Pairwise Alignments

Query, 1231 a.a., Multifunctional alpha-ketoglutarate metabolic enzyme from Mycobacterium tuberculosis H37Rv

Subject, 940 a.a., 2-oxoglutarate dehydrogenase E1 component (RefSeq) from Shewanella amazonensis SB2B

 Score =  665 bits (1715), Expect = 0.0
 Identities = 369/874 (42%), Positives = 531/874 (60%), Gaps = 42/874 (4%)

Query: 368  KNARVMNLIAAYRNRGHLMADTDPLRLDKARFRSHPDLEVLTHGLTLWDLDRVFKVDGFA 427
            K  +V+ LI AYR RGH  A+ DPL L K    +  +L+   HGLT  D+ R F    FA
Sbjct: 93   KQVKVLQLINAYRFRGHQNANLDPLELWKRD--AVVELDPAFHGLTADDMQREFNTGSFA 150

Query: 428  -GAQYKKLRDVLGLLRDAYCRHIGVEYAHILDPEQKEWLEQRVETKHVKPTVAQ--QKYI 484
             G +  KL +++  L+  YC  IG EY HI D ++K W++QR+E    +    +  +  I
Sbjct: 151  YGGETLKLGELVKALKATYCGSIGAEYMHITDTDEKRWIQQRLEPSMGRAAFDKGVKTRI 210

Query: 485  LSKLNAAEAFETFLQTKYVGQKRFSLEGAESVIPMMDAAIDQCAEHGLDEVVIGMPHRGR 544
            L  LNAAE  E +L  K+ G KRFSLEG ++++PMM   I +  E G  E+V+GM HRGR
Sbjct: 211  LEGLNAAEGMEKYLGAKFPGAKRFSLEGGDALVPMMREIIYRAGEAGTKEIVVGMAHRGR 270

Query: 545  LNVLANIVGKPYSQIFTEFEGNLNPSQAHGSGDVKYHLGATGLYLQMFGDNDIQVSLTAN 604
            LNVL N++GK  +++F EF G    +++ GSGDVKYH G +  +    G+  + ++L  N
Sbjct: 271  LNVLVNVLGKRPAELFDEFAGK--HAESSGSGDVKYHQGFSSDFETPGGN--VHLALAFN 326

Query: 605  PSHLEAVDPVLEGLVRAKQDLLDHGSIDSDGQRAFSVVPLMLHGDAAFAGQGVVAETLNL 664
            PSHLE V+PV+ G VRA+QD    G  D       SV+P+ +HGD+A AGQG+V ET N+
Sbjct: 327  PSHLEIVNPVVMGSVRARQDR--RGCKDG-----LSVMPITIHGDSAIAGQGIVQETFNM 379

Query: 665  ANLPGYRVGGTIHIIVNNQIGFTTAPEYS-RSSEYCTDVAKMIGAPIFHVNGDDPEACVW 723
            +   G+RVGG+I I+VNNQ+GFTT+  +  RS+EYCTD+AKM+ APIFHVN DDPEA  +
Sbjct: 380  SQTRGFRVGGSIRIVVNNQVGFTTSNHHDVRSTEYCTDIAKMVQAPIFHVNADDPEAVAF 439

Query: 724  VARLAVDFRQRFKKDVVIDMLCYRRRGHNEGDDPSMTNPYVYDVVDTKRGARKSYTEALI 783
            VA++AVD+R  FK+DVVID++CYRR GHNE D+PS T P +Y  +      RK Y + LI
Sbjct: 440  VAQVAVDYRNAFKRDVVIDLVCYRRHGHNEADEPSATQPLMYQKIKKHPTPRKIYADRLI 499

Query: 784  GRGDISMKEAEDALRDYQGQLER---VFNEVRELEKHGVQPSESVESDQMIPAGLATAVD 840
                +S  +    +  Y+  L++   V  E R +    V  S  +  D  +      A+ 
Sbjct: 500  AENAVSADDVTAMINGYRDALDQGDCVVKEWRPMSLRTVDWSPFIGQDWDVSYEPTVALA 559

Query: 841  KSLLARIGDAFLALPNGFTAHPRVQPVLEKRREMAYEGKI-DWAFGELLALGSLVAEGKL 899
            +  L ++ +    +P       RV  +   R  MA   K+ DW F E LA  +++ +   
Sbjct: 560  R--LQKLAEKLAYVPETHPLQSRVAKIYADRVAMAKGEKLLDWGFAETLAYATILEDNNR 617

Query: 900  VRLSGQDSRRGTFSQRHSVLIDRHTGEEFTPLQLLATNSDGSPTGGKFLVYDSPLSEYAA 959
            VR++GQDS RGTF  RH+VL +++    + PL+ LA         G   + DS LSE + 
Sbjct: 618  VRITGQDSGRGTFFHRHAVLHNQNDATTYMPLRNLAQEQ------GPVDITDSVLSEASV 671

Query: 960  VGFEYGYTVGNPDAVVLWEAQFGDFVNGAQSIIDEFISSGEAKWGQLSNVVLLLPHGHEG 1019
            + FEYGY    P  + +WEAQFGDF N AQ +ID+F+SSGE KWG+L  + +LLPHG+EG
Sbjct: 672  LAFEYGYATAEPGGLTIWEAQFGDFANCAQVVIDQFLSSGEQKWGRLCGLTMLLPHGYEG 731

Query: 1020 QGPDHTSARIERFLQLWAEGSMTIAMPSTPSNYFHLLRRHALDGIQRPLIVFTPKSMLRH 1079
            QGP+H+SAR+ERFLQL A  +M + +PSTP+  +H+LRR  +  ++RPL+V +PKS+LRH
Sbjct: 732  QGPEHSSARLERFLQLCANHNMQVCVPSTPAQVYHMLRRQVVRPLRRPLVVMSPKSLLRH 791

Query: 1080 KAAVSEIKDFTEIKFRSVLEEPTYEDGIGDRNKVSRILLTSGKLYYELAARKAKDNRNDL 1139
              AVS +++     F++V+ E    D + D   V+R++  SGK+Y+EL  R+ K+N  ++
Sbjct: 792  PLAVSSLEELANGTFQNVIGE---IDSL-DPKAVNRVVFCSGKVYFELLERRRKENLTNV 847

Query: 1140 AIVRLEQLAPLPRRRLRETLDRYENVKEFFWVQEEPANQGAW----PRFGLELPELLPDK 1195
            AI+R+EQL P P   +   L  Y++V +F W QEEP NQGAW      F   +P     K
Sbjct: 848  AIIRVEQLYPFPAEEMAAILAEYQHVTDFVWCQEEPQNQGAWYCSQHHFWAAIP-----K 902

Query: 1196 LAGIKRISRRAMSAPSSGSSKVHAVEQQEILDEA 1229
             A +    R A +AP+ G  ++HA +Q+ ++ +A
Sbjct: 903  GATLTYAGREAAAAPACGYPELHAHQQESLVVDA 936



 Score = 33.5 bits (75), Expect = 9e-05
 Identities = 13/35 (37%), Positives = 19/35 (54%)

Query: 8  FGQNEWLVEEMYRKFRDDPSSVDPSWHEFLVDYSP 42
          +G N   VEEMY  +++DP+SV   W     +  P
Sbjct: 16 YGSNATYVEEMYEAYQEDPTSVSDDWRAVFDNLPP 50