Pairwise Alignments

Query, 1231 a.a., Multifunctional alpha-ketoglutarate metabolic enzyme from Mycobacterium tuberculosis H37Rv

Subject, 998 a.a., 2-oxoglutarate dehydrogenase E1 component from Sinorhizobium meliloti 1021

 Score =  729 bits (1883), Expect = 0.0
 Identities = 405/885 (45%), Positives = 548/885 (61%), Gaps = 33/885 (3%)

Query: 369  NARVMNLIAAYRNRGHLMADTDPLRLDKARFRSHPDLEVLTHGLTLWDLDRVFKVDGFAG 428
            + R + +I AYR RGHL A  DPL L       + +L   T+G    D DR   +D   G
Sbjct: 124  SVRAIMMIRAYRMRGHLHAKLDPLGLADP-VEDYDELSPKTYGFEEKDYDRKIFIDNVLG 182

Query: 429  AQYKKLRDVLGLLRDAYCRHIGVEYAHILDPEQKEWLEQRVE--TKHVKPTVAQQKYILS 486
             +Y  +R+++ +L   YC  IGVE+ H+ +PE+K W+++R+E   K V+ T   +K IL 
Sbjct: 183  LEYATVREMVEILERTYCSTIGVEFMHMSNPEEKGWIQERIEGPDKGVEFTPEGKKAILQ 242

Query: 487  KLNAAEAFETFLQTKYVGQKRFSLEGAESVIPMMDAAIDQCAEHGLDEVVIGMPHRGRLN 546
            KL  AE FE F+  KY G KRF ++G ES+IP ++  I +  + GL E+V+GM HRGRLN
Sbjct: 243  KLIEAEGFEQFIDVKYKGTKRFGVDGGESLIPALEQIIKRGGQLGLKEIVLGMAHRGRLN 302

Query: 547  VLANIVGKPYSQIFTEFEG-NLNPSQAHGSGDVKYHLGATGLYLQMFGDNDIQVSLTANP 605
            VL+ ++ KP+  IF EF+G +  P    GSGDVKYHLGA+    + F  N + +SLTANP
Sbjct: 303  VLSQVMAKPHRAIFHEFKGGSYTPDDVEGSGDVKYHLGASSD--REFDGNKVHLSLTANP 360

Query: 606  SHLEAVDPVLEGLVRAKQDLLD---HGSIDSDGQRAFSVVPLMLHGDAAFAGQGVVAETL 662
            SHLE V+PV+ G  RAKQD +     G I    +R   V+PL+LHGDAAFAGQGVVAE L
Sbjct: 361  SHLEIVNPVVMGKARAKQDQMATVFEGDIIPLRERV-KVMPLILHGDAAFAGQGVVAEIL 419

Query: 663  NLANLPGYRVGGTIHIIVNNQIGFTTAPEYSRSSEYCTDVAKMIGAPIFHVNGDDPEACV 722
             L+ L G+RVGGT+H I+NNQIGFTT P +SRSS Y +DVAKMI APIFHVNGDDPEA V
Sbjct: 420  GLSGLRGHRVGGTVHFIINNQIGFTTNPAFSRSSPYPSDVAKMIEAPIFHVNGDDPEAVV 479

Query: 723  WVARLAVDFRQRFKKDVVIDMLCYRRRGHNEGDDPSMTNPYVYDVVDTKRGARKSYTEAL 782
            + A++A +FR +F K VVIDM CYRR GHNEGD+P+ T P +Y  +   +   + Y++ L
Sbjct: 480  YAAKVATEFRMKFHKPVVIDMFCYRRFGHNEGDEPAFTQPKMYKAIRAHKTVVQLYSDRL 539

Query: 783  IGRGDISMKEAEDALRDYQGQLERVFNEVRELEKH------GVQPSESVESDQMIPAGLA 836
            I  G IS  E E    D++  LE+ F   +  + +      G         +Q       
Sbjct: 540  IAEGLISEGEVEKMKADWRAHLEQEFEAGQSYKPNKADWLDGAWSGLRTADNQDEQRRGR 599

Query: 837  TAVDKSLLARIGDAFLALPNGFTAHPRVQPVLEKRREMAYEGK-IDWAFGELLALGSLVA 895
            T+V    L  +G     +P GF+AH  +Q  +E R  M   G+ IDWA  E LA G+LV 
Sbjct: 600  TSVPMKQLKEVGRKLSEIPAGFSAHRTIQRFMENRANMIQTGEGIDWAMAEALAFGTLVT 659

Query: 896  EGKLVRLSGQDSRRGTFSQRHSVLIDRHTGEEFTPLQLLATNSDGSPTGGKFLVYDSPLS 955
            EG  +RLSGQD  RGTFSQRHSVL D+ T E + PL  L      SPT  ++ V +S LS
Sbjct: 660  EGTKIRLSGQDCERGTFSQRHSVLYDQETEERYIPLANL------SPTQARYEVINSMLS 713

Query: 956  EYAAVGFEYGYTVGNPDAVVLWEAQFGDFVNGAQSIIDEFISSGEAKWGQLSNVVLLLPH 1015
            E A +GFEYGY++  P+A+ LWEAQFGDF NGAQ + D+FISSGE KW ++S +V LLPH
Sbjct: 714  EEAVLGFEYGYSLARPNALTLWEAQFGDFANGAQVVFDQFISSGERKWLRMSGLVCLLPH 773

Query: 1016 GHEGQGPDHTSARIERFLQLWAEGSMTIAMPSTPSNYFHLLRRHALDGIQRPLIVFTPKS 1075
            G+EGQGP+H+SAR+ERFLQL AE +M +A  +TP+NYFH+LRR      ++PLI+ TPKS
Sbjct: 774  GYEGQGPEHSSARLERFLQLCAEDNMQVANVTTPANYFHILRRQVKRDFRKPLILMTPKS 833

Query: 1076 MLRHKAAVSEIKDFT-EIKFRSVL--EEPTYEDG---IGDRNKVSRILLTSGKLYYELAA 1129
            +LRHK AVS + +   E  F  +L  +    +DG   +   +K+ R+++ SGK+YY+L  
Sbjct: 834  LLRHKRAVSSLSEMAGESSFHRLLWDDAEVIKDGPIKLQKDSKIRRVVMCSGKVYYDLLE 893

Query: 1130 RKAKDNRNDLAIVRLEQLAPLPRRRLRETLDRYENVKEFFWVQEEPANQGAWPRFGLELP 1189
             + K   +D+ ++R+EQL P P + L   L R+ N  E  W QEEP N GAW      L 
Sbjct: 894  EREKRGIDDIYLLRVEQLYPFPAKALINELSRFRNA-EMVWCQEEPKNMGAWSFIDPYLE 952

Query: 1190 ELLPD---KLAGIKRISRRAMSAPSSGSSKVHAVEQQEILDEAFG 1231
             +L     K   ++   R A ++P++G    H  +    L++A G
Sbjct: 953  WVLAHIDAKYQRVRYTGRPAAASPATGLMSKHLAQLAAFLEDALG 997



 Score = 33.1 bits (74), Expect = 1e-04
 Identities = 34/128 (26%), Positives = 47/128 (36%), Gaps = 20/128 (15%)

Query: 9   GQNEWLVEEMYRKFRDDPSSVDPSWHEFLVDYSPEPTSQPAAEPTRVTSPLVAERAAAAA 68
           G N   +E+++ ++  DPSSV   W  F    +  P                 E    AA
Sbjct: 18  GANAAYIEQLHARYEADPSSVSAEWQSFFKALADRP-----------------EDVVRAA 60

Query: 69  PQAPPKPADTAAAGNG-VVAALAAKTAVPPPAEGDEVAVLRGAAAAV--VKNMSASLEVP 125
             A  K  +     NG +V+AL           G +V      AAAV  V    A +   
Sbjct: 61  KGASWKKQNWPIPANGELVSALDGDWGTVEKVIGKKVKAKAEEAAAVAGVALSEAEVHQS 120

Query: 126 TATSVRAV 133
           T  SVRA+
Sbjct: 121 TRDSVRAI 128