTEIQSL--IKALEPVSAFIHLQPVMAADDGAADVKATARFSDEAFSQ 1864
DA + +MD + + + L P F M D A V R AF
Sbjct: 2085 DDAPLRAAVREMDGAVAGVFHLAPLRPEPLF----EEMDRDAWRASVDRCTR----AF-- 2134
Query: 1865 VSLAFLFAKHLAADFAAEGAHRRAFITAARMDGKLGLSGADVELNQA-ALFGLTKTLAQE 1923
SL + L+A A + A+ M G G G A GL KT+A+E
Sbjct: 2135 YSLLNELGEGLSARTDA------VVVCASAMGGAFGFDGTVPAAPAAGGAPGLLKTVAKE 2188
Query: 1924 WPHTHCRALDVAAQLDATSLADAVIDALYGADDLLEWGI---AADGRFAALATDAQQISA 1980
W CRA+D A L+A A+ V+ D +E G A G FA A +
Sbjct: 2189 WLDVQCRAVDFAPALEAARKAELVLAEAGFRDAPVEIGYLDEARHGLFAEPAPLGAEDPV 2248
Query: 1981 KTALNSTDKILVTGGAKGVTLDCALALAARTHAHFILAGRSKALSLNEFPVWAKGVAATE 2040
L +LVTGGA+G+T A LA HF+LAG + E P A
Sbjct: 2249 TLDLPPGAVVLVTGGARGITAKIARHLAELHKPHFVLAGSTPPPEGPEAPEIAGIAEDRA 2308
Query: 2041 LKQAAIQELLAGGKRPTPKEVDALIAPLASALEIQQALQAFSDLGASAEYLSMDVSSAES 2100
LK A I A G+ TP ++A A +I+ A+ A + GA+AEY++ DV ++
Sbjct: 2309 LKAALIAAAKAAGRPITPAAIEADYRATLKARDIRSAMAAIAAAGATAEYVACDVRDQDA 2368
Query: 2101 IAKALGPIQA-IAPVTGLIHGAGVLADKFIQDKTLDELKRVAGTKVDGLKGLLANL--DG 2157
+ + I A + G++HGAGV+ DK + DKT++ V TK + L L +G
Sbjct: 2369 LEAMVADIYARHGRIDGVLHGAGVIEDKLVLDKTVESFDNVTRTKTESAFALSRALRPEG 2428
Query: 2158 LKLVALFSSAAGFYGNKGQSDYAMANEILNKAAHRLAHAKPDCRVVAFDWGPWD-GGMVT 2216
LK + F+S AG +GN+GQ DY ANE ++K A R+ A+ RV A WGPWD GGMV+
Sbjct: 2429 LKFLVFFTSVAGRFGNRGQGDYGAANETVSKLA-RVLDARWPGRVTAVSWGPWDSGGMVS 2487
Query: 2217 DSLKKMFQERGVYVIPRPLGA-ALFAEAVLGRAESQILV 2254
+K F + I LG AL E GRA + +V
Sbjct: 2488 AEIKAQFDAMNIEPIDPRLGVRALEFEITRGRASAPEVV 2526
Score = 146 bits (369), Expect = 4e-38
Identities = 124/379 (32%), Positives = 181/379 (47%), Gaps = 43/379 (11%)
Query: 1134 PQTAAAVVAAPVAAASQVMAAPVVKAPEAPVTAPVAAQVAAPMPAPAMVIPAAASVAALP 1193
PQTA P AA P A A + AP A V AP PA + AA+ +
Sbjct: 1650 PQTAPVPTPPPAAA-------PAASADPAQLDAPRPAPVVAPA-GPATALGAASQPVSAA 1701
Query: 1194 IQDIML---QVVAAK--TGYPTEMLDLSMDMEADLGIDSIKRVEILGTVQDELPTLPELD 1248
+ D ++ Q + AK M+ +A G+ + V +PT P
Sbjct: 1702 LADSVMKRHQELMAKFLDNNRAVMMQWLAAGQAAPGVAAPMPVPHAAAPVAPVPTPP--- 1758
Query: 1249 AATLAECRTLEDIVAYMHKVAGTSPVTAATSHSQAVPTPVSASADITAVMLKVVADKTGY 1308
+A A A P AT VP P + +T +L +++D+TGY
Sbjct: 1759 --AVAPAPAPSPAPAPQAAPAAAQPQPVATPAPVPVPEPALSETAVTDALLALISDRTGY 1816
Query: 1309 PTEMLDLAMDMEADLGIDSIKRVEILGTVQDELPMLPELDAAT------LAECRTLEDIV 1362
PT+MLD +++EADLG+DSIKRVEILG ++ +L LP+ A ++ RT+ IV
Sbjct: 1817 PTDMLDPDLNLEADLGVDSIKRVEILGALRGDL--LPDAGEAAREKMGPVSRERTVRGIV 1874
Query: 1363 AYMHSMTG--AAVSQAPVSQTAAPASHQAAHSSSDITPVMLKVVADKTGYPAEMLDLAMD 1420
A + A + AP + AA A A S + +T +L +++D+TGYP +MLD ++
Sbjct: 1875 AKFMEVVAEFATPATAPAPEVAASAPATPALSETAVTDALLALISDRTGYPTDMLDPDLN 1934
Query: 1421 MEADLGIDSIKRVEILGTVQDELPTLPELDAAT------LAECRTLADIVAYMHSMTG-- 1472
+EADLG+DSIKRVEILG ++ +L LP+ A ++ RT+ IVA +
Sbjct: 1935 LEADLGVDSIKRVEILGALRGDL--LPDAGEAAREKMGPVSRERTVRGIVAKFMEVVAEF 1992
Query: 1473 -----AAVSQAAVSQVAAQ 1486
A AA + VAAQ
Sbjct: 1993 TAPATAPAPAAAATPVAAQ 2011
Score = 123 bits (309), Expect = 4e-31
Identities = 74/189 (39%), Positives = 114/189 (60%), Gaps = 11/189 (5%)
Query: 1371 AAVSQAPVSQTAAPASHQAAHSSSDITPVMLKVVADKTGYPAEMLDLAMDMEADLGIDSI 1430
AA PV+ A + A S + +T +L +++D+TGYP +MLD +++EADLG+DSI
Sbjct: 1777 AAAQPQPVATPAPVPVPEPALSETAVTDALLALISDRTGYPTDMLDPDLNLEADLGVDSI 1836
Query: 1431 KRVEILGTVQDELPTLPELDAAT------LAECRTLADIVAYMHSMTG--AAVSQAAVSQ 1482
KRVEILG ++ +L LP+ A ++ RT+ IVA + A + A +
Sbjct: 1837 KRVEILGALRGDL--LPDAGEAAREKMGPVSRERTVRGIVAKFMEVVAEFATPATAPAPE 1894
Query: 1483 VAAQGATQSTQNSSDITAVMLNVVADKTGYPAEMLELAMDMEADLGIDSIKRVEILGTVQ 1542
VAA + + +T +L +++D+TGYP +ML+ +++EADLG+DSIKRVEILG ++
Sbjct: 1895 VAASAPATPALSETAVTDALLALISDRTGYPTDMLDPDLNLEADLGVDSIKRVEILGALR 1954
Query: 1543 -DALPGLPE 1550
D LP E
Sbjct: 1955 GDLLPDAGE 1963
Score = 70.1 bits (170), Expect = 5e-15
Identities = 49/143 (34%), Positives = 74/143 (51%), Gaps = 7/143 (4%)
Query: 1603 AVSALAAAQDIVASESATASAFESDNATAAAAAATLPTPTPQQVLDTMLTVVAEKTGYPV 1662
AV+ A A ++A A+A AT A P + V D +L +++++TGYP
Sbjct: 1759 AVAPAPAPSPAPAPQAAPAAAQPQPVATPAPVPVPEPALSETAVTDALLALISDRTGYPT 1818
Query: 1663 EMLDLAMDMEADLGIDSIKRVEILGTVQ-ERLPGLAEV---DAATLAECRTLGQIVESFS 1718
+MLD +++EADLG+DSIKRVEILG ++ + LP E ++ RT+ IV F
Sbjct: 1819 DMLDPDLNLEADLGVDSIKRVEILGALRGDLLPDAGEAAREKMGPVSRERTVRGIVAKFM 1878
Query: 1719 LPNQYVGTDASTDTELAPHTGVA 1741
+ V A+ T AP +
Sbjct: 1879 ---EVVAEFATPATAPAPEVAAS 1898
Score = 29.3 bits (64), Expect = 0.010
Identities = 40/155 (25%), Positives = 58/155 (37%), Gaps = 26/155 (16%)
Query: 1877 ADFAAEGAHRRAFITAARMDGKLGL---SGADVELNQAALFGLTKT-----LAQEWPHTH 1928
AD AA R AA+ G+ GL SG+ E A +++ + Q+
Sbjct: 39 ADAAAPAVRRALTDVAAKARGRWGLKLSSGSAAEFVAGAAQSVSEPACVILVPQDATSLA 98
Query: 1929 CRALDVAAQLDATSLADAVIDALY-------GADDLLEWGIAADGRFA-----------A 1970
C V A + S+ +ID + G D ++ G A GR
Sbjct: 99 CAVDAVRAAVPDASVLVELIDTTFLAAAEAAGVDGVVAKGHEAGGRVGDETTFLLLQRLT 158
Query: 1971 LATDAQQISAKTALNSTDKILVTGGAKGVTLDCAL 2005
ATD I+A +T L GA+G+ LD L
Sbjct: 159 KATDLPVIAAGGVSVNTAAALKVAGARGILLDWPL 193