Pairwise Alignments

Query, 760 a.a., DNA topoisomerase I (TIGR) from Desulfovibrio vulgaris Hildenborough JW710

Subject, 883 a.a., DNA topoisomerase I from Synechococcus elongatus PCC 7942

 Score =  434 bits (1115), Expect = e-125
 Identities = 269/633 (42%), Positives = 366/633 (57%), Gaps = 43/633 (6%)

Query: 5   LIIVESPAKVKTIKKFLGGKYVVQASVGHVRDLPTN--------------EIGVDEANNF 50
           L+IVESP K +TI+ +L   Y V+AS+GHVRDLP +               +GVD  NNF
Sbjct: 4   LVIVESPTKARTIRNYLPKDYRVEASMGHVRDLPQSASDIPTELKGEKWSNLGVDVENNF 63

Query: 51  APQYRVIDGKQKVVDTLREAAAKADTVYLAPDPDREGEAIAWHVAALIEGKADNIKRIQF 110
           AP Y V   K+K+V TL++A   AD + LA D DREGE+I+WH+  L++ +    KR+ F
Sbjct: 64  APLYIVPKDKKKIVKTLKDALKDADELILATDEDREGESISWHLLQLLQPRVPT-KRMVF 122

Query: 111 NEITARAVREALENPRDLNRALFDAQQARRVLDRLVGYKLSPLLWKKVKRGISAGRVQSV 170
           +EIT  A++ AL+N RD+++ L  AQ+ RR+LDRLVGY LSPLLWKK+  G+SAGRVQSV
Sbjct: 123 HEITQEAIQAALKNCRDVDQRLVHAQETRRILDRLVGYTLSPLLWKKIAWGLSAGRVQSV 182

Query: 171 ALRLIVDRESERRAFTPEEYWLFRAMF---AKNVPGATPTSPDPQYA---PFKAELAK-I 223
           A+RL+V RE  RRAF    YW  +A     A        T    + A    F     + I
Sbjct: 183 AVRLLVQRERARRAFRQGSYWDLKAQLTVEAGQFEAKLWTLAGQRLATGNDFDESTGQII 242

Query: 224 DGKKAHVADADAANALEDAMRGKPFVITAVERKKRERQPQPPFITSTLQQAANQRLGYSA 283
            G++  + D   A AL D ++ +P+ + ++E K   R+P PPF TSTLQQ +N++L  SA
Sbjct: 243 AGRQVCLLDQQEAEALRDRLQTQPWQVKSLEEKPTTRKPAPPFTTSTLQQESNRKLRLSA 302

Query: 284 KRTMNIAQRLYEGVELGEMGTVALITYMRTDSVRVSDEARDAARAFVTETWGADFCPAKP 343
           + TM +AQ LYE            ITYMRTDSV +S +A +AAR+ V + +G ++   +P
Sbjct: 303 RETMRVAQSLYER---------GFITYMRTDSVHLSQQAIEAARSCVEQMYGKNYLSPQP 353

Query: 344 RQFKTKG-SAQDAHEAVRPVDVNVTPDSVKHLLPPDQFQLYRLVWSRFVASQMAPARFDD 402
           RQF TK  +AQ+AHEA+RP   N      +  L   +F LY L+W R +ASQMA AR   
Sbjct: 354 RQFTTKSKNAQEAHEAIRPAG-NTFRLPQETGLSGAEFALYDLIWKRTIASQMAEARQTM 412

Query: 403 TTVAIACGPAEWRAKGERMLFPGFLAAMPQ--------KEEGDAELPPLQEGETLHPVSV 454
            +V +    AE+RA G+R+ FPGF  A  +         E+ +  LP L+ G+      +
Sbjct: 413 LSVLLEVDNAEFRASGKRIDFPGFFRAYVEGSDDPDAALEDREILLPALKVGDRPTCQEL 472

Query: 455 EKEQKFTQPPARYTEASLVRELEERGIGRPSTYASIISTLIDRDYTRLEDKHFVPTDLGA 514
                 TQPPARYTEASLV+ LE  GIGRPSTYASII T++DR Y +L      PT    
Sbjct: 473 AAIGHETQPPARYTEASLVKMLENEGIGRPSTYASIIGTIVDRGYAQLVSNTLTPTFTAF 532

Query: 515 TVCDLLARHFTTLMDVGFTAQMEDSLDKVAEGGLDWVELLSRFSADFNPTLESAAKAMET 574
            V  LL +HF  L+D  F+A+ME SLD ++ G +DW+  LS+F    +  LE   K  E+
Sbjct: 533 AVTALLEQHFPDLVDTSFSARMEQSLDDISNGEVDWLPYLSQFYRG-DRGLEEQVKLRES 591

Query: 575 VKGGLPTDVTCPECGKPVVVKFGKAGPFLACTA 607
                       E G P  V+ G+ G +L   A
Sbjct: 592 EIDPAAARTVALE-GLPAKVRIGRFGAYLEAEA 623