Pairwise Alignments

Query, 823 a.a., DNA topoisomerase I from Methanococcus maripaludis S2

Subject, 900 a.a., DNA topoisomerase TopA from Phaeobacter inhibens DSM 17395

 Score =  181 bits (460), Expect = 1e-49
 Identities = 164/658 (24%), Positives = 283/658 (43%), Gaps = 90/658 (13%)

Query: 40  GESIVVASAVGHLYTLQEKTKTKFGDYPVYDINWVPASTLDEKKYIQKYIDALKKVSKDA 99
           G    V ++ GH+  L  K  +   D   + + W   +  D +K+++   DALK    D 
Sbjct: 20  GSDYTVLASYGHVRDLPAKNGSVEPDDD-FAMTWEVGA--DSRKHVKAIADALK----DD 72

Query: 100 NKFYVATDWDIEGELIGYHALNFSCGQKN------AHRLRFSSLTKKEILKAYENPNEID 153
           N   +ATD D EGE I +H       +++        R+ F+++TK+ + +A +NP ++D
Sbjct: 73  NALILATDPDREGEAISWHLQEALTKRRSIKKDTAVSRVTFNAITKEAVTEAMKNPRQVD 132

Query: 154 FGLVDAGDSRHKIDWYFGINVSRALMQAVSSVKRWKTLSTGRVQGPALAFLVDKELEIRN 213
             LV+A  +R  +D+  G N+S  L + +   +     S GRVQ   L  +V++E+EI  
Sbjct: 133 LPLVEAYLARRALDYLVGFNLSPVLWRKLPGAR-----SAGRVQSVCLRLIVEREMEIEA 187

Query: 214 FVPTPYWVLEALLDND----------LIAVHELEKFW--DEEQANKAYEKVKGQKQATVS 261
           F P  YW ++A L             ++   +L+K+   +   A  A + V   +  TV 
Sbjct: 188 FKPQEYWSVKASLATPRGQEFEARLTVLGGDKLDKYALANSTAAELAVQAV-ASRALTVQ 246

Query: 262 DVKKSMKTIPPNPPFDLGALQREAHNMFRFSPKKTQEVAQKLYEKGYCSYPRTSSQKLPD 321
            V+    +  P+ PF    LQ+EA   F    K+    AQ+LYE GY +Y RT    +  
Sbjct: 247 SVEAKPASRNPSAPFMTSTLQQEASRKFGMGAKQCMNAAQRLYEAGYITYMRTDGIDMAP 306

Query: 322 DKAYMDEVLKNLSKNKNYKPYIETILNENRKPISGKNDDPAHPAVHAVDVPKEK-----L 376
           +                Y P    I          KN   AH  +   ++ ++       
Sbjct: 307 EAVQEARAEIANRYGAEYVPGSPRIYKN-----KAKNAQEAHECIRPTEMGRDAKSLKVS 361

Query: 377 PDDELKLYELIARRTIALYWDNAKREYSKINLDING--ETFKLSGSRTVEEGWHEIYYYT 434
            DD+ KLY+LI +RT+A   + A+ E + +++  N      + +G   + +G+  +Y   
Sbjct: 362 EDDQRKLYDLIWKRTLACQMEGARLERTTVDIGSNDGQVVLRATGQVMLFDGFLRVYEEG 421

Query: 435 KFDEVELPELKKNDVINVNNINFEAK--------------------------ETKPPKRY 468
           + D V+  + +   ++   ++ F A                            T+PP R+
Sbjct: 422 RDDVVDDDDKRLPQIMQGESLKFAASLAAQAEKADTGGAILSDDKAVLGLQHHTQPPPRF 481

Query: 469 TMASIIKELEKRKLGTKATRADILEKLTKRGYVIED-GSLTVTDLGIGVTETLRKYCPEI 527
           T A+++K +E+  +G  +T A ++  +  R YV +D   L   D G  VT  L  +    
Sbjct: 482 TEATLVKRMEELGIGRPSTYASVITTIQDREYVRKDKNRLFPEDKGRIVTIFLLNFFRTY 541

Query: 528 VEETLTRDLEDKLELIQDKKIKKEEVIQETKDKLTKILGEFRLKEKEIG----TELVDKL 583
           V    T +LE +L+ +           ++ KD L++   +F     E      TE++D L
Sbjct: 542 VGYEFTANLEGELDDVSAGD-------RDYKDLLSRFWRDFSAAISETSDLRITEVLDVL 594

Query: 584 DST-------NRSLQIIGKC--KCGGDMIIIRTKGKKRFVGCSNYPDCEVTFPLPQKG 632
           D          R   +  +   KCG   + ++T     FVGC NYP+C  T P+  +G
Sbjct: 595 DDALAPQLYPPREDGVDPRVCPKCGAGQLHLKTSRTGGFVGCGNYPECNYTRPISGEG 652



 Score = 56.2 bits (134), Expect = 8e-12
 Identities = 27/71 (38%), Positives = 44/71 (61%), Gaps = 5/71 (7%)

Query: 680 EEKICPKCG-NKLLIKKGPYGVFRGCENYPKCKYTEKLNGESNE--KEIVGKCPKCGSDL 736
           + ++CPKCG  +L +K    G F GC NYP+C YT  ++GE  E  + I+G+    G ++
Sbjct: 611 DPRVCPKCGAGQLHLKTSRTGGFVGCGNYPECNYTRPISGEGAEGYERILGE--DDGDEI 668

Query: 737 YKRKGRFGEFI 747
           + + GRFG ++
Sbjct: 669 HLKSGRFGPYV 679



 Score = 43.5 bits (101), Expect = 5e-08
 Identities = 17/34 (50%), Positives = 23/34 (67%), Gaps = 1/34 (2%)

Query: 729 CPKCGS-DLYKRKGRFGEFIGCSNYPKCRHTEKI 761
           CPKCG+  L+ +  R G F+GC NYP+C +T  I
Sbjct: 615 CPKCGAGQLHLKTSRTGGFVGCGNYPECNYTRPI 648