Pairwise Alignments

Query, 823 a.a., DNA topoisomerase I from Methanococcus maripaludis S2

Subject, 865 a.a., DNA topoisomerase I from Klebsiella michiganensis M5al

 Score =  229 bits (583), Expect = 7e-64
 Identities = 231/828 (27%), Positives = 361/828 (43%), Gaps = 113/828 (13%)

Query: 4   LIICEKPNVAKKIAEALGKPKKKSHNSVPYYELERNGESIVVASAVGHLYTLQ------- 56
           L+I E P  AK I + LG                      VV S+VGH+  L        
Sbjct: 5   LVIVESPAKAKTINKYLGN-------------------DYVVKSSVGHIRDLPTSGSASK 45

Query: 57  ---EKTKTKFGDYPVYD-----INWV---PASTLDEKKYI----QKYIDALKKVSKDANK 101
              + T TK    P  D     +N +   P    D    I    +K +  LK++++ A+ 
Sbjct: 46  KSADSTSTKGAKKPKKDERGALVNRMGVDPWHDWDAHYEILPGKEKVVSELKQLAEKADH 105

Query: 102 FYVATDWDIEGELIGYHALNFSCGQKNAH-RLRFSSLTKKEILKAYENPNEIDFGLVDAG 160
            Y+ATD D EGE I +H      G +  + R+ F+ +TK  I +A+E P E++   V+A 
Sbjct: 106 IYLATDLDREGEAIAWHLREVIGGDEQRYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQ 165

Query: 161 DSRHKIDWYFGINVSRALMQAVSSVKRWKTLSTGRVQGPALAFLVDKELEIRNFVPTPYW 220
            +R  +D   G  VS  L + ++     + LS GRVQ  A+  +V++E EI+ FVP  YW
Sbjct: 166 QARRFMDRVVGYMVSPLLWKKIA-----RGLSAGRVQSVAVRLVVEREREIKAFVPEEYW 220

Query: 221 VLEALLDND------LIAVHELEKFWDEEQANKAYEKVKGQKQATVSDVKKSMK--TIPP 272
            ++A           L   H  +K +     ++    V   ++A+ S +++  K  +  P
Sbjct: 221 EVDASTTTPGGDALPLQVTHSGDKPFRPVSRDETMAAVALLEKASYSVLEREDKPTSSKP 280

Query: 273 NPPFDLGALQREAHNMFRFSPKKTQEVAQKLYEKGYCSYPRTSSQKLPDDKAYMDEVLKN 332
             PF    LQ+ A     F  KKT  +AQ+LYE G+ +Y RT S  L  D   M      
Sbjct: 281 GAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALNMVRGYIG 340

Query: 333 LSKNKNYKPYIETILNENRKPISGKNDDPAHPAVHAVDVP--KEKLPD---DELKLYELI 387
            +  K Y P          +  S +N   AH A+   DV    E L D   D  KLY+LI
Sbjct: 341 DNFGKKYLP------ESANQYASKENSQEAHEAIRPSDVNVLAETLKDMESDAQKLYQLI 394

Query: 388 ARRTIALYWDNAKREYSKINLDINGETFKLSG-SRTVE-EGWHEIY-YYTKFDEVE-LPE 443
            R+ +A     A  +Y    L +    FKL    RT+  +GW ++     K DE   LP 
Sbjct: 395 WRQFVACQMTPA--QYDSTTLTVKAGDFKLKARGRTLRFDGWTKVMPALRKGDEDRTLPL 452

Query: 444 LKKNDVINVNNINFEAKETKPPKRYTMASIIKELEKRKLGTKATRADILEKLTKRGYV-I 502
           + K + +++  +      TKPP R++ AS++KELEKR +G  +T A I+  +  RGYV +
Sbjct: 453 VNKGESLSLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRV 512

Query: 503 EDGSLTVTDLGIGVTETLRKYCPEIVEETLTRDLEDKLELIQDKKIKKEEVIQETKDKLT 562
           E+       +G  VT+ L +   +++    T  +ED+L+ + + + + ++V+       T
Sbjct: 513 ENRRFYAEKMGEIVTDRLEENFRDLMNYDFTAQMEDRLDQVANHQAEWKQVLDNFFGDFT 572

Query: 563 KILGEFRLKEKEIGTELVDKLDSTNRSLQIIGKCKCGGDMIIIRTKGKKRFVGCSNY--- 619
             L       +E G +        N  +     C   G  + IRT     F+GCS Y   
Sbjct: 573 SQLQTAEKDPEEGGMQ-------PNPMVLTTIDCPTCGRKMGIRTASTGVFLGCSGYALS 625

Query: 620 --PDCEVTFPL-PQKGRIKVL------------NEVCEKCQNPVIGL-----DRIKIC-V 658
               C+ T  L P+   + VL               C+KC   +         ++ +C  
Sbjct: 626 PKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCKKCGTAMDSYLIDPKRKLHVCGN 685

Query: 659 NPDCSTRISEEDKKEIEKAEKEEKICPKCGNKLLIKKGPYGVFRGCENYPKCKYTEKL-- 716
           NP C     EE +  I+  +     C KCG+++ +K G +G +  C N  +CK T K+  
Sbjct: 686 NPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-DECKNTRKILR 744

Query: 717 NGE----SNEKEIVGKCPKCGSDLY--KRKGRFGEFIGCSNYPKCRHT 758
           NGE      +   + + P   SD Y   R G  G F+  + +PK R T
Sbjct: 745 NGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRET 792