Pairwise Alignments
Query, 1037 a.a., CusA/CzcA family heavy metal efflux RND transporter from Ralstonia sp. UNC404CL21Col
Subject, 1047 a.a., CzcA family heavy metal efflux protein (RefSeq) from Shewanella sp. ANA-3
Score = 663 bits (1711), Expect = 0.0
Identities = 396/1033 (38%), Positives = 595/1033 (57%), Gaps = 23/1033 (2%)
Query: 1 MLPRLIEFSLRQRVLVLIAAGVLAVACVWAYLNLPIDAFPDISPTQVKVVLKAPGMTPEE 60
ML ++ FS++++ LVL+ +A +W + LPIDA PDI+ QV + +APG TP E
Sbjct: 1 MLESILRFSIKRKFLVLVMVIAVAGLGLWNFTKLPIDAVPDITNVQVMINTEAPGYTPLE 60
Query: 61 VEQRVSTPIEQELLGLPHKTIVRSVSKYGISDVTVDFEEGVDVYWARQQVSERLAGLARD 120
+EQRV+ P+E L GLP T RSVS+YG+S V F + DVY+ARQ V+ERL+ +
Sbjct: 61 IEQRVTFPLETALAGLPGLTYTRSVSRYGLSQVVAIFSDETDVYFARQLVNERLSAARSE 120
Query: 121 LPSTAVGGLAPITTPLGEMFMFTVEG-------DGYSLA--ERRRVLDWVIRPALRTVAG 171
LP L PI T LGE+FMFTV+ DG + + R V DW IRP L V G
Sbjct: 121 LPLGLEPQLGPIATGLGEIFMFTVDALPDATHADGTPITPMDLRTVHDWTIRPQLMRVPG 180
Query: 172 VADVNALGGEVRSYEVTPDPARLRARGVTLEQLRQALDANNRNDGAGRLDRGDEHWVVRV 231
V +VN +GG R V P +L A G+T + A+ NN+N GAG +++ W++R+
Sbjct: 181 VVEVNPIGGFEREILVAFKPEKLLAFGLTQADVVDAIAKNNQNQGAGFIEQNGAQWLLRM 240
Query: 232 EGGVRGLDDLRAIVVVPAQSLSSPPAVTVGDVATVRLGEATRNGAVSKDGNGEAVEGLVL 291
G +D+ AI +P +S A+T+ DVA + G+ RNGA +++G E V V
Sbjct: 241 PGQA---EDIVAIGNIPLKSTQGS-ALTIKDVADIENGQGLRNGAATQNGR-EVVMSTVF 295
Query: 292 GLRGSDARKLVEAVQERLDTLGPQLPKGMSTHVFYNRGELVTRAANTVVRALIEASVLVV 351
L G ++R + AV E+L + LP+G+ Y+R +LV + TV L+E ++LV+
Sbjct: 296 MLIGENSRTVAHAVGEKLKEINATLPEGIVATAVYDRTKLVDKTLQTVQTNLLEGALLVI 355
Query: 352 ITLYLFLGGVRAALVVAATLPLSMLATFLLMRYVGLTANLMSLGGLAIALGMLVDAAVVV 411
+ L++ LG RAA + A +P +ML T M ++ANLMSLG A+ G+LVD A+++
Sbjct: 356 VVLFVLLGNFRAAFLTALVIPFAMLMTITGMVQTRVSANLMSLG--ALDFGLLVDGAIII 413
Query: 412 VENIETAMARAQDHKTDPALRGAVIRHAVATVAVPMLSGVSIIAIVFLPLLSLQGLEGKL 471
VEN +++A D R ++ A V P L GV II V+LP+ +L+G+EGK+
Sbjct: 414 VENCLRRLSQAGDDPLPLKERLELVFEATREVIRPALFGVFIITAVYLPIFALEGVEGKM 473
Query: 472 FGPVALTIVLALASSVVIAFTVVPALASLLLLAHADEPPWLMRKVASGFARLQAWTTTHR 531
F P+A+T+V+AL S+++++ T VPA +LL E + + A R
Sbjct: 474 FHPMAITVVIALLSAMLLSVTFVPATIALLFKKPVKEKHSPLIRGAGALYRPALNRVIQG 533
Query: 532 RAVFSLAGVALALAVVLYMS--VGKTFMPTMDEGDLIVQLQKAPSVSLAASLDIDQRVQQ 589
R V +A L +AV Y + +G F P +DEGD+ + + P SL+ ++ + + ++
Sbjct: 534 RWVVVIAATLL-VAVFGYQATKLGSEFAPNLDEGDIAMHALRIPGTSLSQAIALQETLED 592
Query: 590 ALLKEVPEIRSIVARSGSDDLGLDPMGLNETDTFLVLKPKDQWRG---SKEDIAMAIRRV 646
+ K++PE+ + A+ G+ D+ D + + D F++LKP++QW SKE I + +
Sbjct: 593 KI-KQMPEVERVFAKIGTADVATDAVPPSVADNFIILKPREQWPNPNKSKEQIVEELAAM 651
Query: 647 MERFPGVIYGFTQPIEMRVSEMLTGTRGDVAIKLFGSDLAAIDAAAQAIAAKVRTIPGAA 706
+E PG Y F QPI+MR +E+L G R ++AIK+FG D + + I A + + G A
Sbjct: 652 VEPIPGNRYEFLQPIQMRFNELLAGVRAELAIKVFGDDFDTLTSLGAQIEAAIAQVDGIA 711
Query: 707 EVIAPSNSGVQYLKVSLDRAAVGQAGFSGDALQAQLRALIEGDRIGVVPEGIVRTPLILR 766
+V +G+ L + R + Q G S LQ+Q+ + G EG +R+ +++R
Sbjct: 712 DVQVEQTTGLPMLNIIPKRQQLMQHGLSMAELQSQVATAMGGTVASKFYEGDIRSDIVVR 771
Query: 767 GGAGLRQAPENLTSLLVTAPDGKVWPLTSLARIERVDGPVRINHEDGARFAVIQANVDGR 826
G RQ + L L ++ PD PL LA +E V G +IN E+G R V+ ANV GR
Sbjct: 772 LGESRRQNLDGLRYLPISLPDRHSIPLQELASLELVSGANQINRENGKRRMVVTANVRGR 831
Query: 827 DLAGFVQEAQAAVGGIGTLPKGLRVVWGGQFENQQRAAARLALVVPLALGAIFLLLMLTF 886
DL FV + Q +G +P G V +GG ++ Q A+ RL++VVP+ L I LL+L
Sbjct: 832 DLGSFVADIQNVIGERVDIPAGYSVEYGGTYQKLQSASHRLSIVVPVTLLMIVGLLILAL 891
Query: 887 RSVRQAVLVVANIPFALVGGIAALRISGEYLSVPASVGFIALLGIAVLNGVVLVSHFNTL 946
S + A+++ +P AL GGIAAL + S+ A+VGFIAL GIA+LNG+V+VS L
Sbjct: 892 SSFKDAMIIFTGVPLALTGGIAALLLRDIPFSISAAVGFIALSGIAILNGLVMVSFIREL 951
Query: 947 LESGIGMAQAVRNGVRDRLRPVLMTACITALGMIPLLLASGPGSEIQRPLAIVVSGGLIS 1006
+ G+G+ +A+ G RLRPVL TA + +LG IP+ L +G GSE+QRPLA VV GG+IS
Sbjct: 952 RKEGMGLDRAIFEGALTRLRPVLTTALVASLGFIPMALNTGIGSEVQRPLATVVIGGIIS 1011
Query: 1007 STALTLLLLPLLF 1019
ST LTL ++P L+
Sbjct: 1012 STLLTLFVIPALY 1024
Score = 68.6 bits (166), Expect = 2e-15
Identities = 106/526 (20%), Positives = 222/526 (42%), Gaps = 63/526 (11%)
Query: 10 LRQRVLVLIAAGVLAVACVWAYLNLPIDAFPDISPTQVKV-VLKAPGMTPEEVEQRVSTP 68
++ R +V+IAA +L + L + P++ + + L+ PG + + T
Sbjct: 531 IQGRWVVVIAATLLVAVFGYQATKLGSEFAPNLDEGDIAMHALRIPGTSLSQAIALQET- 589
Query: 69 IEQELLGLPHKTIVRSVSKYGISDVTVDF---------------EEGVDVYWARQQVSER 113
+E ++ +P + R +K G +DV D E+ + +++Q+ E
Sbjct: 590 LEDKIKQMPE--VERVFAKIGTADVATDAVPPSVADNFIILKPREQWPNPNKSKEQIVEE 647
Query: 114 LAGLARDLPSTAVGGLAPITTPLGEMFM-------FTVEGDGYSLAERRRVLDWVIRPAL 166
LA + +P L PI E+ V GD + L I A+
Sbjct: 648 LAAMVEPIPGNRYEFLQPIQMRFNELLAGVRAELAIKVFGDDFDTLTS---LGAQIEAAI 704
Query: 167 RTVAGVADVNALGGE-VRSYEVTPDPARLRARGVTLEQLRQALDANNRNDGAGRLDRGD- 224
V G+ADV + + P +L G+++ +L+ + A + GD
Sbjct: 705 AQVDGIADVQVEQTTGLPMLNIIPKRQQLMQHGLSMAELQSQVATAMGGTVASKFYEGDI 764
Query: 225 -EHWVVRV-EGGVRGLDDLRAIVVVPAQSLSSPPAVTVGDVATVRLGEATRNGAVSKDGN 282
VVR+ E + LD LR + + SL ++ + ++A++ L ++++ N
Sbjct: 765 RSDIVVRLGESRRQNLDGLRYLPI----SLPDRHSIPLQELASLELVSGANQ--INRE-N 817
Query: 283 GEAVEGLVLGLRGSDARKLVEAVQ----ERLDTLGPQLPKGMSTHVFYNRGELVTRAANT 338
G+ + +RG D V +Q ER+D +P G S V Y ++A+
Sbjct: 818 GKRRMVVTANVRGRDLGSFVADIQNVIGERVD-----IPAGYS--VEYGGTYQKLQSASH 870
Query: 339 VVRALIEASVLVVI-TLYLFLGGVRAALVVAATLPLSMLATF--LLMRYVGLTANLMSLG 395
+ ++ ++L+++ L L L + A+++ +PL++ LL+R + +
Sbjct: 871 RLSIVVPVTLLMIVGLLILALSSFKDAMIIFTGVPLALTGGIAALLLRDIPFS------- 923
Query: 396 GLAIALGMLVDAAVVVVENIETAMARAQDHKTDPALRGAVIRHAVATVAVPMLSGVSIIA 455
++ A+G + + + ++ + + K L A+ A+ + P+L+ + +
Sbjct: 924 -ISAAVGFIALSGIAILNGLVMVSFIRELRKEGMGLDRAIFEGALTRLR-PVLTTALVAS 981
Query: 456 IVFLPLLSLQGLEGKLFGPVALTIVLALASSVVIAFTVVPALASLL 501
+ F+P+ G+ ++ P+A ++ + SS ++ V+PAL +L
Sbjct: 982 LGFIPMALNTGIGSEVQRPLATVVIGGIISSTLLTLFVIPALYRIL 1027