Pairwise Alignments

Query, 823 a.a., DNA topoisomerase I from Methanococcus maripaludis S2

Subject, 651 a.a., DNA topoisomerase III from Klebsiella michiganensis M5al

 Score =  166 bits (420), Expect = 4e-45
 Identities = 168/616 (27%), Positives = 277/616 (44%), Gaps = 61/616 (9%)

Query: 4   LIICEKPNVAKKIAEALGKPKKKSHNSVPYYELERNGESIVVASAVGHLYTLQEKT--KT 61
           L I EKP++ + IAE L KP +K      Y E    G   VV   +GHL    +      
Sbjct: 3   LFIAEKPSLGRAIAEVLPKPHRKGDG---YIEC---GNGQVVTWCIGHLLEQAQPDVYDA 56

Query: 62  KFGDYPVYDINWVPAS-TLDEKKYIQKYIDALKKVSKDANKFYVATDWDIEGELIGYHAL 120
           ++  + + D+  VP    L  K  + K ++ +K++  DA +   A D D EG+L+    L
Sbjct: 57  RYARWNLLDLPIVPEKWQLQPKPSVTKQLNVIKRLLGDAQEVIHAGDPDREGQLLVDEVL 116

Query: 121 NFSC----GQKNAHRLRFSSLTKKEILKAYEN--PNEIDFGLVDAGDSRHKIDWYFGINV 174
           ++       ++   R   + L  + + +A      N     L  +  +R + DW +GIN+
Sbjct: 117 DYLQLAPEKRQQVQRCLINDLNPQAVERAINRLRANSEFVPLCVSALARARADWLYGINM 176

Query: 175 SRALMQAVSSVKRWKTLSTGRVQGPALAFLVDKELEIRNFVPTPYWVLEALL----DNDL 230
           +RA      +      LS GRVQ P L  +V ++ EI NFV   ++ ++A +    D   
Sbjct: 177 TRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFDVKAHIVTPKDERF 236

Query: 231 IAV----HELEKFWDEEQ-------ANKAYEKVKGQKQATVSDVKKSMKTIPPNPPFDLG 279
           +A        E + DEE        A    ++++GQ  ATV+       + P   PF L 
Sbjct: 237 VATWVPSEACEPYQDEEGRLLHRSLAEHVVKRIEGQP-ATVTAYNDKRDSEPAPLPFSLS 295

Query: 280 ALQREAHNMFRFSPKKTQEVAQKLYE-KGYCSYPRTSSQKLPDDK-AYMDEVLKNLSKN- 336
           ALQ EA   F FS +   ++ QKLYE     +YPR+ S+ LP++  A    VL  +S + 
Sbjct: 296 ALQIEAAKRFGFSAQNVLDICQKLYETHKLITYPRSDSRYLPEEHFAGRHAVLNAISVHA 355

Query: 337 KNYKPYIETILNENRKPISGKNDDPAHPAVHAVDVPKEKLPDDELKLYELIARRTIALYW 396
            +  P          +    K  D  H  +      + KL D+E K+Y LIAR+ +  + 
Sbjct: 356 ADLLPQPVVDPEIRNRCWDDKKVDAHHAIIPTARSSQVKLSDNEEKVYGLIARQYLMQFC 415

Query: 397 DNAKREYSKINLDINGETFKLSGSRTVEEGWHEIYYYTKFDE----VELPELKKNDVINV 452
            +A     +I+LDI    F        E GW  +    + DE    + LP + K+D +  
Sbjct: 416 PDAVFRKCQIDLDIANGKFVAKARFLAEAGWRTLLGNKERDEENDGMPLPVVAKDDELLC 475

Query: 453 NNINFEAKETKPPKRYTMASII------------KELEK-----RKLGTKATRADILEKL 495
                  ++T+PP+ +T A+++            K+L+K       LGT+ATRA I+E L
Sbjct: 476 EKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELL 535

Query: 496 TKRGYVIEDGS-LTVTDLGIGVTETLRKYCPEI-VEETLTRDLEDKLELIQDKKIKKEEV 553
            KRG++ + G  +  TD G  +  +L    PE+     +T   E  L  I +K+ + ++ 
Sbjct: 536 FKRGFLTKKGRYIHSTDAGKALFHSL----PEMATRPDMTAHWESILTQISEKQCRYQDF 591

Query: 554 IQETKDKLTKILGEFR 569
           +Q     L +++ + R
Sbjct: 592 MQPLVGTLFQLIDQAR 607