Pairwise Alignments

Query, 1062 a.a., Multidrug efflux pump subunit AcrB from Paraburkholderia bryophila 376MFSha3.1

Subject, 1036 a.a., AcrB/AcrD/AcrF family protein from Vibrio cholerae E7946 ATCC 55056

 Score =  345 bits (886), Expect = 8e-99
 Identities = 264/1043 (25%), Positives = 495/1043 (47%), Gaps = 46/1043 (4%)

Query: 1    MWIVNVALKRPYTFIVMAILIVLATPFVLFTTPVDVLPEINIPVVSIIWTYNGLSAEDMA 60
            MW+ +V++KRP   +V+++L+ +          V  +P+I  PVVS+   Y G SA  + 
Sbjct: 1    MWLSDVSVKRPVAALVLSMLLCVFGVVSFTKLAVREMPDIESPVVSVSTRYQGASATIIE 60

Query: 61   HRIASVNERSLTTTVNDIEHIESQSLAGITILKVFLQPTANIQTAIAQTV-AVEQAQLKQ 119
             +I SV E  L   ++ I+ I S S  G++ + V  +   ++ T ++    AV +AQ + 
Sbjct: 61   SQITSVLEDQLAG-ISGIDEITSVSRNGMSRITVTFELGYDLNTGVSDIRDAVARAQ-RS 118

Query: 120  MPPGATPPLVISYSASSIPVIQLGLSSTKLSEQQLNDTALNFLRPQLVTIPGAAVPYPYG 179
            +P  A  P V   + S    + + LSS+++   QL D     L  +   I G +     G
Sbjct: 119  LPEEADDPQVFKNNGSGQASVYINLSSSEMDRTQLTDYIERVLLDRFSLISGVSSVDVSG 178

Query: 180  GKSRLISVDLNTRALLSKGLTPLDVVSAFNAQNLILPTGTAKIGPKEYTINMNGSPATLE 239
            G  +++ V +    +  +G+   D+  A N +NL  P G  +      ++       + E
Sbjct: 179  GLYKVMYVRIKPELMAGRGVATSDISDALNKENLESPGGQVRNDSTVMSVRTARGYQSAE 238

Query: 240  GLNDIPV-RTVNGATTYLREVAHVRDGFSPQTNIVRENGHRGVLMSVLKNGSASTLSIVN 298
                + V R  +G   YL++VA V  G   + +  + +G   V M ++    A+ L +  
Sbjct: 239  DFEYLVVKRASDGTPIYLKDVADVFIGAENENSTFKSDGIVNVSMGIVPQSDANPLEVAK 298

Query: 299  TLHGLLPAARAALPPDLKITALFDQSVFVKAAVQGVVREAVVAAALTAAMILLFLGNWRS 358
             +H  +   +  LP   ++   +D +VF++ ++  V     +   L   ++ +F+G  R+
Sbjct: 299  RVHEEVDKVQQFLPKGTRLAIDYDSTVFIERSISEVYSTLFITGGLVILVLYIFIGQLRA 358

Query: 359  TCIIAISIPLSILSSLIALHALGQTINIMTLGGLALAVGILVDDATVTIENIERHLHMGT 418
            T I A+++P+S++S+ +A +  G +IN++TL  L L++G++VDDA V +ENI  H+  G 
Sbjct: 359  TLIPAVTVPVSLISAFMAAYYFGFSINLITLMALILSIGLVVDDAIVVVENIFHHIERGE 418

Query: 419  NLHDAILEGAGEIAIPALVSTLCICIVFVPMFFLTGVARYLFVPLAEAVVFAMLASYVLS 478
                A  +G  E+    + +TL + +VF+P+ F+ G+   LF   +  +  A++ S +++
Sbjct: 419  KPLLAAYKGTREVGFAVIATTLVLVMVFLPISFMDGMVGLLFTEFSVLLAMAVIFSSLIA 478

Query: 479  RTLVPTLAMLLMGHAHKPKADMKPSLFARLYRRFDNGFERMRAAYIVILSSLLVRRARFG 538
             TL P L   L+      KA++KP  F +L    D  F R+ + Y  ++S   +R     
Sbjct: 479  LTLTPVLGSKLL------KANVKPGRFNQL---IDRLFARLESGYRQVVSR-AIRWRWAA 528

Query: 539  SIFLGFCV-VSMGLAFVLGEDFFPSVDAGNIRLHMRAPTGTRIEETARLADEVEKVIREV 597
             + +  C+  S GL  ++     PS D G I   +R    T     A   D VE+ +  +
Sbjct: 529  PVVIAACIGGSYGLMQLVPAQLTPSEDRGVIFSFVRGADATSYNRMAANMDLVEQRLMPL 588

Query: 598  VPEKELGTILDNLGLPYSGINLSYSNAGTIGTLDGEIQIALKEGHEPT---QLYVDKLRA 654
            + +  L +   ++  P  G        G  G   G + + L++ ++ T   Q  + ++R 
Sbjct: 589  LGQGFLKSF--SIQSPAFG--------GNAGDQTGFVIMILEDWNDRTVTAQEALSQVRK 638

Query: 655  MLPQRFPGVEFF-FQPADIVTQILNFGLPAAVDIQIAGADQQGNFDVARKLLKQVRMIPG 713
             L    P V  F F P          G    V   + G+D       A KL ++    P 
Sbjct: 639  AL-AGIPDVRVFPFMPG------FRGGSNEPVQFVLGGSDYSELKTWAEKLEEEAEKSPF 691

Query: 714  TVDTHIQQKLDEPAINLQMDRTRLQQLNLTASNVAQNVLISLSGSSQTSPGFWYNDRNGV 773
                 I      P + + +D+ R  +L ++  +++  + + L G   T+    + +R G 
Sbjct: 692  MTGADIDYSEKTPELVVTIDKQRAAELGISVKSISDTLEVMLGGKKVTT----FVER-GE 746

Query: 774  EYNVAVQTPQYSISSIDDLLRTPVSASATGPTQLLGNLVRVQPQNQFAVVTHYNIRPVID 833
            EY+V ++  + S ++  DL +     +ATG    L  + R+        + HYN +  + 
Sbjct: 747  EYDVYLRGDENSFNNAADLSQI-YMRTATGELVTLDTVTRIDEVASAIRLAHYNKQKSVT 805

Query: 834  LYVSVDK-RDLGSVADQVDKLVEQARASLPRGSQITVRGQVQTMRSSYFGLGLGVAMAIV 892
            +  +++    LG   D +D   ++A+  LP    ++  G+ +  + +   + +  A+A++
Sbjct: 806  ITANLEAGYTLGQALDFLD---QKAQEILPNDISVSYSGESKDFKENQSSVAIVFALALL 862

Query: 893  LVYLLIVVNFQSWVDPLIIVSALPAALAGIVWMLFLTGTHLSVPALTGAIMTMGVATANS 952
            + YL++   F+S+++PL+++  +P  + G    LF+ G  +++ +  G IM +G+ T N 
Sbjct: 863  VAYLVLAAQFESFINPLVVMLTVPMGVFGGFLGLFVMGQGMNIYSQIGMIMLIGMVTKNG 922

Query: 953  ILMVAFARQRLSAGAPPLTAALEAGASRIRPVLMTAFAMIIGMIPMALGLGEGAEQNAPL 1012
            IL+V FA Q    G     A ++A A R+RP+LMTAF  + G IP+ +  G G E    +
Sbjct: 923  ILIVEFANQLRDRGVEFEKAIIDASARRLRPILMTAFTTLAGSIPLIVSTGAGYESRIAV 982

Query: 1013 GRAVIGGLLFATVSTLFFVPLVF 1035
            G  +  G+ FAT+ TL  +P ++
Sbjct: 983  GTVIFFGMGFATLVTLLVIPAMY 1005



 Score = 59.7 bits (143), Expect = 1e-12
 Identities = 76/418 (18%), Positives = 164/418 (39%), Gaps = 28/418 (6%)

Query: 89   ITILKVFLQPTANIQTAIAQTVAVEQAQLKQMPPGATPPLVISYSASSIPVIQLGLSSTK 148
            I IL+ +   T   Q A++Q     +  L  +P     P +  +   S   +Q  L  + 
Sbjct: 616  IMILEDWNDRTVTAQEALSQV----RKALAGIPDVRVFPFMPGFRGGSNEPVQFVLGGSD 671

Query: 149  LSEQQLNDTALNFLRPQLVTIPGAAVPYPYGGKSRLISVDLNTRALLSKGLTPLDVVSAF 208
             SE +     L     +   + GA + Y       ++++D    A L      + V S  
Sbjct: 672  YSELKTWAEKLEEEAEKSPFMTGADIDYSEKTPELVVTIDKQRAAELG-----ISVKSIS 726

Query: 209  NAQNLILPTGTAKIGP-----KEYTINMNGSPATLEG---LNDIPVRTVNGATTYLREVA 260
            +   ++L  G  K+       +EY + + G   +      L+ I +RT  G    L  V 
Sbjct: 727  DTLEVML--GGKKVTTFVERGEEYDVYLRGDENSFNNAADLSQIYMRTATGELVTLDTVT 784

Query: 261  HVRDGFSPQTNIVRENGHRGVLMSVLKNGSASTLSIVNTLHGLLPAARAALPPDLKITAL 320
             + D  +    +   N  + V ++       +  ++   L  L   A+  LP D+ ++  
Sbjct: 785  RI-DEVASAIRLAHYNKQKSVTITA---NLEAGYTLGQALDFLDQKAQEILPNDISVSYS 840

Query: 321  FDQSVFVKAAVQGVVREAVVAAALTAAMILLF--LGNWRSTCIIAISIPLSILSSLIALH 378
             +   F +      +   V A AL  A ++L     ++ +  ++ +++P+ +    + L 
Sbjct: 841  GESKDFKENQSSVAI---VFALALLVAYLVLAAQFESFINPLVVMLTVPMGVFGGFLGLF 897

Query: 379  ALGQTINIMTLGGLALAVGILVDDATVTIENIERHLHMGTNLHDAILEGAGEIAIPALVS 438
             +GQ +NI +  G+ + +G++  +  + +E   +    G     AI++ +     P L++
Sbjct: 898  VMGQGMNIYSQIGMIMLIGMVTKNGILIVEFANQLRDRGVEFEKAIIDASARRLRPILMT 957

Query: 439  TLCICIVFVPMFFLTGVARYLFVPLAEAVVFAMLASYVLSRTLVPTLAMLLMGHAHKP 496
                    +P+   TG      + +   + F M  + +++  ++P +  L+ G    P
Sbjct: 958  AFTTLAGSIPLIVSTGAGYESRIAVGTVIFFGMGFATLVTLLVIPAMYRLISGSTQAP 1015