Pairwise Alignments

Query, 514 a.a., 2-isopropylmalate synthase from Methanococcus maripaludis S2

Subject, 644 a.a., 2-isopropylmalate synthase LeuA (alpha-isopropylmalate synthase) (alpha-IPM synthetase) (IPMS) from Mycobacterium tuberculosis H37Rv

 Score =  100 bits (250), Expect = 1e-25
 Identities = 122/502 (24%), Positives = 208/502 (41%), Gaps = 62/502 (12%)

Query: 31  LRDGEQTPGVSLMPDQKMDIAKNLSEIGVDAIEAGFPVSSEGEQESIKNITSLGL---DA 87
           LRDG Q     + P +K  +   L  +G   IE GFP +S+ + + ++ I   G    D 
Sbjct: 79  LRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDV 138

Query: 88  EICGLARA----VKKDIDVAIDCGVDSIHTFIATSPLHREYKLKMSKEKIIDIAVESIEY 143
            I  L +     +++            +H + +TS L R    + ++ ++  IA +    
Sbjct: 139 TIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVVFRANRAEVQAIATDGARK 198

Query: 144 IKEHGVIV-------EFSAEDATRTELDYLKEVYKKAVEAGADR------INVPDTVGVM 190
             E            E+S E  T TEL+Y K+V     E  A         N+P TV + 
Sbjct: 199 CVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIAPTPERPIIFNLPATVEMT 258

Query: 191 VPN----SMSYLIKELKNDIKVPISVHCHNDFGIAVSNSVAAVEAGAEQVHCTVNGLGER 246
            PN    S+ ++ + L N   V +S+H HND G AV+ +     AGA+++   + G GER
Sbjct: 259 TPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGER 318

Query: 247 AGNASLEETVMTLNMV-YGINTNVNTKMLTKLSKLVSHYTGIKTQPNKAIVGENSFAHES 305
            GN  L    + LN+   G++  ++   + ++ + V +   +         G+  +   S
Sbjct: 319 TGNVCL--VTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFS 376

Query: 306 GIHAHGV--------------------LANALTYEPIDPEIVGNRRRIVL------GKHS 339
           G H   +                    +   + Y PIDP  VG     V+      GK  
Sbjct: 377 GSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGG 436

Query: 340 GAHAIKSKLSEIGVEVGEIVSEEQFCEIVERVK--AIGDKGKIVTDADVMAIAEDITKRT 397
            A+ +K   ++ G+ +   +  E F ++++++     G+ G++       A AE+     
Sbjct: 437 VAYIMK---TDHGLSLPRRLQIE-FSQVIQKIAEGTAGEGGEVSPKEMWDAFAEEYLAPV 492

Query: 398 LKSERIVDLEQFAVITGNHVLPTASVALKVKDKIYKTSELGVGPVDAALKAIQAAVGENI 457
              ERI      A   G     TA+V  K+     + S  G GP+ A + A+ A VG ++
Sbjct: 493 RPLERIRQHVDAADDDGGTTSITATV--KINGVETEISGSGNGPLAAFVHAL-ADVGFDV 549

Query: 458 RLNEYNISAISGGTDAIAEVTV 479
            + +Y   A+S G DA A   V
Sbjct: 550 AVLDYYEHAMSAGDDAQAAAYV 571