Pairwise Alignments

Query, 590 a.a., SmdA family multidrug ABC transporter permease/ATP-binding protein from Rahnella sp. WP5

Subject, 1194 a.a., Probable transmembrane multidrug efflux pump from Mycobacterium tuberculosis H37Rv

 Score =  283 bits (723), Expect = 4e-80
 Identities = 193/563 (34%), Positives = 287/563 (50%), Gaps = 11/563 (1%)

Query: 8   GWYFRREWRRYLGAVALLVIIAVLQLLPPKLVGVIIDGVTSKQMSYGVLFAWLGLMLGTA 67
           G+  R      LG  A L    +  L+P     VI D + +    +  L  W  +++  A
Sbjct: 11  GYVMRHRRDLLLGFGAALAGTVIAVLVPLVTKRVIDDAIAA---DHRPLAPWAVVLVAAA 67

Query: 68  VVVYLLRYVWRVLLFGASYQLAVELRQDFFRQLSRQHPAFYLRHRTGDLIARATNDVDRV 127
              YLL YV R      ++ +  +LR D F+ L R       R  +G LI R TND+  V
Sbjct: 68  GATYLLMYVRRYYGGRIAHLVQHDLRMDAFQALLRWDGRQQDRWSSGQLIVRTTNDLQLV 127

Query: 128 VFAAGE--GVLTLVDSLVMGLAVLIVMATQISWELTLLSLVPMPVMAIIIKRYGDQLHSR 185
                +   VL  V +L++G+AV+    T +S  L LL+++ +PV+ +I  R    L + 
Sbjct: 128 QALLFDVPNVLRHVLTLLLGVAVM----TWLSVPLALLAVLLVPVIGLIAHRSRRLLAAA 183

Query: 186 FKTAQAAFSSLNDQAQESLTSIRMIKAFGLENHQSSQFADVAADTGAKNMRVARVDARFD 245
              AQ   +++      ++  IR++KAFG E  ++ +    +    A  +RVAR++A F 
Sbjct: 184 THCAQEHKAAVTGVVDAAVCGIRVVKAFGQEERETVKLVTASRALYAAQLRVARLNAHFG 243

Query: 246 PTIYVSIGMANLLAIGGGSWMVVNGHLTLGELTSFVMYLGLMIWPMLALAWMFNIVERGS 305
           P +     +  +     G WM   G +T+G   +F   L L+  P   LA M  I ++  
Sbjct: 244 PLLQTLPALGQMAVFALGGWMAAQGSITVGTFVAFWACLTLLARPACDLAGMLTIAQQAR 303

Query: 306 AAYSRIRSLLQEAPAVVDGTTPL-PAGRATLEAHINDFHYPENSHAALTTVTFSLQPGQM 364
           A   R+  L+   P +VDGT PL P  R +LE     F Y  +    L  ++ S++ G+ 
Sbjct: 304 AGAVRVLELIDSRPTLVDGTKPLSPEARLSLEFQRVSFGYVAD-RPVLREISLSVRAGET 362

Query: 365 LGLCGPTGSGKSTLLSLLQRQFDVTDGDVCYHGLSLKEIQLDDWRARLAVVSQTPFLFSD 424
           L + G  GSGKSTL SL  R +DVT G V   G  ++E+ LD  R+ + +V +   LFS 
Sbjct: 363 LAVVGAPGSGKSTLASLATRCYDVTQGAVRIGGQDVRELTLDSLRSAIGLVPEDAVLFSG 422

Query: 425 TVAQNIALGRPDATQEEIEEAARLASVHDDILRLPQGYETEVGERGVMLSGGQKQRISIA 484
           T+  NIA GRPDAT E+I  AAR A + + +  LP GY+T VG RG+ LSGGQ+QRI++A
Sbjct: 423 TIGANIAYGRPDATPEQIATAARAAHIEEFVNTLPDGYQTAVGARGLTLSGGQRQRIALA 482

Query: 485 RALLLKAEILILDDALSAVDGRTEHQILHNLRQWGSDRTVIISAHRLSALTEASEILVFS 544
           RALL +  +LI+DD  SAVD   E  I   LR+  +DRT +I   R S LT A  + V  
Sbjct: 483 RALLHQPRLLIMDDPTSAVDAVIECGIQEVLREAIADRTAVIFTRRRSMLTLADRVAVLD 542

Query: 545 QGSISQRGNHDQLAAEAGWYRDM 567
            G +   G  D++      YR++
Sbjct: 543 SGRLLDVGTPDEVWERCPRYREL 565



 Score =  223 bits (569), Expect = 3e-62
 Identities = 165/560 (29%), Positives = 263/560 (46%), Gaps = 12/560 (2%)

Query: 12   RREWRRYLGAVALLVIIAVLQ----LLPPKLVGVIID-GVTSKQMSYGVLFAWLGLMLGT 66
            RR  R + G +AL +++  +Q    LLPP L+   ID G+    +S      W   + GT
Sbjct: 617  RRLLREFRGPLALSLLLVAVQTCAGLLPPLLIRHGIDVGIRRHVLSA----LWWAALAGT 672

Query: 67   AVVVYLLRYVWRVLLFGA--SYQLAVELRQDFFRQLSRQHPAFYLRHRTGDLIARATNDV 124
            A VV      W   +       Q+   LR   F    R     +       ++   T DV
Sbjct: 673  ATVVIRWVVQWGSAMVAGYTGEQVLFRLRSVVFAHAQRLGLDAFEDDGDAQIVTAVTADV 732

Query: 125  DRVVFAAGEGVLTLVDSLVMGLAVLIVMATQISWELTLLSLVPMPVMAIIIKRYGDQLHS 184
            + +V     G++  V S+V  + +L+ +   I   L LL    MPV+A+   ++    + 
Sbjct: 733  EAIVAFLRTGLVVAVISVVTLVGILVALLA-IRARLVLLIFTTMPVLALATWQFRRASNW 791

Query: 185  RFKTAQAAFSSLNDQAQESLTSIRMIKAFGLENHQSSQFADVAADTGAKNMRVARVDARF 244
             ++ A+    ++    +E    +R+ +AF  E      +   + D     +R  R+ A +
Sbjct: 792  TYRRARHRLGTVTATLREYAAGLRIAQAFRAEYRGLQSYFAHSDDYRRLGVRGQRLLALY 851

Query: 245  DPTIYVSIGMANLLAIGGGSWMVVNGHLTLGELTSFVMYLGLMIWPMLALAWMFNIVERG 304
             P + +   +A  L +  G+  V  G +++G L ++++Y+ L+  P+  LA MF+  +R 
Sbjct: 852  YPFVALLCSLATTLVLLDGAREVRAGVISVGALVTYLLYIELLYTPIGELAQMFDDYQRA 911

Query: 305  SAAYSRIRSLLQEAPAVVDGTTPLPAGRATLEAHINDFHYPENSHAALTTVTFSLQPGQM 364
            + A  RIRSLL           P+   R  +      + Y      AL  +   +  GQ 
Sbjct: 912  AVAAGRIRSLLSTRTPSSPAARPVGTLRGEVVFDAVHYSYRTREVPALAGINLRIPAGQT 971

Query: 365  LGLCGPTGSGKSTLLSLLQRQFDVTDGDVCYHGLSLKEIQLDDWRARLAVVSQTPFLFSD 424
            +   G TGSGKSTL+ L+ R +D T G V   G  L+E  +D +R RL +V+Q  ++F+ 
Sbjct: 972  VVFVGSTGSGKSTLIKLVARFYDPTHGTVRVDGCDLREFDVDGYRNRLGIVTQEQYVFAG 1031

Query: 425  TVAQNIALGRPDATQEEIEEAARLASVHDDILRLPQGYETEVGERGVMLSGGQKQRISIA 484
            TV   IA GRPDAT  ++E AAR    H  I  L  GY  +V   G  LS GQ Q +++A
Sbjct: 1032 TVRDAIAYGRPDATDAQVERAAREVGAHPMITALDNGYLHQVTAGGRNLSAGQLQLLALA 1091

Query: 485  RALLLKAEILILDDALSAVDGRTEHQILHNLRQWGSDRTVIISAHRLSALTEASEILVFS 544
            RA L+  +IL+LD+A  A+D  TE  +        + RT +I AH L+    A  I+V  
Sbjct: 1092 RARLVDPDILLLDEATVALDPATEAVVQRATLTLAARRTTLIVAHGLAIAEHADRIVVLE 1151

Query: 545  QGSISQRGNHDQLAAEAGWY 564
             G++ + G H +L A  G Y
Sbjct: 1152 HGTVVEDGAHTELLAAGGHY 1171