Pairwise Alignments

Query, 1231 a.a., Multifunctional alpha-ketoglutarate metabolic enzyme from Mycobacterium tuberculosis H37Rv

Subject, 939 a.a., 2-oxoglutarate dehydrogenase E1 component (RefSeq) from Shewanella sp. ANA-3

 Score =  681 bits (1756), Expect = 0.0
 Identities = 378/878 (43%), Positives = 533/878 (60%), Gaps = 50/878 (5%)

Query: 368  KNARVMNLIAAYRNRGHLMADTDPLRLDKARFRSHPDLEVLTHGLTLWDLDRVFKVDGFA 427
            K  +V+ LI A+R RGH  A+ DPL L K       DL+   HGLT  D++R F    FA
Sbjct: 93   KQVKVLQLINAHRFRGHQGANLDPLELWKRE--PVADLDPAFHGLTKEDMEREFNTGSFA 150

Query: 428  -GAQYKKLRDVLGLLRDAYCRHIGVEYAHILDPEQKEWLEQRVETKHVKPTVAQQKY--- 483
             G +  KL D++  L+  YC  IG EY HI D ++K W++QR+E     P++ +  Y   
Sbjct: 151  HGGETMKLADLVKALKATYCGSIGAEYMHITDTDEKRWIQQRLE-----PSLGKANYDKS 205

Query: 484  ----ILSKLNAAEAFETFLQTKYVGQKRFSLEGAESVIPMMDAAIDQCAEHGLDEVVIGM 539
                IL  LNAAE  E +L  K+ G KRFSLEG ++++PMM   I +  E G  E+V+GM
Sbjct: 206  VKTRILEGLNAAEGIEKYLGAKFPGAKRFSLEGGDALVPMMREIIYRAGEAGTKEIVVGM 265

Query: 540  PHRGRLNVLANIVGKPYSQIFTEFEGNLNPSQAHGSGDVKYHLGATGLYLQMFGDNDIQV 599
             HRGRLNVL N++GK  +++F EF G    +  HGSGDVKYH G +  +    G+  + +
Sbjct: 266  AHRGRLNVLVNVLGKRPAELFDEFAGK--HADTHGSGDVKYHQGFSSDFETPGGN--VHL 321

Query: 600  SLTANPSHLEAVDPVLEGLVRAKQDLLDHGSIDSDGQRAFSVVPLMLHGDAAFAGQGVVA 659
            +L  NPSHLE V+PV+ G VRA+QD    G  D        V+P+ +HGD+A AGQG+V 
Sbjct: 322  ALAFNPSHLEIVNPVVMGSVRARQDR--RGCKDG-----LQVMPITIHGDSAIAGQGIVQ 374

Query: 660  ETLNLANLPGYRVGGTIHIIVNNQIGFTTAPEYS-RSSEYCTDVAKMIGAPIFHVNGDDP 718
            ET N++   G++VGG+I I+VNNQ+GFTT+  +  RS+EYCTD+AKM+ APIFHVN DDP
Sbjct: 375  ETFNMSQTRGFKVGGSIRIVVNNQVGFTTSNHFDVRSTEYCTDIAKMVQAPIFHVNSDDP 434

Query: 719  EACVWVARLAVDFRQRFKKDVVIDMLCYRRRGHNEGDDPSMTNPYVYDVVDTKRGARKSY 778
            EA  +VA+LAVD+R  FK+DVVID++CYRR GHNE D+PS T P +Y  +      RK Y
Sbjct: 435  EAVAFVAQLAVDYRNEFKRDVVIDLVCYRRHGHNEADEPSATQPLMYAKIKKHPTPRKIY 494

Query: 779  TEALIGRGDISMKEAEDALRDYQGQLER---VFNEVRELEKHGVQ--PSESVESDQMIPA 833
             + LI    I   E    +  Y+  L++   V  E R +  H V   P    E D++  A
Sbjct: 495  ADKLIAENSIGADEVTSMINTYRDALDQGDCVVKEWRPMTLHTVDWTPYIGREWDEVYQA 554

Query: 834  GLATAVDKSLLARIGDAFLALPNGFTAHPRVQPVLEKRREMAYEGKI-DWAFGELLALGS 892
             L        L  + D    +P     H RV  +   R  MA   K+ DW F E LA  +
Sbjct: 555  SLPL----ERLQNLADKLSYVPESHPLHSRVAKIYGDRVAMAKGEKLLDWGFAETLAYAT 610

Query: 893  LVAEGKLVRLSGQDSRRGTFSQRHSVLIDRHTGEEFTPLQLLATNSDGSPTGGKFLVYDS 952
            ++ + K VR++GQDS RGTF  RH+VL +++    + PL+ L+ +       G   + DS
Sbjct: 611  ILEDNKRVRITGQDSGRGTFFHRHAVLHNQNDATTYMPLRNLSEDQ------GPIDITDS 664

Query: 953  PLSEYAAVGFEYGYTVGNPDAVVLWEAQFGDFVNGAQSIIDEFISSGEAKWGQLSNVVLL 1012
             LSE + + FEYGYT   P  + +WEAQFGDF N AQ +ID+F+SSGE KWG+L  + +L
Sbjct: 665  VLSEASVLAFEYGYTTAEPGGLAIWEAQFGDFANCAQVVIDQFLSSGEQKWGRLCGLTML 724

Query: 1013 LPHGHEGQGPDHTSARIERFLQLWAEGSMTIAMPSTPSNYFHLLRRHALDGIQRPLIVFT 1072
            LPHG+EGQGP+H+SAR+ERFLQL A  +M + +PSTP+  +H+LRR  +  ++RPL+V +
Sbjct: 725  LPHGYEGQGPEHSSARLERFLQLCANHNMQVCVPSTPAQVYHMLRRQVVRPMRRPLVVMS 784

Query: 1073 PKSMLRHKAAVSEIKDFTEIKFRSVLEE-PTYEDGIGDRNKVSRILLTSGKLYYELAARK 1131
            PKS+LRH  AVS +++     F++V+ E  T E      +KV R++  SGK+Y+EL  ++
Sbjct: 785  PKSLLRHPLAVSSMEELANGTFQNVIGEIDTLE-----ASKVDRVVFCSGKVYFELLEKR 839

Query: 1132 AKDNRNDLAIVRLEQLAPLPRRRLRETLDRYENVKEFFWVQEEPANQGAWPRFGLELPEL 1191
             K+N N++AI+R+EQL P P   +   L  Y++V +F W QEEP NQGAW          
Sbjct: 840  RKENINNIAIIRVEQLYPFPHEEMVAALADYQHVTDFVWCQEEPQNQGAWYSSQHHFWAA 899

Query: 1192 LPDKLAGIKRISRRAMSAPSSGSSKVHAVEQQEILDEA 1229
            +P   A +    R A +AP+ G  ++HA +Q+ +++ A
Sbjct: 900  IPAG-AKLTYAGREASAAPACGYPELHAHQQESLVNSA 936



 Score = 32.0 bits (71), Expect = 3e-04
 Identities = 13/34 (38%), Positives = 17/34 (50%)

Query: 9  GQNEWLVEEMYRKFRDDPSSVDPSWHEFLVDYSP 42
          G N   VEEMY  +++DP SV   W     +  P
Sbjct: 17 GANSTYVEEMYEAYQEDPQSVSDDWRAVFDNLPP 50