Pairwise Alignments

Query, 1231 a.a., Multifunctional alpha-ketoglutarate metabolic enzyme from Mycobacterium tuberculosis H37Rv

Subject, 985 a.a., 2-oxoglutarate dehydrogenase E1 component SucA from Phaeobacter inhibens DSM 17395

 Score =  727 bits (1877), Expect = 0.0
 Identities = 404/893 (45%), Positives = 554/893 (62%), Gaps = 38/893 (4%)

Query: 355  VRWSTDNPDSIVDKNARVMNLIAAYRNRGHLMADTDPLRLDKARFRSHPDLEVLTHGLTL 414
            V  + D     V  + R + LI AYR RGHL A+ DPL + +     HP+L+  T+G T 
Sbjct: 108  VEVTDDQVQRAVLDSIRALMLIRAYRIRGHLAANLDPLGMREEA--QHPELDPRTYGFTE 165

Query: 415  WDLDRVFKVDGFAGAQYKKLRDVLGLLRDAYCRHIGVEYAHILDPEQKEWLEQRVE--TK 472
             D+DR   +D   G Q   +R ++ +++  YC    ++Y HI DPEQ  WL++R+E   K
Sbjct: 166  ADMDRPIFIDNVLGLQVASMRQIVSIVKRTYCGTFALQYMHISDPEQASWLKERIEGYDK 225

Query: 473  HVKPTVAQQKYILSKLNAAEAFETFLQTKYVGQKRFSLEGAESVIPMMDAAIDQCAEHGL 532
             +  T   +K IL+K+  AE FE FL  KY+G KRF L+G ES+IP M+  I +    G+
Sbjct: 226  EITFTREGRKAILNKMVEAEGFEKFLHVKYMGTKRFGLDGGESLIPAMEQIIKRGGALGI 285

Query: 533  DEVVIGMPHRGRLNVLANIVGKPYSQIFTEFEG-NLNPSQAHGSGDVKYHLGATGLYLQM 591
             ++VIGMPHRGRL+VLAN++ KPY  IF EF+G +  P    GSGDVKYHLGA+    + 
Sbjct: 286  RDIVIGMPHRGRLSVLANVMQKPYKAIFNEFQGGSFKPEDVDGSGDVKYHLGASSD--RE 343

Query: 592  FGDNDIQVSLTANPSHLEAVDPVLEGLVRAKQDLLDHGSIDSDGQRAFSVVPLMLHGDAA 651
            F  N + +SLTANPSHLEAV+PV+ G VRAKQD L       D +R   V+P++LHGDAA
Sbjct: 344  FDGNSVHLSLTANPSHLEAVNPVVLGKVRAKQDQL------KDSERT-KVLPILLHGDAA 396

Query: 652  FAGQGVVAETLNLANLPGYRVGGTIHIIVNNQIGFTTAPEYSRSSEYCTDVAKMIGAPIF 711
            FAGQGVVAE   L+ L G++ GGT+HI+VNNQIGFTTAP +SRSS Y TD A ++ APIF
Sbjct: 397  FAGQGVVAECFALSGLRGHKAGGTMHIVVNNQIGFTTAPHFSRSSPYPTDNALVVEAPIF 456

Query: 712  HVNGDDPEACVWVARLAVDFRQRFKKDVVIDMLCYRRRGHNEGDDPSMTNPYVYDVVDTK 771
            HVNGDDPEA V  AR+A +FRQ+F KDVV+D+ CYRR GHNEGD+P  TNP +Y  +   
Sbjct: 457  HVNGDDPEAVVHAARVATEFRQKFHKDVVLDIFCYRRFGHNEGDEPMFTNPLMYKKIKGH 516

Query: 772  RGARKSYTEALIGRGDISMKEAEDALRDYQGQLERVFNEVRELEKHGV-----QPSESVE 826
            +     YTE L+  G I   E ED    +Q +L   F   +  + +       + S   +
Sbjct: 517  KTTLSLYTERLVKDGLIPEGEIEDMKASFQARLNEEFEAGKNFKPNKADWLDGRWSHLDK 576

Query: 827  SDQMIPAGLATAVDKSLLARIGDAFLALPNGFTAHPRVQPVLEKRREMAYEGK-IDWAFG 885
             D     G  T+V       +G A   +P GF  H  +   L+ R +M   G+ IDWA G
Sbjct: 577  KDTDYQRG-QTSVSPETFKEVGTALSRVPEGFPVHKTIGRFLDARAKMVDSGEGIDWATG 635

Query: 886  ELLALGSLVAEGKLVRLSGQDSRRGTFSQRHSVLIDRHTGEEFTPLQLLATNSDGSPTGG 945
            E LA GSL+ EG  VRLSGQD+ RGTFSQRHS +++++T E + PL  + +         
Sbjct: 636  EALAFGSLLTEGYPVRLSGQDATRGTFSQRHSGIVNQNTEERYYPLNNIRSGQ------S 689

Query: 946  KFLVYDSPLSEYAAVGFEYGYTVGNPDAVVLWEAQFGDFVNGAQSIIDEFISSGEAKWGQ 1005
             + V DS LSEYA +GFEYGY++  P+A+ LWEAQFGDF NGAQ + D+FISSGE+KW +
Sbjct: 690  HYEVIDSALSEYAVLGFEYGYSLAEPNALTLWEAQFGDFANGAQIMFDQFISSGESKWLR 749

Query: 1006 LSNVVLLLPHGHEGQGPDHTSARIERFLQLWAEGSMTIAMPSTPSNYFHLLRRHALDGIQ 1065
            +S +V LLPHG EGQGP+H+SAR+ERFLQ+  + +  +A  +TP+NYFH+LRR      +
Sbjct: 750  MSGLVCLLPHGFEGQGPEHSSARLERFLQMCGQDNWIVANCTTPANYFHILRRQLHRTFR 809

Query: 1066 RPLIVFTPKSMLRHKAAVSEIKDFTE-IKFRSVLEEPTYEDGIGDR-----NKVSRILLT 1119
            +PLI+ TPKS+LRHK AVS+ ++FT    F  VL +   + G  D      +K+ R++L 
Sbjct: 810  KPLIMMTPKSLLRHKLAVSKAEEFTTGSSFHRVLWDDA-QHGNSDTKLVADDKIKRVVLC 868

Query: 1120 SGKLYYELAARKAKDNRNDLAIVRLEQLAPLPRRRLRETLDRYENVKEFFWVQEEPANQG 1179
            SGK+YY+L   +     +D+ ++R+EQ  P P   L + L+R++   E  W QEEP NQG
Sbjct: 869  SGKVYYDLLEERDARGLDDVYLMRIEQYYPFPAISLVKELERFKGA-EVVWCQEEPKNQG 927

Query: 1180 AWPRFGLELPELLPDKLAGIKR---ISRRAMSAPSSGSSKVHAVEQQEILDEA 1229
            AW      +  +L    A   R   + R   ++P++G +  H  +Q  +++EA
Sbjct: 928  AWSFIEPNIEWVLTRIGAKHSRPTYVGRATSASPATGLASEHKAQQAALVNEA 980



 Score = 36.2 bits (82), Expect = 1e-05
 Identities = 30/125 (24%), Positives = 49/125 (39%), Gaps = 16/125 (12%)

Query: 9   GQNEWLVEEMYRKFRDDPSSVDPSWHEFLVDYSPEPTSQPAAEPTRVTSPLVAERAAAAA 68
           G N   +E++Y ++ +DP++VD +W EF            A           A   + A 
Sbjct: 18  GHNAEYLEQLYAQYANDPNAVDAAWAEFFRQMGDAELDVKAE----------AAGPSWAR 67

Query: 69  PQAPPKPADTAAAGNGVVAALAAKTAVPPPAEGDEVAVLRGAAAAVVKNMSASLEVPTAT 128
              PP P D       +  AL  +   P  A+G    +   AAA  V+     ++     
Sbjct: 68  ADWPPAPND------DLTGALTGEWPAPAEAKGAGKKIKEQAAAKGVEVTDDQVQRAVLD 121

Query: 129 SVRAV 133
           S+RA+
Sbjct: 122 SIRAL 126