Pairwise Alignments
Query, 1037 a.a., CusA/CzcA family heavy metal efflux RND transporter from Ralstonia sp. UNC404CL21Col
Subject, 1052 a.a., heavy metal efflux pump, cobalt-zinc-cadmium from Dechlorosoma suillum PS
Score = 694 bits (1790), Expect = 0.0
Identities = 414/1048 (39%), Positives = 615/1048 (58%), Gaps = 38/1048 (3%)
Query: 1 MLPRLIEFSLRQRVLVLIAAGVLAVACVWAYLNLPIDAFPDISPTQVKVVLKAPGMTPEE 60
ML R+I ++ R LVLI + VW+Y LPIDA PDI+ QV+V +APG +P E
Sbjct: 1 MLERMIRAAIAHRWLVLILVLGTSALGVWSYGRLPIDAVPDITNVQVQVNSEAPGYSPLE 60
Query: 61 VEQRVSTPIEQELLGLPHKTIVRSVSKYGISDVTVDFEEGVDVYWARQQVSERLAGLARD 120
EQRV+ P+E L G+ RS+S+YG+S VTV FE+G D+Y+ARQQVSERL +
Sbjct: 61 AEQRVTFPVETALAGMARLKYTRSISRYGLSQVTVVFEDGTDIYFARQQVSERLQQASSQ 120
Query: 121 LPSTAVGGLAPITTPLGEMFMFTVE---------GDGYSLAERRRVLDWVIRPALRTVAG 171
LP+ L P+ T LGE+FM+TVE G + + R + DWVIRP LR + G
Sbjct: 121 LPAGVKPTLGPVATGLGEIFMYTVEATPGATKADGKPWMPTDLRTLQDWVIRPQLRNLKG 180
Query: 172 VADVNALGGEVRSYEVTPDPARLRARGVTLEQLRQALDANNRNDGAGRLDRGDEHWVVRV 231
V +VN +GG V+ + VTPDPA++ A +T++ L QA++ NN N GAG ++RG E ++R+
Sbjct: 181 VTEVNTIGGNVQQFHVTPDPAKMVAYKLTIDDLLQAIERNNANTGAGYIERGGEQNLIRI 240
Query: 232 EGGVRGLDDLRAIVVVPAQSLSSPPAVTVGDVATVRLGEATRNGAVSKDGNGEAVEGLVL 291
G V LR IVV L + + D+ATV++G R GA ++DG E V G V
Sbjct: 241 PGQVGDEAGLREIVVAMRDGLP----LRISDIATVQIGSELRTGAATRDGR-EVVLGTVF 295
Query: 292 GLRGSDARKLVEAVQERLDTLGPQLPKGMSTHVFYNRGELVTRAANTVVRALIEASVLVV 351
L G ++R++ RL + LP+G+S Y+R +LV R+ TV + L+E ++LV+
Sbjct: 296 MLIGENSREVAMRAATRLKEIDASLPEGVSARAVYDRTQLVDRSIATVQKNLLEGALLVI 355
Query: 352 ITLYLFLGGVRAALVVAATLPLSMLATFLLMRYVGLTANLMSLGGLAIALGMLVDAAVVV 411
+ L+L LG +RAAL+ AA +P++ML T M ++ANLMSLG A+ G++VD AV++
Sbjct: 356 VVLFLLLGNIRAALITAAVIPVAMLMTITGMVQNRVSANLMSLG--ALDFGLIVDGAVII 413
Query: 412 VENIETAMARAQDHKTDPAL----RGAVIRHAVATVAVPMLSGVSIIAIVFLPLLSLQGL 467
VEN Q H L R + A A V P L G+ IIA V+LP+ +L G+
Sbjct: 414 VENCLRRFGERQ-HALGRLLSIEERFQLAAKASAEVIKPSLFGLFIIAAVYLPIFALSGV 472
Query: 468 EGKLFGPVALTIVLALASSVVIAFTVVPALASLLLLAHADEPPW-LMRKVASGFARLQAW 526
EGK F P+A+T+V+AL +++V++ T VPA + + +E LM+++ +A L
Sbjct: 473 EGKTFHPMAITVVMALVAAMVLSLTFVPAAIAQFVTGKVEEKETRLMQRLHGIYAPLLEK 532
Query: 527 TTTHRRAVFSLAGVALALAVVLYMSVGKTFMPTMDEGDLIVQLQKAPSVSLAASLDIDQR 586
+ + ++ V A V + L +L +G F+P +DEGD+ + + P SL ++ + +
Sbjct: 533 SLSLQKPVIGAAAVLVVLCGLLATRLGTEFIPNLDEGDIALHALRIPGTSLTQAIGMQAQ 592
Query: 587 VQQALLKEVPEIRSIVARSGSDDLGLDPMGLNETDTFLVLKPKDQW---RGSKEDIAMAI 643
++ A +K+ PE+ +V + G+ ++ DPM + DTF++LK + W R SK + +
Sbjct: 593 LE-ARIKQFPEVDKVVGKLGTAEVATDPMPPSVADTFILLKERKDWPDPRKSKATLVAEL 651
Query: 644 RRVMERFPGVIYGFTQPIEMRVSEMLTGTRGDVAIKLFGSDLAAIDAAAQAIAAKVRTIP 703
+ PG Y FTQP++MR++E++ G R +VAIK+FG DL A+ A + I +I
Sbjct: 652 EEAVRAIPGNNYEFTQPVQMRMNELIAGVRAEVAIKVFGDDLQALTAVGKQIEKVAGSIS 711
Query: 704 GAAEVIAPSNSGVQYLKVSLDRAAVGQAGFSGDALQAQLRALIEGDRIGVVPEGIVRTPL 763
G+A+V +G+ L + DRAA+ + G + +Q + A + G G + EG R +
Sbjct: 712 GSADVKLEQVTGLPLLVIKPDRAALARYGLAVADIQDTVSAAMGGATAGQLFEGDRRFDI 771
Query: 764 ILRGGAGLRQAPENLTSLLVTAP-----DGK-------VWPLTSLARIERVDGPVRINHE 811
++R RQ P+ L +L + P DG V PL+++A I GP +++ E
Sbjct: 772 VVRLPDAQRQDPKALAALPIALPATSRADGASLSRMPGVVPLSAVATIAVELGPNQVSRE 831
Query: 812 DGARFAVIQANVDGRDLAGFVQEAQAAVGGIGTLPKGLRVVWGGQFENQQRAAARLALVV 871
+G R VI +NV GRDL FV+E + V LP G V +GG FE A RL++VV
Sbjct: 832 NGKRRVVITSNVRGRDLGSFVEELRGKVAAEVVLPVGSWVEYGGTFEQLISAGQRLSVVV 891
Query: 872 PLALGAIFLLLMLTFRSVRQAVLVVANIPFALVGGIAALRISGEYLSVPASVGFIALLGI 931
P+ L IF LL + F S + A +V + +P AL GG+ AL + G S+ A VGFIAL G+
Sbjct: 892 PVVLVMIFGLLFMAFGSAKDAAIVFSGVPLALTGGVLALWLRGIPFSISAGVGFIALSGV 951
Query: 932 AVLNGVVLVSHFNTLLESGIGMAQAVRNGVRDRLRPVLMTACITALGMIPLLLASGPGSE 991
AVLNG+V+++ L E G + AV G RLRPVLMTA + +LG +P+ L G G+E
Sbjct: 952 AVLNGLVMITFIRKLRELGQPLHTAVTEGALTRLRPVLMTALVASLGFVPMALNVGTGAE 1011
Query: 992 IQRPLAIVVSGGLISSTALTLLLLPLLF 1019
+QRPLA VV GG+ISST LTLL+LP+L+
Sbjct: 1012 VQRPLATVVIGGIISSTLLTLLVLPVLY 1039
Score = 55.8 bits (133), Expect = 2e-11
Identities = 110/541 (20%), Positives = 208/541 (38%), Gaps = 71/541 (13%)
Query: 5 LIEFSLRQRVLVLIAAGVLAVACVWAYLNLPIDAFPDISPTQVKV-VLKAPGMTPEEVEQ 63
L+E SL + V+ AA VL V C L + P++ + + L+ PG + + Q
Sbjct: 529 LLEKSLSLQKPVIGAAAVLVVLCGLLATRLGTEFIPNLDEGDIALHALRIPGTS---LTQ 585
Query: 64 RVSTPIEQELLGLPHKTIVRSVSKYGISDVTVD------------FEEGVDVYWARQQVS 111
+ + E + + V K G ++V D +E D R+ +
Sbjct: 586 AIGMQAQLEARIKQFPEVDKVVGKLGTAEVATDPMPPSVADTFILLKERKDWPDPRKSKA 645
Query: 112 ERLAGL---ARDLPSTAVGGLAPITTPLGEMFM-------FTVEGDGYSLAERRRVLDWV 161
+A L R +P P+ + E+ V GD + +
Sbjct: 646 TLVAELEEAVRAIPGNNYEFTQPVQMRMNELIAGVRAEVAIKVFGDDL---QALTAVGKQ 702
Query: 162 IRPALRTVAGVADVNALGGEVRSYE---VTPDPARLRARGVTLEQLRQALDANNRNDGAG 218
I +++G ADV +V + PD A L G+ + ++ + A AG
Sbjct: 703 IEKVAGSISGSADVKL--EQVTGLPLLVIKPDRAALARYGLAVADIQDTVSAAMGGATAG 760
Query: 219 RLDRGDEHW--VVRVEGGVRGLDDLRAIVVVP----------AQSLSSPPAVT-VGDVAT 265
+L GD + VVR+ R D +A+ +P SLS P V + VAT
Sbjct: 761 QLFEGDRRFDIVVRLPDAQR--QDPKALAALPIALPATSRADGASLSRMPGVVPLSAVAT 818
Query: 266 VRLGEATRNGAVSKDGNGEAVEGLVLGLRGSDARKLVEAVQERLDT-----LGPQLPKGM 320
+ + E N ++G V + +RG D VE ++ ++ +G + G
Sbjct: 819 IAV-ELGPNQVSRENGKRRVV--ITSNVRGRDLGSFVEELRGKVAAEVVLPVGSWVEYGG 875
Query: 321 STHVFYNRGELVTRAANTVVRALIEASVLVVITLYLFLGGVRAALVVAATLPLSMLATFL 380
+ + G+ ++ V+ V++ L++ G + A +V + +PL++ L
Sbjct: 876 TFEQLISAGQRLSVVVPVVL-------VMIFGLLFMAFGSAKDAAIVFSGVPLALTGGVL 928
Query: 381 LMRYVGLTANLMSLGGLAIALGMLVDAAVVVVENIETAMARAQDHKTDPALRGAVIRHAV 440
+ G+ ++ + G G+ V +V++ I Q T +
Sbjct: 929 ALWLRGIPFSISAGVGFIALSGVAVLNGLVMITFIRKLRELGQPLHT-------AVTEGA 981
Query: 441 ATVAVPMLSGVSIIAIVFLPLLSLQGLEGKLFGPVALTIVLALASSVVIAFTVVPALASL 500
T P+L + ++ F+P+ G ++ P+A ++ + SS ++ V+P L L
Sbjct: 982 LTRLRPVLMTALVASLGFVPMALNVGTGAEVQRPLATVVIGGIISSTLLTLLVLPVLYRL 1041
Query: 501 L 501
+
Sbjct: 1042 I 1042
Score = 38.9 bits (89), Expect = 2e-06
Identities = 78/355 (21%), Positives = 139/355 (39%), Gaps = 46/355 (12%)
Query: 695 IAAKVRTIPGAAEVIAPSNSGVQYLKVSLDRAAVGQAGFSGDALQAQLRALIEGDRIGVV 754
I ++R + G EV + VQ V+ D A + + D L + G +
Sbjct: 171 IRPQLRNLKGVTEVNTIGGN-VQQFHVTPDPAKMVAYKLTIDDLLQAIERNNANTGAGYI 229
Query: 755 PEG----IVRTPLILRGGAGLRQAPENLTSLLVTAPDGKVWPLTSLARIE-----RVDGP 805
G ++R P + AGLR+ ++V DG ++ +A ++ R
Sbjct: 230 ERGGEQNLIRIPGQVGDEAGLRE-------IVVAMRDGLPLRISDIATVQIGSELRTGAA 282
Query: 806 VRINHED--GARFAVIQANVDGRDLAGFVQEAQAAVGGIGTLPKGLRVVWGGQFENQQRA 863
R E G F +I N R++A ++ A +LP+G+ ++ Q
Sbjct: 283 TRDGREVVLGTVFMLIGEN--SREVA--MRAATRLKEIDASLPEGVSA--RAVYDRTQLV 336
Query: 864 AARLALVVPLALGAIFLLLMLTFR---SVRQAVLVVANIPFAL---VGGIAALRISGEYL 917
+A V L L++++ F ++R A++ A IP A+ + G+ R+S +
Sbjct: 337 DRSIATVQKNLLEGALLVIVVLFLLLGNIRAALITAAVIPVAMLMTITGMVQNRVSANLM 396
Query: 918 SVPASVGFIALLGIAVLNGVVLVS----------HFNTLLESGIGMAQAVRNGVRDRLRP 967
S+ A G+ V V++V H L S Q + ++P
Sbjct: 397 SLGALD-----FGLIVDGAVIIVENCLRRFGERQHALGRLLSIEERFQLAAKASAEVIKP 451
Query: 968 VLMTACITALGMIPLLLASGPGSEIQRPLAIVVSGGLISSTALTLLLLPLLFERF 1022
L I A +P+ SG + P+AI V L+++ L+L +P +F
Sbjct: 452 SLFGLFIIAAVYLPIFALSGVEGKTFHPMAITVVMALVAAMVLSLTFVPAAIAQF 506