Pairwise Alignments

Query, 823 a.a., DNA topoisomerase I from Methanococcus maripaludis S2

Subject, 876 a.a., DNA topoisomerase 1 from Vibrio cholerae E7946 ATCC 55056

 Score =  243 bits (620), Expect = 3e-68
 Identities = 239/842 (28%), Positives = 367/842 (43%), Gaps = 135/842 (16%)

Query: 4   LIICEKPNVAKKIAEALGKPKKKSHNSVPYYELERNGESIVVASAVGHLYTLQEKTKTKF 63
           L+I E P  AK I + LGK                     +V S+VGH+  L    +T  
Sbjct: 5   LVIVESPAKAKTINKYLGK-------------------DFIVKSSVGHVRDLPTAGQTAT 45

Query: 64  GDYPVYDINWVPASTLDEKKYI------------------------------QKYIDALK 93
                   +   AST D+++                                +K +  L+
Sbjct: 46  PTGKAAAASTKKASTTDKEQQKREKERAALIKKMGVDPYHGWQANYQILPGKEKVVAELQ 105

Query: 94  KVSKDANKFYVATDWDIEGELIGYHALNFSCG-QKNAHRLRFSSLTKKEILKAYENPNEI 152
           K++KDA+  Y+ATD D EGE I +H      G +K   R+ F+ +TK  I +A++ P E+
Sbjct: 106 KLAKDADSVYLATDLDREGEAIAWHLREIIGGDEKRYKRVVFNEITKNAIQQAFKQPGEL 165

Query: 153 DFGLVDAGDSRHKIDWYFGINVSRALMQAVSSVKRWKTLSTGRVQGPALAFLVDKELEIR 212
           +   V+A  +R  +D   G  VS  L + V+     + LS GRVQ  A+  LV++E EI+
Sbjct: 166 NMDGVNAQQARRFMDRVVGFMVSPLLWKKVA-----RGLSAGRVQSVAVKLLVEREREIK 220

Query: 213 NFVPTPYWVLEA-------------LLDNDLIA---VHELEKFWDEEQANKA-YEKVKGQ 255
            FVP  +W + A             +   D +A   V+E E        NKA YE  K +
Sbjct: 221 AFVPEEFWDINADTLTADKQDFRLLVAQKDGLAFKPVNETEALAAVAALNKAQYEVCKRE 280

Query: 256 KQATVSDVKKSMKTIPPNPPFDLGALQREAHNMFRFSPKKTQEVAQKLYEKGYCSYPRTS 315
            + T S          P+ PF    LQ+ A     +  KKT  +AQ+LYE GY +Y RT 
Sbjct: 281 DKPTTSK---------PSAPFITSTLQQAASTRLGYGVKKTMMLAQRLYEAGYITYMRTD 331

Query: 316 SQKLPDDKAYMDEVLKNLSKNKNYKPYIETILNENRKPISGK-NDDPAHPAVHAVDVPK- 373
           S  L        E ++NL +    K Y E  L         K N   AH A+   DV   
Sbjct: 332 STNLSA------EAVENL-RGYITKHYGEAYLPSQPNVYGSKQNAQEAHEAIRPSDVTVT 384

Query: 374 ----EKLPDDELKLYELIARRTIALYWDNAKREYSKINLDINGETFKLSGSRTVEEGWHE 429
               E +  D  KLY LI  + +A     A+ + + +++     T K  G     +GW  
Sbjct: 385 ADDLEGMEADAHKLYALIWNQFVACQMTPAQYDSTTVSVKAAEYTLKAKGRILKFDGWTR 444

Query: 430 IYY-YTKFDEVELPELKKNDVINVNNINFEAKETKPPKRYTMASIIKELEKRKLGTKATR 488
           +     K ++  LP +K  D + + +++ +   TKPP RYT A+++KELEKR +G  +T 
Sbjct: 445 VQRPLGKNEDQILPPVKVGDSLKLVSLDPKQHFTKPPARYTEAALVKELEKRGIGRPSTY 504

Query: 489 ADILEKLTKRGYV-IEDGSLTVTDLGIGVTETLRKYCPEIVEETLTRDLEDKLELIQDKK 547
           A I+  +  RGYV ++        +G  VT+ L +   +++    T  +E+KL+ I + +
Sbjct: 505 ASIISTIQDRGYVKVDQRRFFAEKMGEIVTDRLDENFDDLMNYDFTARMEEKLDQIAEGE 564

Query: 548 IKKEEVIQETKDKLTKILGEFRLKEKEIGTELVDKLDSTNRSLQIIGKCKCGGDMIIIRT 607
           +    V+ E     ++ L E   +++ +G    + +  TN        C      + IRT
Sbjct: 565 VNWTAVLDEFFADFSRDL-ETAEQDESLGGMKPNHIVMTNI------LCPTCSRPMGIRT 617

Query: 608 KGKKRFVGCSNY-----PDCEVTFPL-PQKGRIKVLNE--------------VCEKCQNP 647
                F+GCS Y       C+ T  L  ++G I VL E              +CE   + 
Sbjct: 618 ASTGVFLGCSGYGLPPKERCKTTINLGDEEGVINVLEEDVETAALRAKKRCPICETAMDA 677

Query: 648 VIGLDRIKICV---NPDCSTRISEEDKKEIEKAEKEEKICPKCGNKLLIKKGPYGVFRGC 704
            +  D+ K+ V   NP+C   I EE + +++  E     C KCG+ +++K G +G + GC
Sbjct: 678 YLIDDKRKLHVCGNNPNCEGFIVEEGEFKVKGYEGPTVECDKCGSDMVLKNGRFGKYMGC 737

Query: 705 ENYPKCKYTEKL--NGE----SNEKEIVGKCPKCGSDLY--KRKGRFGEFIGCSNYPKCR 756
            N   CK T K+  NGE      E     + P   SD Y   R G  G F   SN+PK R
Sbjct: 738 TN-DACKNTRKILKNGEVAPPKEEPVHFPELPCENSDAYFVLRDGASGLFFAASNFPKSR 796

Query: 757 HT 758
            T
Sbjct: 797 ET 798