Pairwise Alignments

Query, 760 a.a., DNA topoisomerase I (TIGR) from Desulfovibrio vulgaris Hildenborough JW710

Subject, 823 a.a., DNA topoisomerase I from Methanococcus maripaludis S2

 Score =  213 bits (542), Expect = 3e-59
 Identities = 201/813 (24%), Positives = 332/813 (40%), Gaps = 170/813 (20%)

Query: 22  GGKYVVQASVGHVR-----------DLPTNEIGVDEANNFAPQYRVIDGK--QKVVDTLR 68
           G   VV ++VGH+            D P  +I      N+ P   + + K  QK +D L+
Sbjct: 40  GESIVVASAVGHLYTLQEKTKTKFGDYPVYDI------NWVPASTLDEKKYIQKYIDALK 93

Query: 69  EAAAKADTVYLAPDPDREGEAIAWHVAALIEGKADNIKRIQFNEITARAVREALENPRDL 128
           + +  A+  Y+A D D EGE I +H      G+  N  R++F+ +T + + +A ENP ++
Sbjct: 94  KVSKDANKFYVATDWDIEGELIGYHALNFSCGQK-NAHRLRFSSLTKKEILKAYENPNEI 152

Query: 129 NRALFDAQQARRVLDRLVGYKLSPLLWKKVK-----RGISAGRVQSVALRLIVDRESERR 183
           +  L DA  +R  +D   G  +S  L + V      + +S GRVQ  AL  +VD+E E R
Sbjct: 153 DFGLVDAGDSRHKIDWYFGINVSRALMQAVSSVKRWKTLSTGRVQGPALAFLVDKELEIR 212

Query: 184 AFTPEEYWLFRAMFAKNVPGATPTSPDPQYAPFKAELAKIDGKKAHVADADAANALEDAM 243
            F P  YW+  A+   ++                 EL K         D + AN   + +
Sbjct: 213 NFVPTPYWVLEALLDNDLIAVH-------------ELEKF-------WDEEQANKAYEKV 252

Query: 244 RG-KPFVITAVERKKRERQPQPPFITSTLQQAANQRLGYSAKRTMNIAQRLYEGVELGEM 302
           +G K   ++ V++  +   P PPF    LQ+ A+    +S K+T  +AQ+LYE       
Sbjct: 253 KGQKQATVSDVKKSMKTIPPNPPFDLGALQREAHNMFRFSPKKTQEVAQKLYEK------ 306

Query: 303 GTVALITYMRTDSVRVSDEARDAARAFVTETWGADFCP-----AKPRQFKTKGSAQD-AH 356
                 +Y RT S ++ D+           +   ++ P         +    G   D AH
Sbjct: 307 ---GYCSYPRTSSQKLPDDKAYMDEVLKNLSKNKNYKPYIETILNENRKPISGKNDDPAH 363

Query: 357 EAVRPVDVNVTPDSVKHLLPPDQFQLYRLVWSRFVASQMAPARFDDTTVAIACGPAEWRA 416
            AV  VDV       K  LP D+ +LY L+  R +A     A+ + + + +      ++ 
Sbjct: 364 PAVHAVDVP------KEKLPDDELKLYELIARRTIALYWDNAKREYSKINLDINGETFKL 417

Query: 417 KGERMLFPGFLAAMPQKEEGDAELPPLQEGETLHPVSVEKEQKFTQPPARYTEASLVREL 476
            G R +  G+       +  + ELP L++ + ++  ++  E K T+PP RYT AS+++EL
Sbjct: 418 SGSRTVEEGWHEIYYYTKFDEVELPELKKNDVINVNNINFEAKETKPPKRYTMASIIKEL 477

Query: 477 EERGIGRPSTYASIISTLIDRDYTRLEDKHFVPTDLGATVCDLLARHFTTLMDVGFTAQM 536
           E+R +G  +T A I+  L  R Y  +ED     TDLG  V + L ++   +++   T  +
Sbjct: 478 EKRKLGTKATRADILEKLTKRGYV-IEDGSLTVTDLGIGVTETLRKYCPEIVEETLTRDL 536

Query: 537 EDSLDKVAEGGLDWVELLSRFSADFNPTLESAAKAMETVKGGLPTDVTCPECGKPVVVKF 596
           ED L+ + +  +   E++         T +   K +   +      +   E G  +V K 
Sbjct: 537 EDKLELIQDKKIKKEEVIQE-------TKDKLTKILGEFR------LKEKEIGTELVDKL 583

Query: 597 GKAGPFLACTAYPDCKFTSNFSRDEKGDIVIEQRAREELEAVGTCPECGKDLVVKKARTG 656
                                                 L+ +G C +CG D+++ + +  
Sbjct: 584 DSTN--------------------------------RSLQIIGKC-KCGGDMIIIRTKGK 610

Query: 657 SRFIACTGYPDCRHTEPFST-------------------GI----ACPREGC-------D 686
            RF+ C+ YPDC  T P                      G+     C    C       D
Sbjct: 611 KRFVGCSNYPDCEVTFPLPQKGRIKVLNEVCEKCQNPVIGLDRIKICVNPDCSTRISEED 670

Query: 687 GQLVEKSSKRGKI-----------------FYSCNRFPKCDYA------LWDWPVPGPCP 723
            + +EK+ K  KI                 F  C  +PKC Y         +  + G CP
Sbjct: 671 KKEIEKAEKEEKICPKCGNKLLIKKGPYGVFRGCENYPKCKYTEKLNGESNEKEIVGKCP 730

Query: 724 VCGSPLLVKKSTRAKGLHIACPE-KTCRYTQEL 755
            CGS L  +K     G  I C     CR+T+++
Sbjct: 731 KCGSDLYKRKG--RFGEFIGCSNYPKCRHTEKI 761



 Score = 79.7 bits (195), Expect = 6e-19
 Identities = 42/114 (36%), Positives = 56/114 (49%), Gaps = 16/114 (14%)

Query: 585 CPECGKPVVVKFGKAGPFLACTAYPDCKFTSNFSRDEKGDIVIEQRAREELEAVGTCPEC 644
           CP+CG  +++K G  G F  C  YP CK+T   + +             E E VG CP+C
Sbjct: 684 CPKCGNKLLIKKGPYGVFRGCENYPKCKYTEKLNGESN-----------EKEIVGKCPKC 732

Query: 645 GKDLVVKKARTGSRFIACTGYPDCRHTEPFSTGIACPREGCDGQLVEKSSKRGK 698
           G DL  +K R G  FI C+ YP CRHTE     I   +E   G+   ++ K  K
Sbjct: 733 GSDLYKRKGRFGE-FIGCSNYPKCRHTEK----IDKKKEDTPGETKAETKKEAK 781



 Score = 42.0 bits (97), Expect = 1e-07
 Identities = 23/71 (32%), Positives = 35/71 (49%), Gaps = 4/71 (5%)

Query: 585 CPECGKPVVVKFGKAGPFLACTAYPDCKFTSNFSRDEKGDIVIEQRAREELEAVGTCPEC 644
           CP+CG  +  + G+ G F+ C+ YP C+ T    + +K D   E +A  + EA    P+ 
Sbjct: 729 CPKCGSDLYKRKGRFGEFIGCSNYPKCRHTEKIDK-KKEDTPGETKAETKKEAK---PKT 784

Query: 645 GKDLVVKKART 655
            K    KK  T
Sbjct: 785 TKKAAPKKTAT 795