Pairwise Alignments

Query, 994 a.a., Glutamate-ammonia-ligase adenylyltransferase GlnE (glutamine-synthetase adenylyltransferase) from Mycobacterium tuberculosis H37Rv

Subject, 948 a.a., [glutamate--ammonia-ligase] adenylyltransferase from Vibrio cholerae E7946 ATCC 55056

 Score =  234 bits (596), Expect = 3e-65
 Identities = 249/894 (27%), Positives = 399/894 (44%), Gaps = 128/894 (14%)

Query: 86  SLRGRLFSVLGSSLALGDHLVAHPQSWKLLRGKVTLPSHDQLQRS-----FVECVEESEG 140
           S+  +L  VLG S  +   L       ++L   +  PS +Q  RS       EC +E+  
Sbjct: 31  SVLNQLRYVLGLSQFVAQTLQRDDPLCQVLPSLLAKPSREQYYRSELAQWLAECQDEAVA 90

Query: 141 MPGSLVHRLRTQYRDYVLMLAALDLAATVEDEPVLPFTVVAARLADAADAALAAALRVAE 200
                  RLR      ++ +A  D  A+   E  L      + L+  A+A +  + +   
Sbjct: 91  QK-----RLRQFRNQEMVYIAWRDFCASWTLEESL------SHLSQLAEALIFESYQWLY 139

Query: 201 ASVCGEHPPP--------RLAVIAMGKCGARELNYVSDVDVIFVAERSDPRNARVASEMM 252
              C E   P         + +I MGK G  ELN+ SD+D+IF      P N        
Sbjct: 140 QRCCLEMGTPCNAQGEAQPMLIIGMGKLGGGELNFSSDIDLIFTY----PENGETQGARR 195

Query: 253 RVASAAFF---------------------EVDAALRPEGRNGELVRTLESHIAYYQRWAK 291
            +A+A FF                      VD  LRP G +G L  +  +   YYQ   +
Sbjct: 196 SIANAQFFTRLGQRLIKLLDQSTPDGFCYRVDMRLRPFGDSGPLAMSYAALEDYYQEQGR 255

Query: 292 TWEFQALLKARPVVGDAELGERYLTA---LMPMVWRACEREDFVVEVQAMRRRVEQLVPA 348
            WE  A++KAR  V   E+  +Y      L P V+R     DF   +Q++RR ++ ++ +
Sbjct: 256 DWERYAMIKAR--VMGREMYPQYQELRQMLRPFVFR--RYIDFSA-IQSLRR-MKSMISS 309

Query: 349 DVRGREL----KLGSGGLRDVEFAVQLLQLVHARSDESLRVASTVDALAALGEGGYIGRE 404
           +VR R L    KLG+GG+R+VEF  Q+ QL+    + SLR    ++ L A+ E   + RE
Sbjct: 310 EVRRRGLSNNIKLGAGGIREVEFIAQVFQLIRGGREPSLRKRGLLETLDAIAELELLTRE 369

Query: 405 DAANMTASYEFLRLLEHRLQLQRLKRTHLLPDPEDEEAVRWLARAAHIRPDGRNDA---- 460
              ++  +Y FLR LE+ LQ    K+T  LPD ED++    +A      P  + +     
Sbjct: 370 QVQDLRDAYRFLRRLENLLQAMADKQTQTLPDKEDDQLRLSIAIGLADWPSLQREVSEHM 429

Query: 461 -------AGVLREELKKQNVRVSKLHTKLF---YQP-LLESIGPTGLEIAHGMTLEAAGR 509
                  A ++ EE +++   V++   +L+   ++P ++E I      I   + L  AG 
Sbjct: 430 QRVHRVFATLIGEEDEEEEHTVARHFHELWDMAHKPEVIEHI------IEQDLGLSDAGE 483

Query: 510 RLAALGYEGPQTALKHMSALVNQSGRRGR-VQSVLLPRLLDWMSYAPDPDGGLLAYRRLS 568
           ++  +       A + +       G RGR V + L+P++   +   PD + GL     L 
Sbjct: 484 QIRTITQFKDDLAKRTI-------GPRGREVLNRLMPKVYQAVFAHPDAEFGLSRVLALL 536

Query: 569 EALATESWYLATLRDKPAVAKRLMHVLGTSAYVPDLLMRAPRVIQQYEDGPA--GPKLLE 626
            ++AT + YL  L + PA   +L+ +   S  + + L R P ++ +  D      P  LE
Sbjct: 537 HSIATRTTYLELLDEHPAALVQLVRLCTASPMISEQLARYPILLDELIDPQHLYNPIPLE 596

Query: 627 TEPAAVARALIASASRYP--DPERAIAGARTLRRRELARIGSADLLGLLEVTEVCRALTS 684
           +    +   L    +R P  D E+ + G R  ++  + RI +AD+ G+L V +V   LT 
Sbjct: 597 SYQTELRDFL----ARIPEEDMEQQMEGLRQFKQISILRIAAADIAGVLPVMKVSDHLTY 652

Query: 685 VWVAVLQAA-----LDVMIRASLPDD--DRAPAAIAVIGMGRLGGAELGYGSDADVMFV- 736
           +  A+++A      L V  +   P     R     AV+G G++GG ELGY SD D++F+ 
Sbjct: 653 LAEAIVEAVVSQAWLQVSSKYGEPTHLKHRDGRGFAVVGYGKVGGWELGYNSDLDIVFMH 712

Query: 737 -CEPATGVDDARAV---KWSTSIAERVRALLGTPSVDPPL-ELDANLRPEGRNGPLVRTL 791
            C      D  +++   ++   +A+R+  +  T +    L E+D  LRP G +G LV   
Sbjct: 713 DCPVEVNTDGEKSIDGRQFYLRLAQRIIHIFSTRTASGILYEVDTRLRPSGASGLLVSPT 772

Query: 792 GSYAAYYEQWAQPWEIQALLRAHAVAGDAELGQRFLRMVDKTRYPPDGVSADSVREIRRI 851
            ++  Y  Q A  WE QAL+RA  + GDA L Q F     +    P        RE  ++
Sbjct: 773 DAFDEYQRQEAWTWEHQALVRARMIYGDAPLQQAFANTRHQILCLP--------REEHKL 824

Query: 852 KARIESERLPRGADPNTHTKLGR-------GGLADIEWTVQLLQLQHAHQVPAL 898
           K  +   R+ +  D     K GR       GG+ DIE+  Q L L+ +HQ P L
Sbjct: 825 KQEVVEMRI-KMRDHLGGKKAGRFMLKQDEGGITDIEFLAQYLVLRFSHQQPKL 877



 Score =  115 bits (288), Expect = 1e-29
 Identities = 101/390 (25%), Positives = 174/390 (44%), Gaps = 17/390 (4%)

Query: 586 AVAKRLMHVLGTSAYVPDLLMRAPRVIQQYEDGPAGPKLLETEPAAVARALIASASRYPD 645
           +V  +L +VLG S +V   L R   + Q      A P   +   + +A+ L    +   D
Sbjct: 31  SVLNQLRYVLGLSQFVAQTLQRDDPLCQVLPSLLAKPSREQYYRSELAQWL----AECQD 86

Query: 646 PERAIAGARTLRRRELARIGSADLLGLLEVTEVCRALTSVWVAVLQAALDVM-----IRA 700
              A    R  R +E+  I   D      + E    L+ +  A++  +   +     +  
Sbjct: 87  EAVAQKRLRQFRNQEMVYIAWRDFCASWTLEESLSHLSQLAEALIFESYQWLYQRCCLEM 146

Query: 701 SLPDDDRAPAA-IAVIGMGRLGGAELGYGSDADVMFVCEPATGVDDARA----VKWSTSI 755
             P + +  A  + +IGMG+LGG EL + SD D++F          AR      ++ T +
Sbjct: 147 GTPCNAQGEAQPMLIIGMGKLGGGELNFSSDIDLIFTYPENGETQGARRSIANAQFFTRL 206

Query: 756 AERVRALLGTPSVDP-PLELDANLRPEGRNGPLVRTLGSYAAYYEQWAQPWEIQALLRAH 814
            +R+  LL   + D     +D  LRP G +GPL  +  +   YY++  + WE  A+++A 
Sbjct: 207 GQRLIKLLDQSTPDGFCYRVDMRLRPFGDSGPLAMSYAALEDYYQEQGRDWERYAMIKAR 266

Query: 815 AVAGDAELGQRFLRMVDKTRYPPDGVSADSVREIRRIKARIESERLPRGADPNTHTKLGR 874
            +  +     + LR + +       +   +++ +RR+K+ I SE   RG   N   KLG 
Sbjct: 267 VMGREMYPQYQELRQMLRPFVFRRYIDFSAIQSLRRMKSMISSEVRRRGLSNNI--KLGA 324

Query: 875 GGLADIEWTVQLLQLQHAHQVPALHNTSTLQSLDVIAAADLVPAADVELLRQAWLTATRA 934
           GG+ ++E+  Q+ QL    + P+L     L++LD IA  +L+    V+ LR A+    R 
Sbjct: 325 GGIREVEFIAQVFQLIRGGREPSLRKRGLLETLDAIAELELLTREQVQDLRDAYRFLRRL 384

Query: 935 RNALVLVRGKPTDQLPGPGRQLNAVAVAAG 964
            N L  +  K T  LP        +++A G
Sbjct: 385 ENLLQAMADKQTQTLPDKEDDQLRLSIAIG 414



 Score = 98.6 bits (244), Expect = 2e-24
 Identities = 97/340 (28%), Positives = 147/340 (43%), Gaps = 37/340 (10%)

Query: 115 LRGKVTLPSHDQLQRSFVECVEESEGMPGSLVHRLRTQYRDYVLMLAALDLAATVEDEPV 174
           L   + L S+    R F+  + E +      +  LR   +  +L +AA D+A       V
Sbjct: 589 LYNPIPLESYQTELRDFLARIPEED--MEQQMEGLRQFKQISILRIAAADIAG------V 640

Query: 175 LPFTVVAARLADAADAALAAALRVAEASVCGEHPPPR---------LAVIAMGKCGAREL 225
           LP   V+  L   A+A + A +  A   V  ++  P           AV+  GK G  EL
Sbjct: 641 LPVMKVSDHLTYLAEAIVEAVVSQAWLQVSSKYGEPTHLKHRDGRGFAVVGYGKVGGWEL 700

Query: 226 NYVSDVDVIFV----------AERS-DPRN--ARVASEMM-----RVASAAFFEVDAALR 267
            Y SD+D++F+           E+S D R    R+A  ++     R AS   +EVD  LR
Sbjct: 701 GYNSDLDIVFMHDCPVEVNTDGEKSIDGRQFYLRLAQRIIHIFSTRTASGILYEVDTRLR 760

Query: 268 PEGRNGELVRTLESHIAYYQRWAKTWEFQALLKARPVVGDAELGERYLTALMPMVWRACE 327
           P G +G LV   ++   Y ++ A TWE QAL++AR + GDA L + +      ++    E
Sbjct: 761 PSGASGLLVSPTDAFDEYQRQEAWTWEHQALVRARMIYGDAPLQQAFANTRHQILCLPRE 820

Query: 328 REDFVVEVQAMRRRVEQLVPADVRGR-ELKLGSGGLRDVEFAVQLLQLVHARSDESL-RV 385
                 EV  MR ++   +     GR  LK   GG+ D+EF  Q L L  +     L R 
Sbjct: 821 EHKLKQEVVEMRIKMRDHLGGKKAGRFMLKQDEGGITDIEFLAQYLVLRFSHQQPKLTRW 880

Query: 386 ASTVDALAALGEGGYIGREDAANMTASYEFLRLLEHRLQL 425
           +  V    +L     +    A  +T +Y  +R   HR  L
Sbjct: 881 SDNVRIFESLMNHQVMSESQALALTHAYTSMRDQIHRRNL 920