Pairwise Alignments
Query, 754 a.a., Phosphoribosylformylglycinamidine synthase II PurL (FGAM synthase II) from Mycobacterium tuberculosis H37Rv
Subject, 989 a.a., AIR synthase related protein from Methanococcus maripaludis S2
Score = 257 bits (657), Expect = 2e-72
Identities = 204/758 (26%), Positives = 351/758 (46%), Gaps = 80/758 (10%)
Query: 12 PDQPQPYGELGLKDDEYRRIRQIL---GRRPTDTELAMYSVMWSEHCSYK---------S 59
P+ + G L L D I++ GR PTD EL + WSEHC +
Sbjct: 205 PETGERRGPLALDLDYITAIKEYYQKEGRNPTDIELEALAQTWSEHCKHTIFASQIDDIE 264
Query: 60 SKVHLRYFGETTSDEMRAAM------LAGIGENAGVVDIGDGWAVTFKVESHNHPSYVEP 113
+ +Y T+ E+R + ++ +N+G + D W VT K E+HN PS ++P
Sbjct: 265 EGIFKKYIRNATN-EIREELGEKDFCISVFSDNSGGIIFDDEWMVTDKAETHNSPSALDP 323
Query: 114 YQGAATGVGGIVRDIMAMGARPVAVMDQLRFGAADAPDT----------------RRVLD 157
+ GA TG+ G+ RD + G + V ++ F DT RR+LD
Sbjct: 324 FGGAITGIVGVNRDTVGFGLGALPVANKYGFCVGRPEDTEIIYRGQNKTNPSLLPRRILD 383
Query: 158 GVVRGIGGYGNSLGLPNIGGETVFDPCYAGNPLVNALCVGVLRQE--DLHLAFASGA--G 213
G+V G+ GN G+P G FD Y G PLV +G++ ++ D L+ A G
Sbjct: 384 GIVHGVNVGGNQSGIPTPNGFVYFDDTYKGKPLVFVGTIGLIPRKLPDGRLSHEKAAENG 443
Query: 214 NKIILFGARTGLDGIGGVSVLASDTFDAEGSRKKLPSVQVGDPFMEKVLIECCL-ELYAG 272
+ I++ G R G DGI G + +S+ D EGS +VQ+GDP +K L + + E
Sbjct: 444 DNIVIIGGRVGKDGIHG-ATFSSEAMD-EGS--PAAAVQIGDPITQKKLSDAVIKEARDK 499
Query: 273 GLVIGIQDLGGAGLSCATSELASAGDGGMTIQLDSVPLRAKEMTPAEVLCSESQERMCAV 332
GL I D G G+SC+ +E+A GG ++L+ VPL+ + P E+ SESQER+
Sbjct: 500 GLYNSITDNGAGGISCSVAEMAEE-CGGFVVELEEVPLKYPGLEPWEIWISESQERVTLS 558
Query: 333 VSPKNVDAFLAVCRKWEVLATVIGEVTDGDRLQITWHGETVVDVPPRTVAHEGPVYQRPV 392
V ++ F+ + + V A VIG+ + DR + ++G+T++D+ H G ++ +
Sbjct: 559 VPDDKLEEFMDLMKIRGVEAVVIGKFNNTDRAVVNYNGKTIMDL-EMDFLHNGLPKRKLI 617
Query: 393 ARPDTQDALNADRSAKLSRP-VTGDELRATLLALLGSPHLCSRAFITEQYDRYVRGNTVL 451
+P S + P +T + T +LG+ + CS +I++QYD V+ N+V+
Sbjct: 618 TKP---------YSYRTEEPEITVENQLETFEKILGNHNNCSFEYISKQYDHEVQNNSVI 668
Query: 452 AE-------HADGGMLRIDESTGRGIAVSTDASGRYTLLDPYAGAQLALAEAYRNVAVTG 504
+ ++R S+ +G+ +S R + + Y A A+ A RN G
Sbjct: 669 KPLQGKGRVNGTASVIRPLLSSQKGLVMSQSLLPRLSEISCYDMAACAMDTAIRNCVAVG 728
Query: 505 A--TPVAVTNCLNFGSPEDPGVMWQFTQAVRGLADGCADLGIPVTGGNVSFYNQTG---- 558
+A+ + + S ++P ++Q A + D P+ G S +N
Sbjct: 729 GNINHIAIMDNFCWCSSDEPERLYQLKDAAKSCYDYAKTYLTPLISGKDSMFNDFKGFDE 788
Query: 559 -----SAAILPTPVVGVLGVIDDVRRRIPTGLGAEPGETLMLLGDTRDEFDGSVWAQVTA 613
++ PT ++ LGVID++ L + + + ++G+T+DE GS +
Sbjct: 789 NNNPIKISVHPTLMMSALGVIDNIEHTNSMDLKLK-DDLIYVIGETKDECGGSEFYHAFG 847
Query: 614 DHLGGLPPVVDLAREKLLAAVLSSASRDGLVSAAHDLSEGGLAQAIVESALAGETGCRIV 673
+ +GG+ P VD + L + S+ G+ S+ ++ GGL + + A++G G
Sbjct: 848 E-VGGISPKVDAKSARKLYEKMYELSQKGIFSSCASVAAGGLVITLAKMAISGCLGLEAD 906
Query: 674 LPEGADPFV----LLFSESAGRVLVAVPRTEESRFRGM 707
L + + + +++SE+ R +V + E F +
Sbjct: 907 LSKAPNENISFEKIMYSETQSRFIVTIAPENEKEFENL 944
Score = 67.8 bits (164), Expect = 3e-15
Identities = 74/281 (26%), Positives = 121/281 (43%), Gaps = 45/281 (16%)
Query: 483 LDPYAGAQLALAEAYRNVAVTGATPVAVTNCLNF--GSPEDPGVMWQ------------- 527
LDP+ GA + R+ G + V N F G PED ++++
Sbjct: 321 LDPFGGAITGIVGVNRDTVGFGLGALPVANKYGFCVGRPEDTEIIYRGQNKTNPSLLPRR 380
Query: 528 -FTQAVRGLADGCADLGIPVTGGNVSFYNQTGSAAILPTPVVGVLGVIDDVRRRIPTGL- 585
V G+ G GIP G V +++ T P VG +G+I R++P G
Sbjct: 381 ILDGIVHGVNVGGNQSGIPTPNGFV-YFDDTYKGK--PLVFVGTIGLIP---RKLPDGRL 434
Query: 586 ----GAEPGETLMLLGDT--RDEFDGSVWAQVTADHLGGLPPVV-----DLAREKLLAAV 634
AE G+ ++++G +D G+ ++ D G P + ++KL AV
Sbjct: 435 SHEKAAENGDNIVIIGGRVGKDGIHGATFSSEAMDE--GSPAAAVQIGDPITQKKLSDAV 492
Query: 635 LSSASRDGLVSAAHDLSEGGLAQAIVESALAGETGCRIVLPE-------GADPFVLLFSE 687
+ A GL ++ D GG++ ++ E +A E G +V E G +P+ + SE
Sbjct: 493 IKEARDKGLYNSITDNGAGGISCSVAE--MAEECGGFVVELEEVPLKYPGLEPWEIWISE 550
Query: 688 SAGRVLVAVPRTEESRFRGMCEARGLPAVRIGVVDQGSDAV 728
S RV ++VP + F + + RG+ AV IG + AV
Sbjct: 551 SQERVTLSVPDDKLEEFMDLMKIRGVEAVVIGKFNNTDRAV 591
Score = 39.3 bits (90), Expect = 1e-06
Identities = 53/279 (18%), Positives = 109/279 (39%), Gaps = 48/279 (17%)
Query: 109 SYVEPYQGAATGVGGIVRDIMAMGAR--PVAVMDQLRFGAADAPDTRRVLDGVVRGIGGY 166
S + Y AA + +R+ +A+G +A+MD + ++D P+ L + Y
Sbjct: 705 SEISCYDMAACAMDTAIRNCVAVGGNINHIAIMDNFCWCSSDEPERLYQLKDAAKSCYDY 764
Query: 167 GNSLGLPNIGGETVFDPCYAG------------NPLVNALCVGVLRQEDLHLAFASGAGN 214
+ P I G+ + G +P + +GV+ + + +
Sbjct: 765 AKTYLTPLISGKDSMFNDFKGFDENNNPIKISVHPTLMMSALGVIDNIEHTNSMDLKLKD 824
Query: 215 KIILFGART-----------GLDGIGGVSVLASDTFDAEGSRKKLPSVQVGDPFMEKVLI 263
+I T +GG+S DA+ +RK + +K +
Sbjct: 825 DLIYVIGETKDECGGSEFYHAFGEVGGIS----PKVDAKSARKLYEKMY---ELSQKGIF 877
Query: 264 ECCLELYAGGLVIGIQDLGGAGLSCATSELASAGDGGMTIQLDSVPLRAKEMTPAEVLCS 323
C + AGGLVI + + +G ++L+ A + ++ + +++ S
Sbjct: 878 SSCASVAAGGLVITLAKMAISGCLGLEADLSKAPNENISFE--------------KIMYS 923
Query: 324 ESQERMCAVVSPKNVDAFLAVCRKWEVLATVIGEVTDGD 362
E+Q R ++P+N F + +++++ IG VT+ D
Sbjct: 924 ETQSRFIVTIAPENEKEFENLMKEFKI--GKIGNVTEKD 960